{"id":23655,"date":"2025-04-13T17:40:11","date_gmt":"2025-04-13T17:40:11","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23655"},"modified":"2025-10-22T14:57:47","modified_gmt":"2025-10-22T14:57:47","slug":"idra-21-10-mg-graanulid","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/et\/product\/idra-21-10-mg-graanulid\/","title":{"rendered":"IDRA-21 10 mg graanulit"},"content":{"rendered":"

IDRA-21 10 MG graanulid \u2013 teaduslik kirjeldus ja kasutusjuhend<\/span><\/span><\/strong><\/h3>\n

Toote kirjeldus<\/span><\/span><\/strong><\/h4>\n

IDRA-21 (10 mg graanulid)<\/span><\/span><\/strong> \u00a0on potentsiaalne\u00a0 <\/span><\/span>AMPA retseptori potentseerija<\/span><\/span><\/strong> \u00a0klassi kuuluv\u00a0 <\/span><\/span>nootroopsed ja neuroprotektiivsed uurimiskemikaalid<\/span><\/span><\/strong> . See toimib, v\u00f5imendades glutamaadi poolt indutseeritud signaali\u00fclekannet ajus, mis v\u00f5ib parandada kognitiivset funktsiooni, neuroplastilisust ja potentsiaalselt neuroloogilist taastumist.<\/span><\/span><\/p>\n

Need graanulid on\u00a0 <\/span><\/span>v\u00e4ga puhas (\u226598%)<\/span><\/span><\/strong> , standardiseeritud doseeringuga ja m\u00f5eldud ainult\u00a0 <\/span><\/span>teaduslikud uuringud ja prekliinilised uuringud<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n

\n

Kasutusalad ja rakendused<\/span><\/span><\/strong><\/h3>\n

IDRA-21 v\u00f5imalikku m\u00f5ju uuritakse j\u00e4rgmistele terviseprobleemidele:<\/span><\/span><\/p>\n

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  1. \n

    Kognitiivse v\u00f5imekuse parandamine<\/span><\/span><\/strong> \u00a0\u2013 V\u00f5ib suurendada erksust, \u00f5ppimisv\u00f5imet ja m\u00e4lu konsolideerumist.<\/span><\/span><\/p>\n<\/li>\n

  2. \n

    Neuroprotektsioon<\/span><\/span><\/strong> \u00a0\u2013 Potentsiaalne kaitsev toime neurodegeneratiivsete haiguste (nt Alzheimeri t\u00f5bi, insult) korral.<\/span><\/span><\/p>\n<\/li>\n

  3. \n

    Neuroloogiline taastumine<\/span><\/span><\/strong> \u00a0\u2013 V\u00f5ib soodustada s\u00fcnaptilist plastilisust p\u00e4rast ajukahjustust.<\/span><\/span><\/p>\n<\/li>\n

  4. \n

    Teaduslikud uuringud<\/span><\/span><\/strong> \u00a0\u2013 AMPA retseptori modulatsiooni ja glutamaadi signaali\u00fclekande uuring.<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

    \u26a0\u00a0Ei ole heaks kiidetud kasutamiseks inimestel ega veterinaarias \u2013 ainult in vitro ja kontrollitud prekliinilistes uuringutes.<\/span><\/span><\/strong><\/p>\n

    \n

    Annustamine ja ohutusjuhised<\/span><\/span><\/strong><\/h3>\n
      \n
    • \n

      Uuringus kasutatav annus (in vitro\/prekliiniline): <\/span><\/span><\/strong>\u00a05\u201320 mg\/kg<\/span><\/span><\/strong> \u00a0(s\u00f5ltuvalt mudelist).<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Pelletilahus:<\/span><\/span><\/strong> \u00a0V\u00f5ib lahustada\u00a0 <\/span><\/span>destilleeritud vesi v\u00f5i DMSO<\/span><\/span><\/strong> \u00a0katsete jaoks.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Haldus:<\/span><\/span><\/strong> \u00a0Suukaudselt (loommudelites) v\u00f5i otse rakukultuurides.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Sagedus:<\/span><\/span><\/strong> \u00a0\u00c4geda toime korral \u00fchekordne annus; pikaajalised uuringud vajavad hoolikat j\u00e4lgimist.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      \ud83d\udea8\u00a0NB!<\/span><\/span><\/strong><\/p>\n

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      • \n

        Inimese rakendust pole<\/span><\/span><\/strong> \u00a0\u2013 Inimestele m\u00f5eldud ohutusandmed puuduvad.<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Suured annused v\u00f5ivad p\u00f5hjustada neuroeksitotoksilisust.<\/span><\/span><\/strong><\/p>\n<\/li>\n

      • \n

        V\u00e4ltida koosmanustamist teiste glutamaadi modulaatoritega.<\/span><\/span><\/strong><\/p>\n<\/li>\n<\/ul>\n

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        Puudused ja riskid<\/span><\/span><\/strong><\/h3>\n
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        • \n

          Neuronite \u00fclestimuleerimine<\/span><\/span><\/strong> \u00a0(\u00fcleannustamise korral eksitotoksilisuse oht).<\/span><\/span><\/p>\n<\/li>\n

        • \n

          V\u00f5imalik \u00e4revus v\u00f5i agitatsioon<\/span><\/span><\/strong> \u00a0vastuv\u00f5tlikes mudelites.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Piiratud pikaajalised andmed<\/span><\/span><\/strong> \u00a0tolerantsuse ja k\u00f5rvaltoimete kohta.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Ei sobi krooniliseks kasutamiseks<\/span><\/span><\/strong> \u00a0ilma ulatuslike toksilisuse uuringuteta.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Korduma kippuvad k\u00fcsimused (KKK)<\/span><\/span><\/strong><\/h3>\n

