{"id":23504,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23504"},"modified":"2025-10-22T17:00:59","modified_gmt":"2025-10-22T17:00:59","slug":"5-%d9%85%d9%8a%d9%88-%d8%af%d9%8a-%d8%a5%d9%85-%d8%aa%d9%8a-%d9%87%d9%8a%d8%af%d8%b1%d9%88%d9%83%d9%84%d9%88%d8%b1%d9%8a%d8%af","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/ar\/%d9%85%d9%86%d8%aa%d8%ac\/5-%d9%85%d9%8a%d9%88-%d8%af%d9%8a-%d8%a5%d9%85-%d8%aa%d9%8a-%d9%87%d9%8a%d8%af%d8%b1%d9%88%d9%83%d9%84%d9%88%d8%b1%d9%8a%d8%af\/","title":{"rendered":"\u0647\u064a\u062f\u0631\u0648\u0643\u0644\u0648\u0631\u064a\u062f 5-MeO-DMT"},"content":{"rendered":"

5-MeO-DMT Hydrochloride \u2013 Scientific Product Documentation<\/span><\/span><\/strong><\/h3>\n

\u0627\u0644\u0648\u0635\u0641 \u0627\u0644\u0639\u0627\u0645<\/span><\/span><\/strong><\/h4>\n

5-MeO-DMT hydrochloride (5-Methoxy-N,N-dimethyltryptamine HCl) is a water-soluble salt of classical tryptamine, particularly suitable for pharmacological research due to its increased stability and bioavailability compared to the freebase form.<\/span><\/span><\/p>\n

\n

\u0627\u0644\u0645\u0648\u0627\u0635\u0641\u0627\u062a \u0627\u0644\u0641\u0646\u064a\u0629<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
\u0627\u0644\u0645\u0639\u0644\u0645\u0629<\/span><\/span><\/strong><\/th>\n\u0645\u0648\u0627\u0635\u0641\u0629<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
Chemical Formula<\/span><\/span><\/strong><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O \u00b7 HCl<\/span><\/span><\/td>\n<\/tr>\n
Molecular Weight<\/span><\/span><\/strong><\/td>\n254.75 \u062c\u0645\/\u0645\u0648\u0644<\/span><\/span><\/td>\n<\/tr>\n
\u0646\u0642\u0627\u0621<\/span><\/span><\/strong><\/td>\n\u226598% (analyzed by HPLC-UV)<\/span><\/span><\/td>\n<\/tr>\n
\u0645\u0638\u0647\u0631<\/span><\/span><\/strong><\/td>\n\u0645\u0633\u062d\u0648\u0642 \u0628\u0644\u0648\u0631\u064a \u0623\u0628\u064a\u0636 \u0625\u0644\u0649 \u0623\u0635\u0641\u0631 \u0641\u0627\u062a\u062d<\/span><\/span><\/td>\n<\/tr>\n
\u0627\u0644\u0630\u0648\u0628\u0627\u0646\u064a\u0629<\/span><\/span><\/strong><\/td>\nHigh in water (>50 mg\/ml), methanol, PBS<\/span><\/span><\/td>\n<\/tr>\n
\u0646\u0642\u0637\u0629 \u0627\u0644\u0627\u0646\u0635\u0647\u0627\u0631<\/span><\/span><\/strong><\/td>\n243-247\u00b0C (decomposes)<\/span><\/span><\/td>\n<\/tr>\n
\u0627\u0633\u062a\u0642\u0631\u0627\u0631<\/span><\/span><\/strong><\/td>\nHygroscopic; store in dry conditions<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

\u0627\u0644\u062a\u0637\u0628\u064a\u0642\u0627\u062a \u0627\u0644\u0639\u0644\u0645\u064a\u0629<\/span><\/span><\/strong><\/h3>\n

