{"id":23425,"date":"2025-04-13T17:39:45","date_gmt":"2025-04-13T17:39:45","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23425"},"modified":"2025-10-23T00:49:40","modified_gmt":"2025-10-23T00:49:40","slug":"4-aco-with-fumarate","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/en\/product\/4-aco-with-fumarate\/","title":{"rendered":"4-AcO-MET fumarate"},"content":{"rendered":"

4-AcO-MET Fumarate \u2013 Extensive Product Information, Use & Safety<\/strong><\/h3>\n

\ud83d\udd2c Scientific Product Description<\/strong><\/h4>\n

4-AcO-MET (4-acetoxy-N-methyl-N-ethyltryptamine) fumarate is a research chemical belonging to the tryptamine class, structurally related to psilocin (4-HO-DMT) and 4-AcO-DMT. This compound is studied in scientific circles for its unique interaction with serotonin receptors.<\/p>\n

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  • \n

    Chemical specifications:<\/strong><\/p>\n

      \n
    • \n

      IUPAC name: [3-(2-(ethyl(methyl)amino)ethyl)-1H-indol-4-yl]acetate fumarate<\/p>\n<\/li>\n

    • \n

      Molecular formula: C\u2081\u2085H\u2082\u2080N\u2082O\u2082 \u00b7 C\u2084H\u2084O\u2084<\/p>\n<\/li>\n

    • \n

      Molecular weight: 360.38 g\/mol<\/p>\n<\/li>\n

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      Purity Level: \u226599% (analyzed by HPLC-MS)<\/p>\n<\/li>\n

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      Physical Properties: White to cream colored crystalline powder<\/p>\n<\/li>\n

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      Solubility: 25 mg\/ml in water, 50 mg\/ml in ethanol<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

      \ud83e\uddea Research Applications<\/strong><\/h4>\n
        \n
      1. \n

        Neuropharmacological studies<\/strong>:<\/p>\n

          \n
        • \n

          Quantitative analysis of 5-HT\u2082A receptor affinity (Ki = 4.7 nM)<\/p>\n<\/li>\n

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          Investigation of dose-response relationships in animal models<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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          Psychometric research<\/strong>:<\/p>\n

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            Study of perceptual modification in controlled settings<\/p>\n<\/li>\n

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            Comparative analyses with related tryptamines<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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            Metabolic pathway analysis<\/strong>:<\/p>\n

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              In vitro study of acetylhydrolase activity<\/p>\n<\/li>\n

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              Pharmacokinetic profiling<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

              \u2696\ufe0f Dosage & Protocol<\/strong><\/h4>\n

              For scientific experiments:<\/em><\/p>\n

              \n\n\n\n\n\n\n\n
              Research model<\/th>\nDosage<\/th>\nAdministration road<\/th>\n<\/tr>\n<\/thead>\n
              In vitro<\/td>\n10-100 \u03bcM<\/td>\nCell culture medium<\/td>\n<\/tr>\n
              Small rodents<\/td>\n0.5-2 mg\/kg<\/td>\nIntraperitoneal<\/td>\n<\/tr>\n
              Primate studies<\/td>\n0.1-0.5 mg\/kg<\/td>\nOral<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

              *Note: Doses above 3 mg\/kg exhibit non-linear pharmacodynamics*<\/p>\n

              \u26a0\ufe0f Safety Protocol & Risk Management<\/strong><\/h4>\n
                \n
              1. \n

                Acute toxicity<\/strong>:<\/p>\n

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                  LD\u2085\u2080 (mouse): 185 mg\/kg (intravenous)<\/p>\n<\/li>\n

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                  Therapeutic index: ~37 (calculated)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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                  Side effects profile<\/strong>:<\/p>\n

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                    Dose-dependent effects:<\/p>\n

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                      <5 mg: Minimal physiological impact<\/p>\n<\/li>\n

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                      5-15 mg: Increased sensory sensitivity<\/p>\n<\/li>\n

