{"id":23504,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23504"},"modified":"2025-10-22T17:00:59","modified_gmt":"2025-10-22T17:00:59","slug":"5-meo-dmt-hidroklorida","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/hr\/product\/5-meo-dmt-hidroklorida\/","title":{"rendered":"5-MeO-DMT hidroklorid"},"content":{"rendered":"

5-MeO-DMT hidroklorid \u2013 Znanstvena dokumentacija proizvoda<\/span><\/span><\/strong><\/h3>\n

Op\u0107i opis<\/span><\/span><\/strong><\/h4>\n

5-MeO-DMT hidroklorid (5-metoksi-N,N-dimetiltriptamin HCl) je vodotopiva sol klasi\u010dnog triptamina, posebno pogodna za farmakolo\u0161ka istra\u017eivanja zbog pove\u0107ane stabilnosti i bioraspolo\u017eivosti u usporedbi sa slobodnim baznim oblikom.<\/span><\/span><\/p>\n

\n

Tehni\u010dke specifikacije<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Parametar<\/span><\/span><\/strong><\/th>\nSpecifikacija<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
Kemijska formula<\/span><\/span><\/strong><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O \u00b7 HCl<\/span><\/span><\/td>\n<\/tr>\n
Molekularna te\u017eina<\/span><\/span><\/strong><\/td>\n254,75 g\/mol<\/span><\/span><\/td>\n<\/tr>\n
\u010cisto\u0107a<\/span><\/span><\/strong><\/td>\n\u226598% (analizirano HPLC-UV metodom)<\/span><\/span><\/td>\n<\/tr>\n
Izgled<\/span><\/span><\/strong><\/td>\nBijeli do svijetlo\u017euti kristalni prah<\/span><\/span><\/td>\n<\/tr>\n
Topljivost<\/span><\/span><\/strong><\/td>\nVisok udio vode (>50 mg\/ml), metanol, PBS<\/span><\/span><\/td>\n<\/tr>\n
To\u010dka taljenja<\/span><\/span><\/strong><\/td>\n243-247\u00b0C (raspada se)<\/span><\/span><\/td>\n<\/tr>\n
Stabilnost<\/span><\/span><\/strong><\/td>\nHigroskopno; \u010duvati na suhom mjestu<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

Znanstvene primjene<\/span><\/span><\/strong><\/h3>\n

1. Neurofarmakologija i bihevioralna istra\u017eivanja<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    Studije serotoninskih receptora:<\/span><\/span><\/strong> \u00a0Sna\u017ean 5-HT1\u2081\u2090\/\u2082\u2090 agonist s brzom penetracijom u mozak.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Pokusi na \u017eivotinjama (in vivo):<\/span><\/span><\/strong> \u00a0Bihevioralne paradigme (npr. reakcija trzanja glave kod glodavaca).<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Elektrofiziologija:<\/span><\/span><\/strong> \u00a0U\u010dinci na neuronske oscilacije (npr. aktivnost gama pojasa).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. Biokemijske i molekularne studije<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      Intracelularna signalizacija:<\/span><\/span><\/strong> \u00a0testovi akumulacije cAMP-a i regrutiranja \u03b2-arestina.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Kinetika enzima:<\/span><\/span><\/strong> \u00a0Metabolizam MAO-A (IC\u2085\u2080 ~2-5 \u03bcM).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. Klini\u010dki relevantna istra\u017eivanja<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        Odnosi doze i odgovora:<\/span><\/span><\/strong> \u00a0Predklini\u010dko profiliranje sigurnosti.<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Komparativna farmakologija:<\/span><\/span><\/strong> \u00a0Prema psilocibinu, DMT-u i drugim triptaminima.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Eksperimentalne smjernice<\/span><\/span><\/strong><\/h3>\n

        Preporu\u010dene koncentracije<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        Primjena<\/span><\/span><\/strong><\/th>\nRaspon koncentracije<\/span><\/span><\/strong><\/th>\nOtapalo<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
        Stani\u010dne kulture (in vitro)<\/span><\/span><\/td>\n1 nM \u2013 10 \u03bcM<\/span><\/span><\/td>\nPBS\/DMEM (\u22640,1% DMSO)<\/span><\/span><\/td>\n<\/tr>\n
        Receptorski testovi<\/span><\/span><\/td>\n0,1 \u2013 100 \u03bcM<\/span><\/span><\/td>\nTris-HCl pufer (pH 7,4)<\/span><\/span><\/td>\n<\/tr>\n
        Studije na \u017eivotinjama (ip\/iv)<\/span><\/span><\/td>\n0,1 \u2013 5 mg\/kg<\/span><\/span><\/td>\nSterilna otopina soli<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        Sigurnosne mjere<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          Osobna za\u0161tita:<\/span><\/span><\/strong> \u00a0Laboratorijski ogrta\u010d, rukavice (nitrilne), za\u0161titne nao\u010dale.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Rukovanje:<\/span><\/span><\/strong> \u00a0Higroskopno \u2013 odmah zatvoriti nakon upotrebe.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Pohrana:<\/span><\/span><\/strong> \u00a0Hermeti\u010dki zatvoreno, pod argonom, na -20\u00b0C (sprije\u010diti hidrolizu).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Stabilnost i skladi\u0161tenje<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            Rok trajanja:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              -20\u00b0C:<\/span><\/span><\/strong> \u00a0>2 godine (nepromijenjena \u010disto\u0107a).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4\u00b0C:<\/span><\/span><\/strong> \u00a06 mjeseci (u suhom okru\u017eenju).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              Ispadanje:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Hidroliza pri duljem izlaganju vlazi (pra\u0107eno HPLC-om).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Analiti\u010dka validacija<\/span><\/span><\/strong><\/h3>\n

