{"id":27437,"date":"2025-08-30T09:12:39","date_gmt":"2025-08-30T09:12:39","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&#038;p=27437"},"modified":"2025-11-17T11:48:53","modified_gmt":"2025-11-17T11:48:53","slug":"jjc8-089","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/hr\/product\/jjc8-089\/","title":{"rendered":"JJC8-089"},"content":{"rendered":"<p class=\"ds-markdown-paragraph\"><strong>JJC8-089: Sna\u017ean i selektivan DAT inhibitor za istra\u017eivanje motivacije<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">JJC8-089 je potencijalna istra\u017eiva\u010dka molekula posebno dizajnirana za prou\u010davanje motivacije i pona\u0161anja povezanog s naporom. Kao selektivni inhibitor dopaminskog transportera (DAT), pove\u0107ava izvanstani\u010dne razine dopamina u mozgu.<\/p>\n<p class=\"ds-markdown-paragraph\">U predklini\u010dkim modelima, pokazalo se da JJC8-089 zna\u010dajno preokre\u0107e motivacijske deficite uzrokovane tetrabenazinom (inhibitor VMAT2). Obnavlja spremnost na ulaganje velikog napora (poput odabira zadatka s 5 pritisaka na gumbe) umjesto lak\u0161e, manje nagra\u0111uju\u0107e opcije. Ova svojstva \u010dine JJC8-089 (CAS br. 1627576-64-0) vrijednim farmakolo\u0161kim alatom za neuroznanstvena istra\u017eivanja poreme\u0107aja poput depresije, apatije i umora.<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>Klju\u010dne zna\u010dajke:<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Molekularna formula:<\/strong>\u00a0C\u2082\u2082H\u2082\u2088F\u2082N\u2082OS<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Molekularna te\u017eina:<\/strong>\u00a0406,53 g\/mol<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Primarni mehanizam djelovanja:<\/strong>\u00a0Inhibicija dopaminskog transportera (DAT)<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Glavna istra\u017eiva\u010dka primjena:<\/strong>\u00a0Prou\u010davanje motivacije i pona\u0161anja usmjerenog na trud.<\/p>\n<\/li>\n<\/ul>\n<hr \/>\n<h3>Verzija 2: Detaljniji i opisniji tekst (za znanstvenu bro\u0161uru ili tehni\u010dki list)<\/h3>\n<p class=\"ds-markdown-paragraph\"><strong>Naslov: JJC8-089: Obe\u0107avaju\u0107i alat za prou\u010davanje motivacijskih patologija<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">JJC8-089 je sintetizirani spoj koji igra klju\u010dnu ulogu u razotkrivanju neurobiologije motivacije. Njegov primarni mehanizam djelovanja je inhibicija dopaminskog transportera (DAT), \u0161to dovodi do pove\u0107ane dopaminergi\u010dke neurotransmisije u sinapti\u010dkoj pukotini. Ovaj u\u010dinak klju\u010dan je za modulaciju nagrade, motivacije i spremnosti na sudjelovanje u napornom i ciljno usmjerenom pona\u0161anju.<\/p>\n<p class=\"ds-markdown-paragraph\">Diskriminacijski potencijal JJC8-089 eksperimentalno je potvr\u0111en. Pokazalo se da molekula zna\u010dajno poni\u0161tava manjak motivacije za napor izazvan inhibitorom VMAT2 tetrabenazinom (HY-B0590). U testovima operantnog pona\u0161anja (zadaci izbora temeljeni na naporima), JJC8-089 je obnovio sklonost \u017eivotinja zadatku s visokim naporom (pritisci s 5 \u0161ipki fiksnog omjera) koji je dao ve\u0107u nagradu u odnosu na alternativu s niskim naporom. Ovo otkri\u0107e nagla\u0161ava njegov potencijal kao mo\u0107nog alata za istra\u017eivanje stanja karakteriziranih patolo\u0161kom apatijom i smanjenom motivacijom.<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>Tehni\u010dke specifikacije:<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Kemijski naziv:<\/strong>\u00a0[Na temelju strukture, npr. derivat benzhidril sulfida]<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>CAS broj:<\/strong>\u00a01627576-64-0<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Molekularna formula:<\/strong>\u00a0C\u2082\u2082H\u2082\u2088F\u2082N\u2082OS<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Molekularna te\u017eina:<\/strong>\u00a0406,53<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Oznaka SMILES-a:<\/strong>\u00a0CC(CN1CCN(CC1)CCSC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Napomena:<\/strong>\u00a0Samo u istra\u017eiva\u010dke svrhe\u00a0<em>in vitro<\/em>\u00a0i u predklini\u010dkim modelima. Nije za ljudsku ili veterinarsku uporabu.<\/p>\n<\/li>\n<\/ul>\n<hr \/>\n<h3>Verzija 3: Vrlo kratka \u201epredstava\u201c (za tra\u017eilicu ili metapodatke)<\/h3>\n<p class=\"ds-markdown-paragraph\"><strong>JJC8-089 | DAT inhibitor | Za istra\u017eivanje motivacije i truda<\/strong><br \/>\nSna\u017ean i selektivni inhibitor dopaminskog transportera (DAT). Istra\u017eiva\u010dka kemikalija za neuroznanost. Poni\u0161tava u\u010dinke tetrabenazina i pove\u0107ava toleranciju na vje\u017ebanje u predklini\u010dkim modelima. CAS 1627576-64-0. Formula: C\u2082\u2082H\u2082\u2088F\u2082N\u2082OS. MW: 406,53.<\/p>\n<p>JC8-089 je inhibitor dopaminskog transportera (DAT) koji mo\u017ee pobolj\u0161ati motivacijske deficite i pove\u0107ati naporno pona\u0161anje u ciljnim aktivnostima. JJC8-089 zna\u010dajno je preokrenuo u\u010dinke niskog napora izazvane inhibitorom VMAT-2 tetrabenazinom (HY-B0590) kod \u0161takora i pove\u0107ao izbor izme\u0111u potiska od 5 bara s visokim naporom i fiksnim omjerom u odnosu na unos hrane.<\/p>\n<p>Molekularna te\u017eina<br \/>\n406,53<\/p>\n<p>Formula<br \/>\nC22H28F2N2OS<\/p>\n<p>CAS broj<br \/>\n1627576-64-0<\/p>\n<p>OSMIJESI<br \/>\nCC(CN1CCN(CC1)CCSC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)<\/p>","protected":false},"excerpt":{"rendered":"<p>JJC8-089: Een Krachtige en Selectieve DAT-Remmer voor Motivatieonderzoek JJC8-089 is een potentieel onderzoeksmolecuul dat specifiek is ontworpen voor de studie<\/p>","protected":false},"featured_media":28805,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[1085],"product_tag":[],"class_list":{"0":"post-27437","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-okategoriserad","8":"first","9":"instock","10":"taxable","11":"shipping-taxable","12":"purchasable","13":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product\/27437","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/comments?post=27437"}],"version-history":[{"count":2,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product\/27437\/revisions"}],"predecessor-version":[{"id":27443,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product\/27437\/revisions\/27443"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/media\/28805"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/media?parent=27437"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product_brand?post=27437"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product_cat?post=27437"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/hr\/wp-json\/wp\/v2\/product_tag?post=27437"}],"curies":[{"name":"radni list","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}