{"id":23504,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23504"},"modified":"2025-10-22T17:00:59","modified_gmt":"2025-10-22T17:00:59","slug":"5-meo-dmt-hydrochlorid","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/de_at\/produkt\/5-meo-dmt-hydrochlorid\/","title":{"rendered":"5-MeO-DMT-Hydrochlorid"},"content":{"rendered":"

5-MeO-DMT Hydrochlorid \u2013 Wissenschaftliche Produktdokumentation<\/span><\/span><\/strong><\/h3>\n

Allgemeine Beschreibung<\/span><\/span><\/strong><\/h4>\n

5-MeO-DMT-Hydrochlorid (5-Methoxy-N,N-dimethyltryptamin HCl) ist ein wasserl\u00f6sliches Salz des klassischen Tryptamines, das sich aufgrund seiner erh\u00f6hten Stabilit\u00e4t und Bioverf\u00fcgbarkeit im Vergleich zur freien Baseform besonders f\u00fcr die pharmakologische Forschung eignet.<\/span><\/span><\/p>\n

\n

Technische Spezifikationen<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Parameter<\/span><\/span><\/strong><\/th>\nSpezifikation<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
Chemische Formel<\/span><\/span><\/strong><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O \u00b7 HCl<\/span><\/span><\/td>\n<\/tr>\n
Molekulargewicht<\/span><\/span><\/strong><\/td>\n254,75 g\/mol<\/span><\/span><\/td>\n<\/tr>\n
Reinheit<\/span><\/span><\/strong><\/td>\n\u226598% (analysiert mittels HPLC-UV)<\/span><\/span><\/td>\n<\/tr>\n
Aussehen<\/span><\/span><\/strong><\/td>\nWei\u00dfes bis hellgelbes kristallines Pulver<\/span><\/span><\/td>\n<\/tr>\n
L\u00f6slichkeit<\/span><\/span><\/strong><\/td>\nHoher Gehalt an Wasser (>50 mg\/ml), Methanol, PBS<\/span><\/span><\/td>\n<\/tr>\n
Schmelzpunkt<\/span><\/span><\/strong><\/td>\n243-247\u00b0C (zersetzt sich)<\/span><\/span><\/td>\n<\/tr>\n
Stabilit\u00e4t<\/span><\/span><\/strong><\/td>\nHygroskopisch; trocken lagern.<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

Wissenschaftliche Anwendungen<\/span><\/span><\/strong><\/h3>\n

1. Neuropharmakologie und Verhaltensforschung<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    Serotonin-Rezeptor-Studien:<\/span><\/span><\/strong> \u00a0Starker 5-HT\u2081\u2090\/\u2082\u2090-Agonist mit schneller zerebraler Penetration.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Tierversuche (in vivo):<\/span><\/span><\/strong> \u00a0Verhaltensparadigmen (z. B. Kopfzuckungsreaktion bei Nagetieren).<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Elektrophysiologie:<\/span><\/span><\/strong> \u00a0Auswirkungen auf neuronale Schwingungen (z. B. Gammabandaktivit\u00e4t).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. Biochemische und molekulare Studien<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      Intrazellul\u00e4re Signalgebung:<\/span><\/span><\/strong> \u00a0cAMP-Akkumulations- und \u03b2-Arrestin-Rekrutierungstests.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Enzymkinetik:<\/span><\/span><\/strong> \u00a0MAO-A-Stoffwechsel (IC\u2085\u2080 ~2-5 \u03bcM).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. Klinisch relevante Forschung<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        Dosis-Wirkungs-Beziehungen:<\/span><\/span><\/strong> \u00a0Pr\u00e4klinisches Sicherheitsprofil.<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Vergleichende Pharmakologie:<\/span><\/span><\/strong> \u00a0In Richtung Psilocybin, DMT und andere Tryptamine.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Experimentelle Richtlinien<\/span><\/span><\/strong><\/h3>\n

