{"id":23531,"date":"2025-04-13T17:39:56","date_gmt":"2025-04-13T17:39:56","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23531"},"modified":"2025-10-22T16:39:51","modified_gmt":"2025-10-22T16:39:51","slug":"fumarate-dept-n-ethyl-n-propyl-tryptamine","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/fr\/produit\/fumarate-dept-n-ethyl-n-propyl-tryptamine\/","title":{"rendered":"Fumarate d'EPT (N-\u00e9thyl-N-propyltryptamine)"},"content":{"rendered":"

Fumarate d'EPT (N-\u00e9thyl-N-propyltryptamine) \u2013 Description scientifique du produit<\/span><\/span><\/strong><\/h3>\n

Caract\u00e9ristiques g\u00e9n\u00e9rales<\/span><\/span><\/strong><\/h4>\n

Le fumarate d'EPT est un produit chimique de recherche de la classe des tryptamines, caract\u00e9ris\u00e9 par son profil de substitution N-\u00e9thyl-N-propyle unique. Ce compos\u00e9 pr\u00e9sente des similitudes structurelles avec des tryptamines connues telles que la DMT et la MET, mais s'en distingue par des propri\u00e9t\u00e9s pharmacodynamiques sp\u00e9cifiques.<\/span><\/span><\/p>\n

Sp\u00e9cifications de base :<\/span><\/span><\/strong><\/p>\n

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  • \n

    Puret\u00e9 chimique :<\/span><\/span><\/strong> \u00a0>98% (v\u00e9rifi\u00e9 par HPLC-MS)<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Stabilit\u00e9 mol\u00e9culaire :<\/span><\/span><\/strong> \u00a0Excellente stabilit\u00e9 gr\u00e2ce \u00e0 la formation de sel de fumarate<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Solubilit\u00e9:<\/span><\/span><\/strong> \u00a0Librement soluble dans l'eau et les solvants organiques<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Conditions de stockage :<\/span><\/span><\/strong> \u00a0Stabilit\u00e9 \u00e0 long terme \u00e0 -20\u00b0C en atmosph\u00e8re de gaz inerte<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    Applications scientifiques<\/span><\/span><\/strong><\/h4>\n
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    1. \n

      Recherche neuropharmacologique :<\/span><\/span><\/strong><\/p>\n

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      • \n

        Interactions avec les r\u00e9cepteurs s\u00e9rotoninergiques (5-HT1A\/2A\/2C)<\/span><\/span><\/p>\n<\/li>\n

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        \u00c9tudes d'inhibition de la monoamine oxydase<\/span><\/span><\/p>\n<\/li>\n

      • \n

        M\u00e9canismes de lib\u00e9ration des neurotransmetteurs<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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        \u00c9tudes m\u00e9taboliques :<\/span><\/span><\/strong><\/p>\n

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        • \n

          Profil du m\u00e9tabolisme des microsomes h\u00e9patiques<\/span><\/span><\/p>\n<\/li>\n

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          Analyse de l'interaction du cytochrome P450<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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          Pharmacologie compar\u00e9e :<\/span><\/span><\/strong><\/p>\n

            \n
          • \n

            Relations structure-activit\u00e9 par rapport aux autres N,N-dialkyltryptamines<\/span><\/span><\/p>\n<\/li>\n

          • \n

            Caract\u00e9risation dose-r\u00e9ponse in vitro<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            Directives exp\u00e9rimentales<\/span><\/span><\/strong><\/h4>\n

            Plages de dosage pour les \u00e9tudes in vitro\u00a0:<\/span><\/span><\/strong><\/p>\n

            \n\n\n\n\n\n\n\n
            Application<\/span><\/span><\/th>\nPlage de concentration<\/span><\/span><\/th>\nP\u00e9riode d'incubation optimale<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
            Liaison au r\u00e9cepteur<\/span><\/span><\/td>\n10 nM \u2013 1 \u03bcM<\/span><\/span><\/td>\n30 \u00e0 60 minutes<\/span><\/span><\/td>\n<\/tr>\n
            \u00c9tudes du m\u00e9tabolisme<\/span><\/span><\/td>\n1-100 \u03bcM<\/span><\/span><\/td>\n2 \u00e0 4 heures<\/span><\/span><\/td>\n<\/tr>\n
            Toxicit\u00e9 cellulaire<\/span><\/span><\/td>\n10-500 \u03bcM<\/span><\/span><\/td>\n24 \u00e0 48 heures<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            Protocoles de s\u00e9curit\u00e9 :<\/span><\/span><\/strong><\/p>\n