1. Neuropharmacology & Behavioral Research<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    Serotonin receptor studies:<\/span><\/span><\/strong> \u00a0Potent 5-HT\u2081\u2090\/\u2082\u2090 agonist with rapid cerebral penetration.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Animal experiments (in vivo):<\/span><\/span><\/strong> \u00a0Behavioural paradigms (e.g. head-twitch response in rodents).<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Electrophysiology:<\/span><\/span><\/strong> \u00a0Effects on neuronal oscillations (e.g., gamma-band activity).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. Biochemical & Molecular Studies<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      Intracellular signaling:<\/span><\/span><\/strong> \u00a0cAMP accumulation and \u03b2-arrestin recruitment assays.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Enzyme kinetics:<\/span><\/span><\/strong> \u00a0MAO-A metabolism (IC\u2085\u2080 ~2-5 \u03bcM).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. Clinically Relevant Research<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        Dose-response relationships:<\/span><\/span><\/strong> \u00a0Preclinical safety profiling.<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Comparative pharmacology:<\/span><\/span><\/strong> \u00a0Towards psilocybin, DMT, and other tryptamines.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Experimental Guidelines<\/span><\/span><\/strong><\/h3>\n

        Recommended Concentrations<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        \u0637\u0644\u0628<\/span><\/span><\/strong><\/th>\nConcentration range<\/span><\/span><\/strong><\/th>\n\u0645\u0630\u064a\u0628<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
        Cell cultures (in vitro)<\/span><\/span><\/td>\n1 \u0646\u0627\u0646\u0648\u0645\u0648\u0644 \u2013 10 \u0645\u064a\u0643\u0631\u0648\u0645\u0648\u0644<\/span><\/span><\/td>\nPBS\/DMEM (\u22640.1% DMSO)<\/span><\/span><\/td>\n<\/tr>\n
        Receptor assays<\/span><\/span><\/td>\n0.1 \u2013 100 \u0645\u064a\u0643\u0631\u0648\u0645\u062a\u0631<\/span><\/span><\/td>\n\u0645\u062d\u0644\u0648\u0644 \u0645\u0646\u0638\u0645 Tris-HCl (\u062f\u0631\u062c\u0629 \u0627\u0644\u062d\u0645\u0648\u0636\u0629 7.4)<\/span><\/span><\/td>\n<\/tr>\n
        Animal studies (ip\/iv)<\/span><\/span><\/td>\n0.1 \u2013 5 \u0645\u0644\u063a\/\u0643\u063a<\/span><\/span><\/td>\nSterile saline solution<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        \u0625\u062c\u0631\u0627\u0621\u0627\u062a \u0627\u0644\u0633\u0644\u0627\u0645\u0629<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          \u0627\u0644\u062d\u0645\u0627\u064a\u0629 \u0627\u0644\u0634\u062e\u0635\u064a\u0629:<\/span><\/span><\/strong> \u00a0Lab coat, gloves (nitrile), safety glasses.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          \u0627\u0644\u062a\u0639\u0627\u0645\u0644:<\/span><\/span><\/strong> \u00a0Hygroscopic \u2013 close promptly after use.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          \u062a\u062e\u0632\u064a\u0646:<\/span><\/span><\/strong> \u00a0Airtight, under argon, at -20\u00b0C (prevent hydrolysis).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Stability & Storage<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            \u0645\u062f\u0629 \u0627\u0644\u0635\u0644\u0627\u062d\u064a\u0629:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              -20 \u062f\u0631\u062c\u0629 \u0645\u0626\u0648\u064a\u0629:<\/span><\/span><\/strong> \u00a0>2 years (unchanged purity).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4 \u062f\u0631\u062c\u0629 \u0645\u0626\u0648\u064a\u0629:<\/span><\/span><\/strong> \u00a06 months (in dry environment).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              Relegation:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Hydrolysis on prolonged exposure to moisture (monitor by HPLC).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Analytical Validation<\/span><\/span><\/strong><\/h3>\n

