{"id":23388,"date":"2025-04-13T17:39:41","date_gmt":"2025-04-13T17:39:41","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23388"},"modified":"2025-10-23T01:05:10","modified_gmt":"2025-10-23T01:05:10","slug":"methallylescalinfumarat","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/de\/produkt\/methallylescalinfumarat\/","title":{"rendered":"Methallylescalinfumarat"},"content":{"rendered":"

Methallylescalinfumarat \u2013 Wissenschaftliche Produktdokumentation<\/span><\/span><\/strong><\/h3>\n

\ud83d\udd2cChemische Spezifikationen<\/span><\/span><\/strong><\/h4>\n

Methallylescalin (MAL, 3,5-Dimethoxy-4-(2-methylallyloxy)phenethylamin)fumarat ist ein halbsynthetisches Phenethylamin-Derivat, das strukturell mit Meskalin verwandt ist. Diese Forschungsverbindung wird aufgrund ihrer einzigartigen pharmakologischen Eigenschaften untersucht.<\/span><\/span><\/p>\n

Kernparameter:<\/span><\/span><\/em><\/p>\n

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    IUPAC-Name<\/span><\/span><\/strong> : 2-(3,5-Dimethoxy-4-[(2-methylprop-2-en-1-yl)oxy]phenyl)ethan-1-aminfumarat<\/span><\/span><\/p>\n<\/li>\n

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    Summenformel<\/span><\/span><\/strong> : C\u2081\u2084H\u2082\u2081NO\u2083 \u00b7 C\u2084H\u2084O\u2084<\/span><\/span><\/p>\n<\/li>\n

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    Molekulargewicht<\/span><\/span><\/strong> : 351,38 g\/mol<\/span><\/span><\/p>\n<\/li>\n

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    Reinheit<\/span><\/span><\/strong> : \u226597% (HPLC-UV bei 280 nm)<\/span><\/span><\/p>\n<\/li>\n

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    Aussehen<\/span><\/span><\/strong> : Wei\u00dfes bis hellbeiges kristallines Pulver<\/span><\/span><\/p>\n<\/li>\n

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    Schmelzpunkt<\/span><\/span><\/strong> : 158-160\u00b0C (zersetzt sich)<\/span><\/span><\/p>\n<\/li>\n

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    L\u00f6slichkeit<\/span><\/span><\/strong> : 12 mg\/ml in Wasser, 25 mg\/ml in Ethanol<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddeaWissenschaftliche Anwendungen<\/span><\/span><\/strong><\/h4>\n
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    1. \n

      Neuropharmakologische Forschung<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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        5-HT\u2082A-Rezeptoraffinit\u00e4tsstudien (Ki = 85 nM)<\/span><\/span><\/p>\n<\/li>\n

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        Vergleichende Analysen mit Meskalin und Allyleskalin<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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        Psychometrische Bewertungen<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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          Wahrnehmungseffekte in kontrollierten Tierstudien<\/span><\/span><\/p>\n<\/li>\n

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          Dosis-Wirkungs-Beziehungen in S\u00e4ugetiermodellen<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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          Stoffwechselstudien<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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            O-Demethylierungskinetikstudie<\/span><\/span><\/p>\n<\/li>\n

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            CYP-Enzym-Interaktionsprofil<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0fEmpfohlene Dosierungen f\u00fcr die Forschung<\/span><\/span><\/strong><\/h4>\n

            Experimentelle Richtlinien:<\/span><\/span><\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Modell<\/span><\/span><\/th>\nDosierung<\/span><\/span><\/th>\nVerwaltungsstra\u00dfe<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/span><\/span><\/td>\n5\u201350 \u03bcM<\/span><\/span><\/td>\nZellkulturmedium<\/span><\/span><\/td>\n<\/tr>\n
            Kleine Tiere<\/span><\/span><\/td>\n0,5-3 mg\/kg<\/span><\/span><\/td>\nIntraperitoneal<\/span><\/span><\/td>\n<\/tr>\n
            Primaten<\/span><\/span><\/td>\n0,1-0,4 mg\/kg<\/span><\/span><\/td>\nOral<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Hinweis: Nichtlineare Pharmakokinetik \u00fcber 4 mg\/kg*<\/span><\/span><\/p>\n

            \u26a0\ufe0fSicherheitsaspekte und Risiken<\/span><\/span><\/strong><\/h4>\n
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            1. \n

              Toxikologische Daten<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                LD\u2085\u2080 (Ratte, oral): 290 mg\/kg<\/span><\/span><\/p>\n<\/li>\n

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                NOAEL: 0,5 mg\/kg\/Tag (14-t\u00e4gige Studie)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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                Nebenwirkungsprofil<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                  <2 mg\/kg: Minimale physiologische Wirkungen<\/span><\/span><\/p>\n<\/li>\n

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                  2-5 mg\/kg: Erh\u00f6hte sensorische Empfindlichkeit<\/span><\/span><\/p>\n<\/li>\n

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                  5 mg\/kg: M\u00f6gliche kardiovaskul\u00e4re Auswirkungen<\/span><\/span><\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

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                  Kritische Interaktionen<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                    Gef\u00e4hrlich<\/span><\/span><\/strong> : MAO-Hemmer, serotonerge Wirkstoffe<\/span><\/span><\/p>\n<\/li>\n

