{"id":23399,"date":"2025-04-13T17:39:42","date_gmt":"2025-04-13T17:39:42","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23399"},"modified":"2025-10-23T00:56:39","modified_gmt":"2025-10-23T00:56:39","slug":"proscaline-fumarate","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/en\/product\/proscaline-fumarate\/","title":{"rendered":"Proscaline fumarate"},"content":{"rendered":"

Proscaline Fumarate \u2013 Scientific Product Documentation<\/strong><\/h3>\n

\ud83d\udd2c Chemical Specifications<\/strong><\/h4>\n

Proscaline (4-propoxy-3,5-dimethoxyphenethylamine) fumarate is a semisynthetic phenethylamine derivative with structural similarity to mescaline. This research compound is being studied for its unique receptor interaction profile.<\/p>\n

Core parameters:<\/em><\/p>\n

    \n
  • \n

    IUPAC name<\/strong>: 2-(4-propoxy-3,5-dimethoxyphenyl)ethan-1-amine fumarate<\/p>\n<\/li>\n

  • \n

    Molecular formula<\/strong>: C\u2081\u2083H\u2082\u2081NO\u2083 \u00b7 C\u2084H\u2084O\u2084<\/p>\n<\/li>\n

  • \n

    Molecular weight<\/strong>: 339.36 g\/mol<\/p>\n<\/li>\n

  • \n

    Purity<\/strong>: \u226598% (HPLC-UV at 254 nm)<\/p>\n<\/li>\n

  • \n

    Form<\/strong>: White crystalline powder<\/p>\n<\/li>\n

  • \n

    Melting point<\/strong>: 172-174\u00b0C (decomposes)<\/p>\n<\/li>\n

  • \n

    Solubility<\/strong>: 15 mg\/ml in water, 30 mg\/ml in warm ethanol<\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddeb Research applications<\/strong><\/h4>\n
      \n
    1. \n

      Receptor binding studies<\/strong>:<\/p>\n

        \n
      • \n

        5-HT\u2082A agonism (EC\u2085\u2080 = 280 nM)<\/p>\n<\/li>\n

      • \n

        Dopaminergic modulation research<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Neurophysiological research<\/strong>:<\/p>\n

          \n
        • \n

          EEG pattern analysis in laboratory animals<\/p>\n<\/li>\n

        • \n

          Comparative studies with classical psychedelics<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

        • \n

          Metabolic pathway analysis<\/strong>:<\/p>\n

            \n
          • \n

            O-demethylation kinetics<\/p>\n<\/li>\n

          • \n

            CYP2D6 interaction profile<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2697\ufe0f Experimental Protocols<\/strong><\/h4>\n

            Standard research conditions:<\/em><\/p>\n

            \n\n\n\n\n\n\n
            Model<\/th>\nConcentration<\/th>\nExposure time<\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/td>\n10-100 \u03bcM<\/td>\n15-60 minutes<\/td>\n<\/tr>\n
            In vivo<\/td>\n1-5 mg\/kg<\/td>\nAcute\/chronic<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Note: Show non-linear pharmacokinetics above 8 mg\/kg*<\/p>\n

            \u26a0\ufe0f Safety Profile<\/strong><\/h4>\n
              \n
            1. \n

              Toxicological data<\/strong>:<\/p>\n

                \n
              • \n

                LD\u2085\u2080 (rat, oral): 320 mg\/kg<\/p>\n<\/li>\n

              • \n

                NOAEL: 0.75 mg\/kg\/day (28-day study)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

              • \n

                Side effects spectrum<\/strong>:<\/p>\n

                  \n
                • \n

                  Dose-dependent effects:<\/p>\n

                    \n
                  • \n

                    <3 mg\/kg: Subtle sensory changes<\/p>\n<\/li>\n

                  • \n

                    3-6 mg\/kg: Vegetative symptoms<\/p>\n<\/li>\n

                  • \n
                    \n

                    6 mg\/kg: Potential hemodynamic instability<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n