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            • \n

              Toujours travailler dans des conditions de laboratoire contr\u00f4l\u00e9es<\/span><\/span><\/p>\n<\/li>\n

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              \u00c9quipement de protection individuelle (blouse de laboratoire, gants en nitrile, lunettes de s\u00e9curit\u00e9) obligatoire<\/span><\/span><\/p>\n<\/li>\n

            • \n

              Utiliser uniquement sous une hotte aspirante lors de la manipulation de solvants<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

              Donn\u00e9es de stabilit\u00e9<\/span><\/span><\/strong><\/h4>\n

              Stabilit\u00e9 document\u00e9e :<\/span><\/span><\/strong><\/p>\n

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              • \n

                Temp\u00e9rature ambiante : < 72 heures en solution<\/span><\/span><\/p>\n<\/li>\n

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                R\u00e9frig\u00e9r\u00e9 (4\u00b0C) : stable 1 semaine<\/span><\/span><\/p>\n<\/li>\n

              • \n

                Congel\u00e9 (-20\u00b0C) : stable >6 mois<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                Stockage recommand\u00e9\u00a0:<\/span><\/span><\/strong><\/p>\n

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                • \n

                  Emballage primaire : Flacons en verre ambr\u00e9 avec bouchon en PTFE<\/span><\/span><\/p>\n<\/li>\n

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                  Emballage secondaire : Scell\u00e9 sous vide avec un sachet de gel de silice<\/span><\/span><\/p>\n<\/li>\n

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                  Conditions de stockage : -20\u00b0C sous atmosph\u00e8re d'argon<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                  Certification analytique<\/span><\/span><\/strong><\/h4>\n

                  Chaque lot est livr\u00e9 avec :<\/span><\/span><\/p>\n

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                  1. \n

                    Analyse HPLC approfondie (d\u00e9tection UV\/VIS)<\/span><\/span><\/p>\n<\/li>\n

                  2. \n

                    Confirmation par spectrom\u00e9trie de masse (LC-MS\/MS)<\/span><\/span><\/p>\n<\/li>\n

                  3. \n

                    Analyse des solvants r\u00e9siduels<\/span><\/span><\/p>\n<\/li>\n

                  4. \n

                    D\u00e9termination de la teneur en eau (Karl Fischer)<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                    Statut juridique et \u00e9thique<\/span><\/span><\/strong><\/h4>\n

                    R\u00e9glementation n\u00e9erlandaise :<\/span><\/span><\/strong><\/p>\n

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                    • \n

                      Actuellement non inclus dans la loi sur l'opium<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Valable en vertu de la l\u00e9gislation g\u00e9n\u00e9rale sur les m\u00e9dicaments pour les produits chimiques de recherche<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Inscription obligatoire pour les institutions scientifiques<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      Lignes directrices \u00e9thiques :<\/span><\/span><\/strong><\/p>\n

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                      • \n

                        Pour usage non clinique uniquement<\/span><\/span><\/p>\n<\/li>\n

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                        Interdit \u00e0 l'administration humaine ou animale<\/span><\/span><\/p>\n<\/li>\n

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                        Examen \u00e9thique obligatoire pour la recherche universitaire<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        Questions fr\u00e9quemment pos\u00e9es<\/span><\/span><\/strong><\/h4>\n

                        Q1 : Comment l'EPT se compare-t-il aux tryptamines structurellement similaires ?<\/span><\/span><\/strong>
                        \n A : La substitution \u00e9thyle-propyle pr\u00e9sente des propri\u00e9t\u00e9s pharmacocin\u00e9tiques uniques, notamment dans :<\/span><\/span><\/p>\n

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                        • \n

                          Profil de lipophilie (valeur logP\u00a0: 2,1)<\/span><\/span><\/p>\n<\/li>\n

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                          Capacit\u00e9 de liaison aux prot\u00e9ines (88-92%)<\/span><\/span><\/p>\n<\/li>\n

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                          P\u00e9n\u00e9tration de la barri\u00e8re c\u00e9r\u00e9brale (rapport de 0,65 au DMT)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          Q2 : Quelles sont les options de d\u00e9tection dans les d\u00e9pistages de drogues standard ?<\/span><\/span><\/strong>
                          \n R : L'EPT n'est pas reconnu par les immuno-essais conventionnels, mais est d\u00e9tectable via :<\/span><\/span><\/p>\n

