{"id":24319,"date":"2025-04-13T17:41:27","date_gmt":"2025-04-13T17:41:27","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=24319"},"modified":"2025-10-21T17:26:51","modified_gmt":"2025-10-21T17:26:51","slug":"chlorhydrate-de-tropacocaine","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/fr\/produit\/chlorhydrate-de-tropacocaine\/","title":{"rendered":"Chlorhydrate de tropacoca\u00efne"},"content":{"rendered":"

D\u00e9finition du produit\u00a0: Tropacoca\u00efne HCl (produit chimique de recherche)<\/span><\/span><\/strong><\/p>\n

Nom chimique :<\/span><\/span><\/strong> \u00a0Chlorhydrate de tropacoca\u00efne <\/span><\/span>
\nSynonymes:<\/span><\/span><\/strong> \u00a0Tropacoca\u00efne HCl, ester m\u00e9thylique de benzoylecgonine <\/span><\/span>
\nFormule mol\u00e9culaire:<\/span><\/span><\/strong> \u00a0C\u2081\u2085H\u2081\u2089NO\u2082\u2022HCl <\/span><\/span>
\nPoids mol\u00e9culaire:<\/span><\/span><\/strong> \u00a0281,78 g\/mol <\/span><\/span>
\nN\u00b0 CAS :<\/span><\/span><\/strong> \u00a0537-26-8 <\/span><\/span>
\nApparence:<\/span><\/span><\/strong> \u00a0Poudre cristalline blanche <\/span><\/span>
\nPuret\u00e9:<\/span><\/span><\/strong> \u00a0\u226598% (v\u00e9rifi\u00e9 par HPLC) <\/span><\/span>
\nSolubilit\u00e9:<\/span><\/span><\/strong> \u00a050 mg\/ml dans l'eau<\/span><\/span><\/p>\n

Description et pharmacologie :<\/span><\/span><\/strong>
\n La tropacoca\u00efne est un analogue naturel de la coca\u00efne avec : <\/span><\/span>
\n\u2714Effets anesth\u00e9siques locaux <\/span><\/span>
\n\u2714Propri\u00e9t\u00e9s stimulantes <\/span><\/span>
\n\u2714Dur\u00e9e d'action plus courte que la coca\u00efne (1 \u00e0 2 heures) <\/span><\/span>
\n\u2714Inhibition plus s\u00e9lective de la recapture de la noradr\u00e9naline<\/span><\/span><\/p>\n

Applications de recherche :<\/span><\/span><\/strong><\/p>\n

    \n
  1. \n

    Recherche en neurosciences :<\/span><\/span><\/p>\n

      \n
    • \n

      \u00c9tudes sur les transporteurs de la dopamine<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Pharmacologie compar\u00e9e des stimulants<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

    • \n

      Examen m\u00e9dical :<\/span><\/span><\/p>\n

        \n
      • \n

        M\u00e9canismes d'anesth\u00e9sie locale<\/span><\/span><\/p>\n<\/li>\n

      • \n

        \u00c9tudes de vasoconstriction<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Chimie analytique :<\/span><\/span><\/p>\n

          \n
        • \n

          Norme de r\u00e9f\u00e9rence pour l'analyse des m\u00e9dicaments<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Enqu\u00eate m\u00e9dico-l\u00e9gale<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

          Avantages pour la recherche :<\/span><\/span><\/strong>
          \n\u2705 Compos\u00e9 d'origine naturelle <\/span><\/span>
          \n\u2705Moins de potentiel addictif que la coca\u00efne <\/span><\/span>
          \n\u2705Bonne stabilit\u00e9 en solution <\/span><\/span>
          \n\u2705Convient aux \u00e9tudes de r\u00e9cepteurs in vitro<\/span><\/span><\/p>\n

          Risques et limites :<\/span><\/span><\/strong>
          \n\u274c Effets secondaires possibles :<\/span><\/span><\/p>\n

            \n
          • \n

            Tachycardie<\/span><\/span><\/p>\n<\/li>\n

          • \n

            Hypertension<\/span><\/span><\/p>\n<\/li>\n

          • \n

            stimulation du SNC <\/span><\/span>
            \n\u274cDonn\u00e9es pharmacocin\u00e9tiques limit\u00e9es disponibles <\/span><\/span>
            \n\u274cPotentiel d'abus<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

            Protocole de dosage (pour la recherche) :<\/span><\/span><\/strong><\/p>\n

            \n\n\n\n\n\n\n\n
            Application<\/span><\/span><\/th>\nConcentration<\/span><\/span><\/th>\nEffet attendu<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
            \u00c9tudes in vitro<\/span><\/span><\/td>\n1 \u00e0 10 \u03bcM<\/span><\/span><\/td>\nLiaison au r\u00e9cepteur<\/span><\/span><\/td>\n<\/tr>\n
            Test d'anesth\u00e9sie locale<\/span><\/span><\/td>\nSolution 0,1-0,5%<\/span><\/span><\/td>\nBloc nerveux<\/span><\/span><\/td>\n<\/tr>\n
            \u00c9tudes sur les neurotransporteurs<\/span><\/span><\/td>\n5 \u00e0 50 \u03bcM<\/span><\/span><\/td>\nEffet dopamine\/noradr\u00e9naline<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            Mesures de s\u00e9curit\u00e9 :<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              Portez un EPI appropri\u00e9 (gants, blouse de laboratoire)<\/span><\/span><\/p>\n<\/li>\n

