{"id":23504,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23504"},"modified":"2025-10-22T17:00:59","modified_gmt":"2025-10-22T17:00:59","slug":"5-mg-dmt-vesinikkloriidi","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/et\/product\/5-mg-dmt-vesinikkloriidi\/","title":{"rendered":"5-MeO-DMT vesinikkloriid"},"content":{"rendered":"

5-MeO-DMT vesinikkloriid \u2013 teaduslik tootedokumentatsioon<\/span><\/span><\/strong><\/h3>\n

\u00dcldine kirjeldus<\/span><\/span><\/strong><\/h4>\n

5-MeO-DMT vesinikkloriid (5-metoks\u00fc-N,N-dimet\u00fc\u00fcltr\u00fcptamiin HCl) on klassikalise tr\u00fcptamiini vees lahustuv sool, mis sobib eriti h\u00e4sti farmakoloogiliseks uurimist\u00f6\u00f6ks t\u00e4nu oma suuremale stabiilsusele ja biosaadavusele v\u00f5rreldes vaba alusega.<\/span><\/span><\/p>\n

\n

Tehnilised andmed<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Parameeter<\/span><\/span><\/strong><\/th>\nSpetsifikatsioon<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
Keemiline valem<\/span><\/span><\/strong><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O \u00b7 HCl<\/span><\/span><\/td>\n<\/tr>\n
Molekulaarmass<\/span><\/span><\/strong><\/td>\n254,75 g\/mol<\/span><\/span><\/td>\n<\/tr>\n
Puhtus<\/span><\/span><\/strong><\/td>\n\u226598% (anal\u00fc\u00fcsitud HPLC-UV abil)<\/span><\/span><\/td>\n<\/tr>\n
V\u00e4limus<\/span><\/span><\/strong><\/td>\nValge kuni helekollane kristalliline pulber<\/span><\/span><\/td>\n<\/tr>\n
Lahustuvus<\/span><\/span><\/strong><\/td>\nK\u00f5rge veesisaldus (>50 mg\/ml), metanool, PBS<\/span><\/span><\/td>\n<\/tr>\n
Sulamistemperatuur<\/span><\/span><\/strong><\/td>\n243\u2013247 \u00b0C (laguneb)<\/span><\/span><\/td>\n<\/tr>\n
Stabiilsus<\/span><\/span><\/strong><\/td>\nH\u00fcgroskoopne; hoida kuivas kohas<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

Teaduslikud rakendused<\/span><\/span><\/strong><\/h3>\n

1. Neurofarmakoloogia ja k\u00e4itumusuuringud<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    Serotoniini retseptori uuringud:<\/span><\/span><\/strong> \u00a0Tugevatoimeline 5-HT\u2081\u2090\/\u2082\u2090 agonist, millel on kiire penetratsioon ajus.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Loomkatsed (in vivo):<\/span><\/span><\/strong> \u00a0K\u00e4itumuslikud paradigmad (nt pea t\u00f5mblemise reaktsioon n\u00e4rilistel).<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Elektrof\u00fcsioloogia:<\/span><\/span><\/strong> \u00a0M\u00f5ju neuronaalsetele v\u00f5nkumistele (nt gamma-riba aktiivsus).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. Biokeemilised ja molekulaarsed uuringud<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      Rakusisene signaalimine:<\/span><\/span><\/strong> \u00a0cAMP akumulatsiooni ja \u03b2-arrestiini v\u00e4rbamise testid.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Ens\u00fc\u00fcmi kineetika:<\/span><\/span><\/strong> \u00a0MAO-A metabolism (IC\u2085\u2080 ~2-5 \u03bcM).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. Kliiniliselt olulised uuringud<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        Annuse-vastuse seosed:<\/span><\/span><\/strong> \u00a0Prekliiniline ohutusprofiil.<\/span><\/span><\/p>\n<\/li>\n

      • \n

        V\u00f5rdlev farmakoloogia:<\/span><\/span><\/strong> \u00a0Psilots\u00fcbiini, DMT ja teiste tr\u00fcptamiinide suunas.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Katsejuhised<\/span><\/span><\/strong><\/h3>\n