                \u0643\u0644 \u062f\u0641\u0639\u0629 \u062a\u0623\u062a\u064a \u0645\u0639:<\/span><\/span><\/p>\n

                  \n
                1. \n

                  \u0643\u0631\u0648\u0645\u0627\u062a\u0648\u063a\u0631\u0627\u0645 HPLC-UV<\/span><\/span><\/strong> \u00a0(C18 column, retention time ~6.2 min).<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  MS\/MS fragmentation<\/span><\/span><\/strong> \u00a0(characteristic ions: m\/z 219 \u2192 174, 160).<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  \u0627\u0644\u0645\u0630\u064a\u0628\u0627\u062a \u0627\u0644\u0645\u062a\u0628\u0642\u064a\u0629<\/span><\/span><\/strong> \u00a0(meet ICH Q3C guidelines).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  Legal Status (Netherlands\/EU)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    Narcotics legislation:<\/span><\/span><\/strong> \u00a0Not explicitly mentioned in the Opium Act, but possibly under analogous legislation (Appendix II).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Scientific use:<\/span><\/span><\/strong> \u00a0Permit required for institutions (CCMO approval for animal testing).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    \u0627\u0644\u0631\u0642\u0627\u0628\u0629 \u0639\u0644\u0649 \u0627\u0644\u0635\u0627\u062f\u0631\u0627\u062a:<\/span><\/span><\/strong> \u00a0Subject to EU Regulation 2019\/1998 (psychotropic substances).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    \u0627\u0644\u0623\u0633\u0626\u0644\u0629 \u0627\u0644\u0634\u0627\u0626\u0639\u0629<\/span><\/span><\/strong><\/h3>\n

                    Q1 <\/span>: What are the advantages of HCl over freebase?<\/span><\/strong><\/span><\/p>\n

                      \n
                    • \n

                      Improved solubility<\/span><\/span><\/strong> \u00a0(ideal for injection studies).<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Longer shelf stability<\/span><\/span><\/strong> \u00a0at room temperature.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      Q2: Is 5-MeO-DMT-HCl detectable in drug tests?<\/span><\/span><\/strong>
                      \n A: Yes, via:<\/span><\/span><\/p>\n

                        \n
                      • \n

                        LC-MS\/MS<\/span><\/span><\/strong> \u00a0(recognized as 5-MeO-DMT + HCl adduct).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629:<\/span><\/span><\/strong> \u00a0Cross-reactivity with DMT (~15-20%).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        Q3: Are there risks when combining with MAO inhibitors?<\/span><\/span><\/strong>
                        \n \u0623:\u00a0 <\/span><\/span>Absolutely.<\/span><\/span><\/strong><\/p>\n

                          \n
                        • \n

                          Increased risk of\u00a0 <\/span><\/span>serotonin syndrome<\/span><\/span><\/strong> \u00a0(avoid combination!).<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Use only in MAO-free models.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          Q4: How to dispose of waste?<\/span><\/span><\/strong>
                          \n \u0623:<\/span><\/span><\/p>\n

                            \n
                          1. \n

                            Neutralize with\u00a0 <\/span><\/span>sodium bicarbonate<\/span><\/span><\/strong> \u00a0(\u062f\u0631\u062c\u0629 \u0627\u0644\u062d\u0645\u0648\u0636\u0629 7-8).<\/span><\/span><\/p>\n<\/li>\n

                          2. \n

                            Adsorb with\u00a0 <\/span><\/span>activated carbon<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n<\/li>\n

                          3. \n

                            Dispose of as\u00a0 <\/span><\/span>hazardous chemical waste<\/span><\/span><\/strong> \u00a0(UN 3249, Class 6.1).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                            \n