        Empfohlene Konzentrationen<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        Anwendung<\/span><\/span><\/strong><\/th>\nKonzentrationsbereich<\/span><\/span><\/strong><\/th>\nL\u00f6sungsmittel<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
        Zellkulturen (in vitro)<\/span><\/span><\/td>\n1 nM \u2013 10 \u03bcM<\/span><\/span><\/td>\nPBS\/DMEM (\u22640,1% DMSO)<\/span><\/span><\/td>\n<\/tr>\n
        Rezeptortests<\/span><\/span><\/td>\n0,1 \u2013 100 \u03bcM<\/span><\/span><\/td>\nTris-HCl-Puffer (pH 7,4)<\/span><\/span><\/td>\n<\/tr>\n
        Tierstudien (ip\/iv)<\/span><\/span><\/td>\n0,1 \u2013 5 mg\/kg<\/span><\/span><\/td>\nSterile Kochsalzl\u00f6sung<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        Sicherheitsma\u00dfnahmen<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          Pers\u00f6nlicher Schutz:<\/span><\/span><\/strong> \u00a0Laborkittel, Handschuhe (Nitril), Schutzbrille.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Handhabung:<\/span><\/span><\/strong> \u00a0Hygroskopisch \u2013 nach Gebrauch sofort verschlie\u00dfen.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Lagerung:<\/span><\/span><\/strong> \u00a0Luftdicht, unter Argon, bei -20\u00b0C (Hydrolyse verhindern).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Stabilit\u00e4t und Lagerung<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            Haltbarkeit:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              -20\u00b0C:<\/span><\/span><\/strong> \u00a0>2 Jahre (unver\u00e4nderte Reinheit).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4\u00b0C:<\/span><\/span><\/strong> \u00a06 Monate (in trockener Umgebung).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              Abstieg:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Hydrolyse bei l\u00e4ngerer Einwirkung von Feuchtigkeit (\u00dcberwachung durch HPLC).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Analytische Validierung<\/span><\/span><\/strong><\/h3>\n

                Jede Charge wird geliefert mit:<\/span><\/span><\/p>\n

                  \n
                1. \n

                  HPLC-UV-Chromatogramm<\/span><\/span><\/strong> \u00a0(C18-S\u00e4ule, Retentionszeit ~6,2 Min.).<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  MS\/MS-Fragmentierung<\/span><\/span><\/strong> \u00a0(charakteristische Ionen: m\/z 219 \u2192 174, 160).<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  Restl\u00f6semittel<\/span><\/span><\/strong> \u00a0(erf\u00fcllt die ICH Q3C-Richtlinien).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  Rechtsstatus (Niederlande\/EU)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    Bet\u00e4ubungsmittelgesetzgebung:<\/span><\/span><\/strong> \u00a0Im Opiumgesetz nicht ausdr\u00fccklich erw\u00e4hnt, aber m\u00f6glicherweise in einer analogen Gesetzgebung (Anhang II).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Wissenschaftliche Verwendung:<\/span><\/span><\/strong> \u00a0F\u00fcr Einrichtungen ist eine Genehmigung erforderlich (CCMO-Genehmigung f\u00fcr Tierversuche).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Exportkontrolle:<\/span><\/span><\/strong> \u00a0Unterliegt der EU-Verordnung 2019\/1998 (psychotrope Substanzen).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    H\u00e4ufig gestellte Fragen (FAQ)<\/span><\/span><\/strong><\/h3>\n

                    1. Quartal <\/span>: Welche Vorteile hat HCl gegen\u00fcber Freebase?<\/span><\/strong><\/span><\/p>\n

                      \n
                    • \n

                      Verbesserte L\u00f6slichkeit<\/span><\/span><\/strong> \u00a0(ideal f\u00fcr Injektionsstudien).<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      L\u00e4ngere Haltbarkeit<\/span><\/span><\/strong> \u00a0bei Raumtemperatur.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      F2: Ist 5-MeO-DMT-HCl in Drogentests nachweisbar?<\/span><\/span><\/strong>
                      \n A: Ja, \u00fcber:<\/span><\/span><\/p>\n

