{"id":23399,"date":"2025-04-13T17:39:42","date_gmt":"2025-04-13T17:39:42","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23399"},"modified":"2025-10-23T00:56:39","modified_gmt":"2025-10-23T00:56:39","slug":"proskalin-fumarat","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/hr\/product\/proskalin-fumarat\/","title":{"rendered":"Proskalin fumarat"},"content":{"rendered":"

Proskalin fumarat \u2013 Znanstvena dokumentacija o proizvodu<\/strong><\/h3>\n

\ud83d\udd2c Kemijske specifikacije<\/strong><\/h4>\n

Proskalin (4-propoksi-3,5-dimetoksifenetilamin) fumarat je polusintetski derivat fenetilamina sa strukturnom sli\u010dno\u0161\u0107u s meskalinom. Ovaj istra\u017eiva\u010dki spoj se prou\u010dava zbog svog jedinstvenog profila interakcije s receptorima.<\/p>\n

Osnovni parametri:<\/em><\/p>\n

    \n
  • \n

    Naziv po IUPAC-u<\/strong>2-(4-propoksi-3,5-dimetoksifenil)etan-1-amin fumarat<\/p>\n<\/li>\n

  • \n

    Molekularna formula<\/strong>C\u2081\u2083H\u2082\u2081NO\u2083 \u00b7 C\u2084H\u2084O\u2084<\/p>\n<\/li>\n

  • \n

    Molekularna te\u017eina<\/strong>: 339,36 g\/mol<\/p>\n<\/li>\n

  • \n

    \u010cisto\u0107a<\/strong>: \u226598% (HPLC-UV na 254 nm)<\/p>\n<\/li>\n

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    Oblik<\/strong>Bijeli kristalni prah<\/p>\n<\/li>\n

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    To\u010dka taljenja<\/strong>: 172-174\u00b0C (raspada se)<\/p>\n<\/li>\n

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    Topljivost<\/strong>15 mg\/ml u vodi, 30 mg\/ml u toplom etanolu<\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddeb Istra\u017eiva\u010dke aplikacije<\/strong><\/h4>\n
      \n
    1. \n

      Studije vezanja receptora<\/strong>:<\/p>\n

        \n
      • \n

        5-HT\u2082A agonizam (EC\u2085\u2080 = 280 nM)<\/p>\n<\/li>\n

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        Istra\u017eivanje dopaminergi\u010dke modulacije<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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        Neurofiziolo\u0161ki pregled<\/strong>:<\/p>\n

          \n
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          Analiza EEG obrazaca kod eksperimentalnih \u017eivotinja<\/p>\n<\/li>\n

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          Komparativne studije s klasi\u010dnim psihodelicima<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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          Analiza metaboli\u010dkog puta<\/strong>:<\/p>\n

            \n
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            Kinetika O-demetilacije<\/p>\n<\/li>\n

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            Profil interakcije CYP2D6<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2697\ufe0f Eksperimentalni protokoli<\/strong><\/h4>\n

            Standardni uvjeti istra\u017eivanja:<\/em><\/p>\n

            \n\n\n\n\n\n\n
            Model<\/th>\nKoncentracija<\/th>\nTrajanje izlaganja<\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/td>\n10-100 \u03bcM<\/td>\n15-60 minuta<\/td>\n<\/tr>\n
            In vivo<\/td>\n1-5 mg\/kg<\/td>\nAkutno\/kroni\u010dno<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Napomena: Poka\u017eite nelinearnu farmakokinetiku iznad 8 mg\/kg*<\/p>\n

            \u26a0\ufe0f Sigurnosni profil<\/strong><\/h4>\n
              \n
            1. \n

              Toksikolo\u0161ki podaci<\/strong>:<\/p>\n

                \n
              • \n

                LD\u2085\u2080 (\u0161takor, oralno): 320 mg\/kg<\/p>\n<\/li>\n

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                NOAEL: 0,75 mg\/kg\/dan (28-dnevna studija)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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                Spektar nuspojava<\/strong>:<\/p>\n

                  \n
                • \n

                  U\u010dinci ovisni o dozi:<\/p>\n

                    \n
                  • \n

                    <3 mg\/kg: Suptilne senzorne promjene<\/p>\n<\/li>\n

                  • \n

                    3-6 mg\/kg: Vegetativni simptomi<\/p>\n<\/li>\n

                  • \n
                    \n

                    6 mg\/kg: Potencijalna hemodinamska nestabilnost<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n

