{"id":23504,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23504"},"modified":"2025-10-22T17:00:59","modified_gmt":"2025-10-22T17:00:59","slug":"5-meo-dmt-hydrochlorid","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/cs\/produkt\/5-meo-dmt-hydrochlorid\/","title":{"rendered":"5-MeO-DMT hydrochlorid"},"content":{"rendered":"

5-MeO-DMT hydrochlorid \u2013 v\u011bdeck\u00e1 dokumentace k produktu<\/span><\/span><\/strong><\/h3>\n

Obecn\u00fd popis<\/span><\/span><\/strong><\/h4>\n

5-MeO-DMT hydrochlorid (5-methoxy-N,N-dimethyltryptamin HCl) je ve vod\u011b rozpustn\u00e1 s\u016fl klasick\u00e9ho tryptaminu, obzvl\u00e1\u0161t\u011b vhodn\u00e1 pro farmakologick\u00fd v\u00fdzkum d\u00edky sv\u00e9 zv\u00fd\u0161en\u00e9 stabilit\u011b a biologick\u00e9 dostupnosti ve srovn\u00e1n\u00ed s volnou b\u00e1z\u00ed.<\/span><\/span><\/p>\n

\n

Technick\u00e9 specifikace<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Parametr<\/span><\/span><\/strong><\/th>\nSpecifikace<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
Chemick\u00fd vzorec<\/span><\/span><\/strong><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O \u00b7 HCl<\/span><\/span><\/td>\n<\/tr>\n
Molekulov\u00e1 hmotnost<\/span><\/span><\/strong><\/td>\n254,75 g\/mol<\/span><\/span><\/td>\n<\/tr>\n
\u010cistota<\/span><\/span><\/strong><\/td>\n\u226598% (analyzov\u00e1no pomoc\u00ed HPLC-UV)<\/span><\/span><\/td>\n<\/tr>\n
Vzhled<\/span><\/span><\/strong><\/td>\nB\u00edl\u00fd a\u017e sv\u011btle \u017elut\u00fd krystalick\u00fd pr\u00e1\u0161ek<\/span><\/span><\/td>\n<\/tr>\n
Rozpustnost<\/span><\/span><\/strong><\/td>\nVysok\u00fd obsah vody (>50 mg\/ml), methanolu, PBS<\/span><\/span><\/td>\n<\/tr>\n
Bod t\u00e1n\u00ed<\/span><\/span><\/strong><\/td>\n243\u2013247 \u00b0C (rozkl\u00e1d\u00e1 se)<\/span><\/span><\/td>\n<\/tr>\n
Stabilita<\/span><\/span><\/strong><\/td>\nHygroskopick\u00fd; skladujte v suchu<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

V\u011bdeck\u00e9 aplikace<\/span><\/span><\/strong><\/h3>\n

1. Neurofarmakologie a behavior\u00e1ln\u00ed v\u00fdzkum<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    Studie serotoninov\u00fdch receptor\u016f:<\/span><\/span><\/strong> \u00a0Siln\u00fd agonista 5-HT\u2081\u2090\/\u2082\u2090 receptor\u016f s rychlou penetrac\u00ed do mozku.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Pokusy na zv\u00ed\u0159atech (in vivo):<\/span><\/span><\/strong> \u00a0Behavior\u00e1ln\u00ed paradigmata (nap\u0159. reakce \u0161kubnut\u00edm hlavy u hlodavc\u016f).<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Elektrofyziologie:<\/span><\/span><\/strong> \u00a0Vlivy na neuron\u00e1ln\u00ed oscilace (nap\u0159. aktivita gama p\u00e1sma).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. Biochemick\u00e9 a molekul\u00e1rn\u00ed studie<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      Intracelul\u00e1rn\u00ed signalizace:<\/span><\/span><\/strong> \u00a0Testy akumulace cAMP a n\u00e1boru \u03b2-arestinu.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Kinetika enzym\u016f:<\/span><\/span><\/strong> \u00a0Metabolismus MAO-A (IC\u2085\u2080 ~2\u20135 \u03bcM).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. Klinicky relevantn\u00ed v\u00fdzkum<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        Vztah mezi d\u00e1vkou a odpov\u011bd\u00ed:<\/span><\/span><\/strong> \u00a0P\u0159edklinick\u00e9 bezpe\u010dnostn\u00ed profilov\u00e1n\u00ed.<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Srovn\u00e1vac\u00ed farmakologie:<\/span><\/span><\/strong> \u00a0Sm\u011brem k psilocybinu, DMT a dal\u0161\u00edm tryptamin\u016fm.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Experiment\u00e1ln\u00ed pokyny<\/span><\/span><\/strong><\/h3>\n