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                    Riskant<\/span><\/span><\/strong> : Antihypertensiva, QT-verl\u00e4ngernde Medikamente<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udccaQualit\u00e4tskontrolle und analytische Daten<\/span><\/span><\/strong><\/h4>\n
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                      HPLC-Reinheit<\/span><\/span><\/strong> : 97,31 TP3T (C18-S\u00e4ule, 65:35 H\u2082O:MeCN)<\/span><\/span><\/p>\n<\/li>\n

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                      Restl\u00f6semittel<\/span><\/span><\/strong> : <0,2% (GC-MS)<\/span><\/span><\/p>\n<\/li>\n

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                      Stabilit\u00e4tsdaten<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                        Haltbarkeit: 18 Monate bei -20\u00b0C<\/span><\/span><\/p>\n<\/li>\n

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                        Raumtemperatur: 3 Monate (unter Argon)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753H\u00e4ufig gestellte Forschungsfragen<\/span><\/span><\/strong><\/h4>\n

                        F1: Was ist der Wirkungsmechanismus?<\/span><\/span><\/strong>
                        \n A: Prim\u00e4re Wirkung als 5-HT\u2082A-Rezeptoragonist mit sekund\u00e4ren Wirkungen auf dopaminerge Systeme.<\/span><\/span><\/p>\n

                        F2: Wie ist die Wirksamkeit im Vergleich zu Meskalin?<\/span><\/span><\/strong>
                        \n A: ~2-3x h\u00f6here Rezeptoraffinit\u00e4t, aber k\u00fcrzere Wirkungsdauer (4-6 Stunden).<\/span><\/span><\/p>\n

                        F3: Was sind die optimalen Lagerbedingungen?<\/span><\/span><\/strong>
                        \n A: In bernsteinfarbenen Fl\u00e4schchen unter Inertgas bei -20 \u00b0C.<\/span><\/span><\/p>\n

                        F4: Bestehen genotoxische Risiken?<\/span><\/span><\/strong>
                        \n A: Ames-Test negativ bei <500 \u03bcM, aber begrenzte Chromosomentestdaten.<\/span><\/span><\/p>\n

                        \ud83d\udcccForschungsbeschr\u00e4nkungen<\/span><\/span><\/strong><\/h4>\n
                          \n
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                          Begrenzte Daten zur chronischen Exposition<\/span><\/span><\/p>\n<\/li>\n

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                          Unbekannte neuroplastische Effekte<\/span><\/span><\/p>\n<\/li>\n

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                          Variable Pharmakokinetik zwischen den Arten<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0dFazit f\u00fcr Wissenschaftler<\/span><\/span><\/strong><\/h4>\n

                          Methallylescalinfumarat bietet interessante M\u00f6glichkeiten f\u00fcr die vergleichende Serotoninforschung mit einer einzigartigen Kombination aus hoher Wirksamkeit und kurzer Wirkdauer. Die Fumaratform garantiert optimale Stabilit\u00e4t f\u00fcr Laboranwendungen.<\/span><\/span><\/p>\n

                          Wichtiger Haftungsausschluss: Dieses Produkt ist ausschlie\u00dflich f\u00fcr die wissenschaftliche Forschung in akkreditierten Laboren bestimmt. Nicht f\u00fcr den menschlichen Gebrauch oder diagnostische Anwendungen. Alle Experimente m\u00fcssen gem\u00e4\u00df den lokalen Vorschriften und ethischen Richtlinien durchgef\u00fchrt werden.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Eigenschaften von Methallylescalinfumarat<\/span><\/span><\/span><\/span><\/span><\/h3>\n

                          Synonym:<\/span><\/span><\/span><\/span><\/strong> 3,5-Dimethoxy-4-methallyloxyphenethylaminfumarat <\/span><\/span><\/span><\/span>
                          \nCAS-Nummer:<\/span><\/span><\/span><\/span><\/strong> 207740-41-8 <\/span><\/span><\/span><\/span>
                          \nFormel:<\/span><\/span><\/span><\/span><\/strong> 2-{3,5-Dimethoxy-4-[(2-methylprop-2-en-1-yl)oxy]phenyl}ethan-1-aminfumarat <\/span><\/span><\/span><\/span>
                          \nMolmasse:<\/span><\/span><\/span><\/span><\/strong> 367,4 g\/mol <\/span><\/span><\/span><\/span>
                          \nReinheit:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>","protected":false},"featured_media":28812,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,80,482,398],"product_tag":[326],"class_list":{"0":"post-23388","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-fenethylamine","8":"product_cat-methallylescaline","9":"product_cat-verkoop","10":"product_tag-nl","12":"first","13":"instock","14":"sale","15":"taxable","16":"shipping-taxable","17":"purchasable","18":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/de\/wp-json\/wp\/v2\/product\/23388","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/de\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/de\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/de\/wp-json\/wp\/v2\/comments?post=23388"}],"version-history":[{"count":5,"href":"https:\/\/researchchemicalstore.eu\/de\/wp-json\/wp\/v2\/product\/23388\/revisions"}],"predecessor-version":[{"id":28081,"href":"https:\/\/researchchemicalstore.eu\/de\/wp-json\/wp\/v2\/product\/23388\/revisions\/28081"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/de\/wp-json\/wp\/v2\/media\/28812"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/de\/wp-json\/wp\/v2\/media?parent=23388"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/de\/wp-json\/wp\/v2\/product_brand?post=23388"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/de\/wp-json\/wp\/v2\/product_cat?post=23388"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/de\/wp-json\/wp\/v2\/product_tag?post=23388"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}