{"id":23388,"date":"2025-04-13T17:39:41","date_gmt":"2025-04-13T17:39:41","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23388"},"modified":"2025-10-23T01:05:10","modified_gmt":"2025-10-23T01:05:10","slug":"fumarato-de-metalilescalina","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/es\/producto\/fumarato-de-metalilescalina\/","title":{"rendered":"fumarato de metalilescalina"},"content":{"rendered":"

Fumarato de metalilescalina \u2013 Documentaci\u00f3n cient\u00edfica del producto<\/span><\/span><\/strong><\/h3>\n

\ud83d\udd2cEspecificaciones qu\u00edmicas<\/span><\/span><\/strong><\/h4>\n

El fumarato de metalilescalina (MAL, 3,5-dimetoxi-4-(2-metilaliloxi)fenetilamina) es un derivado semisint\u00e9tico de la fenetilamina, estructuralmente relacionado con la mescalina. Este compuesto se est\u00e1 estudiando por sus propiedades farmacol\u00f3gicas \u00fanicas.<\/span><\/span><\/p>\n

Par\u00e1metros b\u00e1sicos:<\/span><\/span><\/em><\/p>\n

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    Nombre IUPAC<\/span><\/span><\/strong> : fumarato de 2-(3,5-dimetoxi-4-[(2-metilprop-2-en-1-il)oxi]fenil)etan-1-amina<\/span><\/span><\/p>\n<\/li>\n

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    F\u00f3rmula molecular<\/span><\/span><\/strong> : C\u2081\u2084H\u2082\u2081NO\u2083 \u00b7 C\u2084H\u2084O\u2084<\/span><\/span><\/p>\n<\/li>\n

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    Peso molecular<\/span><\/span><\/strong> :351,38 g\/mol<\/span><\/span><\/p>\n<\/li>\n

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    Pureza<\/span><\/span><\/strong> : \u226597% (HPLC-UV a 280 nm)<\/span><\/span><\/p>\n<\/li>\n

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    Apariencia<\/span><\/span><\/strong> : Polvo cristalino de color blanco a beige claro.<\/span><\/span><\/p>\n<\/li>\n

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    Punto de fusi\u00f3n<\/span><\/span><\/strong> : 158-160\u00b0C (se descompone)<\/span><\/span><\/p>\n<\/li>\n

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    Solubilidad<\/span><\/span><\/strong> :12 mg\/ml en agua, 25 mg\/ml en etanol<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddeaAplicaciones cient\u00edficas<\/span><\/span><\/strong><\/h4>\n
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    1. \n

      Investigaci\u00f3n neurofarmacol\u00f3gica<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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        Estudios de afinidad del receptor 5-HT\u2082A (Ki = 85 nM)<\/span><\/span><\/p>\n<\/li>\n

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        An\u00e1lisis comparativos con mescalina y alilescalina<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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        Evaluaciones psicom\u00e9tricas<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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          Efectos perceptuales en estudios controlados con animales<\/span><\/span><\/p>\n<\/li>\n

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          Relaciones dosis-respuesta en modelos mam\u00edferos<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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          Estudios metab\u00f3licos<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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            Estudio de la cin\u00e9tica de la O-desmetilaci\u00f3n<\/span><\/span><\/p>\n<\/li>\n

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            Perfil de interacci\u00f3n de la enzima CYP<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0fDosis recomendadas para la investigaci\u00f3n<\/span><\/span><\/strong><\/h4>\n

            Pautas experimentales:<\/span><\/span><\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Modelo<\/span><\/span><\/th>\nDosificaci\u00f3n<\/span><\/span><\/th>\nCamino de la Administraci\u00f3n<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/span><\/span><\/td>\n5-50 \u03bcM<\/span><\/span><\/td>\nMedio de cultivo celular<\/span><\/span><\/td>\n<\/tr>\n
            Animales peque\u00f1os<\/span><\/span><\/td>\n0,5-3 mg\/kg<\/span><\/span><\/td>\nIntraperitoneal<\/span><\/span><\/td>\n<\/tr>\n
            Primates<\/span><\/span><\/td>\n0,1-0,4 mg\/kg<\/span><\/span><\/td>\nOral<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Nota: Farmacocin\u00e9tica no lineal por encima de 4 mg\/kg*<\/span><\/span><\/p>\n

            \u26a0\ufe0fAspectos y riesgos de seguridad<\/span><\/span><\/strong><\/h4>\n
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            1. \n

              Datos toxicol\u00f3gicos<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                LD\u2085\u2080 (rata, oral): 290 mg\/kg<\/span><\/span><\/p>\n<\/li>\n

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                NOAEL: 0,5 mg\/kg\/d\u00eda (estudio de 14 d\u00edas)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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                Perfil de efectos secundarios<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                  <2 mg\/kg: Efectos fisiol\u00f3gicos m\u00ednimos<\/span><\/span><\/p>\n<\/li>\n

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                  2-5 mg\/kg: aumento de la sensibilidad sensorial<\/span><\/span><\/p>\n<\/li>\n

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                  5 mg\/kg: Posibles efectos cardiovasculares<\/span><\/span><\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

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                  Interacciones cr\u00edticas<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                    Peligroso<\/span><\/span><\/strong> : Inhibidores de la MAO, agentes serotonin\u00e9rgicos<\/span><\/span><\/p>\n<\/li>\n

