{"id":23497,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23497"},"modified":"2025-10-22T16:53:50","modified_gmt":"2025-10-22T16:53:50","slug":"5-meo-dmt-slobodne-baze","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/hr\/product\/5-meo-dmt-slobodne-baze\/","title":{"rendered":"5-MeO-DMT slobodna baza"},"content":{"rendered":"

5-MeO-DMT Freebase \u2013 Scientific Product Documentation<\/span><\/span><\/strong><\/h3>\n

Op\u0107i opis<\/span><\/span><\/strong><\/h4>\n

5-MeO-DMT (5-Methoxy-N,N-dimethyltryptamine) freebase is a naturally occurring tryptamine with a potent psychoactive profile, found in various plants and animal secretions. In its freebase form, it offers superior volatility for certain research methods, making it valuable for pharmacological and neuroscience studies.<\/span><\/span><\/p>\n

\n

Tehni\u010dke specifikacije<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Parametar<\/span><\/span><\/strong><\/th>\nSpecifikacija<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
Kemijska formula<\/span><\/span><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O<\/span><\/span><\/td>\n<\/tr>\n
Molekularna te\u017eina<\/span><\/span><\/td>\n218,29 g\/mol<\/span><\/span><\/td>\n<\/tr>\n
\u010cisto\u0107a<\/span><\/span><\/td>\n\u226598% (HPLC-UV analyzed)<\/span><\/span><\/td>\n<\/tr>\n
Oblik<\/span><\/span><\/td>\nCrystalline\/white powder<\/span><\/span><\/td>\n<\/tr>\n
Topljivost<\/span><\/span><\/td>\nSoluble in organic solvents (ethanol, methanol, DMSO), limited in water<\/span><\/span><\/td>\n<\/tr>\n
To\u010dka taljenja<\/span><\/span><\/td>\n60-65\u00b0C (slobodna baza)<\/span><\/span><\/td>\n<\/tr>\n
Stabilnost<\/span><\/span><\/td>\nLight and oxygen sensitive; store under inert gas<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

Znanstvene primjene<\/span><\/span><\/strong><\/h3>\n

1. Neuropharmacological Research<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    Serotonergic Action:<\/span><\/span><\/strong> \u00a0Potent 5-HT\u2081\u2090\/\u2082\u2090 agonist, relevant for studies of consciousness modulation.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    EEG\/fMRI studies:<\/span><\/span><\/strong> \u00a0Investigation of acute effects on brain wave patterns (e.g. gamma oscillations).<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Neuroplasticity:<\/span><\/span><\/strong> \u00a0Possible BDNF-enhancing effects (in animal models).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. Metabolic & Toxicological Studies<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      MAO-dependent metabolism:<\/span><\/span><\/strong> \u00a0Investigation of CYP2D6 and MAO-A degradation pathways.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Dose-dependent toxicity:<\/span><\/span><\/strong> \u00a0Determination of safety margins in cell cultures.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. Komparativna farmakologija<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        Compared to DMT:<\/span><\/span><\/strong> \u00a0Higher potency but shorter duration of action (15-30 min when inhaled).<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Compared to psilocybin:<\/span><\/span><\/strong> \u00a0Differences in receptor affinity and subjective effects.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Eksperimentalne smjernice<\/span><\/span><\/strong><\/h3>\n

        Recommended Concentrations (In Vitro)<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        Primjena<\/span><\/span><\/th>\nRaspon koncentracije<\/span><\/span><\/th>\nOtapalo<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
        Testovi vezanja receptora<\/span><\/span><\/td>\n1 nM \u2013 10 \u00b5M<\/span><\/span><\/td>\nPBS\/DMSO (\u22640,1%)<\/span><\/span><\/td>\n<\/tr>\n
        Cell culture experiments<\/span><\/span><\/td>\n0,1 \u2013 100 \u00b5M<\/span><\/span><\/td>\nDMEM\/FBS<\/span><\/span><\/td>\n<\/tr>\n
        Gas chromatography<\/span><\/span><\/td>\n1 mg\/ml (u metanolu)<\/span><\/span><\/td>\nMetanol (HPLC kvalitete)<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        Sigurnosni protokoli<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          Personal Protection:<\/span><\/span><\/strong> \u00a0Lab coat, nitrile gloves, safety glasses, FFP2 mask when handling powder.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Ventilation:<\/span><\/span><\/strong> \u00a0Always work under a fume cupboard when heating\/evaporating.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Pohrana:<\/span><\/span><\/strong> \u00a0In amber vials, under argon, at -20\u00b0C (long term).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Stabilnost i skladi\u0161tenje<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            Rok trajanja:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              Room temperature: <24 hours in solution.<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4\u00b0C: Stable for 3 days (under argon).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              -20\u00b0C: >6 months (unchanged purity).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              Degradation products:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Oxidation to indole derivatives (check by TLC\/HPLC).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Analiti\u010dka certifikacija<\/span><\/span><\/strong><\/h3>\n

