{"id":27437,"date":"2025-08-30T09:12:39","date_gmt":"2025-08-30T09:12:39","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&#038;p=27437"},"modified":"2025-11-17T11:48:53","modified_gmt":"2025-11-17T11:48:53","slug":"jjc8-089","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/da\/vare\/jjc8-089\/","title":{"rendered":"JJC8-089"},"content":{"rendered":"<p class=\"ds-markdown-paragraph\"><strong>JJC8-089: En potent og selektiv DAT-h\u00e6mmer til motivationsforskning<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">JJC8-089 er et potentielt forskningsmolekyle, der er specifikt designet til studiet af motivation og indsatsrelateret adf\u00e6rd. Som en selektiv dopamintransport\u00f8r (DAT)-h\u00e6mmer \u00f8ger det ekstracellul\u00e6re dopaminniveauer i hjernen.<\/p>\n<p class=\"ds-markdown-paragraph\">I pr\u00e6kliniske modeller har JJC8-089 vist sig at kunne vende motivationsunderskud induceret af tetrabenazin (en VMAT2-h\u00e6mmer) signifikant. Det genopretter viljen til at yde en h\u00f8j indsats (s\u00e5som at v\u00e6lge en opgave med 5 tryk p\u00e5 knappen) frem for en lettere, mindre givende l\u00f8sning. Disse egenskaber g\u00f8r JJC8-089 (CAS-nr. 1627576-64-0) til et v\u00e6rdifuldt farmakologisk v\u00e6rkt\u00f8j til neurovidenskabelig forskning i lidelser som depression, apati og tr\u00e6thed.<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>N\u00f8glefunktioner:<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Molekylformel:<\/strong>\u00a0C\u2082\u2082H\u2082\u2088F\u2082N\u2082OS<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Molekylv\u00e6gt:<\/strong>\u00a0406,53 g\/mol<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Prim\u00e6r virkningsmekanisme:<\/strong>\u00a0H\u00e6mning af dopamintransport\u00f8ren (DAT)<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Prim\u00e6r forskningsans\u00f8gning:<\/strong>\u00a0Studier af motivation og indsatsorienteret adf\u00e6rd.<\/p>\n<\/li>\n<\/ul>\n<hr \/>\n<h3>Version 2: Mere detaljeret og beskrivende tekst (Til en videnskabelig brochure eller et teknisk datablad)<\/h3>\n<p class=\"ds-markdown-paragraph\"><strong>Titel: JJC8-089: Et lovende v\u00e6rkt\u00f8j til studiet af motivationspatologier<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">JJC8-089 er en syntetiseret forbindelse, der spiller en afg\u00f8rende rolle i at afd\u00e6kke motivationens neurobiologi. Dens prim\u00e6re virkningsmekanisme er h\u00e6mning af dopamintransport\u00f8ren (DAT), hvilket f\u00f8rer til \u00f8get dopaminerg neurotransmission i den synaptiske kl\u00f8ft. Denne effekt er afg\u00f8rende for at modulere bel\u00f8nning, motivation og viljen til at engagere sig i m\u00e5lrettet adf\u00e6rd.<\/p>\n<p class=\"ds-markdown-paragraph\">JJC8-089&#039;s diskriminerende potentiale er blevet eksperimentelt valideret. Molekylet har vist sig signifikant at vende den mangelfulde indsatsmotivation induceret af VMAT2-h\u00e6mmeren tetrabenazin (HY-B0590). I operante adf\u00e6rdstests (indsatsbaserede valgopgaver) gendannede JJC8-089 dyrenes pr\u00e6ference for en opgave med h\u00f8j indsats (5-bar pres med fast forhold), der gav en st\u00f8rre bel\u00f8nning i forhold til et alternativ med lav indsats. Dette fund understreger dets potentiale som et st\u00e6rkt v\u00e6rkt\u00f8j til forskning i tilstande karakteriseret ved patologisk apati og reduceret motivation.