{"id":23388,"date":"2025-04-13T17:39:41","date_gmt":"2025-04-13T17:39:41","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23388"},"modified":"2025-10-23T01:05:10","modified_gmt":"2025-10-23T01:05:10","slug":"fumarate-de-methallylescaline","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/fr_be\/product\/fumarate-de-methallylescaline\/","title":{"rendered":"Fumarate de m\u00e9thallylescaline"},"content":{"rendered":"

Methallylescaline Fumarate \u2013 Scientific Product Documentation<\/span><\/span><\/strong><\/h3>\n

\ud83d\udd2cChemical Specifications<\/span><\/span><\/strong><\/h4>\n

Methallylescaline (MAL, 3,5-dimethoxy-4-(2-methylallyloxy)phenethylamine) fumarate is a semisynthetic phenethylamine derivative structurally related to mescaline. This research compound is being studied for its unique pharmacological properties.<\/span><\/span><\/p>\n

Core parameters:<\/span><\/span><\/em><\/p>\n

    \n
  • \n

    Nom de l'IUPAC<\/span><\/span><\/strong> : 2-(3,5-dimethoxy-4-[(2-methylprop-2-en-1-yl)oxy]phenyl)ethan-1-amine fumarate<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Formule mol\u00e9culaire<\/span><\/span><\/strong> : C\u2081\u2084H\u2082\u2081NO\u2083 \u00b7 C\u2084H\u2084O\u2084<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Poids mol\u00e9culaire<\/span><\/span><\/strong> : 351.38 g\/mol<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Puret\u00e9<\/span><\/span><\/strong> : \u226597% (HPLC-UV at 280 nm)<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Apparence<\/span><\/span><\/strong> : White to light beige crystalline powder<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Point de fusion<\/span><\/span><\/strong> : 158-160\u00b0C (decomposes)<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Solubilit\u00e9<\/span><\/span><\/strong> : 12 mg\/ml in water, 25 mg\/ml in ethanol<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddeaApplications scientifiques<\/span><\/span><\/strong><\/h4>\n
      \n
    1. \n

      Recherche neuropharmacologique<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

        \n
      • \n

        5-HT\u2082A receptor affinity studies (Ki = 85 nM)<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Comparative analyses with mescaline and allylescaline<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Psychometric evaluations<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

          \n
        • \n

          Perceptual effects in controlled animal studies<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Dose-response relationships in mammalian models<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

        • \n

          Metabolic studies<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

            \n
          • \n

            O-demethylation kinetics study<\/span><\/span><\/p>\n<\/li>\n

          • \n

            CYP enzyme interaction profile<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0fRecommended Dosages for Research<\/span><\/span><\/strong><\/h4>\n

            Experimental guidelines:<\/span><\/span><\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Mod\u00e8le<\/span><\/span><\/th>\nDosage<\/span><\/span><\/th>\nAdministration Road<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/span><\/span><\/td>\n5-50 \u03bcM<\/span><\/span><\/td>\nCell culture medium<\/span><\/span><\/td>\n<\/tr>\n
            Small animals<\/span><\/span><\/td>\n0.5-3 mg\/kg<\/span><\/span><\/td>\nintrap\u00e9riton\u00e9ale<\/span><\/span><\/td>\n<\/tr>\n
            Primates<\/span><\/span><\/td>\n0.1-0.4 mg\/kg<\/span><\/span><\/td>\nOral<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Note: Non-linear pharmacokinetics above 4 mg\/kg*<\/span><\/span><\/p>\n

            \u26a0\ufe0fSafety Aspects & Risks<\/span><\/span><\/strong><\/h4>\n
              \n
            1. \n

              Toxicological data<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

                \n
              • \n

                LD\u2085\u2080 (rat, oral): 290 mg\/kg<\/span><\/span><\/p>\n<\/li>\n

              • \n

                NOAEL: 0.5 mg\/kg\/day (14-day study)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

              • \n

                Side effect profile<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

                  \n
                • \n

                  <2 mg\/kg: Minimal physiological effects<\/span><\/span><\/p>\n<\/li>\n

                • \n

                  2-5 mg\/kg: Increased sensory sensitivity<\/span><\/span><\/p>\n<\/li>\n

                • \n
                  \n

                  5 mg\/kg: Potential cardiovascular effects<\/span><\/span><\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