          1. Kas IDRA-21 on Hollandis seaduslik?<\/span><\/span><\/strong><\/h4>\n

          Jah, aga ainult selleks\u00a0 <\/span><\/span>teaduslik uurimist\u00f6\u00f6<\/span><\/span><\/strong> . See ei kuulu oopiumiseaduse alla, kuid see pole ka ravimina heaks kiidetud.<\/span><\/span><\/p>\n

          2. Kuidas IDRA-21 t\u00e4pselt t\u00f6\u00f6tab?<\/span><\/span><\/strong><\/h4>\n

          See\u00a0 <\/span><\/span>v\u00f5imendab AMPA retseptori vastust<\/span><\/span><\/strong> , muutes glutamaadi signaali\u00fclekande pikemaks ja intensiivsemaks. See v\u00f5ib parandada s\u00fcnaptilist kommunikatsiooni.<\/span><\/span><\/p>\n

          3. Kas IDRA-21-e saab v\u00f5rrelda teiste nootroopikumidega?<\/span><\/span><\/strong><\/h4>\n

          Sellel on ainulaadne toimemehhanism, kuid\u00a0 <\/span><\/span>sarnased sihtm\u00e4rgid nagu ratsetaamid v\u00f5i ampakiinid<\/span><\/span><\/strong> \u00a0(nt Sunifiram).<\/span><\/span><\/p>\n

          4. Kas on teadaolevaid koostoimeid?<\/span><\/span><\/strong><\/h4>\n
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          • \n

            NMDA antagonistid<\/span><\/span><\/strong> \u00a0(nt memantiin) \u2013 V\u00f5imalikud k\u00f5rvaltoimed.<\/span><\/span><\/p>\n<\/li>\n

          • \n

            GABAergilised ained<\/span><\/span><\/strong> \u00a0(nt bensodiasepiinid) \u2013 V\u00f5ib v\u00e4hendada anksiol\u00fc\u00fctilist toimet.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

            \n

            Laboriaruanne ja kvaliteedikontroll<\/span><\/span><\/strong><\/h3>\n
              \n
            • \n

              HPLC anal\u00fc\u00fcs: <\/span><\/span><\/strong>\u00a0puhtus \u226598%<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n<\/li>\n

            • \n

              Raskmetalle ega lahustij\u00e4\u00e4ke ei ole tuvastatavad<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n<\/li>\n

            • \n

              Homogeenne pelletite koostis<\/span><\/span><\/strong> \u00a0j\u00e4rjepideva annustamise tagamiseks.<\/span><\/span><\/p>\n<\/li>\n

            • \n

              Partii sertifitseerimine<\/span><\/span><\/strong> \u00a0teadusasutustele k\u00e4ttesaadav.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

              \n

              Soovitatavad uurimisstsenaariumid<\/span><\/span><\/strong><\/h3>\n
                \n
              1. \n

                Kognitiivsed uuringud<\/span><\/span><\/strong> \u00a0\u2013 M\u00f5ju m\u00e4lule ja \u00f5ppimisele loommudelites.<\/span><\/span><\/p>\n<\/li>\n

              2. \n

                Neuroprotektiivsed uuringud<\/span><\/span><\/strong> \u00a0\u2013 V\u00f5imalik roll isheemilise kahjustuse tekkes (insuldi mudelid).<\/span><\/span><\/p>\n<\/li>\n

              3. \n

                Elektrof\u00fcsioloogia<\/span><\/span><\/strong> \u00a0\u2013 AMPA retseptori vastuse m\u00f5\u00f5tmised neuronaalsetes kultuurides.<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                \ud83d\udd2c\u00a0Ainult kontrollitud laborikasutuseks \u2013 Mitte harrastuslikuks kasutamiseks!<\/span><\/span><\/strong><\/p>\n

                ","protected":false},"excerpt":{"rendered":"

                IDRA-21 pelletite omadused<\/span><\/span><\/h3>\n

                S\u00fcnon\u00fc\u00fcm<\/span><\/span><\/strong> 7-kloro-3-met\u00fc\u00fcl-3,4-dih\u00fcdro-2H-1,2,4-bensotiadiasiin-1,1-dioksiid <\/span><\/span>
                \nCAS <\/span><\/span><\/strong> Number<\/span><\/span><\/strong> : 22503-72-6 <\/span><\/span>
                \nValem<\/span><\/span><\/strong> C8H9ClN2O2S <\/span><\/span>
                \nMolaarmass<\/span><\/span><\/strong> 232,6 g\/mol <\/span><\/span>
                \nPuhtus<\/span><\/span><\/strong> : >97%<\/span><\/span><\/p>","protected":false},"featured_media":28802,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[548,549,330,324],"product_tag":[326],"class_list":["post-23655","product","type-product","status-publish","has-post-thumbnail","product_cat-idra-21","product_cat-idra-21-pellets","product_cat-nootropics","product_cat-pellets-for-pellet","product_tag-nl","first","instock","taxable","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/product\/23655","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/comments?post=23655"}],"version-history":[{"count":5,"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/product\/23655\/revisions"}],"predecessor-version":[{"id":28058,"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/product\/23655\/revisions\/28058"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/media\/28802"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/media?parent=23655"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/product_brand?post=23655"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/product_cat?post=23655"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/et\/wp-json\/wp\/v2\/product_tag?post=23655"}],"curies":[{"name":"t\u00f6\u00f6leht","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}