                  • \n

                    Critical Interactions<\/strong>:<\/p>\n

                      \n
                    • \n

                      Dangerous<\/strong>: MAO inhibitors, sympathomimetics<\/p>\n<\/li>\n

                    • \n

                      Risky<\/strong>: Serotonergic agents, vasopressors<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                      \ud83d\udcc9 Stability data<\/strong><\/h4>\n
                        \n
                      • \n

                        Shelf life<\/strong>: 24 months at -20\u00b0C (under argon)<\/p>\n<\/li>\n

                      • \n

                        Degradation products<\/strong>: <2% after 12 months RT<\/p>\n<\/li>\n

                      • \n

                        Compatible buffers<\/strong>: PBS (pH 7.4), hydrochloric acid (0.1N)<\/p>\n<\/li>\n<\/ul>\n

                        \ud83d\udd0d Analytical Features<\/strong><\/h4>\n
                          \n
                        • \n

                          HPLC retention time<\/strong>: 6.8 min (C18, 70:30 H\u2082O:MeCN)<\/p>\n<\/li>\n

                        • \n

                          Mass spectrum<\/strong>: [M+H]\u207a 240.2 m\/z<\/p>\n<\/li>\n

                        • \n

                          UV absorption<\/strong>: \u03bbmax 282 nm (\u03b5 = 4200)<\/p>\n<\/li>\n<\/ul>\n

                          \u2753 Research-oriented FAQ<\/strong><\/h4>\n

                          Q1: What is the mechanism of action?<\/strong>
                          \nA: Primary 5-HT\u2082A receptor partial agonist with secondary DAT interaction.<\/p>\n

                          Q2: How does the potency compare to mescaline?<\/strong>
                          \nA: ~3x higher 5-HT\u2082A affinity but lower blood-brain barrier penetration.<\/p>\n

                          Q3: Are there genotoxic risks?<\/strong>
                          \nA: Ames test negative up to 1 mM, but limited chromosome test data.<\/p>\n

                          Q4: What is the optimal formulation?<\/strong>
                          \nA: Sterile saline solution (0.9% NaCl) for in vivo studies.<\/p>\n

                          \ud83d\udccc Research limitations<\/strong><\/h4>\n
                            \n
                          • \n

                            Limited data on chronic exposure<\/p>\n<\/li>\n

                          • \n

                            Unknown neuroplastic effects<\/p>\n<\/li>\n

                          • \n

                            Variable interspecies metabolism<\/p>\n<\/li>\n<\/ul>\n

                            Scientific Disclaimer: This product is intended for research use in accredited laboratories only. Not for human or veterinary use. All experiments must comply with relevant safety and ethical guidelines. Please be aware of local regulations regarding psychoactive research substances.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                            Proscaline fumarate<\/span><\/span><\/h3>\n

                            Synonym:<\/span><\/span><\/strong> 3,5-dimethoxy-4-propoxyphenethylamine fumarate <\/span><\/span>
                            \nCAS Number:<\/span><\/span><\/strong> 39201-78-0 <\/span><\/span>
                            \nFormula:<\/span><\/span><\/strong> 2-{3,5-dimethoxy-4-propyloxyphenyl}ethan-1-amine fumarate <\/span><\/span>
                            \nMolar Mass:<\/span><\/span><\/strong> 355.4 g\/mol <\/span><\/span>
                            \nPurity:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>","protected":false},"featured_media":28847,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,80,536],"product_tag":[326],"class_list":{"0":"post-23399","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-fenethylamine","8":"product_cat-proscaline","9":"product_tag-nl","11":"first","12":"instock","13":"taxable","14":"shipping-taxable","15":"purchasable","16":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/product\/23399","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/comments?post=23399"}],"version-history":[{"count":3,"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/product\/23399\/revisions"}],"predecessor-version":[{"id":26541,"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/product\/23399\/revisions\/26541"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/media\/28847"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/media?parent=23399"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/product_brand?post=23399"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/product_cat?post=23399"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/product_tag?post=23399"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}