{"id":23388,"date":"2025-04-13T17:39:41","date_gmt":"2025-04-13T17:39:41","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23388"},"modified":"2025-10-23T01:05:10","modified_gmt":"2025-10-23T01:05:10","slug":"fumarate-de-methallylescaline","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/fr\/produit\/fumarate-de-methallylescaline\/","title":{"rendered":"Fumarate de m\u00e9thallylescaline"},"content":{"rendered":"

Fumarate de m\u00e9thallylescaline \u2013 Documentation scientifique du produit<\/span><\/span><\/strong><\/h3>\n

\ud83d\udd2cSp\u00e9cifications chimiques<\/span><\/span><\/strong><\/h4>\n

Le fumarate de m\u00e9thallylescaline (MAL, 3,5-dim\u00e9thoxy-4-(2-m\u00e9thylallyloxy)ph\u00e9n\u00e9thylamine) est un d\u00e9riv\u00e9 semi-synth\u00e9tique de la ph\u00e9n\u00e9thylamine, structurellement apparent\u00e9 \u00e0 la mescaline. Ce compos\u00e9 de recherche est \u00e9tudi\u00e9 pour ses propri\u00e9t\u00e9s pharmacologiques uniques.<\/span><\/span><\/p>\n

Param\u00e8tres de base :<\/span><\/span><\/em><\/p>\n

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    Nom de l'IUPAC<\/span><\/span><\/strong> : fumarate de 2-(3,5-dim\u00e9thoxy-4-[(2-m\u00e9thylprop-2-\u00e9n-1-yl)oxy]ph\u00e9nyl)\u00e9than-1-amine<\/span><\/span><\/p>\n<\/li>\n

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    Formule mol\u00e9culaire<\/span><\/span><\/strong> : C\u2081\u2084H\u2082\u2081NO\u2083 \u00b7 C\u2084H\u2084O\u2084<\/span><\/span><\/p>\n<\/li>\n

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    Poids mol\u00e9culaire<\/span><\/span><\/strong> : 351,38 g\/mol<\/span><\/span><\/p>\n<\/li>\n

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    Puret\u00e9<\/span><\/span><\/strong> : \u226597% (HPLC-UV \u00e0 280 nm)<\/span><\/span><\/p>\n<\/li>\n

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    Apparence<\/span><\/span><\/strong> :Poudre cristalline blanche \u00e0 beige clair<\/span><\/span><\/p>\n<\/li>\n

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    Point de fusion<\/span><\/span><\/strong> : 158-160\u00b0C (se d\u00e9compose)<\/span><\/span><\/p>\n<\/li>\n

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    Solubilit\u00e9<\/span><\/span><\/strong> : 12 mg\/ml dans l'eau, 25 mg\/ml dans l'\u00e9thanol<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddeaApplications scientifiques<\/span><\/span><\/strong><\/h4>\n
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    1. \n

      Recherche neuropharmacologique<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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        \u00c9tudes d'affinit\u00e9 du r\u00e9cepteur 5-HT\u2082A (Ki = 85 nM)<\/span><\/span><\/p>\n<\/li>\n

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        Analyses comparatives avec la mescaline et l'allylescaline<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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        \u00c9valuations psychom\u00e9triques<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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          Effets perceptifs dans les \u00e9tudes animales contr\u00f4l\u00e9es<\/span><\/span><\/p>\n<\/li>\n

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          Relations dose-r\u00e9ponse dans les mod\u00e8les mammif\u00e8res<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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          \u00c9tudes m\u00e9taboliques<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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            \u00c9tude de la cin\u00e9tique de l'O-d\u00e9m\u00e9thylation<\/span><\/span><\/p>\n<\/li>\n

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            Profil d'interaction enzymatique CYP<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0fDosages recommand\u00e9s pour la recherche<\/span><\/span><\/strong><\/h4>\n

            Directives exp\u00e9rimentales :<\/span><\/span><\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Mod\u00e8le<\/span><\/span><\/th>\nDosage<\/span><\/span><\/th>\nRoute de l'Administration<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/span><\/span><\/td>\n5 \u00e0 50 \u03bcM<\/span><\/span><\/td>\nMilieu de culture cellulaire<\/span><\/span><\/td>\n<\/tr>\n
            Petits animaux<\/span><\/span><\/td>\n0,5-3 mg\/kg<\/span><\/span><\/td>\nintrap\u00e9riton\u00e9ale<\/span><\/span><\/td>\n<\/tr>\n
            Primates<\/span><\/span><\/td>\n0,1-0,4 mg\/kg<\/span><\/span><\/td>\nOral<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Remarque\u00a0: pharmacocin\u00e9tique non lin\u00e9aire au-dessus de 4\u00a0mg\/kg*<\/span><\/span><\/p>\n

            \u26a0\ufe0fAspects et risques li\u00e9s \u00e0 la s\u00e9curit\u00e9<\/span><\/span><\/strong><\/h4>\n
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            1. \n

              Donn\u00e9es toxicologiques<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                DL\u2085\u2080 (rat, voie orale) : 290 mg\/kg<\/span><\/span><\/p>\n<\/li>\n

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                NOAEL\u00a0: 0,5 mg\/kg\/jour (\u00e9tude de 14 jours)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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                Profil des effets secondaires<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                • \n

                  < 2 mg\/kg : effets physiologiques minimes<\/span><\/span><\/p>\n<\/li>\n

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                  2-5 mg\/kg : Augmentation de la sensibilit\u00e9 sensorielle<\/span><\/span><\/p>\n<\/li>\n

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                  \n

                  5 mg\/kg : effets cardiovasculaires potentiels<\/span><\/span><\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

