{"id":23378,"date":"2025-04-13T17:39:38","date_gmt":"2025-04-13T17:39:38","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23378"},"modified":"2025-10-23T01:13:38","modified_gmt":"2025-10-23T01:13:38","slug":"eskalin-hydrochlorid","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/cs\/produkt\/eskalin-hydrochlorid\/","title":{"rendered":"Eskalin hydrochlorid"},"content":{"rendered":"

Eskalin hydrochlorid \u2013 v\u011bdeck\u00e1 dokumentace k produktu<\/strong><\/h3>\n

\ud83d\udd2c Chemick\u00e9 specifikace<\/strong><\/h4>\n

Eskalin (4-ethoxy-3,5-dimethoxyfenethylamin) hydrochlorid je polosyntetick\u00fd deriv\u00e1t fenethylaminu strukturn\u011b podobn\u00fd meskalinu. Tato v\u00fdzkumn\u00e1 slou\u010denina je studov\u00e1na pro sv\u016fj zaj\u00edmav\u00fd farmakologick\u00fd profil.<\/p>\n

Z\u00e1kladn\u00ed parametry:<\/em><\/p>\n

    \n
  • \n

    N\u00e1zev IUPAC<\/strong>2-(4-ethoxy-3,5-dimethoxyfenyl)ethan-1-amin hydrochlorid<\/p>\n<\/li>\n

  • \n

    Molekul\u00e1rn\u00ed vzorec<\/strong>C\u2081\u2082H\u2081\u2089NO\u2083 \u00b7 HCl<\/p>\n<\/li>\n

  • \n

    Molekulov\u00e1 hmotnost<\/strong>: 261,75 g\/mol<\/p>\n<\/li>\n

  • \n

    \u010cistota<\/strong>: \u226598% (HPLC-UV p\u0159i 280 nm)<\/p>\n<\/li>\n

  • \n

    Formul\u00e1\u0159<\/strong>B\u00edl\u00fd krystalick\u00fd pr\u00e1\u0161ek<\/p>\n<\/li>\n

  • \n

    Bod t\u00e1n\u00ed<\/strong>: 243\u2013245 \u00b0C (rozkl\u00e1d\u00e1 se)<\/p>\n<\/li>\n

  • \n

    Rozpustnost<\/strong>50 mg\/ml ve vod\u011b, 30 mg\/ml v methanolu<\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddea V\u011bdeck\u00e9 aplikace<\/strong><\/h4>\n
      \n
    1. \n

      Neurofarmakologick\u00fd v\u00fdzkum<\/strong>:<\/p>\n

        \n
      • \n

        Studie vazby na receptor 5-HT\u2082A (Ki = 120 nM)<\/p>\n<\/li>\n

      • \n

        Srovn\u00e1vac\u00ed studie meskalinu a dal\u0161\u00edch fenethylamin\u016f<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Behavior\u00e1ln\u00ed v\u00fdzkum<\/strong>:<\/p>\n

          \n
        • \n

          Vlivy na chov\u00e1n\u00ed zv\u00ed\u0159at v kontrolovan\u00e9m prost\u0159ed\u00ed<\/p>\n<\/li>\n

        • \n

          Vztahy mezi d\u00e1vkou a odpov\u011bd\u00ed v sav\u010d\u00edch modelech<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

        • \n

          Metabolick\u00e9 studie<\/strong>:<\/p>\n

            \n
          • \n

            Studie kinetiky O-dealkylace<\/p>\n<\/li>\n

          • \n

            Profil interakce s CYP2D6<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0f Doporu\u010den\u00e9 d\u00e1vkov\u00e1n\u00ed pro v\u00fdzkum<\/strong><\/h4>\n

            Experiment\u00e1ln\u00ed pokyny:<\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Model<\/th>\nD\u00e1vkov\u00e1n\u00ed<\/th>\nAdministrativn\u00ed silnice<\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/td>\n10\u2013100 \u03bcM<\/td>\nM\u00e9dium pro bun\u011b\u010dn\u00e9 kultury<\/td>\n<\/tr>\n
            Mal\u00e1 zv\u00ed\u0159ata<\/td>\n1\u20135 mg\/kg<\/td>\nIntraperitone\u00e1ln\u00ed<\/td>\n<\/tr>\n
            Prim\u00e1ti<\/td>\n0,2\u20131 mg\/kg<\/td>\n\u00dastn\u00ed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Pozn\u00e1mka: \u00da\u010dinky z\u00e1visl\u00e9 na d\u00e1vce nad 3 mg\/kg*<\/p>\n

            \u26a0\ufe0f Bezpe\u010dnostn\u00ed aspekty a rizika<\/strong><\/h4>\n
              \n
            1. \n

              Toxikologick\u00e9 \u00fadaje<\/strong>:<\/p>\n

                \n
              • \n

                LD\u2085\u2080 (my\u0161, i.v.): 185 mg\/kg<\/p>\n<\/li>\n

              • \n

                NOAEL: 0,75 mg\/kg\/den (28denn\u00ed studie)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

              • \n

                Profil ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f<\/strong>:<\/p>\n

                  \n
                • \n

                  <2 mg\/kg: Minim\u00e1ln\u00ed fyziologick\u00e9 \u00fa\u010dinky<\/p>\n<\/li>\n

                • \n

                  2\u20136 mg\/kg: Senzorick\u00e1 modulace<\/p>\n<\/li>\n

                • \n
                  \n

                  6 mg\/kg: Potenci\u00e1ln\u00ed hemodynamick\u00e9 \u00fa\u010dinky<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