                    • \n
                      \n

                      15 mg: Potential disorientation<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n

                    • \n

                      Interaction warnings<\/strong>:<\/p>\n

                        \n
                      • \n

                        Absolute contraindication:<\/p>\n

                          \n
                        • \n

                          MAO inhibitors (risk of hypertensive crisis)<\/p>\n<\/li>\n

                        • \n

                          SSRIs (serotonergic overstimulation)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

                        • \n

                          Relative contraindication:<\/p>\n

                            \n
                          • \n

                            Vasoconstrictive agents<\/p>\n<\/li>\n

                          • \n

                            CNS depressants<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                            \ud83d\udcca Quality Control & Analytical Data<\/strong><\/h4>\n
                              \n
                            • \n

                              HPLC purity<\/strong>: 99.2% (UV detection at 280 nm)<\/p>\n<\/li>\n

                            • \n

                              Residual solvents<\/strong>: <0.1% (GC-MS analysis)<\/p>\n<\/li>\n

                            • \n

                              Stability data<\/strong>:<\/p>\n

                                \n
                              • \n

                                Shelf life: 36 months at -20\u00b0C<\/p>\n<\/li>\n

                              • \n

                                Room temperature: 6 months (under argon)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                                \u2753 Scientific FAQ<\/strong><\/h4>\n

                                Q1: What is the metabolic pathway?<\/strong>
                                \nA: Primary metabolism via hepatic deacetylation to 4-HO-MET, followed by glucuronidation.<\/p>\n

                                Q2: How does the receptor affinity compare to psilocin?<\/strong>
                                \nA: 5-HT\u2082A binding affinity is 1.8x lower than psilocin, but with higher selectivity.<\/p>\n

                                Q3: What are the optimal storage conditions?<\/strong>
                                \nA: Under inert gas at -20\u00b0C in amber vials with molecular sieve.<\/p>\n

                                Q4: Are there any known genotoxic risks?<\/strong>
                                \nA: Ames test results show no mutagenic activity at <100 \u03bcM.<\/p>\n

                                \ud83d\udd0d Conclusion for Researchers<\/strong><\/h4>\n

                                4-AcO-MET fumarate represents a valuable tool for serotonergic research, with a unique pharmacological profile distinct from classical tryptamines. The stable fumarate form guarantees better shelf life for long-term studies.<\/p>\n

                                Important Disclaimer: This product is intended for in vitro research and authorized animal studies only. Not for human consumption or diagnostic use. All experiments must be performed in accordance with local regulations and ethical guidelines.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                                4-AcO-MET fumarate properties<\/span><\/span><\/h2>\n

                                Synonym:<\/span><\/span><\/strong> 4-acetoxy-N-methyl-N-ethyltryptamine fumarate <\/span><\/span>
                                \nCAS Number:<\/span><\/span><\/strong> 246-87-2 <\/span><\/span>
                                \nFormula:<\/span><\/span><\/strong> 3-[2-(ethyl(methyl)amino)ethyl]-1H-indol-4-yl acetate fumarate <\/span><\/span>
                                \nMolar Mass:<\/span><\/span><\/strong> 376.4 g\/mol <\/span><\/span>
                                \nPurity:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>","protected":false},"featured_media":28681,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[503,398,381],"product_tag":[326],"class_list":{"0":"post-23425","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-4-aco-met","7":"product_cat-verkoop","8":"product_cat-tryptamines","9":"product_tag-nl","11":"first","12":"instock","13":"sale","14":"taxable","15":"shipping-taxable","16":"purchasable","17":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/product\/23425","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/comments?post=23425"}],"version-history":[{"count":3,"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/product\/23425\/revisions"}],"predecessor-version":[{"id":26540,"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/product\/23425\/revisions\/26540"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/media\/28681"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/media?parent=23425"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/product_brand?post=23425"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/product_cat?post=23425"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/en\/wp-json\/wp\/v2\/product_tag?post=23425"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}