                Svaka serija dolazi s:<\/span><\/span><\/p>\n

                  \n
                1. \n

                  HPLC-UV kromatogram<\/span><\/span><\/strong> \u00a0(C18 kolona, vrijeme zadr\u017eavanja ~6,2 min).<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  MS\/MS fragmentacija<\/span><\/span><\/strong> \u00a0(karakteristi\u010dni ioni: m\/z 219 \u2192 174, 160).<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  Preostala otapala<\/span><\/span><\/strong> \u00a0(u skladu sa smjernicama ICH Q3C).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  Pravni status (Nizozemska\/EU)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    Zakonodavstvo o narkoticima:<\/span><\/span><\/strong> \u00a0Nije izri\u010dito spomenuto u Zakonu o opijumu, ali mogu\u0107e u analognom zakonodavstvu (Dodatak II).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Znanstvena upotreba:<\/span><\/span><\/strong> \u00a0Za institucije je potrebna dozvola (odobrenje CCMO-a za testiranje na \u017eivotinjama).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Kontrola izvoza:<\/span><\/span><\/strong> \u00a0Podlo\u017eno Uredbi EU 2019\/1998 (psihotropne tvari).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    \u010cesto postavljana pitanja (FAQ)<\/span><\/span><\/strong><\/h3>\n

                    Q1 <\/span>Koje su prednosti HCl u odnosu na slobodnu bazu?<\/span><\/strong><\/span><\/p>\n

                      \n
                    • \n

                      Pobolj\u0161ana topljivost<\/span><\/span><\/strong> \u00a0(idealno za studije injekcija).<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Dulja stabilnost na polici<\/span><\/span><\/strong> \u00a0na sobnoj temperaturi.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      P2: Je li 5-MeO-DMT-HCl detektibilan u testovima na droge?<\/span><\/span><\/strong>
                      \n O: Da, putem:<\/span><\/span><\/p>\n

                        \n
                      • \n

                        LC-MS\/MS<\/span><\/span><\/strong> \u00a0(prepoznat kao adukt 5-MeO-DMT + HCl).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Imunotestovi:<\/span><\/span><\/strong> \u00a0Kri\u017ena reaktivnost s DMT-om (~15-20%).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        P3: Postoje li rizici pri kombiniranju s MAO inhibitorima?<\/span><\/span><\/strong>
                        \n O:\u00a0 <\/span><\/span>Apsolutno.<\/span><\/span><\/strong><\/p>\n

                          \n
                        • \n

                          Pove\u0107ani rizik od\u00a0 <\/span><\/span>serotoninski sindrom<\/span><\/span><\/strong> \u00a0(izbjegavajte kombinacije!).<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Koristiti samo u modelima bez MAO.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          P4: Kako zbrinuti otpad?<\/span><\/span><\/strong>
                          \n O:<\/span><\/span><\/p>\n

                            \n
                          1. \n

                            Neutralizirati s\u00a0 <\/span><\/span>natrijev bikarbonat<\/span><\/span><\/strong> \u00a0(pH 7-8).<\/span><\/span><\/p>\n<\/li>\n

                          2. \n

                            Apsorbirajte s\u00a0 <\/span><\/span>aktivni ugljen<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n<\/li>\n

                          3. \n

                            Zbrinuti kao\u00a0 <\/span><\/span>opasni kemijski otpad<\/span><\/span><\/strong> \u00a0(UN 3249, Klasa 6.1).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                            \n

                            Reference i kontakt<\/span><\/span><\/strong><\/h3>\n

                            Osnovna literatura:<\/span><\/span><\/strong><\/p>\n

                              \n
                            1. \n

                              Shen i dr. (2010). \u201eFarmakologija derivata 5-MeO-DMT\u201c.\u00a0 <\/span><\/span>J Psychopharmacol<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n

                            2. \n

                              Kaasik i sur. (2021). \u201eMetaboli\u010dki putevi 5-MeO-DMT-a\u201c.\u00a0 <\/span><\/span>Ksenobiotici<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                              \n

                              Ovaj proizvod namijenjen je samo za ovla\u0161tena znanstvena istra\u017eivanja. Nije za ljudsku konzumaciju ili dijagnosti\u010dku upotrebu. Molimo pridr\u017eavajte se lokalnih propisa.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                              Svojstva 5-MeO-DMT hidroklorida<\/span><\/span><\/span><\/h3>\n

                              Sinonim:<\/span><\/span><\/strong> 5-metoksi-N,N-dimetiltriptamin hidroklorid <\/span><\/span>
                              \nCAS broj:<\/span><\/span><\/strong> nakon <\/span><\/span>
                              \nFormula:<\/span><\/span><\/strong> 3-[2-(dimetilamino)etil]-5-metoksiindol hidroklorid <\/span><\/span>
                              \nMolarna masa:<\/span><\/span><\/strong> 254,8 g\/mol <\/span><\/span>
                              \n\u010cisto\u0107a:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>","protected":false},"featured_media":28720,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[511,381],"product_tag":[326],"class_list":{"0":"post-23504","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-5-meo-dmt-kopen","7":"product_cat-tryptamines","8":"product_tag-nl","10":"first","11":"instock","12":"taxable","13":"shipping-taxable","14":"purchasable","15":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product\/23504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/comments?post=23504"}],"version-history":[{"count":6,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product\/23504\/revisions"}],"predecessor-version":[{"id":28467,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product\/23504\/revisions\/28467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/media\/28720"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/media?parent=23504"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product_brand?post=23504"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product_cat?post=23504"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product_tag?post=23504"}],"curies":[{"name":"radni list","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}