Metallüüleskaliinfumaraat

Methallylescaline Fumarate – Scientific Product Documentation

🔬Keemilised spetsifikatsioonid

Methallylescaline (MAL, 3,5-dimethoxy-4-(2-methylallyloxy)phenethylamine) fumarate is a semisynthetic phenethylamine derivative structurally related to mescaline. This research compound is being studied for its unique pharmacological properties.

Põhiparameetrid:

• IUPAC-nimetus : 2-(3,5-dimethoxy-4-[(2-methylprop-2-en-1-yl)oxy]phenyl)ethan-1-amine fumarate

• Molekulaarne valem : C₁₄H₂₁NO₃ · C₄H₄O₄

• Molekulaarmass : 351.38 g/mol

• Puhtus : ≥97% (HPLC-UV at 280 nm)

• Välimus : White to light beige crystalline powder

• Sulamistemperatuur : 158-160°C (decomposes)

• Lahustuvus : 12 mg/ml in water, 25 mg/ml in ethanol

🧪Teaduslikud rakendused

1. Neurofarmakoloogilised uuringud :

   • 5-HT₂A receptor affinity studies (Ki = 85 nM)

   • Comparative analyses with mescaline and allylescaline

2. Psychometric evaluations :

   • Perceptual effects in controlled animal studies

   • Dose-response relationships in mammalian models

3. Metabolic studies :

   • O-demethylation kinetics study

   • CYP enzyme interaction profile

⚖️Recommended Dosages for Research

Katsejuhised:

*Note: Non-linear pharmacokinetics above 4 mg/kg*

⚠️Safety Aspects & Risks

1. Toksikoloogilised andmed :

   • LD₅₀ (rat, oral): 290 mg/kg

   • NOAEL: 0.5 mg/kg/day (14-day study)

2. Side effect profile :

   • <2 mg/kg: Minimal physiological effects

   • 2-5 mg/kg: Increased sensory sensitivity

   • 5 mg/kg: Potential cardiovascular effects

3. Kriitilised interaktsioonid :

   • Ohtlik : MAO inhibitors, serotonergic agents

   • Riskantne : Antihypertensives, QT-prolonging medications

📊Kvaliteedikontroll ja analüütilised andmed

• HPLC puhtus : 97.3% (C18 column, 65:35 H₂O:MeCN)

• Jäänud lahustid : <0.2% (GC-MS)

• Stabiilsusandmed :

  • Shelf life: 18 months at -20°C

  • Room temperature: 3 months (under argon)

❓Korduma kippuvad uurimisküsimused

K1: Milline on toimemehhanism?
A: Primary action as a 5-HT₂A receptor agonist with secondary effects on dopaminergic systems.

Q2: How does the potency compare to mescaline?
A: ~2-3x higher receptor affinity but shorter duration of action (4-6 hours).

Q3: What are the optimal storage conditions?
A: In amber vials under inert gas at -20°C.

Q4: Are there genotoxic risks?
A: Ames test negative at <500 μM, but limited chromosome test data.

📌Uuringu piirangud

• Limited data on chronic exposure

• Unknown neuroplastic effects

• Variable interspecies pharmacokinetics

🔍Conclusion for Scientists

Methallylescaline fumarate offers interesting possibilities for comparative serotonin research, with a unique combination of high potency and short duration of action. The fumarate form guarantees optimal stability for laboratory applications.

Important disclaimer: This product is intended solely for scientific research in accredited laboratories. Not for human use or diagnostic applications. All experiments must be conducted in accordance with local regulations and ethical guidelines.