{"id":23399,"date":"2025-04-13T17:39:42","date_gmt":"2025-04-13T17:39:42","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23399"},"modified":"2025-10-23T00:56:39","modified_gmt":"2025-10-23T00:56:39","slug":"proskalin-fumarat","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/cs\/produkt\/proskalin-fumarat\/","title":{"rendered":"Proskalin fumar\u00e1t"},"content":{"rendered":"

Proskalin fumar\u00e1t \u2013 v\u011bdeck\u00e1 dokumentace k produktu<\/strong><\/h3>\n

\ud83d\udd2c Chemick\u00e9 specifikace<\/strong><\/h4>\n

Proskalin (4-propoxy-3,5-dimethoxyfenethylamin)fumar\u00e1t je polosyntetick\u00fd deriv\u00e1t fenethylaminu se strukturn\u00ed podobnost\u00ed s meskalinem. Tato v\u00fdzkumn\u00e1 slou\u010denina je studov\u00e1na pro sv\u016fj jedine\u010dn\u00fd profil interakce s receptory.<\/p>\n

Z\u00e1kladn\u00ed parametry:<\/em><\/p>\n

    \n
  • \n

    N\u00e1zev IUPAC<\/strong>2-(4-propoxy-3,5-dimethoxyfenyl)ethan-1-aminu fumar\u00e1t<\/p>\n<\/li>\n

  • \n

    Molekul\u00e1rn\u00ed vzorec<\/strong>C\u2081\u2083H\u2082\u2081NO\u2083 \u00b7 C\u2084H\u2084O\u2084<\/p>\n<\/li>\n

  • \n

    Molekulov\u00e1 hmotnost<\/strong>: 339,36 g\/mol<\/p>\n<\/li>\n

  • \n

    \u010cistota<\/strong>: \u226598% (HPLC-UV p\u0159i 254 nm)<\/p>\n<\/li>\n

  • \n

    Formul\u00e1\u0159<\/strong>B\u00edl\u00fd krystalick\u00fd pr\u00e1\u0161ek<\/p>\n<\/li>\n

  • \n

    Bod t\u00e1n\u00ed<\/strong>: 172\u2013174 \u00b0C (rozkl\u00e1d\u00e1 se)<\/p>\n<\/li>\n

  • \n

    Rozpustnost<\/strong>15 mg\/ml ve vod\u011b, 30 mg\/ml v tepl\u00e9m ethanolu<\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddeb V\u00fdzkumn\u00e9 aplikace<\/strong><\/h4>\n
      \n
    1. \n

      Studie vazby receptor\u016f<\/strong>:<\/p>\n

        \n
      • \n

        Agonismus 5-HT\u2082A receptoru (EC\u2085\u2080 = 280 nM)<\/p>\n<\/li>\n

      • \n

        V\u00fdzkum dopaminergn\u00ed modulace<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Neurofyziologick\u00fd v\u00fdzkum<\/strong>:<\/p>\n

          \n
        • \n

          Anal\u00fdza EEG vzor\u016f u laboratorn\u00edch zv\u00ed\u0159at<\/p>\n<\/li>\n

        • \n

          Srovn\u00e1vac\u00ed studie s klasick\u00fdmi psychedeliky<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

        • \n

          Anal\u00fdza metabolick\u00fdch drah<\/strong>:<\/p>\n

            \n
          • \n

            Kinetika O-demetylace<\/p>\n<\/li>\n

          • \n

            Profil interakce s CYP2D6<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2697\ufe0f Experiment\u00e1ln\u00ed protokoly<\/strong><\/h4>\n

            Standardn\u00ed v\u00fdzkumn\u00e9 podm\u00ednky:<\/em><\/p>\n

            \n\n\n\n\n\n\n
            Model<\/th>\nKoncentrace<\/th>\nDoba vystaven\u00ed<\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/td>\n10\u2013100 \u03bcM<\/td>\n15\u201360 minut<\/td>\n<\/tr>\n
            In vivo<\/td>\n1\u20135 mg\/kg<\/td>\nAkutn\u00ed\/chronick\u00e9<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Pozn\u00e1mka: Nad 8 mg\/kg vykazuje neline\u00e1rn\u00ed farmakokinetiku*<\/p>\n

            \u26a0\ufe0f Bezpe\u010dnostn\u00ed profil<\/strong><\/h4>\n
              \n
            1. \n

              Toxikologick\u00e9 \u00fadaje<\/strong>:<\/p>\n

                \n
              • \n

                LD\u2085\u2080 (krysa, or\u00e1ln\u011b): 320 mg\/kg<\/p>\n<\/li>\n

              • \n

                NOAEL: 0,75 mg\/kg\/den (28denn\u00ed studie)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

              • \n

                Spektrum vedlej\u0161\u00edch \u00fa\u010dink\u016f<\/strong>:<\/p>\n

                  \n
                • \n

                  \u00da\u010dinky z\u00e1visl\u00e9 na d\u00e1vce:<\/p>\n

                    \n
                  • \n

                    <3 mg\/kg: Jemn\u00e9 senzorick\u00e9 zm\u011bny<\/p>\n<\/li>\n

                  • \n

                    3\u20136 mg\/kg: Vegetativn\u00ed p\u0159\u00edznaky<\/p>\n<\/li>\n

                  • \n
                    \n

                    6 mg\/kg: Potenci\u00e1ln\u00ed hemodynamick\u00e1 nestabilita<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n

                  • \n

                    Kritick\u00e9 interakce<\/strong>:<\/p>\n

                      \n
                    • \n

                      Nebezpe\u010dn\u00fd<\/strong>Inhibitory MAO, sympatomimetika<\/p>\n<\/li>\n

                    • \n

                      Riskantn\u00ed<\/strong>Serotonergn\u00ed l\u00e1tky, vazopresory<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                      \ud83d\udcc9 \u00dadaje o stabilit\u011b<\/strong><\/h4>\n
                        \n
                      • \n

