{"id":23504,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23504"},"modified":"2025-10-22T17:00:59","modified_gmt":"2025-10-22T17:00:59","slug":"chlorhydrate-de-5-meo-dmt","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/fr\/produit\/chlorhydrate-de-5-meo-dmt\/","title":{"rendered":"chlorhydrate de 5-MeO-DMT"},"content":{"rendered":"

Chlorhydrate de 5-MeO-DMT \u2013 Documentation scientifique du produit<\/span><\/span><\/strong><\/h3>\n

Description g\u00e9n\u00e9rale<\/span><\/span><\/strong><\/h4>\n

Le chlorhydrate de 5-MeO-DMT (5-m\u00e9thoxy-N,N-dim\u00e9thyltryptamine HCl) est un sel hydrosoluble de tryptamine classique, particuli\u00e8rement adapt\u00e9 \u00e0 la recherche pharmacologique en raison de sa stabilit\u00e9 et de sa biodisponibilit\u00e9 accrues par rapport \u00e0 la forme base libre.<\/span><\/span><\/p>\n

\n

Sp\u00e9cifications techniques<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Param\u00e8tre<\/span><\/span><\/strong><\/th>\nSp\u00e9cification<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
Formule chimique<\/span><\/span><\/strong><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O \u00b7 HCl<\/span><\/span><\/td>\n<\/tr>\n
Poids mol\u00e9culaire<\/span><\/span><\/strong><\/td>\n254,75 g\/mol<\/span><\/span><\/td>\n<\/tr>\n
Puret\u00e9<\/span><\/span><\/strong><\/td>\n\u226598% (analys\u00e9 par HPLC-UV)<\/span><\/span><\/td>\n<\/tr>\n
Apparence<\/span><\/span><\/strong><\/td>\nPoudre cristalline blanche \u00e0 jaune clair<\/span><\/span><\/td>\n<\/tr>\n
Solubilit\u00e9<\/span><\/span><\/strong><\/td>\nRiche en eau (> 50 mg\/ml), m\u00e9thanol, PBS<\/span><\/span><\/td>\n<\/tr>\n
Point de fusion<\/span><\/span><\/strong><\/td>\n243-247\u00b0C (se d\u00e9compose)<\/span><\/span><\/td>\n<\/tr>\n
Stabilit\u00e9<\/span><\/span><\/strong><\/td>\nHygroscopique; conserver dans des conditions s\u00e8ches<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

Applications scientifiques<\/span><\/span><\/strong><\/h3>\n

1. Neuropharmacologie et recherche comportementale<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    \u00c9tudes sur les r\u00e9cepteurs de la s\u00e9rotonine :<\/span><\/span><\/strong> \u00a0Agoniste 5-HT\u2081\u2090\/\u2082\u2090 puissant \u00e0 p\u00e9n\u00e9tration c\u00e9r\u00e9brale rapide.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Exp\u00e9riences sur les animaux (in vivo) :<\/span><\/span><\/strong> \u00a0Paradigmes comportementaux (par exemple, r\u00e9ponse de contraction de la t\u00eate chez les rongeurs).<\/span><\/span><\/p>\n<\/li>\n

  • \n

    \u00c9lectrophysiologie :<\/span><\/span><\/strong> \u00a0Effets sur les oscillations neuronales (par exemple, activit\u00e9 de la bande gamma).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. \u00c9tudes biochimiques et mol\u00e9culaires<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      Signalisation intracellulaire :<\/span><\/span><\/strong> \u00a0Dosages d'accumulation d'AMPc et de recrutement de \u03b2-arrestine.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Cin\u00e9tique enzymatique :<\/span><\/span><\/strong> \u00a0M\u00e9tabolisme de la MAO-A (IC\u2085\u2080 ~2-5 \u03bcM).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. Recherche cliniquement pertinente<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        Relations dose-r\u00e9ponse :<\/span><\/span><\/strong> \u00a0Profilage de s\u00e9curit\u00e9 pr\u00e9clinique.<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Pharmacologie compar\u00e9e :<\/span><\/span><\/strong> \u00a0Vers la psilocybine, le DMT et d\u2019autres tryptamines.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Directives exp\u00e9rimentales<\/span><\/span><\/strong><\/h3>\n