        Soovitatavad kontsentratsioonid<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        Taotlus<\/span><\/span><\/strong><\/th>\nKontsentratsioonivahemik<\/span><\/span><\/strong><\/th>\nLahusti<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
        Rakukultuurid (in vitro)<\/span><\/span><\/td>\n1 nM \u2013 10 \u03bcM<\/span><\/span><\/td>\nPBS\/DMEM (\u22640,1% DMSO)<\/span><\/span><\/td>\n<\/tr>\n
        Retseptori testid<\/span><\/span><\/td>\n0,1\u2013100 \u03bcM<\/span><\/span><\/td>\nTris-HCl puhver (pH 7,4)<\/span><\/span><\/td>\n<\/tr>\n
        Loomkatsed (ip\/iv)<\/span><\/span><\/td>\n0,1\u20135 mg\/kg<\/span><\/span><\/td>\nSteriilne soolalahus<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        Ohutusmeetmed<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          Isikukaitse:<\/span><\/span><\/strong> \u00a0Laborikittel, kindad (nitriil), kaitseprillid.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          K\u00e4itlemine:<\/span><\/span><\/strong> \u00a0H\u00fcgroskoopne \u2013 sulgege kohe p\u00e4rast kasutamist.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          S\u00e4ilitamine:<\/span><\/span><\/strong> \u00a0\u00d5hutihe, argooni atmosf\u00e4\u00e4ris, temperatuuril -20\u00b0C (v\u00e4ltida h\u00fcdrol\u00fc\u00fcsi).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Stabiilsus ja ladustamine<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            S\u00e4ilivusaeg:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              -20\u00b0C:<\/span><\/span><\/strong> \u00a0>2 aastat (muutumatu puhtus).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4\u00b0C:<\/span><\/span><\/strong> \u00a06 kuud (kuivas keskkonnas).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              V\u00e4ljalangemine:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                H\u00fcdrol\u00fc\u00fcs pikaajalisel kokkupuutel niiskusega (j\u00e4lgida HPLC abil).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Anal\u00fc\u00fctiline valideerimine<\/span><\/span><\/strong><\/h3>\n

                Iga partiiga on kaasas:<\/span><\/span><\/p>\n

                  \n
                1. \n

                  HPLC-UV kromatogramm<\/span><\/span><\/strong> \u00a0(C18 kolonn, retentsiooniaeg ~6,2 min).<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  MS\/MS fragmentatsioon<\/span><\/span><\/strong> \u00a0(iseloomulikud ioonid: m\/z 219 \u2192 174, 160).<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  J\u00e4\u00e4nud lahustid<\/span><\/span><\/strong> \u00a0(vastab ICH Q3C suunistele).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  \u00d5iguslik staatus (Holland\/EL)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    Narkootikumidega seotud \u00f5igusaktid:<\/span><\/span><\/strong> \u00a0Oopiumiseaduses otseselt ei mainita, aga v\u00f5imalik, et analoogsete \u00f5igusaktide alusel (II lisa).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Teaduslik kasutamine:<\/span><\/span><\/strong> \u00a0Asutuste jaoks on vajalik luba (CCMO heakskiit loomkatseteks).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Ekspordi kontroll:<\/span><\/span><\/strong> \u00a0Vastavalt EL m\u00e4\u00e4rusele 2019\/1998 (ps\u00fchhotroopsed ained).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    Korduma kippuvad k\u00fcsimused (KKK)<\/span><\/span><\/strong><\/h3>\n

                    Q1 <\/span>Millised on HCl eelised vaba aluse ees?<\/span><\/strong><\/span><\/p>\n

                      \n
                    • \n

                      Parem lahustuvus<\/span><\/span><\/strong> \u00a0(ideaalne s\u00fcstimisuuringuteks).<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Pikem s\u00e4ilivusaeg<\/span><\/span><\/strong> \u00a0toatemperatuuril.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      K2: Kas 5-MeO-DMT-HCl on uimastitestides tuvastatav?<\/span><\/span><\/strong>
                      \n V: Jah, l\u00e4bi:<\/span><\/span><\/p>\n