                        Trvanlivost<\/strong>24 m\u011bs\u00edc\u016f p\u0159i -20 \u00b0C (pod argonem)<\/p>\n<\/li>\n

                      • \n

                        Produkty degradace<\/strong><2% po 12 m\u011bs\u00edc\u00edch RT<\/p>\n<\/li>\n

                      • \n

                        Kompatibiln\u00ed vyrovn\u00e1vac\u00ed pam\u011bti<\/strong>PBS (pH 7,4), kyselina chlorovod\u00edkov\u00e1 (0,1N)<\/p>\n<\/li>\n<\/ul>\n

                        \ud83d\udd0d Analytick\u00e9 funkce<\/strong><\/h4>\n
                          \n
                        • \n

                          Reten\u010dn\u00ed \u010das HPLC<\/strong>: 6,8 min (C18, 70:30 H20:MeCN)<\/p>\n<\/li>\n

                        • \n

                          Hmotnostn\u00ed spektrum<\/strong>: [M+H]\u207a 240,2 m\/z<\/p>\n<\/li>\n

                        • \n

                          Absorpce UV z\u00e1\u0159en\u00ed<\/strong>\u03bbmax 282 nm (\u03b5 = 4200)<\/p>\n<\/li>\n<\/ul>\n

                          \u2753 \u010casto kladen\u00e9 ot\u00e1zky zam\u011b\u0159en\u00e9 na v\u00fdzkum<\/strong><\/h4>\n

                          Ot\u00e1zka 1: Jak\u00fd je mechanismus \u00fa\u010dinku?<\/strong>
                          \nA: Prim\u00e1rn\u00ed parci\u00e1ln\u00ed agonista receptoru 5-HT\u2082A se sekund\u00e1rn\u00ed interakc\u00ed DAT.<\/p>\n

                          Ot\u00e1zka 2: Jak\u00e1 je \u00fa\u010dinnost v porovn\u00e1n\u00ed s meskalinem?<\/strong>
                          \nA: ~3x vy\u0161\u0161\u00ed afinita k 5-HT\u2082A, ale ni\u017e\u0161\u00ed penetrace hematoencefalickou bari\u00e9rou.<\/p>\n

                          Ot\u00e1zka 3: Existuj\u00ed genotoxick\u00e1 rizika?<\/strong>
                          \nA: Ames\u016fv test negativn\u00ed do 1 mM, ale omezen\u00e1 data z chromozom\u00e1ln\u00edch test\u016f.<\/p>\n

                          Q4: Jak\u00e1 je optim\u00e1ln\u00ed formulace?<\/strong>
                          \nA: Steriln\u00ed fyziologick\u00fd roztok (0,9% NaCl) pro studie in vivo.<\/p>\n

                          \ud83d\udccc Omezen\u00ed v\u00fdzkumu<\/strong><\/h4>\n
                            \n
                          • \n

                            Omezen\u00e9 \u00fadaje o chronick\u00e9 expozici<\/p>\n<\/li>\n

                          • \n

                            Nezn\u00e1m\u00e9 neuroplastick\u00e9 \u00fa\u010dinky<\/p>\n<\/li>\n

                          • \n

                            Variabiln\u00ed mezidruhov\u00fd metabolismus<\/p>\n<\/li>\n<\/ul>\n

                            V\u011bdeck\u00e9 prohl\u00e1\u0161en\u00ed: Tento produkt je ur\u010den pouze pro v\u00fdzkumn\u00e9 pou\u017eit\u00ed v akreditovan\u00fdch laborato\u0159\u00edch. Nen\u00ed ur\u010den pro hum\u00e1nn\u00ed ani veterin\u00e1rn\u00ed pou\u017eit\u00ed. V\u0161echny experimenty mus\u00ed spl\u0148ovat p\u0159\u00edslu\u0161n\u00e9 bezpe\u010dnostn\u00ed a etick\u00e9 pokyny. Vezm\u011bte pros\u00edm na v\u011bdom\u00ed m\u00edstn\u00ed p\u0159edpisy t\u00fdkaj\u00edc\u00ed se psychoaktivn\u00edch l\u00e1tek pro v\u00fdzkum.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                            Proskalin fumar\u00e1t<\/span><\/span><\/h3>\n

                            Synonymum:<\/span><\/span><\/strong> 3,5-dimethoxy-4-propoxyfenethylamin fumar\u00e1t <\/span><\/span>
                            \n\u010c\u00edslo CAS:<\/span><\/span><\/strong> 39201-78-0 <\/span><\/span>
                            \nVzorec:<\/span><\/span><\/strong> 2-{3,5-dimethoxy-4-propyloxyfenyl}ethan-1-amin fumar\u00e1t <\/span><\/span>
                            \nMol\u00e1rn\u00ed hmotnost:<\/span><\/span><\/strong> 355,4 g\/mol <\/span><\/span>
                            \n\u010cistota:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>","protected":false},"featured_media":28847,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,80,536],"product_tag":[326],"class_list":{"0":"post-23399","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-fenethylamine","8":"product_cat-proscaline","9":"product_tag-nl","11":"first","12":"instock","13":"taxable","14":"shipping-taxable","15":"purchasable","16":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product\/23399","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/comments?post=23399"}],"version-history":[{"count":3,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product\/23399\/revisions"}],"predecessor-version":[{"id":26541,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product\/23399\/revisions\/26541"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/media\/28847"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/media?parent=23399"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product_brand?post=23399"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product_cat?post=23399"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product_tag?post=23399"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}