<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>Tekniske specifikationer:<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Kemisk navn:<\/strong>\u00a0[Baseret p\u00e5 struktur, f.eks. et derivat af benzhydrylsulfid]<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>CAS-nummer:<\/strong>\u00a01627576-64-0<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Molekylformel:<\/strong>\u00a0C\u2082\u2082H\u2082\u2088F\u2082N\u2082OS<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Molekylv\u00e6gt:<\/strong>\u00a0406,53<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>SMILES-notation:<\/strong>\u00a0CC(CN1CCN(CC1)CCSC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Bem\u00e6rkning:<\/strong>\u00a0Kun til forskningsform\u00e5l\u00a0<em>in vitro<\/em>\u00a0og i pr\u00e6kliniske modeller. Ikke til human eller veterin\u00e6r brug.<\/p>\n<\/li>\n<\/ul>\n<hr \/>\n<h3>Version 3: Meget kort \u201cPitch\u201d (Til en s\u00f8gemaskine eller metadata)<\/h3>\n<p class=\"ds-markdown-paragraph\"><strong>JJC8-089 | DAT-h\u00e6mmer | Til forskning i motivation og indsats<\/strong><br \/>\nPotent og selektiv dopamintransport\u00f8r (DAT)-h\u00e6mmer. Forskningskemikalie til neurovidenskab. Modvirker tetrabenazins virkninger og \u00f8ger tr\u00e6ningstolerancen i pr\u00e6kliniske modeller. CAS 1627576-64-0. Formel: C\u2082\u2082H\u2082\u2088F\u2082N\u2082OS. MW: 406,53.<\/p>\n<p>JC8-089 er en dopamintransport\u00f8r (DAT)-h\u00e6mmer, der kan forbedre motivationsunderskud og \u00f8ge anstrengelsesbaseret adf\u00e6rd i m\u00e5lrettede aktiviteter. JJC8-089 vendte signifikant de lavanstrengelseseffekter induceret af VMAT-2-h\u00e6mmeren tetrabenazin (HY-B0590) hos rotter og \u00f8gede valget mellem h\u00f8janstrengelsesbaserede 5-bars tryk med fast forhold versus f\u00f8deindtag.<\/p>\n<p>Molekylv\u00e6gt<br \/>\n406,53<\/p>\n<p>Formel<br \/>\nC22H28F2N2OS<\/p>\n<p>CAS-nr.<br \/>\n1627576-64-0<\/p>\n<p>SMIL<br \/>\nCC(CN1CCN(CC1)CCSC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)<\/p>","protected":false},"excerpt":{"rendered":"<p>JJC8-089: Een Krachtige en Selectieve DAT-Remmer voor Motivatieonderzoek JJC8-089 is een potentieel onderzoeksmolecuul dat specifiek is ontworpen voor de studie<\/p>","protected":false},"featured_media":28805,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[1085],"product_tag":[],"class_list":{"0":"post-27437","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-okategoriserad","8":"first","9":"instock","10":"taxable","11":"shipping-taxable","12":"purchasable","13":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/da\/wp-json\/wp\/v2\/product\/27437","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/da\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/da\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/da\/wp-json\/wp\/v2\/comments?post=27437"}],"version-history":[{"count":2,"href":"https:\/\/researchchemicalstore.eu\/da\/wp-json\/wp\/v2\/product\/27437\/revisions"}],"predecessor-version":[{"id":27443,"href":"https:\/\/researchchemicalstore.eu\/da\/wp-json\/wp\/v2\/product\/27437\/revisions\/27443"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/da\/wp-json\/wp\/v2\/media\/28805"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/da\/wp-json\/wp\/v2\/media?parent=27437"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/da\/wp-json\/wp\/v2\/product_brand?post=27437"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/da\/wp-json\/wp\/v2\/product_cat?post=27437"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/da\/wp-json\/wp\/v2\/product_tag?post=27437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}