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                  Interactions critiques<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                    Dangereux<\/span><\/span><\/strong> : Inhibiteurs de la MAO, agents s\u00e9rotoninergiques<\/span><\/span><\/p>\n<\/li>\n

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                    Risqu\u00e9<\/span><\/span><\/strong> : Antihypertenseurs, m\u00e9dicaments allongeant l'intervalle QT<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udccaContr\u00f4le qualit\u00e9 et donn\u00e9es analytiques<\/span><\/span><\/strong><\/h4>\n
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                      Puret\u00e9 HPLC<\/span><\/span><\/strong> : 97.3% (colonne C18, 65:35 H\u2082O:MeCN)<\/span><\/span><\/p>\n<\/li>\n

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                      Solvants r\u00e9siduels<\/span><\/span><\/strong> : <0,2% (GC-MS)<\/span><\/span><\/p>\n<\/li>\n

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                      Donn\u00e9es de stabilit\u00e9<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                        Dur\u00e9e de conservation : 18 mois \u00e0 -20\u00b0C<\/span><\/span><\/p>\n<\/li>\n

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                        Temp\u00e9rature ambiante : 3 mois (sous argon)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753Questions de recherche fr\u00e9quemment pos\u00e9es<\/span><\/span><\/strong><\/h4>\n

                        Q1 : Quel est le m\u00e9canisme d\u2019action ?<\/span><\/span><\/strong>
                        \n A : Action primaire en tant qu\u2019agoniste du r\u00e9cepteur 5-HT\u2082A avec effets secondaires sur les syst\u00e8mes dopaminergiques.<\/span><\/span><\/p>\n

                        Q2 : Comment la puissance se compare-t-elle \u00e0 celle de la mescaline ?<\/span><\/span><\/strong>
                        \n A : Affinit\u00e9 du r\u00e9cepteur environ 2 \u00e0 3 fois sup\u00e9rieure mais dur\u00e9e d'action plus courte (4 \u00e0 6 heures).<\/span><\/span><\/p>\n

                        Q3 : Quelles sont les conditions de stockage optimales ?<\/span><\/span><\/strong>
                        \n A : Dans des flacons ambr\u00e9s sous gaz inerte \u00e0 -20\u00b0C.<\/span><\/span><\/p>\n

                        Q4 : Existe-t-il des risques g\u00e9notoxiques ?<\/span><\/span><\/strong>
                        \n A : Test d'Ames n\u00e9gatif \u00e0 < 500 \u03bcM, mais donn\u00e9es de test chromosomique limit\u00e9es.<\/span><\/span><\/p>\n

                        \ud83d\udcccLimites de la recherche<\/span><\/span><\/strong><\/h4>\n
                          \n
                        • \n

                          Donn\u00e9es limit\u00e9es sur l'exposition chronique<\/span><\/span><\/p>\n<\/li>\n

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                          Effets neuroplastiques inconnus<\/span><\/span><\/p>\n<\/li>\n

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                          Pharmacocin\u00e9tique intersp\u00e9cifique variable<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0dConclusion pour les scientifiques<\/span><\/span><\/strong><\/h4>\n

                          Le fumarate de m\u00e9thallylescaline offre des perspectives int\u00e9ressantes pour la recherche comparative sur la s\u00e9rotonine, gr\u00e2ce \u00e0 sa combinaison unique de puissance \u00e9lev\u00e9e et de courte dur\u00e9e d'action. La forme fumarate garantit une stabilit\u00e9 optimale pour les applications en laboratoire.<\/span><\/span><\/p>\n

                          Avertissement important\u00a0: Ce produit est destin\u00e9 uniquement \u00e0 la recherche scientifique dans des laboratoires accr\u00e9dit\u00e9s. Il n\u2019est pas destin\u00e9 \u00e0 un usage humain ni \u00e0 des applications diagnostiques. Toutes les exp\u00e9riences doivent \u00eatre men\u00e9es conform\u00e9ment \u00e0 la r\u00e9glementation locale et aux principes \u00e9thiques.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Propri\u00e9t\u00e9s du fumarate de m\u00e9thallylescaline<\/span><\/span><\/span><\/span><\/span><\/h3>\n

                          Synonyme:<\/span><\/span><\/span><\/span><\/strong> Fumarate de 3,5-dim\u00e9thoxy-4-m\u00e9thallyloxyph\u00e9n\u00e9thylamine <\/span><\/span><\/span><\/span>
                          \nNum\u00e9ro CAS :<\/span><\/span><\/span><\/span><\/strong> 207740-41-8 <\/span><\/span><\/span><\/span>
                          \nFormule:<\/span><\/span><\/span><\/span><\/strong> Fumarate de 2-{3,5-dim\u00e9thoxy-4-[(2-m\u00e9thylprop-2-\u00e9n-1-yl)oxy]ph\u00e9nyl}\u00e9than-1-amine <\/span><\/span><\/span><\/span>
                          \nMasse molaire :<\/span><\/span><\/span><\/span><\/strong> 367,4 g\/mol <\/span><\/span><\/span><\/span>
                          \nPuret\u00e9:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>","protected":false},"featured_media":28812,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,80,482,398],"product_tag":[326],"class_list":{"0":"post-23388","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-fenethylamine","8":"product_cat-methallylescaline","9":"product_cat-verkoop","10":"product_tag-nl","12":"first","13":"instock","14":"sale","15":"taxable","16":"shipping-taxable","17":"purchasable","18":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product\/23388","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/comments?post=23388"}],"version-history":[{"count":5,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product\/23388\/revisions"}],"predecessor-version":[{"id":28081,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product\/23388\/revisions\/28081"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/media\/28812"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/media?parent=23388"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product_brand?post=23388"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product_cat?post=23388"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product_tag?post=23388"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}