{"id":23531,"date":"2025-04-13T17:39:56","date_gmt":"2025-04-13T17:39:56","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23531"},"modified":"2025-10-22T16:39:51","modified_gmt":"2025-10-22T16:39:51","slug":"ept-fumarat-n-etil-n-propil-triptamin","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/hr\/product\/ept-fumarat-n-etil-n-propil-triptamin\/","title":{"rendered":"EPT fumarat (N-etil-N-propiltriptamin)"},"content":{"rendered":"

EPT fumarat (N-etil-N-propiltriptamin) \u2013 Znanstveni opis proizvoda<\/span><\/span><\/strong><\/h3>\n

Op\u0107e zna\u010dajke<\/span><\/span><\/strong><\/h4>\n

EPT fumarat je istra\u017eiva\u010dka kemikalija iz klase triptamina, karakterizirana jedinstvenim obrascem supstitucije N-etil-N-propil. Ovaj spoj pokazuje strukturne sli\u010dnosti s poznatim triptaminima kao \u0161to su DMT i MET, ali se razlikuje po specifi\u010dnim farmakodinami\u010dkim svojstvima.<\/span><\/span><\/p>\n

Osnovne specifikacije:<\/span><\/span><\/strong><\/p>\n

    \n
  • \n

    Kemijska \u010disto\u0107a:<\/span><\/span><\/strong> \u00a0>98% (potvr\u0111eno HPLC-MS metodom)<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Molekularna stabilnost:<\/span><\/span><\/strong> \u00a0Izvrsna stabilnost zbog stvaranja fumaratnih soli<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Topljivost:<\/span><\/span><\/strong> \u00a0Dobro topljiv u vodi i organskim otapalima<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Uvjeti skladi\u0161tenja:<\/span><\/span><\/strong> \u00a0Dugotrajna stabilnost na -20\u00b0C u atmosferi inertnog plina<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    Znanstvene primjene<\/span><\/span><\/strong><\/h4>\n
      \n
    1. \n

      Neurofarmakolo\u0161ka istra\u017eivanja:<\/span><\/span><\/strong><\/p>\n

        \n
      • \n

        Interakcije serotonergi\u010dnih receptora (5-HT1A\/2A\/2C)<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Studije inhibicije monoaminooksidaze<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Mehanizmi osloba\u0111anja neurotransmitera<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Metaboli\u010dke studije:<\/span><\/span><\/strong><\/p>\n

          \n
        • \n

          Profil metabolizma jetrenih mikrosoma<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Analiza interakcije citokroma P450<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

        • \n

          Komparativna farmakologija:<\/span><\/span><\/strong><\/p>\n

            \n
          • \n

            Odnosi strukture i aktivnosti u usporedbi s drugim N,N-dialkiltriptaminima<\/span><\/span><\/p>\n<\/li>\n

          • \n

            Karakterizacija doza-odgovor in vitro<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            Eksperimentalne smjernice<\/span><\/span><\/strong><\/h4>\n

            Rasponi doziranja za in vitro studije:<\/span><\/span><\/strong><\/p>\n

            \n\n\n\n\n\n\n\n
            Primjena<\/span><\/span><\/th>\nRaspon koncentracije<\/span><\/span><\/th>\nOptimalno razdoblje inkubacije<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
            Vezivanje receptora<\/span><\/span><\/td>\n10 nM \u2013 1 \u03bcM<\/span><\/span><\/td>\n30-60 minuta<\/span><\/span><\/td>\n<\/tr>\n
            Studije metabolizma<\/span><\/span><\/td>\n1-100 \u03bcM<\/span><\/span><\/td>\n2-4 sata<\/span><\/span><\/td>\n<\/tr>\n
            Toksi\u010dnost stanica<\/span><\/span><\/td>\n10-500 \u03bcM<\/span><\/span><\/td>\n24-48 sati<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            Sigurnosni protokoli:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              Uvijek radite u kontroliranim laboratorijskim uvjetima<\/span><\/span><\/p>\n<\/li>\n