                            \n
                          • \n

                            GC-MS (fragmentation caract\u00e9ristique \u00e0 m\/z 130, 144)<\/span><\/span><\/p>\n<\/li>\n

                          • \n

                            LC-QTOF (mesure de pr\u00e9cision de la masse mol\u00e9culaire)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                            Q3 : Existe-t-il des interactions connues avec des m\u00e9dicaments ?<\/span><\/span><\/strong>
                            \n A : Des interactions th\u00e9oriques sont possibles avec :<\/span><\/span><\/p>\n

                              \n
                            • \n

                              Inhibiteurs de la MAO (effet de potentialisation)<\/span><\/span><\/p>\n<\/li>\n

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                              ISRS (inhibition comp\u00e9titive)<\/span><\/span><\/p>\n<\/li>\n

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                              Antipsychotiques (comp\u00e9tition des r\u00e9cepteurs)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                              Q4 : Quelle est l\u2019\u00e9limination des d\u00e9chets recommand\u00e9e ?<\/span><\/span><\/strong>
                              \n A : Suivez le protocole relatif aux d\u00e9chets dangereux :<\/span><\/span><\/p>\n

                                \n
                              • \n

                                Neutraliser avec de l'acide chlorhydrique dilu\u00e9 (0,1 M)<\/span><\/span><\/p>\n<\/li>\n

                              • \n

                                Absorber avec un mat\u00e9riau appropri\u00e9 (par exemple de la vermiculite)<\/span><\/span><\/p>\n<\/li>\n

                              • \n

                                \u00c9liminer comme d\u00e9chet chimique dangereux (num\u00e9ro CE : 404-860-3)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                                R\u00e9f\u00e9rences scientifiques<\/span><\/span><\/strong><\/h4>\n

                                R\u00e9f\u00e9rences bibliographiques importantes :<\/span><\/span><\/p>\n

                                  \n
                                1. \n

                                  Nichols, D. E. (2018). \u201c Relations structure-activit\u00e9 des tryptamines \u201d<\/span><\/span><\/p>\n<\/li>\n

                                2. \n

                                  Brandt et al. (2020). \u00ab\u00a0Caract\u00e9risation analytique de nouvelles substances psychoactives\u00a0\u00bb<\/span><\/span><\/p>\n<\/li>\n

                                3. \n

                                  Syst\u00e8me d'alerte pr\u00e9coce de l'UE (2023). \u00ab\u00a0\u00c9valuation des risques li\u00e9s aux nouveaux d\u00e9riv\u00e9s de la tryptamine\u00a0\u00bb<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                                  Ce produit est destin\u00e9 exclusivement \u00e0 la recherche scientifique autoris\u00e9e par du personnel qualifi\u00e9. Toutes les informations sont fournies sans aucune garantie implicite. Il incombe aux utilisateurs de se conformer \u00e0 la r\u00e9glementation locale.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                                  EPT fumarate properties<\/span><\/span><\/span><\/span><\/span><\/h3>\n

                                  Synonym:<\/span><\/span><\/span><\/span><\/strong> N-ethyl-N-propyltryptamine fumarate <\/span><\/span><\/span><\/span>
                                  \nCAS Number:<\/span><\/span><\/span><\/span><\/strong> n\/a <\/span><\/span><\/span><\/span>
                                  \nFormula:<\/span><\/span><\/span><\/span><\/strong> 3-[2-(ethyl(propyl)amino)ethyl]-1H-indole fumarate <\/span><\/span><\/span><\/span>
                                  \nMolar Mass:<\/span><\/span><\/span><\/span><\/strong> 346.4 g\/mol <\/span><\/span><\/span><\/span>
                                  \nPurity:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>\n","protected":false},"featured_media":28774,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[509,381],"product_tag":[326],"class_list":["post-23531","product","type-product","status-publish","has-post-thumbnail","product_cat-ept","product_cat-tryptamines","product_tag-nl","first","instock","taxable","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product\/23531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/comments?post=23531"}],"version-history":[{"count":5,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product\/23531\/revisions"}],"predecessor-version":[{"id":28071,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product\/23531\/revisions\/28071"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/media\/28774"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/media?parent=23531"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product_brand?post=23531"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product_cat?post=23531"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product_tag?post=23531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}