                Each batch includes:<\/span><\/span><\/p>\n

                  \n
                1. \n

                  HPLC-UV kromatogram<\/span><\/span><\/strong> \u00a0(\u03bb=280 nm, C18 column)<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  GC-MS confirmation<\/span><\/span><\/strong> \u00a0(characteristic fragments: m\/z 174, 160)<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  Analiza rezidualnog otapala<\/span><\/span><\/strong> \u00a0(\u2264500 ppm)<\/span><\/span><\/p>\n<\/li>\n

                4. \n

                  Water content<\/span><\/span><\/strong> \u00a0(Karl Fischer, <1%)<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  Legal Status (Netherlands)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    Opium Act:<\/span><\/span><\/strong> \u00a0Not explicitly regulated, but possibly under analogous legislation.<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Legislation:<\/span><\/span><\/strong> \u00a0A licence is required for scientific institutions (Appendix 2, Opium Act).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Export restrictions:<\/span><\/span><\/strong> \u00a0CITES listing (due to natural sources such as\u00a0 <\/span><\/span>Incilius alvarius<\/span><\/span><\/em> ).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    \u010cesto postavljana pitanja (FAQ)<\/span><\/span><\/strong><\/h3>\n

                    Q1: What is the difference between freebase and fumaric acid salt?<\/span><\/span><\/strong>
                    \n A: Freebase is more volatile (suitable for evaporation experiments), while fumaric acid salt is more stable in solutions.<\/span><\/span><\/p>\n

                    Q2: How is 5-MeO-DFT detected in toxicology screens?<\/span><\/span><\/strong>
                    \n A: Identifiable by:<\/span><\/span><\/p>\n

                      \n
                    • \n

                      LC-MS\/MS (prekursorski ion m\/z 219 \u2192 produktni ion m\/z 174)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Immunoassays: Cross-reactivity with some DMT tests (\u226430%).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      Q3: Are there any known pharmacokinetic interactions?<\/span><\/span><\/strong>
                      \n O:\u00a0 <\/span><\/span>Dangerous combinations:<\/span><\/span><\/strong><\/p>\n

                        \n
                      • \n

                        MAO inhibitors (risk of serotonin syndrome).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        SSRIs (reduced efficacy due to competition).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        P4: Kako zbrinuti otpad?<\/span><\/span><\/strong>
                        \n A: Inactivate with:<\/span><\/span><\/p>\n

                          \n
                        1. \n

                          Dilute hydrochloric acid (0.1M) for neutralization.<\/span><\/span><\/p>\n<\/li>\n

                        2. \n

                          Absorption with activated carbon.<\/span><\/span><\/p>\n<\/li>\n

                        3. \n

                          Zbrinuti kao\u00a0 <\/span><\/span>opasni kemijski otpad<\/span><\/span><\/em> \u00a0(UN number: 3249).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                          \n

                          Reference i kontakt<\/span><\/span><\/strong><\/h3>\n

                          Key publications:<\/span><\/span><\/strong><\/p>\n

                            \n
                          • \n

                            Sz\u00e1ra, S. (2007). \u201cDMT i 5-MeO-DMT: Rane studije na ljudima\u201d.<\/span><\/span><\/p>\n<\/li>\n

                          • \n

                            Uthaug i sur. (2021). \u201cPsihofarmakologija 5-MeO-DMT-a\u201d.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                            \n

                            This product is intended solely for legitimate scientific research. Not for human or veterinary use. Users must comply with all local regulations.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                            Svojstva slobodne baze 5-MeO-DMT-a<\/span><\/span><\/span><\/span><\/h3>\n

                            Sinonim:<\/span><\/span><\/span><\/span><\/strong> 5-metoksi-N,N-dimetiltriptamin <\/span><\/span><\/span><\/span>
                            \nCAS broj:<\/span><\/span><\/span><\/span><\/strong> 1019-45-0 <\/span><\/span><\/span><\/span>
                            \nFormula:<\/span><\/span><\/span><\/span><\/strong> 3-[2-(dimetilamino)etil]-5-metoksiindol <\/span><\/span><\/span><\/span>
                            \nMolarna masa:<\/span><\/span><\/span><\/span><\/strong> 218,3 g\/mol <\/span><\/span><\/span><\/span>
                            \n\u010cisto\u0107a:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>","protected":false},"featured_media":28719,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[511,381],"product_tag":[326],"class_list":{"0":"post-23497","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-5-meo-dmt-kopen","7":"product_cat-tryptamines","8":"product_tag-nl","10":"first","11":"instock","12":"taxable","13":"shipping-taxable","14":"purchasable","15":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product\/23497","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/comments?post=23497"}],"version-history":[{"count":4,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product\/23497\/revisions"}],"predecessor-version":[{"id":28072,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product\/23497\/revisions\/28072"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/media\/28719"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/media?parent=23497"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product_brand?post=23497"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product_cat?post=23497"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product_tag?post=23497"}],"curies":[{"name":"radni list","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}