        Concentrations recommand\u00e9es<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        Application<\/span><\/span><\/strong><\/th>\nPlage de concentration<\/span><\/span><\/strong><\/th>\nSolvant<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
        Cultures cellulaires (in vitro)<\/span><\/span><\/td>\n1 nM \u2013 10 \u03bcM<\/span><\/span><\/td>\nPBS\/DMEM (\u22640,1% DMSO)<\/span><\/span><\/td>\n<\/tr>\n
        Dosages des r\u00e9cepteurs<\/span><\/span><\/td>\n0,1 \u2013 100 \u03bcM<\/span><\/span><\/td>\nTampon Tris-HCl (pH 7,4)<\/span><\/span><\/td>\n<\/tr>\n
        \u00c9tudes animales (ip\/iv)<\/span><\/span><\/td>\n0,1 \u2013 5 mg\/kg<\/span><\/span><\/td>\nSolution saline st\u00e9rile<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        Mesures de s\u00e9curit\u00e9<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          Protection individuelle :<\/span><\/span><\/strong> \u00a0Blouse de laboratoire, gants (nitrile), lunettes de s\u00e9curit\u00e9.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Manutention:<\/span><\/span><\/strong> \u00a0Hygroscopique \u2013 refermer rapidement apr\u00e8s utilisation.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Stockage:<\/span><\/span><\/strong> \u00a0Herm\u00e9tique, sous argon, \u00e0 -20\u00b0C (\u00e9vite l'hydrolyse).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Stabilit\u00e9 et stockage<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            Dur\u00e9e de conservation :<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              -20\u00b0C :<\/span><\/span><\/strong> \u00a0>2 ans (puret\u00e9 inchang\u00e9e).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4\u00b0C :<\/span><\/span><\/strong> \u00a06 mois (en milieu sec).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              Rel\u00e9gation:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Hydrolyse lors d'une exposition prolong\u00e9e \u00e0 l'humidit\u00e9 (surveillance par HPLC).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Validation analytique<\/span><\/span><\/strong><\/h3>\n

                Chaque lot est livr\u00e9 avec :<\/span><\/span><\/p>\n

                  \n
                1. \n

                  Chromatogramme HPLC-UV<\/span><\/span><\/strong> \u00a0(colonne C18, temps de r\u00e9tention ~6,2 min).<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  Fragmentation MS\/MS<\/span><\/span><\/strong> \u00a0(ions caract\u00e9ristiques : m\/z 219 \u2192 174, 160).<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  Solvants r\u00e9siduels<\/span><\/span><\/strong> \u00a0(conforme aux directives ICH Q3C).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  Statut juridique (Pays-Bas\/UE)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    L\u00e9gislation sur les stup\u00e9fiants :<\/span><\/span><\/strong> \u00a0Non mentionn\u00e9 explicitement dans la loi sur l'opium, mais peut-\u00eatre dans une l\u00e9gislation analogue (annexe II).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Utilisation scientifique :<\/span><\/span><\/strong> \u00a0Permis requis pour les institutions (approbation du CCMO pour les tests sur les animaux).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Contr\u00f4le des exportations :<\/span><\/span><\/strong> \u00a0Soumis au R\u00e8glement UE 2019\/1998 (substances psychotropes).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    Foire aux questions (FAQ)<\/span><\/span><\/strong><\/h3>\n

                    Q1 <\/span>:Quels sont les avantages du HCl par rapport au freebase ?<\/span><\/strong><\/span><\/p>\n

                      \n
                    • \n

                      Solubilit\u00e9 am\u00e9lior\u00e9e<\/span><\/span><\/strong> \u00a0(id\u00e9al pour les \u00e9tudes d'injection).<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Stabilit\u00e9 de conservation plus longue<\/span><\/span><\/strong> \u00a0\u00e0 temp\u00e9rature ambiante.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      Q2 : Le 5-MeO-DMT-HCl est-il d\u00e9tectable dans les tests de d\u00e9pistage de drogues ?<\/span><\/span><\/strong>
                      \n R : Oui, via :<\/span><\/span><\/p>\n