                  • \n

                    Kriti\u010dne interakcije<\/strong>:<\/p>\n

                      \n
                    • \n

                      Opasno<\/strong>MAO inhibitori, simpatomimetici<\/p>\n<\/li>\n

                    • \n

                      Riskantno<\/strong>Serotonergi\u010dki agensi, vazopresori<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                      \ud83d\udcc9 Podaci o stabilnosti<\/strong><\/h4>\n
                        \n
                      • \n

                        Rok trajanja<\/strong>24 mjeseca na -20\u00b0C (pod argonom)<\/p>\n<\/li>\n

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                        Produkti razgradnje<\/strong><2% nakon 12 mjeseci radioterapije<\/p>\n<\/li>\n

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                        Kompatibilni me\u0111uspremnici<\/strong>PBS (pH 7,4), klorovodi\u010dna kiselina (0,1 N)<\/p>\n<\/li>\n<\/ul>\n

                        \ud83d\udd0d Analiti\u010dke zna\u010dajke<\/strong><\/h4>\n
                          \n
                        • \n

                          HPLC vrijeme zadr\u017eavanja<\/strong>: 6,8 min (C18, 70:30 H2O:MeCN)<\/p>\n<\/li>\n

                        • \n

                          Maseni spektar<\/strong>: [M+H]\u207a 240,2 m\/z<\/p>\n<\/li>\n

                        • \n

                          Apsorpcija UV zra\u010denja<\/strong>\u03bbmax 282 nm (\u03b5 = 4200)<\/p>\n<\/li>\n<\/ul>\n

                          \u2753 \u010cesto postavljana pitanja usmjerena na istra\u017eivanje<\/strong><\/h4>\n

                          P1: Koji je mehanizam djelovanja?<\/strong>
                          \nA: Primarni parcijalni agonist 5-HT\u2082A receptora sa sekundarnom DAT interakcijom.<\/p>\n

                          P2: Kako se ja\u010dina djelovanja uspore\u0111uje s meskalinom?<\/strong>
                          \nA: ~3x ve\u0107i afinitet za 5-HT\u2082A, ali ni\u017ea penetracija kroz krvno-mo\u017edanu barijeru.<\/p>\n

                          P3: Postoje li genotoksi\u010dni rizici?<\/strong>
                          \nA: Amesov test negativan do 1 mM, ali ograni\u010deni podaci o kromosomskom testu.<\/p>\n

                          P4: Koja je optimalna formulacija?<\/strong>
                          \nA: Sterilna otopina soli (0,9% NaCl) za in vivo studije.<\/p>\n

                          \ud83d\udccc Ograni\u010denja istra\u017eivanja<\/strong><\/h4>\n
                            \n
                          • \n

                            Ograni\u010deni podaci o kroni\u010dnoj izlo\u017eenosti<\/p>\n<\/li>\n

                          • \n

                            Nepoznati neuroplasti\u010dni u\u010dinci<\/p>\n<\/li>\n

                          • \n

                            Varijabilni me\u0111uvrsni metabolizam<\/p>\n<\/li>\n<\/ul>\n

                            Znanstvena izjava o odricanju od odgovornosti: Ovaj je proizvod namijenjen isklju\u010divo za istra\u017eiva\u010dku upotrebu u akreditiranim laboratorijima. Nije za ljudsku ili veterinarsku upotrebu. Svi eksperimenti moraju biti u skladu s relevantnim sigurnosnim i eti\u010dkim smjernicama. Molimo vas da imate na umu lokalne propise u vezi s psihoaktivnim tvarima za istra\u017eivanje.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                            Proskalin fumarat<\/span><\/span><\/h3>\n

                            Sinonim:<\/span><\/span><\/strong> 3,5-dimetoksi-4-propoksifenetilamin fumarat <\/span><\/span>
                            \nCAS broj:<\/span><\/span><\/strong> 39201-78-0 <\/span><\/span>
                            \nFormula:<\/span><\/span><\/strong> 2-{3,5-dimetoksi-4-propiloksifenil}etan-1-amin fumarat <\/span><\/span>
                            \nMolarna masa:<\/span><\/span><\/strong> 355,4 g\/mol <\/span><\/span>
                            \n\u010cisto\u0107a:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>","protected":false},"featured_media":28847,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,80,536],"product_tag":[326],"class_list":{"0":"post-23399","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-fenethylamine","8":"product_cat-proscaline","9":"product_tag-nl","11":"first","12":"instock","13":"taxable","14":"shipping-taxable","15":"purchasable","16":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product\/23399","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/comments?post=23399"}],"version-history":[{"count":3,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product\/23399\/revisions"}],"predecessor-version":[{"id":26541,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product\/23399\/revisions\/26541"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/media\/28847"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/media?parent=23399"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product_brand?post=23399"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product_cat?post=23399"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product_tag?post=23399"}],"curies":[{"name":"radni list","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}