        Doporu\u010den\u00e9 koncentrace<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        Aplikace<\/span><\/span><\/strong><\/th>\nRozsah koncentrace<\/span><\/span><\/strong><\/th>\nRozpou\u0161t\u011bdlo<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
        Bun\u011b\u010dn\u00e9 kultury (in vitro)<\/span><\/span><\/td>\n1 nM \u2013 10 \u03bcM<\/span><\/span><\/td>\nPBS\/DMEM (\u22640,1% DMSO)<\/span><\/span><\/td>\n<\/tr>\n
        Receptorov\u00e9 testy<\/span><\/span><\/td>\n0,1 \u2013 100 \u03bcM<\/span><\/span><\/td>\nTris-HCl pufr (pH 7,4)<\/span><\/span><\/td>\n<\/tr>\n
        Studie na zv\u00ed\u0159atech (ip\/iv)<\/span><\/span><\/td>\n0,1 \u2013 5 mg\/kg<\/span><\/span><\/td>\nSteriln\u00ed fyziologick\u00fd roztok<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        Bezpe\u010dnostn\u00ed opat\u0159en\u00ed<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          Osobn\u00ed ochrana:<\/span><\/span><\/strong> \u00a0Laboratorn\u00ed pl\u00e1\u0161\u0165, rukavice (nitrilov\u00e9), ochrann\u00e9 br\u00fdle.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Zach\u00e1zen\u00ed:<\/span><\/span><\/strong> \u00a0Hygroskopick\u00e9 \u2013 po pou\u017eit\u00ed ihned uzav\u0159ete.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Skladov\u00e1n\u00ed:<\/span><\/span><\/strong> \u00a0Vzduchot\u011bsn\u00e9, pod argonem, p\u0159i teplot\u011b -20 \u00b0C (zabra\u0148te hydrol\u00fdze).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Stabilita a skladov\u00e1n\u00ed<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            Trvanlivost:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              -20 \u00b0C:<\/span><\/span><\/strong> \u00a0>2 roky (nezm\u011bn\u011bn\u00e1 \u010distota).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4 \u00b0C:<\/span><\/span><\/strong> \u00a06 m\u011bs\u00edc\u016f (v such\u00e9m prost\u0159ed\u00ed).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              Sestup:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Hydrol\u00fdza p\u0159i del\u0161\u00edm vystaven\u00ed vlhkosti (monitorov\u00e1no pomoc\u00ed HPLC).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Analytick\u00e1 validace<\/span><\/span><\/strong><\/h3>\n

                Ka\u017ed\u00e1 v\u00e1rka obsahuje:<\/span><\/span><\/p>\n

                  \n
                1. \n

                  HPLC-UV chromatogram<\/span><\/span><\/strong> \u00a0(Kolona C18, reten\u010dn\u00ed \u010das ~6,2 min).<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  Fragmentace MS\/MS<\/span><\/span><\/strong> \u00a0(charakteristick\u00e9 ionty: m\/z 219 \u2192 174, 160).<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  Zbytkov\u00e1 rozpou\u0161t\u011bdla<\/span><\/span><\/strong> \u00a0(spl\u0148uj\u00ed sm\u011brnice ICH Q3C).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  Pr\u00e1vn\u00ed status (Nizozemsko\/EU)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    Legislativa t\u00fdkaj\u00edc\u00ed se omamn\u00fdch l\u00e1tek:<\/span><\/span><\/strong> \u00a0Nen\u00ed v\u00fdslovn\u011b zm\u00edn\u011bno v z\u00e1kon\u011b o opiu, ale pravd\u011bpodobn\u011b v analogick\u00fdch pr\u00e1vn\u00edch p\u0159edpisech (p\u0159\u00edloha II).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    V\u011bdeck\u00e9 vyu\u017eit\u00ed:<\/span><\/span><\/strong> \u00a0Pro instituce je vy\u017eadov\u00e1no povolen\u00ed (schv\u00e1len\u00ed CCMO pro testov\u00e1n\u00ed na zv\u00ed\u0159atech).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Kontrola v\u00fdvozu:<\/span><\/span><\/strong> \u00a0Podl\u00e9h\u00e1 na\u0159\u00edzen\u00ed EU 2019\/1998 (psychotropn\u00ed l\u00e1tky).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    \u010casto kladen\u00e9 ot\u00e1zky (FAQ)<\/span><\/span><\/strong><\/h3>\n

                    Q1 <\/span>Jak\u00e9 jsou v\u00fdhody HCl oproti voln\u00e9 b\u00e1zi?<\/span><\/strong><\/span><\/p>\n