                        \n
                      • \n

                        LC-MS\/MS<\/span><\/span><\/strong> \u00a0(reconnu comme adduit 5-MeO-DMT + HCl).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Immunoessais :<\/span><\/span><\/strong> \u00a0R\u00e9activit\u00e9 crois\u00e9e avec DMT (~15-20%).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        Q3 : Existe-t-il des risques lors de l\u2019association avec des inhibiteurs de la MAO ?<\/span><\/span><\/strong>
                        \n UN:\u00a0 <\/span><\/span>Absolument.<\/span><\/span><\/strong><\/p>\n

                          \n
                        • \n

                          Risque accru de\u00a0 <\/span><\/span>syndrome s\u00e9rotoninergique<\/span><\/span><\/strong> \u00a0(\u00e9vitez la combinaison !).<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Utiliser uniquement dans les mod\u00e8les sans MAO.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          Q4 : Comment \u00e9liminer les d\u00e9chets ?<\/span><\/span><\/strong>
                          \n UN:<\/span><\/span><\/p>\n

                            \n
                          1. \n

                            Neutraliser avec\u00a0 <\/span><\/span>bicarbonate de sodium<\/span><\/span><\/strong> \u00a0(pH 7-8).<\/span><\/span><\/p>\n<\/li>\n

                          2. \n

                            Adsorber avec\u00a0 <\/span><\/span>charbon actif<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n<\/li>\n

                          3. \n

                            \u00c9liminer comme\u00a0 <\/span><\/span>d\u00e9chets chimiques dangereux<\/span><\/span><\/strong> \u00a0(UN 3249, Classe 6.1).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                            \n

                            R\u00e9f\u00e9rences et contact<\/span><\/span><\/strong><\/h3>\n

                            Litt\u00e9rature principale :<\/span><\/span><\/strong><\/p>\n

                              \n
                            1. \n

                              Shen et al. (2010). \u00ab Pharmacologie des d\u00e9riv\u00e9s du 5-MeO-DMT \u00bb.\u00a0 <\/span><\/span>J Psychopharmacol<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n

                            2. \n

                              Kaasik et al. (2021). \u00ab Voies m\u00e9taboliques du 5-MeO-DMT \u00bb.\u00a0 <\/span><\/span>X\u00e9nobiotiques<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                              \n

                              Ce produit est destin\u00e9 uniquement \u00e0 la recherche scientifique autoris\u00e9e. Il n'est pas destin\u00e9 \u00e0 la consommation humaine ni \u00e0 un usage diagnostique. Veuillez respecter la r\u00e9glementation locale.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                              Propri\u00e9t\u00e9s du chlorhydrate de 5-MeO-DMT<\/span><\/span><\/span><\/h3>\n

                              Synonyme:<\/span><\/span><\/strong> chlorhydrate de 5-m\u00e9thoxy-N,N-dim\u00e9thyltryptamine <\/span><\/span>
                              \nNum\u00e9ro CAS :<\/span><\/span><\/strong> apr\u00e8s <\/span><\/span>
                              \nFormule:<\/span><\/span><\/strong> chlorhydrate de 3-[2-(dim\u00e9thylamino)\u00e9thyl]-5-m\u00e9thoxyindole <\/span><\/span>
                              \nMasse molaire :<\/span><\/span><\/strong> 254,8 g\/mol <\/span><\/span>
                              \nPuret\u00e9:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>","protected":false},"featured_media":28720,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[511,381],"product_tag":[326],"class_list":{"0":"post-23504","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-5-meo-dmt-kopen","7":"product_cat-tryptamines","8":"product_tag-nl","10":"first","11":"instock","12":"taxable","13":"shipping-taxable","14":"purchasable","15":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product\/23504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/comments?post=23504"}],"version-history":[{"count":6,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product\/23504\/revisions"}],"predecessor-version":[{"id":28467,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product\/23504\/revisions\/28467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/media\/28720"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/media?parent=23504"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product_brand?post=23504"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product_cat?post=23504"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product_tag?post=23504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}