{"id":23388,"date":"2025-04-13T17:39:41","date_gmt":"2025-04-13T17:39:41","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23388"},"modified":"2025-10-23T01:05:10","modified_gmt":"2025-10-23T01:05:10","slug":"metallyleskalin-fumarat","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/cs\/produkt\/metallyleskalin-fumarat\/","title":{"rendered":"Metallyleskalin fumar\u00e1t"},"content":{"rendered":"

Metallyleskalinfumar\u00e1t \u2013 v\u011bdeck\u00e1 dokumentace k produktu<\/span><\/span><\/strong><\/h3>\n

\ud83d\udd2cChemick\u00e9 specifikace<\/span><\/span><\/strong><\/h4>\n

Metallyleskalin (MAL, 3,5-dimethoxy-4-(2-methylallyloxy)fenethylamin)fumar\u00e1t je polosyntetick\u00fd deriv\u00e1t fenethylaminu strukturn\u011b podobn\u00fd meskalinu. Tato v\u00fdzkumn\u00e1 slou\u010denina je studov\u00e1na pro sv\u00e9 jedine\u010dn\u00e9 farmakologick\u00e9 vlastnosti.<\/span><\/span><\/p>\n

Z\u00e1kladn\u00ed parametry:<\/span><\/span><\/em><\/p>\n

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  • \n

    N\u00e1zev IUPAC<\/span><\/span><\/strong> 2-(3,5-dimethoxy-4-[(2-methylprop-2-en-1-yl)oxy]fenyl)ethan-1-aminu fumar\u00e1t<\/span><\/span><\/p>\n<\/li>\n

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    Molekul\u00e1rn\u00ed vzorec<\/span><\/span><\/strong> C\u2081\u2084H\u2082\u2081NO\u2083 \u00b7 C\u2084H\u2084O\u2084<\/span><\/span><\/p>\n<\/li>\n

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    Molekulov\u00e1 hmotnost<\/span><\/span><\/strong> : 351,38 g\/mol<\/span><\/span><\/p>\n<\/li>\n

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    \u010cistota<\/span><\/span><\/strong> : \u226597% (HPLC-UV p\u0159i 280 nm)<\/span><\/span><\/p>\n<\/li>\n

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    Vzhled<\/span><\/span><\/strong> B\u00edl\u00fd a\u017e sv\u011btle b\u00e9\u017eov\u00fd krystalick\u00fd pr\u00e1\u0161ek<\/span><\/span><\/p>\n<\/li>\n

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    Bod t\u00e1n\u00ed<\/span><\/span><\/strong> : 158\u2013160 \u00b0C (rozkl\u00e1d\u00e1 se)<\/span><\/span><\/p>\n<\/li>\n

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    Rozpustnost<\/span><\/span><\/strong> 12 mg\/ml ve vod\u011b, 25 mg\/ml v ethanolu<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddeaV\u011bdeck\u00e9 aplikace<\/span><\/span><\/strong><\/h4>\n
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    1. \n

      Neurofarmakologick\u00fd v\u00fdzkum<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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      • \n

        Studie afinity k receptoru 5-HT\u2082A (Ki = 85 nM)<\/span><\/span><\/p>\n<\/li>\n

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        Srovn\u00e1vac\u00ed anal\u00fdzy s meskalinem a allyleskalinem<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Psychometrick\u00e1 hodnocen\u00ed<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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          Percep\u010dn\u00ed \u00fa\u010dinky v kontrolovan\u00fdch studi\u00edch na zv\u00ed\u0159atech<\/span><\/span><\/p>\n<\/li>\n

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          Vztahy mezi d\u00e1vkou a odpov\u011bd\u00ed v sav\u010d\u00edch modelech<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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          Metabolick\u00e9 studie<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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            Studie kinetiky O-demetylace<\/span><\/span><\/p>\n<\/li>\n

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            Profil interakce enzym\u016f CYP<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0fDoporu\u010den\u00e9 d\u00e1vkov\u00e1n\u00ed pro v\u00fdzkum<\/span><\/span><\/strong><\/h4>\n

