{"id":23504,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23504"},"modified":"2025-10-22T17:00:59","modified_gmt":"2025-10-22T17:00:59","slug":"5-mg-dmt-hydrokloridia","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/fi\/tuote\/5-mg-dmt-hydrokloridia\/","title":{"rendered":"5-MeO-DMT-hydrokloridi"},"content":{"rendered":"

5-MeO-DMT-hydrokloridi \u2013 Tieteellinen tuotedokumentaatio<\/span><\/span><\/strong><\/h3>\n

Yleinen kuvaus<\/span><\/span><\/strong><\/h4>\n

5-MeO-DMT-hydrokloridi (5-metoksi-N,N-dimetyylitryptamiinihydrokloridi) on klassisen tryptamiinin vesiliukoinen suola, joka soveltuu erityisen hyvin farmakologiseen tutkimukseen lis\u00e4\u00e4ntyneen stabiiliutensa ja biologisen hy\u00f6tyosuutensa ansiosta verrattuna vapaaseen em\u00e4smuotoon.<\/span><\/span><\/p>\n

\n

Tekniset tiedot<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Parametri<\/span><\/span><\/strong><\/th>\nTekniset tiedot<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
Kemiallinen kaava<\/span><\/span><\/strong><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O \u00b7 HCl<\/span><\/span><\/td>\n<\/tr>\n
Molekyylipaino<\/span><\/span><\/strong><\/td>\n254,75 g\/mol<\/span><\/span><\/td>\n<\/tr>\n
Puhtaus<\/span><\/span><\/strong><\/td>\n\u226598% (analysoitu HPLC-UV:ll\u00e4)<\/span><\/span><\/td>\n<\/tr>\n
Ulkon\u00e4k\u00f6<\/span><\/span><\/strong><\/td>\nValkoinen tai vaaleankeltainen kiteinen jauhe<\/span><\/span><\/td>\n<\/tr>\n
Liukoisuus<\/span><\/span><\/strong><\/td>\nRunsaasti vett\u00e4 (>50 mg\/ml), metanolia, PBS:\u00e4\u00e4<\/span><\/span><\/td>\n<\/tr>\n
Sulamispiste<\/span><\/span><\/strong><\/td>\n243\u2013247 \u00b0C (hajoaa)<\/span><\/span><\/td>\n<\/tr>\n
Vakaus<\/span><\/span><\/strong><\/td>\nHygroskooppinen; s\u00e4ilyt\u00e4 kuivissa olosuhteissa<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

Tieteelliset sovellukset<\/span><\/span><\/strong><\/h3>\n

1. Neurofarmakologia ja k\u00e4ytt\u00e4ytymistutkimus<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    Serotoniinireseptoritutkimukset:<\/span><\/span><\/strong> \u00a0Voimakas 5-HT\u2081\u2090\/\u2082\u2090-agonisti, jolla on nopea aivoihin tunkeutuminen.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    El\u00e4inkokeet (in vivo):<\/span><\/span><\/strong> \u00a0K\u00e4ytt\u00e4ytymisparadigmat (esim. p\u00e4\u00e4n nykiminen jyrsij\u00f6ill\u00e4).<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Elektrofysiologia:<\/span><\/span><\/strong> \u00a0Vaikutukset hermosolujen v\u00e4r\u00e4htelyihin (esim. gamma-alueen aktiivisuus).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. Biokemialliset ja molekyylitutkimukset<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      Solunsis\u00e4inen signalointi:<\/span><\/span><\/strong> \u00a0cAMP:n kertymis- ja \u03b2-arrestiinin rekrytointim\u00e4\u00e4ritykset.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Entsyymikinetiikka:<\/span><\/span><\/strong> \u00a0MAO-A-metabolia (IC\u2085\u2080 ~2\u20135 \u03bcM).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. Kliinisesti relevantti tutkimus<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        Annos-vastesuhteet:<\/span><\/span><\/strong> \u00a0Prekliininen turvallisuusprofilointi.<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Vertaileva farmakologia:<\/span><\/span><\/strong> \u00a0Kohti psilosybiini\u00e4, DMT:t\u00e4 ja muita tryptamiineja.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Kokeelliset ohjeet<\/span><\/span><\/strong><\/h3>\n