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                    Arriesgado<\/span><\/span><\/strong> :Antihipertensivos, medicamentos que prolongan el intervalo QT<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udccaControl de calidad y datos anal\u00edticos<\/span><\/span><\/strong><\/h4>\n
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                      Pureza de HPLC<\/span><\/span><\/strong> : 97,3% (columna C18, 65:35 H\u2082O:MeCN)<\/span><\/span><\/p>\n<\/li>\n

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                      Disolventes residuales<\/span><\/span><\/strong> : <0,2% (GC-MS)<\/span><\/span><\/p>\n<\/li>\n

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                      Datos de estabilidad<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                        Vida \u00fatil: 18 meses a -20\u00b0C<\/span><\/span><\/p>\n<\/li>\n

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                        Temperatura ambiente: 3 meses (bajo arg\u00f3n)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753Preguntas frecuentes sobre investigaci\u00f3n<\/span><\/span><\/strong><\/h4>\n

                        Q1: \u00bfCu\u00e1l es el mecanismo de acci\u00f3n?<\/span><\/span><\/strong>
                        \n A: Acci\u00f3n primaria como agonista del receptor 5-HT\u2082A con efectos secundarios sobre los sistemas dopamin\u00e9rgicos.<\/span><\/span><\/p>\n

                        P2: \u00bfC\u00f3mo se compara la potencia con la mescalina?<\/span><\/span><\/strong>
                        \n A: ~2-3 veces mayor afinidad del receptor pero duraci\u00f3n de acci\u00f3n m\u00e1s corta (4-6 horas).<\/span><\/span><\/p>\n

                        P3: \u00bfCu\u00e1les son las condiciones \u00f3ptimas de almacenamiento?<\/span><\/span><\/strong>
                        \n A: En viales \u00e1mbar bajo gas inerte a -20\u00b0C.<\/span><\/span><\/p>\n

                        P4: \u00bfExisten riesgos genot\u00f3xicos?<\/span><\/span><\/strong>
                        \n R: La prueba de Ames es negativa a <500 \u03bcM, pero hay datos limitados de pruebas cromos\u00f3micas.<\/span><\/span><\/p>\n

                        \ud83d\udcccLimitaciones de la investigaci\u00f3n<\/span><\/span><\/strong><\/h4>\n
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                          Datos limitados sobre la exposici\u00f3n cr\u00f3nica<\/span><\/span><\/p>\n<\/li>\n

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                          Efectos neuropl\u00e1sticos desconocidos<\/span><\/span><\/p>\n<\/li>\n

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                          Farmacocin\u00e9tica variable entre especies<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0dConclusi\u00f3n para los cient\u00edficos<\/span><\/span><\/strong><\/h4>\n

                          El fumarato de metalilescalina ofrece interesantes posibilidades para la investigaci\u00f3n comparativa de la serotonina, gracias a su combinaci\u00f3n \u00fanica de alta potencia y corta duraci\u00f3n de acci\u00f3n. La forma fumarato garantiza una estabilidad \u00f3ptima para aplicaciones de laboratorio.<\/span><\/span><\/p>\n

                          Aviso importante: Este producto est\u00e1 destinado exclusivamente a la investigaci\u00f3n cient\u00edfica en laboratorios acreditados. No est\u00e1 destinado a uso humano ni a aplicaciones diagn\u00f3sticas. Todos los experimentos deben realizarse de acuerdo con las normativas y directrices \u00e9ticas locales.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Propiedades del fumarato de metalilescalina<\/span><\/span><\/span><\/span><\/span><\/h3>\n

                          Sin\u00f3nimo:<\/span><\/span><\/span><\/span><\/strong> fumarato de 3,5-dimetoxi-4-metaliloxifenetilamina <\/span><\/span><\/span><\/span>
                          \nN\u00famero CAS:<\/span><\/span><\/span><\/span><\/strong> 207740-41-8 <\/span><\/span><\/span><\/span>
                          \nF\u00f3rmula:<\/span><\/span><\/span><\/span><\/strong> fumarato de 2-{3,5-dimetoxi-4-[(2-metilprop-2-en-1-il)oxi]fenil}etan-1-amina <\/span><\/span><\/span><\/span>
                          \nMasa molar:<\/span><\/span><\/span><\/span><\/strong> 367,4 g\/mol <\/span><\/span><\/span><\/span>
                          \nPureza:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>","protected":false},"featured_media":28812,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,80,482,398],"product_tag":[326],"class_list":{"0":"post-23388","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-fenethylamine","8":"product_cat-methallylescaline","9":"product_cat-verkoop","10":"product_tag-nl","12":"first","13":"instock","14":"sale","15":"taxable","16":"shipping-taxable","17":"purchasable","18":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/es\/wp-json\/wp\/v2\/product\/23388","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/es\/wp-json\/wp\/v2\/comments?post=23388"}],"version-history":[{"count":5,"href":"https:\/\/researchchemicalstore.eu\/es\/wp-json\/wp\/v2\/product\/23388\/revisions"}],"predecessor-version":[{"id":28081,"href":"https:\/\/researchchemicalstore.eu\/es\/wp-json\/wp\/v2\/product\/23388\/revisions\/28081"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/es\/wp-json\/wp\/v2\/media\/28812"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/es\/wp-json\/wp\/v2\/media?parent=23388"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/es\/wp-json\/wp\/v2\/product_brand?post=23388"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/es\/wp-json\/wp\/v2\/product_cat?post=23388"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/es\/wp-json\/wp\/v2\/product_tag?post=23388"}],"curies":[{"name":"gracias","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}