            Experiment\u00e1ln\u00ed pokyny:<\/span><\/span><\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Model<\/span><\/span><\/th>\nD\u00e1vkov\u00e1n\u00ed<\/span><\/span><\/th>\nAdministrativn\u00ed silnice<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/span><\/span><\/td>\n5\u201350 \u03bcM<\/span><\/span><\/td>\nM\u00e9dium pro bun\u011b\u010dn\u00e9 kultury<\/span><\/span><\/td>\n<\/tr>\n
            Mal\u00e1 zv\u00ed\u0159ata<\/span><\/span><\/td>\n0,5\u20133 mg\/kg<\/span><\/span><\/td>\nIntraperitone\u00e1ln\u00ed<\/span><\/span><\/td>\n<\/tr>\n
            Prim\u00e1ti<\/span><\/span><\/td>\n0,1\u20130,4 mg\/kg<\/span><\/span><\/td>\n\u00dastn\u00ed<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Pozn\u00e1mka: Neline\u00e1rn\u00ed farmakokinetika nad 4 mg\/kg*<\/span><\/span><\/p>\n

            \u26a0\ufe0fBezpe\u010dnostn\u00ed aspekty a rizika<\/span><\/span><\/strong><\/h4>\n
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            1. \n

              Toxikologick\u00e9 \u00fadaje<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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              • \n

                LD\u2085\u2080 (krysa, or\u00e1ln\u011b): 290 mg\/kg<\/span><\/span><\/p>\n<\/li>\n

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                NOAEL: 0,5 mg\/kg\/den (14denn\u00ed studie)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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                Profil ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                • \n

                  <2 mg\/kg: Minim\u00e1ln\u00ed fyziologick\u00e9 \u00fa\u010dinky<\/span><\/span><\/p>\n<\/li>\n

                • \n

                  2\u20135 mg\/kg: Zv\u00fd\u0161en\u00e1 senzorick\u00e1 citlivost<\/span><\/span><\/p>\n<\/li>\n

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                  \n

                  5 mg\/kg: Potenci\u00e1ln\u00ed kardiovaskul\u00e1rn\u00ed \u00fa\u010dinky<\/span><\/span><\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

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                  Kritick\u00e9 interakce<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                    Nebezpe\u010dn\u00fd<\/span><\/span><\/strong> Inhibitory MAO, serotonergn\u00ed l\u00e1tky<\/span><\/span><\/p>\n<\/li>\n

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                    Riskantn\u00ed<\/span><\/span><\/strong> Antihypertenziva, l\u00e9ky prodlu\u017euj\u00edc\u00ed QT interval<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udccaKontrola kvality a analytick\u00e1 data<\/span><\/span><\/strong><\/h4>\n
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                    • \n

                      \u010cistota HPLC<\/span><\/span><\/strong> 97,3% (kolona C18, 65:35 H\u2082O:MeCN)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Zbytkov\u00e1 rozpou\u0161t\u011bdla<\/span><\/span><\/strong> <0,2% (GC-MS)<\/span><\/span><\/p>\n<\/li>\n

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                      \u00dadaje o stabilit\u011b<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                        Trvanlivost: 18 m\u011bs\u00edc\u016f p\u0159i -20 \u00b0C<\/span><\/span><\/p>\n<\/li>\n

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                        Pokojov\u00e1 teplota: 3 m\u011bs\u00edce (pod argonem)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753\u010casto kladen\u00e9 v\u00fdzkumn\u00e9 ot\u00e1zky<\/span><\/span><\/strong><\/h4>\n

                        Ot\u00e1zka 1: Jak\u00fd je mechanismus \u00fa\u010dinku?<\/span><\/span><\/strong>
                        \n A: Prim\u00e1rn\u00ed \u00fa\u010dinek jako agonista receptoru 5-HT\u2082A se sekund\u00e1rn\u00edmi \u00fa\u010dinky na dopaminergn\u00ed syst\u00e9my.<\/span><\/span><\/p>\n

                        Ot\u00e1zka 2: Jak\u00e1 je \u00fa\u010dinnost v porovn\u00e1n\u00ed s meskalinem?<\/span><\/span><\/strong>
                        \n A: ~2-3x vy\u0161\u0161\u00ed afinita k receptoru, ale krat\u0161\u00ed doba \u00fa\u010dinku (4-6 hodin).<\/span><\/span><\/p>\n

