{"id":27437,"date":"2025-08-30T09:12:39","date_gmt":"2025-08-30T09:12:39","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&#038;p=27437"},"modified":"2025-11-17T11:48:53","modified_gmt":"2025-11-17T11:48:53","slug":"jjc8-089","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/cs\/produkt\/jjc8-089\/","title":{"rendered":"JJC8-089"},"content":{"rendered":"<p class=\"ds-markdown-paragraph\"><strong>JJC8-089: Siln\u00fd a selektivn\u00ed inhibitor DAT pro v\u00fdzkum motivace<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">JJC8-089 je potenci\u00e1ln\u00ed v\u00fdzkumn\u00e1 molekula speci\u00e1ln\u011b navr\u017een\u00e1 pro studium motivace a chov\u00e1n\u00ed souvisej\u00edc\u00edho s \u00fasil\u00edm. Jako selektivn\u00ed inhibitor dopaminov\u00e9ho transport\u00e9ru (DAT) zvy\u0161uje extracelul\u00e1rn\u00ed hladiny dopaminu v mozku.<\/p>\n<p class=\"ds-markdown-paragraph\">V preklinick\u00fdch modelech bylo prok\u00e1z\u00e1no, \u017ee JJC8-089 v\u00fdznamn\u011b zvr\u00e1t\u00ed motiva\u010dn\u00ed deficity vyvolan\u00e9 tetrabenazinem (inhibitor VMAT2). Obnovuje ochotu vynalo\u017eit vysok\u00e9 \u00fasil\u00ed (nap\u0159\u00edklad vybrat si \u00fakol s 5 stisknut\u00edmi tla\u010d\u00edtek) nam\u00edsto jednodu\u0161\u0161\u00ed a m\u00e9n\u011b uspokojiv\u00e9 mo\u017enosti. D\u00edky t\u011bmto vlastnostem je JJC8-089 (CAS \u010d. 1627576-64-0) cenn\u00fdm farmakologick\u00fdm n\u00e1strojem pro neurov\u011bdeck\u00fd v\u00fdzkum poruch, jako je deprese, apatie a \u00fanava.<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>Kl\u00ed\u010dov\u00e9 vlastnosti:<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Molekul\u00e1rn\u00ed vzorec:<\/strong>\u00a0C\u2082\u2082H\u2082\u2088F\u2082N\u2082OS<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Molekulov\u00e1 hmotnost:<\/strong>\u00a0406,53 g\/mol<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Prim\u00e1rn\u00ed mechanismus \u00fa\u010dinku:<\/strong>\u00a0Inhibice dopaminov\u00e9ho transport\u00e9ru (DAT)<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Hlavn\u00ed v\u00fdzkumn\u00e1 aplikace:<\/strong>\u00a0Studium motivace a chov\u00e1n\u00ed zam\u011b\u0159en\u00e9ho na \u00fasil\u00ed.<\/p>\n<\/li>\n<\/ul>\n<hr \/>\n<h3>Verze 2: Podrobn\u011bj\u0161\u00ed a popisn\u011bj\u0161\u00ed text (pro v\u011bdeckou bro\u017euru nebo technick\u00fd list)<\/h3>\n<p class=\"ds-markdown-paragraph\"><strong>N\u00e1zev: JJC8-089: Slibn\u00e1 n\u00e1strojov\u00e1 slou\u010denina pro studium motiva\u010dn\u00edch patologi\u00ed<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">JJC8-089 je syntetizovan\u00e1 slou\u010denina, kter\u00e1 hraje kl\u00ed\u010dovou roli v odhalov\u00e1n\u00ed neurobiologie motivace. Jej\u00edm prim\u00e1rn\u00edm mechanismem \u00fa\u010dinku je inhibice dopaminov\u00e9ho transport\u00e9ru (DAT), co\u017e vede ke zv\u00fd\u0161en\u00e9 dopaminergn\u00ed neurotransmisi v synaptick\u00e9 \u0161t\u011brbin\u011b. Tento \u00fa\u010dinek je kl\u00ed\u010dov\u00fd pro modulaci odm\u011bny, motivace a ochoty zapojit se do c\u00edlev\u011bdom\u00e9ho chov\u00e1n\u00ed vynalo\u017een\u00e9ho na \u00fasil\u00ed.<\/p>\n<p class=\"ds-markdown-paragraph\">Diskrimina\u010dn\u00ed potenci\u00e1l molekuly JJC8-089 byl experiment\u00e1ln\u011b ov\u011b\u0159en. Bylo prok\u00e1z\u00e1no, \u017ee molekula v\u00fdznamn\u011b zvr\u00e1tila nedostate\u010dnou motivaci k \u00fasil\u00ed vyvolanou inhibitorem VMAT2 tetrabenazinem (HY-B0590). V operantn\u00edch behavior\u00e1ln\u00edch testech (\u00fakoly s v\u00fdb\u011brem zalo\u017een\u00fdm na \u00fasil\u00ed) JJC8-089 obnovil u zv\u00ed\u0159at preferenci \u00fakolu s vysok\u00fdm \u00fasil\u00edm (tla\u010den\u00ed o 5 ty\u010d\u00ed s pevn\u00fdm pom\u011brem), kter\u00fd vedl k v\u011bt\u0161\u00ed odm\u011bn\u011b oproti alternativ\u011b s n\u00edzk\u00fdm \u00fasil\u00edm. Toto zji\u0161t\u011bn\u00ed podtrhuje jej\u00ed potenci\u00e1l jako\u017eto \u00fa\u010dinn\u00e9ho n\u00e1stroje pro v\u00fdzkum stav\u016f charakterizovan\u00fdch patologickou apati\u00ed a sn\u00ed\u017eenou motivac\u00ed.