                            References & Contact<\/span><\/span><\/strong><\/h3>\n

                            Core literature:<\/span><\/span><\/strong><\/p>\n

                              \n
                            1. \n

                              \u0634\u064a\u0646 \u0648\u0622\u062e\u0631\u0648\u0646 (2010). "\u0639\u0644\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0644\u0645\u0634\u062a\u0642\u0627\u062a 5-MeO-DMT".\u00a0 <\/span><\/span>\u0645\u062c\u0644\u0629 \u0639\u0644\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0646\u0641\u0633\u064a\u0629<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n

                            2. \n

                              \u0643\u0627\u0633\u064a\u0643 \u0648\u0622\u062e\u0631\u0648\u0646 (2021). "\u0627\u0644\u0645\u0633\u0627\u0631\u0627\u062a \u0627\u0644\u0623\u064a\u0636\u064a\u0629 \u0644\u0640 5-MeO-DMT".\u00a0 <\/span><\/span>Xenobiotics<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                              \n

                              This product is intended only for authorized scientific research. Not for human consumption or diagnostic use. Please observe local regulations.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                              5-MeO-DMT hydrochloride properties<\/span><\/span><\/span><\/h3>\n

                              \u0645\u0631\u0627\u062f\u0641:<\/span><\/span><\/strong> 5-\u0645\u064a\u062b\u0648\u0643\u0633\u064a-N\u060cN-\u062b\u0646\u0627\u0626\u064a \u0645\u064a\u062b\u064a\u0644 \u062a\u0631\u064a\u0628\u062a\u0627\u0645\u064a\u0646 \u0647\u064a\u062f\u0631\u0648\u0643\u0644\u0648\u0631\u064a\u062f <\/span><\/span>
                              \n\u0631\u0642\u0645 CAS:<\/span><\/span><\/strong> \u0628\u0639\u062f <\/span><\/span>
                              \n\u0635\u064a\u063a\u0629:<\/span><\/span><\/strong> 3-[2-(\u062b\u0646\u0627\u0626\u064a \u0645\u064a\u062b\u064a\u0644 \u0623\u0645\u064a\u0646\u0648)\u0625\u064a\u062b\u064a\u0644]-5-\u0645\u064a\u062b\u0648\u0643\u0633\u064a \u0625\u0646\u062f\u0648\u0644 \u0647\u064a\u062f\u0631\u0648\u0643\u0644\u0648\u0631\u064a\u062f <\/span><\/span>
                              \n\u0627\u0644\u0643\u062a\u0644\u0629 \u0627\u0644\u0645\u0648\u0644\u064a\u0629:<\/span><\/span><\/strong> 254.8 \u062c\u0645\/\u0645\u0648\u0644 <\/span><\/span>
                              \n\u0646\u0642\u0627\u0621:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>","protected":false},"featured_media":28720,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[511,381],"product_tag":[326],"class_list":{"0":"post-23504","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-5-meo-dmt-kopen","7":"product_cat-tryptamines","8":"product_tag-nl","10":"first","11":"instock","12":"taxable","13":"shipping-taxable","14":"purchasable","15":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/ar\/wp-json\/wp\/v2\/product\/23504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/ar\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/ar\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/ar\/wp-json\/wp\/v2\/comments?post=23504"}],"version-history":[{"count":6,"href":"https:\/\/researchchemicalstore.eu\/ar\/wp-json\/wp\/v2\/product\/23504\/revisions"}],"predecessor-version":[{"id":28467,"href":"https:\/\/researchchemicalstore.eu\/ar\/wp-json\/wp\/v2\/product\/23504\/revisions\/28467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/ar\/wp-json\/wp\/v2\/media\/28720"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/ar\/wp-json\/wp\/v2\/media?parent=23504"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/ar\/wp-json\/wp\/v2\/product_brand?post=23504"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/ar\/wp-json\/wp\/v2\/product_cat?post=23504"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/ar\/wp-json\/wp\/v2\/product_tag?post=23504"}],"curies":[{"name":"\u0648\u0648\u0631\u062f\u0628\u0631\u064a\u0633","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}