                        Q3: Jak\u00e9 jsou optim\u00e1ln\u00ed skladovac\u00ed podm\u00ednky?<\/span><\/span><\/strong>
                        \n A: V jantarov\u00fdch lahvi\u010dk\u00e1ch pod inertn\u00edm plynem p\u0159i -20 \u00b0C.<\/span><\/span><\/p>\n

                        Ot\u00e1zka 4: Existuj\u00ed genotoxick\u00e1 rizika?<\/span><\/span><\/strong>
                        \n A: Ames\u016fv test negativn\u00ed p\u0159i <500 \u03bcM, ale omezen\u00e1 data z chromozom\u00e1ln\u00edch test\u016f.<\/span><\/span><\/p>\n

                        \ud83d\udcccOmezen\u00ed v\u00fdzkumu<\/span><\/span><\/strong><\/h4>\n
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                          Omezen\u00e9 \u00fadaje o chronick\u00e9 expozici<\/span><\/span><\/p>\n<\/li>\n

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                          Nezn\u00e1m\u00e9 neuroplastick\u00e9 \u00fa\u010dinky<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Variabiln\u00ed mezidruhov\u00e1 farmakokinetika<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0dZ\u00e1v\u011br pro v\u011bdce<\/span><\/span><\/strong><\/h4>\n

                          Metallyleskalinfumar\u00e1t nab\u00edz\u00ed zaj\u00edmav\u00e9 mo\u017enosti pro srovn\u00e1vac\u00ed v\u00fdzkum serotoninu d\u00edky unik\u00e1tn\u00ed kombinaci vysok\u00e9 \u00fa\u010dinnosti a kr\u00e1tk\u00e9ho trv\u00e1n\u00ed \u00fa\u010dinku. Fumar\u00e1tov\u00e1 forma zaru\u010duje optim\u00e1ln\u00ed stabilitu pro laboratorn\u00ed aplikace.<\/span><\/span><\/p>\n

                          D\u016fle\u017eit\u00e9 upozorn\u011bn\u00ed: Tento produkt je ur\u010den v\u00fdhradn\u011b pro v\u011bdeck\u00fd v\u00fdzkum v akreditovan\u00fdch laborato\u0159\u00edch. Nen\u00ed ur\u010den pro pou\u017eit\u00ed u lid\u00ed ani pro diagnostick\u00e9 aplikace. Ve\u0161ker\u00e9 experimenty mus\u00ed b\u00fdt prov\u00e1d\u011bny v souladu s m\u00edstn\u00edmi p\u0159edpisy a etick\u00fdmi pokyny.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Vlastnosti metallyleskalinfumar\u00e1tu<\/span><\/span><\/span><\/span><\/span><\/h3>\n

                          Synonymum:<\/span><\/span><\/span><\/span><\/strong> 3,5-dimethoxy-4-methallyloxyfenethylamin fumar\u00e1t <\/span><\/span><\/span><\/span>
                          \n\u010c\u00edslo CAS:<\/span><\/span><\/span><\/span><\/strong> 207740-41-8 <\/span><\/span><\/span><\/span>
                          \nVzorec:<\/span><\/span><\/span><\/span><\/strong> 2-{3,5-dimethoxy-4-[(2-methylprop-2-en-1-yl)oxy]fenyl}ethan-1-amin fumar\u00e1t <\/span><\/span><\/span><\/span>
                          \nMol\u00e1rn\u00ed hmotnost:<\/span><\/span><\/span><\/span><\/strong> 367,4 g\/mol <\/span><\/span><\/span><\/span>
                          \n\u010cistota:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>","protected":false},"featured_media":28812,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,80,482,398],"product_tag":[326],"class_list":{"0":"post-23388","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-fenethylamine","8":"product_cat-methallylescaline","9":"product_cat-verkoop","10":"product_tag-nl","12":"first","13":"instock","14":"sale","15":"taxable","16":"shipping-taxable","17":"purchasable","18":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product\/23388","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/comments?post=23388"}],"version-history":[{"count":5,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product\/23388\/revisions"}],"predecessor-version":[{"id":28081,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product\/23388\/revisions\/28081"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/media\/28812"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/media?parent=23388"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product_brand?post=23388"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product_cat?post=23388"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product_tag?post=23388"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}