                • \n

                  Kritick\u00e9 interakce<\/strong>:<\/p>\n

                    \n
                  • \n

                    Nebezpe\u010dn\u00fd<\/strong>Inhibitory MAO, serotonergn\u00ed l\u00e1tky<\/p>\n<\/li>\n

                  • \n

                    Riskantn\u00ed<\/strong>Vazokonstriktory, antipsychotika<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udcca Kontrola kvality a analytick\u00e1 data<\/strong><\/h4>\n
                      \n
                    • \n

                      \u010cistota HPLC<\/strong>98,2% (kolona C18, 60:40 H\u2082O:MeCN)<\/p>\n<\/li>\n

                    • \n

                      Zbytkov\u00e1 rozpou\u0161t\u011bdla<\/strong><0,1% (GC-MS)<\/p>\n<\/li>\n

                    • \n

                      \u00dadaje o stabilit\u011b<\/strong>:<\/p>\n

                        \n
                      • \n

                        Trvanlivost: 24 m\u011bs\u00edc\u016f p\u0159i -20 \u00b0C<\/p>\n<\/li>\n

                      • \n

                        Pokojov\u00e1 teplota: 6 m\u011bs\u00edc\u016f (pod argonem)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753 \u010casto kladen\u00e9 v\u00fdzkumn\u00e9 ot\u00e1zky<\/strong><\/h4>\n

                        Ot\u00e1zka 1: Jak\u00fd je mechanismus \u00fa\u010dinku?<\/strong>
                        \nA: Prim\u00e1rn\u00ed \u00fa\u010dinek jako agonista receptoru 5-HT\u2082A se sekund\u00e1rn\u00edmi \u00fa\u010dinky na dopaminergn\u00ed syst\u00e9my.<\/p>\n

                        Ot\u00e1zka 2: Jak\u00e1 je \u00fa\u010dinnost v porovn\u00e1n\u00ed s meskalinem?<\/strong>
                        \nA: P\u0159ibli\u017en\u011b 1,5kr\u00e1t vy\u0161\u0161\u00ed afinita k receptoru, ale del\u0161\u00ed doba \u00fa\u010dinku (8\u201310 hodin).<\/p>\n

                        Q3: Jak\u00e9 jsou optim\u00e1ln\u00ed skladovac\u00ed podm\u00ednky?<\/strong>
                        \nA: V jantarov\u00fdch lahvi\u010dk\u00e1ch pod inertn\u00edm plynem p\u0159i -20 \u00b0C.<\/p>\n

                        Ot\u00e1zka 4: Existuj\u00ed genotoxick\u00e1 rizika?<\/strong>
                        \nA: Ames\u016fv test negativn\u00ed p\u0159i <1 mM, ale omezen\u00e1 data z chromozom\u00e1ln\u00edch test\u016f.<\/p>\n

                        \ud83d\udccc Omezen\u00ed v\u00fdzkumu<\/strong><\/h4>\n
                          \n
                        • \n

                          Omezen\u00e9 \u00fadaje o chronick\u00e9 expozici<\/p>\n<\/li>\n

                        • \n

                          Nezn\u00e1m\u00e9 \u00fa\u010dinky na neuroplasticitu<\/p>\n<\/li>\n

                        • \n

                          Variabiln\u00ed mezidruhov\u00fd metabolismus<\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0d Z\u00e1v\u011br pro v\u011bdce<\/strong><\/h4>\n

                          Eskalin hydrochlorid nab\u00edz\u00ed cenn\u00e9 p\u0159\u00edle\u017eitosti pro srovn\u00e1vac\u00ed serotoninergn\u00ed v\u00fdzkum d\u00edky jedine\u010dn\u00e9 kombinaci stability a trv\u00e1n\u00ed \u00fa\u010dinku. Hydrochloridov\u00e1 forma zaji\u0161\u0165uje vynikaj\u00edc\u00ed rozpustnost pro laboratorn\u00ed aplikace.<\/p>\n

                          D\u016fle\u017eit\u00e9 upozorn\u011bn\u00ed: Tento produkt je ur\u010den pouze pro v\u011bdeck\u00fd v\u00fdzkum v akreditovan\u00fdch laborato\u0159\u00edch. Nen\u00ed ur\u010den pro pou\u017eit\u00ed u lid\u00ed ani pro diagnostick\u00e9 aplikace. Ve\u0161ker\u00e9 experimenty mus\u00ed b\u00fdt prov\u00e1d\u011bny v souladu s m\u00edstn\u00edmi p\u0159edpisy a etick\u00fdmi pokyny.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Vlastnosti eskalin hydrochloridu<\/span><\/h3>\n

                          Synonymum:<\/strong> 3,5-dimethoxy-4-ethoxyfenethylamin hydrochlorid
                          \n\u010c\u00edslo CAS:<\/strong> 39201-82-6
                          \nVzorec:<\/strong> 2-{3,5-dimethoxy-4-ethyloxyfenyl}ethan-1-amin hydrochlorid
                          \nMol\u00e1rn\u00ed hmotnost:<\/strong> 261,8 g\/mol
                          \n\u010cistota:<\/strong> >97%<\/p>","protected":false},"featured_media":28777,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,535,80],"product_tag":[326],"class_list":{"0":"post-23378","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-escaline","8":"product_cat-fenethylamine","9":"product_tag-nl","11":"first","12":"instock","13":"taxable","14":"shipping-taxable","15":"purchasable","16":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product\/23378","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/comments?post=23378"}],"version-history":[{"count":4,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product\/23378\/revisions"}],"predecessor-version":[{"id":26546,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product\/23378\/revisions\/26546"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/media\/28777"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/media?parent=23378"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product_brand?post=23378"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product_cat?post=23378"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product_tag?post=23378"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}