            • \n

              Travailler sous une hotte aspirante<\/span><\/span><\/p>\n<\/li>\n

            • \n

              \u00c9viter le contact avec la peau et les yeux<\/span><\/span><\/p>\n<\/li>\n

            • \n

              Ne pas associer avec des inhibiteurs de la MAO<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

              Questions fr\u00e9quemment pos\u00e9es :<\/span><\/span><\/strong><\/p>\n

                \n
              1. \n

                La tropacoca\u00efne est-elle l\u00e9gale aux Pays-Bas\u00a0?<\/span><\/span><\/strong>
                \n Il pourrait \u00eatre vis\u00e9 par la loi sur l\u2019opium en tant que substance apparent\u00e9e \u00e0 la coca\u00efne.<\/span><\/span><\/p>\n<\/li>\n

              2. \n

                En quoi est-ce diff\u00e9rent de la coca\u00efne ?<\/span><\/span><\/strong>
                \n Effet moins euphorisant, dur\u00e9e d'action plus courte.<\/span><\/span><\/p>\n<\/li>\n

              3. \n

                Peut-il \u00eatre utilis\u00e9 comme anesth\u00e9sique local ?<\/span><\/span><\/strong>
                \n \u00c0 des fins de recherche uniquement, non destin\u00e9 \u00e0 un usage m\u00e9dical.<\/span><\/span><\/p>\n<\/li>\n

              4. \n

                Est-ce d\u00e9tectable lors des tests de d\u00e9pistage de drogue ?<\/span><\/span><\/strong>
                \n Il peut y avoir une r\u00e9action crois\u00e9e avec les tests de d\u00e9pistage de la coca\u00efne.<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                Contr\u00f4le qualit\u00e9 et donn\u00e9es analytiques :<\/span><\/span><\/strong><\/p>\n

                Caract\u00e9ristiques:<\/span><\/span><\/strong><\/p>\n

                  \n
                • \n

                  Puret\u00e9 : \u226598% (HPLC)<\/span><\/span><\/p>\n<\/li>\n

                • \n

                  M\u00e9taux lourds : < 1 ppm<\/span><\/span><\/p>\n<\/li>\n

                • \n

                  Perte au s\u00e9chage : <0,5%<\/span><\/span><\/p>\n<\/li>\n

                • \n

                  Solvants r\u00e9siduels : <0,1%<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                  Donn\u00e9es de stabilit\u00e9 :<\/span><\/span><\/strong><\/p>\n

                    \n
                  • \n

                    Dur\u00e9e de conservation : 36 mois \u00e0 15-25\u00b0C<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Sensibilit\u00e9 \u00e0 la lumi\u00e8re : Mod\u00e9r\u00e9e<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Sensibilit\u00e9 \u00e0 l'humidit\u00e9 : \u00e9lev\u00e9e<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    Conclusion:<\/span><\/span><\/strong>
                    \n Le chlorhydrate de tropacoca\u00efne est une substance de recherche pr\u00e9cieuse pour les \u00e9tudes pharmacologiques et analytiques, mais n\u00e9cessite une utilisation responsable.<\/span><\/span><\/p>\n

                    \u26a0\u00a0\u00c0 des fins de recherche uniquement \u2013 non destin\u00e9 \u00e0 l\u2019usage humain<\/span><\/span><\/strong><\/p>\n

                    Conseils de stockage :<\/span><\/span><\/strong><\/p>\n

                      \n
                    • \n

                      Emballage herm\u00e9tique<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Conserver dans un endroit sombre<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      S\u00e9cher \u00e0 <25\u00b0C<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      Consid\u00e9rations \u00e9thiques :<\/span><\/span><\/strong><\/p>\n

                        \n
                      • \n

                        R\u00e9serv\u00e9 \u00e0 un personnel qualifi\u00e9<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Les tests sur les animaux n\u00e9cessitent une approbation \u00e9thique<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Documentez toutes les exp\u00e9riences avec pr\u00e9cision<\/span><\/span><\/p>\n<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"

                        Propri\u00e9t\u00e9s du chlorhydrate de tropacoca\u00efne<\/span><\/span><\/span><\/h3>\n

                        Synonyme: <\/span><\/span><\/strong>NSC 76018 <\/span><\/span>
                        \n<\/span>Num\u00e9ro CAS :<\/span><\/span><\/strong> 637-23-0 <\/span><\/span>
                        \nFormule:<\/span><\/span><\/strong> C <\/span><\/span>15<\/span><\/span><\/small><\/sub> H <\/span><\/span>19<\/span><\/span><\/small><\/sub> NON <\/span><\/span>2<\/span><\/span><\/small><\/sub> \u00a0\u2022 HCl <\/span><\/span>
                        \nMasse molaire :<\/span><\/span><\/strong> 281.8 <\/span><\/span>
                        \nPuret\u00e9:<\/span><\/span><\/strong> >98%<\/span><\/span><\/p>","protected":false},"featured_media":28871,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[336,473],"product_tag":[326,669,933,934],"class_list":["post-24319","product","type-product","status-publish","has-post-thumbnail","product_cat-overig","product_cat-tropacocaine","product_tag-nl","product_tag-tropacocaine","product_tag-tropacocaine-hcl","product_tag-tropacocaine-kopen","first","instock","taxable","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product\/24319","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/comments?post=24319"}],"version-history":[{"count":5,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product\/24319\/revisions"}],"predecessor-version":[{"id":28018,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product\/24319\/revisions\/28018"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/media\/28871"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/media?parent=24319"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product_brand?post=24319"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product_cat?post=24319"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr\/wp-json\/wp\/v2\/product_tag?post=24319"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}