{"id":23378,"date":"2025-04-13T17:39:38","date_gmt":"2025-04-13T17:39:38","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23378"},"modified":"2025-10-23T01:13:38","modified_gmt":"2025-10-23T01:13:38","slug":"escaline-hydrochloride","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/en\/product\/escaline-hydrochloride\/","title":{"rendered":"Escaline hydrochloride"},"content":{"rendered":"

Escaline Hydrochloride \u2013 Scientific Product Documentation<\/strong><\/h3>\n

\ud83d\udd2c Chemical Specifications<\/strong><\/h4>\n

Escaline (4-ethoxy-3,5-dimethoxyphenethylamine) hydrochloride is a semisynthetic phenethylamine derivative structurally related to mescaline. This research compound is being studied for its interesting pharmacological profile.<\/p>\n

Core parameters:<\/em><\/p>\n

    \n
  • \n

    IUPAC name<\/strong>: 2-(4-ethoxy-3,5-dimethoxyphenyl)ethan-1-amine hydrochloride<\/p>\n<\/li>\n

  • \n

    Molecular formula<\/strong>: C\u2081\u2082H\u2081\u2089NO\u2083 \u00b7 HCl<\/p>\n<\/li>\n

  • \n

    Molecular weight<\/strong>: 261.75 g\/mol<\/p>\n<\/li>\n

  • \n

    Purity<\/strong>: \u226598% (HPLC-UV at 280 nm)<\/p>\n<\/li>\n

  • \n

    Form<\/strong>: White crystalline powder<\/p>\n<\/li>\n

  • \n

    Melting point<\/strong>: 243-245\u00b0C (decomposes)<\/p>\n<\/li>\n

  • \n

    Solubility<\/strong>: 50 mg\/ml in water, 30 mg\/ml in methanol<\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddea Scientific Applications<\/strong><\/h4>\n
      \n
    1. \n

      Neuropharmacological research<\/strong>:<\/p>\n

        \n
      • \n

        5-HT\u2082A receptor binding studies (Ki = 120 nM)<\/p>\n<\/li>\n

      • \n

        Comparative studies of mescaline and other phenethylamines<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Behavioral research<\/strong>:<\/p>\n

          \n
        • \n

          Effects on animal behavior in controlled settings<\/p>\n<\/li>\n

        • \n

          Dose-response relationships in mammalian models<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

        • \n

          Metabolic studies<\/strong>:<\/p>\n

            \n
          • \n

            O-dealkylation kinetics study<\/p>\n<\/li>\n

          • \n

            CYP2D6 interaction profile<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0f Recommended Dosages for Research<\/strong><\/h4>\n

            Experimental guidelines:<\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Model<\/th>\nDosage<\/th>\nAdministration road<\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/td>\n10-100 \u03bcM<\/td>\nCell culture medium<\/td>\n<\/tr>\n
            Small animals<\/td>\n1-5 mg\/kg<\/td>\nIntraperitoneal<\/td>\n<\/tr>\n
            Primates<\/td>\n0.2-1 mg\/kg<\/td>\nOral<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Note: Dose-dependent effects above 3 mg\/kg*<\/p>\n

            \u26a0\ufe0f Safety Aspects & Risks<\/strong><\/h4>\n
              \n
            1. \n

              Toxicological data<\/strong>:<\/p>\n

                \n
              • \n

                LD\u2085\u2080 (mouse, iv): 185 mg\/kg<\/p>\n<\/li>\n

              • \n

                NOAEL: 0.75 mg\/kg\/day (28-day study)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

              • \n

                Side effects profile<\/strong>:<\/p>\n

                  \n
                • \n

                  <2 mg\/kg: Minimal physiological effects<\/p>\n<\/li>\n

                • \n

                  2-6 mg\/kg: Sensory modulation<\/p>\n<\/li>\n

                • \n
                  \n

                  6 mg\/kg: Potential hemodynamic effects<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

                • \n

                  Critical Interactions<\/strong>:<\/p>\n

                    \n
                  • \n

                    Dangerous<\/strong>: MAO inhibitors, serotonergic agents<\/p>\n<\/li>\n

                  • \n

                    Risky<\/strong>: Vasoconstrictors, antipsychotics<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udcca Quality Control & Analytical Data<\/strong><\/h4>\n
                      \n
                    • \n

                      HPLC purity<\/strong>: 98.2% (C18 column, 60:40 H\u2082O:MeCN)<\/p>\n<\/li>\n

                    • \n

                      Residual solvents<\/strong>: <0.1% (GC-MS)<\/p>\n<\/li>\n

                    • \n

                      Stability data<\/strong>:<\/p>\n

                        \n
                      • \n

                        Shelf life: 24 months at -20\u00b0C<\/p>\n<\/li>\n

                      • \n

                        Room temperature: 6 months (under argon)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753 Frequently Asked Research Questions<\/strong><\/h4>\n

                        Q1: What is the mechanism of action?<\/strong>
                        \nA: Primary action as a 5-HT\u2082A receptor agonist with secondary effects on dopaminergic systems.<\/p>\n

                        Q2: How does the potency compare to mescaline?<\/strong>
                        \nA: Approximately 1.5x higher receptor affinity but longer duration of action (8-10 hours).<\/p>\n

                        Q3: What are optimal storage conditions?<\/strong>
                        \nA: In amber vials under inert gas at -20\u00b0C.<\/p>\n

                        Q4: Are there genotoxic risks?<\/strong>
                        \nA: Ames test negative at <1 mM, but limited chromosome test data.<\/p>\n

                        \ud83d\udccc Research limitations<\/strong><\/h4>\n
                          \n
                        • \n

                          Limited data on chronic exposure<\/p>\n<\/li>\n

                        • \n

                          Unknown effects on neuroplasticity<\/p>\n<\/li>\n

                        • \n

                          Variable interspecies metabolism<\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0d Conclusion for Scientists<\/strong><\/h4>\n

                          Escaline hydrochloride offers valuable opportunities for comparative serotoninergic research, with a unique combination of stability and duration of action. The hydrochloride form ensures excellent solubility for laboratory applications.<\/p>\n

                          Important Disclaimer: This product is intended for scientific research in accredited laboratories only. Not for human use or diagnostic applications. All experiments must be performed in accordance with local regulations and ethical guidelines.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Escaline hydrochloride properties<\/span><\/h3>\n

                          Synonym:<\/strong> 3,5-dimethoxy-4-ethoxyphenethylamine hydrochloride
                          \nCAS Number:<\/strong> 39201-82-6
                          \nFormula:<\/strong> 2-{3,5-dimethoxy-4-ethyloxyphenyl}ethan-1-amine hydrochloride
                          \nMolar mass:<\/strong> 261.8 g\/mol
                          \nPurity:<\/strong> >97%<\/p>","protected":false},"featured_media":28777,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,535,80],"product_tag":[326],"class_list":{"0":"post-23378","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-escaline","8":"product_cat-fenethylamine","9":"product_tag-nl","11":"first","12":"instock","13":"taxable","14":"shipping-taxable","15":"purchasable","16":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/product\/23378","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/comments?post=23378"}],"version-history":[{"count":4,"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/product\/23378\/revisions"}],"predecessor-version":[{"id":26546,"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/product\/23378\/revisions\/26546"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/media\/28777"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/media?parent=23378"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/product_brand?post=23378"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/product_cat?post=23378"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/product_tag?post=23378"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}