                        \n
                      • \n

                        LC-MS\/MS<\/span><\/span><\/strong> \u00a0(erkannt als 5-MeO-DMT + HCl-Addukt).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Immunassays:<\/span><\/span><\/strong> \u00a0Kreuzreaktivit\u00e4t mit DMT (~15-20%).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        F3: Gibt es Risiken bei der Kombination mit MAO-Hemmern?<\/span><\/span><\/strong>
                        \n A:\u00a0 <\/span><\/span>Absolut.<\/span><\/span><\/strong><\/p>\n

                          \n
                        • \n

                          Erh\u00f6htes Risiko f\u00fcr\u00a0 <\/span><\/span>Serotonin-Syndrom<\/span><\/span><\/strong> \u00a0(Kombination vermeiden!).<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Nur in MAO-freien Modellen verwenden.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          F4: Wie entsorgt man Abfall?<\/span><\/span><\/strong>
                          \n A:<\/span><\/span><\/p>\n

                            \n
                          1. \n

                            Neutralisieren mit\u00a0 <\/span><\/span>Natriumbicarbonat<\/span><\/span><\/strong> \u00a0(pH 7-8).<\/span><\/span><\/p>\n<\/li>\n

                          2. \n

                            Adsorbieren mit\u00a0 <\/span><\/span>Aktivkohle<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n<\/li>\n

                          3. \n

                            Entsorgen als\u00a0 <\/span><\/span>gef\u00e4hrliche chemische Abf\u00e4lle<\/span><\/span><\/strong> \u00a0(UN 3249, Klasse 6.1).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                            \n

                            Referenzen & Kontakt<\/span><\/span><\/strong><\/h3>\n

                            Kernliteratur:<\/span><\/span><\/strong><\/p>\n

                              \n
                            1. \n

                              Shen et al. (2010). \u201ePharmakologie von 5-MeO-DMT-Derivaten\u201c.\u00a0 <\/span><\/span>J Psychopharmacol<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n

                            2. \n

                              Kaasik et al. (2021). \u201eStoffwechselwege von 5-MeO-DMT\u201c.\u00a0 <\/span><\/span>Xenobiotika<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                              \n

                              Dieses Produkt ist ausschlie\u00dflich f\u00fcr autorisierte wissenschaftliche Forschungszwecke bestimmt. Nicht f\u00fcr den menschlichen Verzehr oder diagnostische Zwecke. Bitte beachten Sie die \u00f6rtlichen Vorschriften.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                              Eigenschaften von 5-MeO-DMT-Hydrochlorid<\/span><\/span><\/span><\/h3>\n

                              Synonym:<\/span><\/span><\/strong> 5-Methoxy-N,N-dimethyltryptaminhydrochlorid <\/span><\/span>
                              \nCAS-Nummer:<\/span><\/span><\/strong> nach <\/span><\/span>
                              \nFormel:<\/span><\/span><\/strong> 3-[2-(Dimethylamino)ethyl]-5-methoxyindolhydrochlorid <\/span><\/span>
                              \nMolmasse:<\/span><\/span><\/strong> 254,8 g\/mol <\/span><\/span>
                              \nReinheit:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>","protected":false},"featured_media":28720,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[511,381],"product_tag":[326],"class_list":{"0":"post-23504","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-5-meo-dmt-kopen","7":"product_cat-tryptamines","8":"product_tag-nl","10":"first","11":"instock","12":"taxable","13":"shipping-taxable","14":"purchasable","15":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/de_at\/wp-json\/wp\/v2\/product\/23504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/de_at\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/de_at\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/de_at\/wp-json\/wp\/v2\/comments?post=23504"}],"version-history":[{"count":6,"href":"https:\/\/researchchemicalstore.eu\/de_at\/wp-json\/wp\/v2\/product\/23504\/revisions"}],"predecessor-version":[{"id":28467,"href":"https:\/\/researchchemicalstore.eu\/de_at\/wp-json\/wp\/v2\/product\/23504\/revisions\/28467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/de_at\/wp-json\/wp\/v2\/media\/28720"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/de_at\/wp-json\/wp\/v2\/media?parent=23504"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/de_at\/wp-json\/wp\/v2\/product_brand?post=23504"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/de_at\/wp-json\/wp\/v2\/product_cat?post=23504"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/de_at\/wp-json\/wp\/v2\/product_tag?post=23504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}