        Suositellut pitoisuudet<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        Hakemus<\/span><\/span><\/strong><\/th>\nPitoisuusalue<\/span><\/span><\/strong><\/th>\nLiuotin<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
        Soluviljelm\u00e4t (in vitro)<\/span><\/span><\/td>\n1 nM \u2013 10 \u03bcM<\/span><\/span><\/td>\nPBS\/DMEM (\u22640,1% DMSO)<\/span><\/span><\/td>\n<\/tr>\n
        Reseptorim\u00e4\u00e4ritykset<\/span><\/span><\/td>\n0,1\u2013100 \u03bcM<\/span><\/span><\/td>\nTris-HCl-puskuri (pH 7,4)<\/span><\/span><\/td>\n<\/tr>\n
        El\u00e4inkokeet (i.p.\/i.v.)<\/span><\/span><\/td>\n0,1\u20135 mg\/kg<\/span><\/span><\/td>\nSteriili suolaliuos<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        Turvatoimenpiteet<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          Henkil\u00f6kohtainen suojaus:<\/span><\/span><\/strong> \u00a0Laboratoriotakki, k\u00e4sineet (nitriili), suojalasit.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          K\u00e4sittely:<\/span><\/span><\/strong> \u00a0Hygroskooppinen \u2013 sulje heti k\u00e4yt\u00f6n j\u00e4lkeen.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          S\u00e4ilytys:<\/span><\/span><\/strong> \u00a0Ilmatiivis argonkaasussa -20 \u00b0C:ssa (est\u00e4 hydrolyysi).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Stabiilisuus ja s\u00e4ilytys<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            S\u00e4ilyvyysaika:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              -20\u00b0C:<\/span><\/span><\/strong> \u00a0>2 vuotta (muuttumaton puhtaus).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4\u00b0C:<\/span><\/span><\/strong> \u00a06 kuukautta (kuivassa ymp\u00e4rist\u00f6ss\u00e4).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              Putoaminen:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Hydrolyysi pitk\u00e4aikaisessa kosteudelle altistumisessa (seuranta HPLC:ll\u00e4).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Analyyttinen validointi<\/span><\/span><\/strong><\/h3>\n

                Jokaisen er\u00e4n mukana tulee:<\/span><\/span><\/p>\n

                  \n
                1. \n

                  HPLC-UV-kromatogrammi<\/span><\/span><\/strong> \u00a0(C18-kolonni, retentioaika ~6,2 min).<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  MS\/MS-fragmentaatio<\/span><\/span><\/strong> \u00a0(karakterisiset ionit: m\/z 219 \u2192 174, 160).<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  J\u00e4\u00e4nn\u00f6sliuottimet<\/span><\/span><\/strong> \u00a0(t\u00e4ytt\u00e4\u00e4 ICH:n Q3C-ohjeet).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  Oikeudellinen asema (Alankomaat\/EU)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    Huumausainelains\u00e4\u00e4d\u00e4nt\u00f6:<\/span><\/span><\/strong> \u00a0Ei nimenomaisesti mainittu oopiumilaissa, mutta mahdollisesti vastaavassa lains\u00e4\u00e4d\u00e4nn\u00f6ss\u00e4 (liite II).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Tieteellinen k\u00e4ytt\u00f6:<\/span><\/span><\/strong> \u00a0Laitoksilta vaaditaan lupa (CCMO:n hyv\u00e4ksynt\u00e4 el\u00e4inkokeille).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Vientivalvonta:<\/span><\/span><\/strong> \u00a0EU-asetuksen 2019\/1998 (psykotrooppiset aineet) alainen.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    Usein kysytyt kysymykset (UKK)<\/span><\/span><\/strong><\/h3>\n

                    Q1 <\/span>Mit\u00e4 etuja HCl:lla on vapaaseen em\u00e4kseen verrattuna?<\/span><\/strong><\/span><\/p>\n

                      \n
                    • \n

                      Parempi liukoisuus<\/span><\/span><\/strong> \u00a0(ihanteellinen injektiotutkimuksiin).<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Pidempi s\u00e4ilyvyysaika<\/span><\/span><\/strong> \u00a0huoneenl\u00e4mm\u00f6ss\u00e4.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      K2: Onko 5-MeO-DMT-HCl havaittavissa huumetesteiss\u00e4?<\/span><\/span><\/strong>
                      \n V: Kyll\u00e4, kautta:<\/span><\/span><\/p>\n