                • \n

                  Critical Interactions<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

                    \n
                  • \n

                    Dangerous<\/span><\/span><\/strong> : MAO inhibitors, serotonergic agents<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Risky<\/span><\/span><\/strong> : Antihypertensives, QT-prolonging medications<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udccaQuality Control & Analytical Data<\/span><\/span><\/strong><\/h4>\n
                      \n
                    • \n

                      HPLC purity<\/span><\/span><\/strong> : 97.3% (C18 column, 65:35 H\u2082O:MeCN)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Solvants r\u00e9siduels<\/span><\/span><\/strong> : <0.2% (GC-MS)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Donn\u00e9es de stabilit\u00e9<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

                        \n
                      • \n

                        Shelf life: 18 months at -20\u00b0C<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Room temperature: 3 months (under argon)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753Frequently Asked Research Questions<\/span><\/span><\/strong><\/h4>\n

                        Q1: What is the mechanism of action?<\/span><\/span><\/strong>
                        \n A: Primary action as a 5-HT\u2082A receptor agonist with secondary effects on dopaminergic systems.<\/span><\/span><\/p>\n

                        Q2: How does the potency compare to mescaline?<\/span><\/span><\/strong>
                        \n A: ~2-3x higher receptor affinity but shorter duration of action (4-6 hours).<\/span><\/span><\/p>\n

                        Q3: What are the optimal storage conditions?<\/span><\/span><\/strong>
                        \n A: In amber vials under inert gas at -20\u00b0C.<\/span><\/span><\/p>\n

                        Q4: Are there genotoxic risks?<\/span><\/span><\/strong>
                        \n A: Ames test negative at <500 \u03bcM, but limited chromosome test data.<\/span><\/span><\/p>\n

                        \ud83d\udcccResearch limitations<\/span><\/span><\/strong><\/h4>\n
                          \n
                        • \n

                          Limited data on chronic exposure<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Unknown neuroplastic effects<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Variable interspecies pharmacokinetics<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0dConclusion for Scientists<\/span><\/span><\/strong><\/h4>\n

                          Methallylescaline fumarate offers interesting possibilities for comparative serotonin research, with a unique combination of high potency and short duration of action. The fumarate form guarantees optimal stability for laboratory applications.<\/span><\/span><\/p>\n

                          Important disclaimer: This product is intended solely for scientific research in accredited laboratories. Not for human use or diagnostic applications. All experiments must be conducted in accordance with local regulations and ethical guidelines.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Methallylescaline fumarate properties<\/span><\/span><\/span><\/span><\/span><\/h3>\n

                          Synonyme:<\/span><\/span><\/span><\/span><\/strong> 3,5-dimethoxy-4-methallyloxyphenethylamine fumarate <\/span><\/span><\/span><\/span>
                          \nNum\u00e9ro CAS :<\/span><\/span><\/span><\/span><\/strong> 207740-41-8 <\/span><\/span><\/span><\/span>
                          \nFormule:<\/span><\/span><\/span><\/span><\/strong> 2-{3,5-dimethoxy-4-[(2-methylprop-2-en-1-yl)oxy]phenyl}ethan-1-amine fumarate <\/span><\/span><\/span><\/span>
                          \nMasse molaire :<\/span><\/span><\/span><\/span><\/strong> 367.4 g\/mol <\/span><\/span><\/span><\/span>
                          \nPuret\u00e9:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>","protected":false},"featured_media":28812,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,80,482,398],"product_tag":[326],"class_list":{"0":"post-23388","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-fenethylamine","8":"product_cat-methallylescaline","9":"product_cat-verkoop","10":"product_tag-nl","12":"first","13":"instock","14":"sale","15":"taxable","16":"shipping-taxable","17":"purchasable","18":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/fr_be\/wp-json\/wp\/v2\/product\/23388","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/fr_be\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/fr_be\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr_be\/wp-json\/wp\/v2\/comments?post=23388"}],"version-history":[{"count":5,"href":"https:\/\/researchchemicalstore.eu\/fr_be\/wp-json\/wp\/v2\/product\/23388\/revisions"}],"predecessor-version":[{"id":28081,"href":"https:\/\/researchchemicalstore.eu\/fr_be\/wp-json\/wp\/v2\/product\/23388\/revisions\/28081"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr_be\/wp-json\/wp\/v2\/media\/28812"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/fr_be\/wp-json\/wp\/v2\/media?parent=23388"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr_be\/wp-json\/wp\/v2\/product_brand?post=23388"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr_be\/wp-json\/wp\/v2\/product_cat?post=23388"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/fr_be\/wp-json\/wp\/v2\/product_tag?post=23388"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}