                      \n
                    • \n

                      Zlep\u0161en\u00e1 rozpustnost<\/span><\/span><\/strong> \u00a0(ide\u00e1ln\u00ed pro injek\u010dn\u00ed studie).<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Del\u0161\u00ed trvanlivost<\/span><\/span><\/strong> \u00a0p\u0159i pokojov\u00e9 teplot\u011b.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      Ot\u00e1zka 2: Je 5-MeO-DMT-HCl detekovateln\u00fd v testech na drogy?<\/span><\/span><\/strong>
                      \n A: Ano, prost\u0159ednictv\u00edm:<\/span><\/span><\/p>\n

                        \n
                      • \n

                        LC-MS\/MS<\/span><\/span><\/strong> \u00a0(rozpozn\u00e1n jako adukt 5-MeO-DMT + HCl).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Imunotesty:<\/span><\/span><\/strong> \u00a0Zk\u0159\u00ed\u017een\u00e1 reaktivita s DMT (~15-20%).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        Ot\u00e1zka 3: Existuj\u00ed ur\u010dit\u00e1 rizika p\u0159i kombinaci s inhibitory MAO?<\/span><\/span><\/strong>
                        \n A:\u00a0 <\/span><\/span>Absolutn\u011b.<\/span><\/span><\/strong><\/p>\n

                          \n
                        • \n

                          Zv\u00fd\u0161en\u00e9 riziko\u00a0 <\/span><\/span>serotoninov\u00fd syndrom<\/span><\/span><\/strong> \u00a0(vyhn\u011bte se kombinaci!).<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Pou\u017e\u00edvejte pouze v modelech bez MAO.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          Ot\u00e1zka 4: Jak se zbavit odpadu?<\/span><\/span><\/strong>
                          \n A:<\/span><\/span><\/p>\n

                            \n
                          1. \n

                            Neutralizovat pomoc\u00ed\u00a0 <\/span><\/span>hydrogenuhli\u010ditan sodn\u00fd<\/span><\/span><\/strong> \u00a0(pH 7\u20138).<\/span><\/span><\/p>\n<\/li>\n

                          2. \n

                            Adsorbovat s\u00a0 <\/span><\/span>aktivn\u00ed uhl\u00ed<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n<\/li>\n

                          3. \n

                            Zlikvidujte jako\u00a0 <\/span><\/span>nebezpe\u010dn\u00fd chemick\u00fd odpad<\/span><\/span><\/strong> \u00a0(UN 3249, t\u0159\u00edda 6.1).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                            \n

                            Reference a kontakt<\/span><\/span><\/strong><\/h3>\n

                            Z\u00e1kladn\u00ed literatura:<\/span><\/span><\/strong><\/p>\n

                              \n
                            1. \n

                              Shen a kol. (2010). \u201eFarmakologie deriv\u00e1t\u016f 5-MeO-DMT\u201c.\u00a0 <\/span><\/span>J Psychopharmacol<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n

                            2. \n

                              Kaasik a kol. (2021). \u201eMetabolick\u00e9 dr\u00e1hy 5-MeO-DMT\u201c.\u00a0 <\/span><\/span>Xenobiotika<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                              \n

                              Tento produkt je ur\u010den pouze pro autorizovan\u00fd v\u011bdeck\u00fd v\u00fdzkum. Nen\u00ed ur\u010den k lidsk\u00e9 spot\u0159eb\u011b ani k diagnostick\u00fdm \u00fa\u010del\u016fm. Dodr\u017eujte pros\u00edm m\u00edstn\u00ed p\u0159edpisy.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                              5-MeO-DMT hydrochloride properties<\/span><\/span><\/span><\/h3>\n

                              Synonym:<\/span><\/span><\/strong> 5-methoxy-N,N-dimethyltryptamine hydrochloride <\/span><\/span>
                              \nCAS Number:<\/span><\/span><\/strong> n\/a <\/span><\/span>
                              \nFormula:<\/span><\/span><\/strong> 3-[2-(dimethylamino)ethyl]-5-methoxyindole hydrochloride <\/span><\/span>
                              \nMolar mass:<\/span><\/span><\/strong> 254.8 g\/mol <\/span><\/span>
                              \nPurity:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>\n","protected":false},"featured_media":28720,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[511,381],"product_tag":[326],"class_list":["post-23504","product","type-product","status-publish","has-post-thumbnail","product_cat-5-meo-dmt-kopen","product_cat-tryptamines","product_tag-nl","first","instock","taxable","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product\/23504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/comments?post=23504"}],"version-history":[{"count":6,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product\/23504\/revisions"}],"predecessor-version":[{"id":28467,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product\/23504\/revisions\/28467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/media\/28720"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/media?parent=23504"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product_brand?post=23504"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product_cat?post=23504"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product_tag?post=23504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}