                        \n
                      • \n

                        LC-MS\/MS<\/span><\/span><\/strong> \u00a0(tunnistetaan 5-MeO-DMT + HCl -adduktina).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Immunom\u00e4\u00e4ritykset:<\/span><\/span><\/strong> \u00a0Ristireaktiivisuus DMT:n (~15-20%) kanssa.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        K3: Onko MAO-est\u00e4jien kanssa yhdist\u00e4miseen riskej\u00e4?<\/span><\/span><\/strong>
                        \n A:\u00a0 <\/span><\/span>T\u00e4ysin.<\/span><\/span><\/strong><\/p>\n

                          \n
                        • \n

                          Lis\u00e4\u00e4ntynyt riski\u00a0 <\/span><\/span>serotoniinioireyhtym\u00e4<\/span><\/span><\/strong> \u00a0(v\u00e4lt\u00e4 yhdistelmi\u00e4!).<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          K\u00e4yt\u00e4 vain MAO-vapaissa malleissa.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          K4: Miten j\u00e4tteet h\u00e4vitet\u00e4\u00e4n?<\/span><\/span><\/strong>
                          \n A:<\/span><\/span><\/p>\n

                            \n
                          1. \n

                            Neutraloi\u00a0 <\/span><\/span>natriumbikarbonaatti<\/span><\/span><\/strong> \u00a0(pH 7\u20138).<\/span><\/span><\/p>\n<\/li>\n

                          2. \n

                            Imeydy\u00a0 <\/span><\/span>aktiivihiili<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n<\/li>\n

                          3. \n

                            H\u00e4vit\u00e4 kuten\u00a0 <\/span><\/span>vaarallinen kemiallinen j\u00e4te<\/span><\/span><\/strong> \u00a0(YK 3249, luokka 6.1).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                            \n

                            Referenssit ja yhteystiedot<\/span><\/span><\/strong><\/h3>\n

                            Keskeinen kirjallisuus:<\/span><\/span><\/strong><\/p>\n

                              \n
                            1. \n

                              Shen ym. (2010). \u201d5-MeO-DMT-johdannaisten farmakologia\u201d.\u00a0 <\/span><\/span>J Psychopharmacol<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n

                            2. \n

                              Kaasik ym. (2021). \u201d5-MeO-DMT:n aineenvaihduntareitit\u201d.\u00a0 <\/span><\/span>Ksenobiootit<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                              \n

                              T\u00e4m\u00e4 tuote on tarkoitettu ainoastaan valtuutettuun tieteelliseen tutkimukseen. Ei ihmisravinnoksi tai diagnostiseen k\u00e4ytt\u00f6\u00f6n. Noudata paikallisia m\u00e4\u00e4r\u00e4yksi\u00e4.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                              5-MeO-DMT hydrochloride properties<\/span><\/span><\/span><\/h3>\n

                              Synonym:<\/span><\/span><\/strong> 5-methoxy-N,N-dimethyltryptamine hydrochloride <\/span><\/span>
                              \nCAS Number:<\/span><\/span><\/strong> n\/a <\/span><\/span>
                              \nFormula:<\/span><\/span><\/strong> 3-[2-(dimethylamino)ethyl]-5-methoxyindole hydrochloride <\/span><\/span>
                              \nMolar mass:<\/span><\/span><\/strong> 254.8 g\/mol <\/span><\/span>
                              \nPurity:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>\n","protected":false},"featured_media":28720,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[511,381],"product_tag":[326],"class_list":["post-23504","product","type-product","status-publish","has-post-thumbnail","product_cat-5-meo-dmt-kopen","product_cat-tryptamines","product_tag-nl","first","instock","taxable","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/fi\/wp-json\/wp\/v2\/product\/23504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/fi\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/fi\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fi\/wp-json\/wp\/v2\/comments?post=23504"}],"version-history":[{"count":6,"href":"https:\/\/researchchemicalstore.eu\/fi\/wp-json\/wp\/v2\/product\/23504\/revisions"}],"predecessor-version":[{"id":28467,"href":"https:\/\/researchchemicalstore.eu\/fi\/wp-json\/wp\/v2\/product\/23504\/revisions\/28467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fi\/wp-json\/wp\/v2\/media\/28720"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/fi\/wp-json\/wp\/v2\/media?parent=23504"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fi\/wp-json\/wp\/v2\/product_brand?post=23504"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fi\/wp-json\/wp\/v2\/product_cat?post=23504"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fi\/wp-json\/wp\/v2\/product_tag?post=23504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}