<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>Technick\u00e9 specifikace:<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Chemick\u00fd n\u00e1zev:<\/strong>\u00a0[Na z\u00e1klad\u011b struktury, nap\u0159. deriv\u00e1t benzhydrylsulfidu]<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>\u010c\u00edslo CAS:<\/strong>\u00a01627576-64-0<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Molekul\u00e1rn\u00ed vzorec:<\/strong>\u00a0C\u2082\u2082H\u2082\u2088F\u2082N\u2082OS<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Molekulov\u00e1 hmotnost:<\/strong>\u00a0406,53<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Z\u00e1pis \u00daSM\u011aV\u016e:<\/strong>\u00a0CC(CN1CCN(CC1)CCSC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Pozn\u00e1mka:<\/strong>\u00a0Pouze pro v\u00fdzkumn\u00e9 \u00fa\u010dely\u00a0<em>in vitro<\/em>\u00a0a v preklinick\u00fdch modelech. Nen\u00ed ur\u010deno k hum\u00e1nn\u00edmu ani veterin\u00e1rn\u00edmu pou\u017eit\u00ed.<\/p>\n<\/li>\n<\/ul>\n<hr \/>\n<h3>Verze 3: Velmi kr\u00e1tk\u00fd \u201ePitch\u201c (pro vyhled\u00e1va\u010d nebo metadata)<\/h3>\n<p class=\"ds-markdown-paragraph\"><strong>JJC8-089 | Inhibitor DAT | Pro v\u00fdzkum motivace a \u00fasil\u00ed<\/strong><br \/>\nSiln\u00fd a selektivn\u00ed inhibitor dopaminov\u00e9ho transport\u00e9ru (DAT). V\u00fdzkumn\u00e1 chemik\u00e1lie pro neurov\u011bdy. V preklinick\u00fdch modelech zvr\u00e1t\u00ed \u00fa\u010dinky tetrabenazinu a zvy\u0161uje toleranci fyzick\u00e9 z\u00e1t\u011b\u017ee. CAS 1627576-64-0. Vzorec: C\u2082\u2082H\u2082\u2088F\u2082N\u2082OS. MW: 406,53.<\/p>\n<p>JC8-089 je inhibitor dopaminov\u00e9ho transport\u00e9ru (DAT), kter\u00fd m\u016f\u017ee zlep\u0161it motiva\u010dn\u00ed deficity a zv\u00fd\u0161it \u00fasil\u00ed vynalo\u017een\u00e9 na c\u00edlen\u00e9 \u010dinnosti. JJC8-089 v\u00fdznamn\u011b zvr\u00e1til \u00fa\u010dinky n\u00edzk\u00e9 n\u00e1mahy vyvolan\u00e9 inhibitorem VMAT-2 tetrabenazinem (HY-B0590) u potkan\u016f a zv\u00fd\u0161il mo\u017enost volby mezi vysok\u00fdm tlakem na 5 ty\u010d\u00ed s pevn\u00fdm pom\u011brem a p\u0159\u00edjmem potravy.<\/p>\n<p>Molekulov\u00e1 hmotnost<br \/>\n406,53<\/p>\n<p>Vzorec<br \/>\nC22H28F2N2OS<\/p>\n<p>\u010c\u00edslo CAS<br \/>\n1627576-64-0<\/p>\n<p>\u00daSM\u011aVY<br \/>\nCC(CN1CCN(CC1)CCSC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)<\/p>","protected":false},"excerpt":{"rendered":"<p>JJC8-089: Een Krachtige en Selectieve DAT-Remmer voor Motivatieonderzoek JJC8-089 is een potentieel onderzoeksmolecuul dat specifiek is ontworpen voor de studie<\/p>","protected":false},"featured_media":28805,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[1085],"product_tag":[],"class_list":{"0":"post-27437","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-okategoriserad","8":"first","9":"instock","10":"taxable","11":"shipping-taxable","12":"purchasable","13":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product\/27437","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/comments?post=27437"}],"version-history":[{"count":2,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product\/27437\/revisions"}],"predecessor-version":[{"id":27443,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product\/27437\/revisions\/27443"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/media\/28805"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/media?parent=27437"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product_brand?post=27437"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product_cat?post=27437"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/cs\/wp-json\/wp\/v2\/product_tag?post=27437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}