            • \n

              Obavezna osobna za\u0161titna oprema (laboratorijski ogrta\u010d, nitrilne rukavice, za\u0161titne nao\u010dale)<\/span><\/span><\/p>\n<\/li>\n

            • \n

              Koristiti samo u digestoru pri rukovanju otapalima<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

              Podaci o stabilnosti<\/span><\/span><\/strong><\/h4>\n

              Dokumentirana stabilnost:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Sobna temperatura: <72 sata u otopini<\/span><\/span><\/p>\n<\/li>\n

              • \n

                Hla\u0111eno (4\u00b0C): stabilno 1 tjedan<\/span><\/span><\/p>\n<\/li>\n

              • \n

                Smrznuto (-20\u00b0C): stabilno >6 mjeseci<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                Preporu\u010deno skladi\u0161tenje:<\/span><\/span><\/strong><\/p>\n

                  \n
                • \n

                  Primarno pakiranje: Bo\u010dice od jantarnog stakla s PTFE zatvara\u010dem<\/span><\/span><\/p>\n<\/li>\n

                • \n

                  Sekundarno pakiranje: Vakuumski zatvoreno sa silikagelom<\/span><\/span><\/p>\n<\/li>\n

                • \n

                  Uvjeti skladi\u0161tenja: -20\u00b0C u atmosferi argona<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                  Analiti\u010dka certifikacija<\/span><\/span><\/strong><\/h4>\n

                  Svaka serija dolazi s:<\/span><\/span><\/p>\n

                    \n
                  1. \n

                    Opse\u017ena HPLC analiza (UV\/VIS detekcija)<\/span><\/span><\/p>\n<\/li>\n

                  2. \n

                    Potvrda masenom spektrometrijom (LC-MS\/MS)<\/span><\/span><\/p>\n<\/li>\n

                  3. \n

                    Analiza rezidualnog otapala<\/span><\/span><\/p>\n<\/li>\n

                  4. \n

                    Odre\u0111ivanje sadr\u017eaja vode (Karl Fischer)<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                    Pravni status i etika<\/span><\/span><\/strong><\/h4>\n

                    Nizozemski propisi:<\/span><\/span><\/strong><\/p>\n

                      \n
                    • \n

                      Trenutno nije uklju\u010deno u Zakon o opijumu<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Vrijedi prema op\u0107im propisima o lijekovima za istra\u017eiva\u010dke kemikalije<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Obvezna registracija za znanstvene institucije<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      Eti\u010dke smjernice:<\/span><\/span><\/strong><\/p>\n

                        \n
                      • \n

                        Samo za neklini\u010dku istra\u017eiva\u010dku upotrebu<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Zabranjeno za primjenu kod ljudi ili \u017eivotinja<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Obavezni eti\u010dki pregled za akademska istra\u017eivanja<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        \u010cesto postavljana pitanja<\/span><\/span><\/strong><\/h4>\n

                        P1: Kako se EPT uspore\u0111uje sa strukturno sli\u010dnim triptaminima?<\/span><\/span><\/strong>
                        \n A: Etil-propilna supstitucija pokazuje jedinstvena farmakokineti\u010dka svojstva, posebno u:<\/span><\/span><\/p>\n

                          \n
                        • \n

                          Profil lipofilnosti (logP vrijednost: 2,1)<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Kapacitet vezanja proteina (88-92%)<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Prodiranje kroz mo\u017edanu barijeru (omjer 0,65 prema DMT-u)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          P2: Koje su mogu\u0107nosti otkrivanja u standardnim testovima na droge?<\/span><\/span><\/strong>
                          \n A: EPT se ne prepoznaje konvencionalnim imunolo\u0161kim testovima, ali se mo\u017ee otkriti putem:<\/span><\/span><\/p>\n