                        \n
                      • \n

                        LC-MS\/MS<\/span><\/span><\/strong> \u00a0(tuvastatud kui 5-MeO-DMT + HCl adukt).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Immunoanal\u00fc\u00fcsid:<\/span><\/span><\/strong> \u00a0Ristreaktsioon DMT-ga (~15-20%).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        K3: Kas MAO inhibiitoritega kombineerimisel on riske?<\/span><\/span><\/strong>
                        \n V:\u00a0 <\/span><\/span>Absoluutselt.<\/span><\/span><\/strong><\/p>\n

                          \n
                        • \n

                          Suurenenud risk\u00a0 <\/span><\/span>serotoniini s\u00fcndroom<\/span><\/span><\/strong> \u00a0(v\u00e4ltige kombineerimist!).<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Kasutage ainult MAO-vabades mudelites.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          K4: Kuidas j\u00e4\u00e4tmeid utiliseerida?<\/span><\/span><\/strong>
                          \n V:<\/span><\/span><\/p>\n

                            \n
                          1. \n

                            Neutraliseerida koos\u00a0 <\/span><\/span>naatriumvesinikkarbonaat<\/span><\/span><\/strong> \u00a0(pH 7\u20138).<\/span><\/span><\/p>\n<\/li>\n

                          2. \n

                            Adsorbeeru koos\u00a0 <\/span><\/span>aktiivs\u00fcsi<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n<\/li>\n

                          3. \n

                            H\u00e4vitage j\u00e4rgmiselt\u00a0 <\/span><\/span>ohtlikud keemilised j\u00e4\u00e4tmed<\/span><\/span><\/strong> \u00a0(\u00dcRO nr 3249, klass 6.1).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                            \n

                            Viited ja kontakt<\/span><\/span><\/strong><\/h3>\n

                            P\u00f5hikirjandus:<\/span><\/span><\/strong><\/p>\n

                              \n
                            1. \n

                              Shen jt (2010). \u201e5-MeO-DMT derivaatide farmakoloogia\u201c.\u00a0 <\/span><\/span>J Psychopharmacol<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n

                            2. \n

                              Kaasik jt (2021). \u201e5-MeO-DMT ainevahetusrajad\u201c.\u00a0 <\/span><\/span>Ksenobiootikumid<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                              \n

                              See toode on ette n\u00e4htud ainult volitatud teaduslikuks uurimist\u00f6\u00f6ks. Mitte inimtoiduks ega diagnostiliseks kasutamiseks. Palun j\u00e4rgige kohalikke eeskirju.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                              5-MeO-DMT vesinikkloriidi omadused<\/span><\/span><\/span><\/h3>\n

                              S\u00fcnon\u00fc\u00fcm:<\/span><\/span><\/strong> 5-metoks\u00fc-N,N-dimet\u00fc\u00fcltr\u00fcptamiinvesinikkloriid <\/span><\/span>
                              \nCAS-number:<\/span><\/span><\/strong> p\u00e4rast <\/span><\/span>
                              \nValem:<\/span><\/span><\/strong> 3-[2-(dimet\u00fc\u00fclamino)et\u00fc\u00fcl]-5-metoks\u00fcindoolvesinikkloriid <\/span><\/span>
                              \nMolaarmass:<\/span><\/span><\/strong> 254,8 g\/mol <\/span><\/span>
                              \nPuhtus:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>","protected":false},"featured_media":28720,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[511,381],"product_tag":[326],"class_list":{"0":"post-23504","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-5-meo-dmt-kopen","7":"product_cat-tryptamines","8":"product_tag-nl","10":"first","11":"instock","12":"taxable","13":"shipping-taxable","14":"purchasable","15":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/product\/23504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/comments?post=23504"}],"version-history":[{"count":6,"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/product\/23504\/revisions"}],"predecessor-version":[{"id":28467,"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/product\/23504\/revisions\/28467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/media\/28720"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/media?parent=23504"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/product_brand?post=23504"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/product_cat?post=23504"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/product_tag?post=23504"}],"curies":[{"name":"t\u00f6\u00f6leht","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}