                            \n
                          • \n

                            GC-MS (karakteristi\u010dna fragmentacija pri m\/z 130, 144)<\/span><\/span><\/p>\n<\/li>\n

                          • \n

                            LC-QTOF (precizno mjerenje molekularne mase)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                            P3: Postoje li poznate interakcije s lijekovima?<\/span><\/span><\/strong>
                            \n A: Teorijske interakcije su mogu\u0107e sa:<\/span><\/span><\/p>\n

                              \n
                            • \n

                              MAO inhibitori (potencijacijski u\u010dinak)<\/span><\/span><\/p>\n<\/li>\n

                            • \n

                              SSRI (kompetitivna inhibicija)<\/span><\/span><\/p>\n<\/li>\n

                            • \n

                              Antipsihotici (kompeticija receptora)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                              P4: Koji je preporu\u010deni na\u010din odlaganja otpada?<\/span><\/span><\/strong>
                              \n A: Slijedite protokol za opasni otpad:<\/span><\/span><\/p>\n

                                \n
                              • \n

                                Neutralizirati razrije\u0111enom klorovodi\u010dnom kiselinom (0,1 M)<\/span><\/span><\/p>\n<\/li>\n

                              • \n

                                Apsorbirati prikladnim materijalom (npr. vermikulitom)<\/span><\/span><\/p>\n<\/li>\n

                              • \n

                                Zbrinuti kao opasni kemijski otpad (EC broj: 404-860-3)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                                Znanstvene reference<\/span><\/span><\/strong><\/h4>\n

                                Va\u017ene reference iz literature:<\/span><\/span><\/p>\n

                                  \n
                                1. \n

                                  Nichols, D. E. (2018). \u201cOdnosi strukture i aktivnosti triptamina\u201d<\/span><\/span><\/p>\n<\/li>\n

                                2. \n

                                  Brandt i dr. (2020). \u201eAnaliti\u010dka karakterizacija novih psihoaktivnih tvari\u201c<\/span><\/span><\/p>\n<\/li>\n

                                3. \n

                                  Sustav ranog upozoravanja EU-a (2023.). \u201eProcjena rizika novih derivata triptamina\u201c<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                                  Ovaj proizvod namijenjen je isklju\u010divo za ovla\u0161tena znanstvena istra\u017eivanja od strane kvalificiranog osoblja. Sve informacije daju se bez ikakvog implicitnog jamstva. Korisnici su odgovorni za po\u0161tivanje lokalnih propisa.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                                  EPT fumarate properties<\/span><\/span><\/span><\/span><\/span><\/h3>\n

                                  Synonym:<\/span><\/span><\/span><\/span><\/strong> N-ethyl-N-propyltryptamine fumarate <\/span><\/span><\/span><\/span>
                                  \nCAS Number:<\/span><\/span><\/span><\/span><\/strong> n\/a <\/span><\/span><\/span><\/span>
                                  \nFormula:<\/span><\/span><\/span><\/span><\/strong> 3-[2-(ethyl(propyl)amino)ethyl]-1H-indole fumarate <\/span><\/span><\/span><\/span>
                                  \nMolar Mass:<\/span><\/span><\/span><\/span><\/strong> 346.4 g\/mol <\/span><\/span><\/span><\/span>
                                  \nPurity:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>\n","protected":false},"featured_media":28774,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[509,381],"product_tag":[326],"class_list":["post-23531","product","type-product","status-publish","has-post-thumbnail","product_cat-ept","product_cat-tryptamines","product_tag-nl","first","instock","taxable","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product\/23531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/comments?post=23531"}],"version-history":[{"count":5,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product\/23531\/revisions"}],"predecessor-version":[{"id":28071,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product\/23531\/revisions\/28071"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/media\/28774"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/media?parent=23531"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product_brand?post=23531"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product_cat?post=23531"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product_tag?post=23531"}],"curies":[{"name":"radni list","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}