{"id":23504,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23504"},"modified":"2025-10-22T17:00:59","modified_gmt":"2025-10-22T17:00:59","slug":"5-meo-dmt-hydroklorid","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/is\/vara\/5-meo-dmt-hydroklorid\/","title":{"rendered":"5-MeO-DMT h\u00fddr\u00f3kl\u00f3r\u00ed\u00f0"},"content":{"rendered":"

5-MeO-DMT h\u00fddr\u00f3kl\u00f3r\u00ed\u00f0 \u2013 V\u00edsindaleg v\u00f6ruuppl\u00fdsingar<\/span><\/span><\/strong><\/h3>\n

Almenn l\u00fdsing<\/span><\/span><\/strong><\/h4>\n

5-MeO-DMT h\u00fddr\u00f3kl\u00f3r\u00ed\u00f0 (5-Metox\u00fd-N,N-d\u00edmet\u00fdltryptam\u00edn HCl) er vatnsleysanlegt salt af klass\u00edskum tryptam\u00edni, s\u00e9rstaklega hentugt til lyfjafr\u00e6\u00f0ilegra ranns\u00f3kna vegna aukinnar st\u00f6\u00f0ugleika og a\u00f0gengis samanbori\u00f0 vi\u00f0 fr\u00edbasaformi\u00f0.<\/span><\/span><\/p>\n

\n

T\u00e6knilegar uppl\u00fdsingar<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
F\u00e6ribreyta<\/span><\/span><\/strong><\/th>\nUppl\u00fdsingar<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
Efnaform\u00fala<\/span><\/span><\/strong><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O \u00b7 HCl<\/span><\/span><\/td>\n<\/tr>\n
M\u00f3l\u00feungi<\/span><\/span><\/strong><\/td>\n254,75 g\/m\u00f3l<\/span><\/span><\/td>\n<\/tr>\n
Hreinleiki<\/span><\/span><\/strong><\/td>\n\u226598% (greint me\u00f0 HPLC-UV)<\/span><\/span><\/td>\n<\/tr>\n
\u00datlit<\/span><\/span><\/strong><\/td>\nHv\u00edtt til lj\u00f3sgult kristalla\u00f0 duft<\/span><\/span><\/td>\n<\/tr>\n
Leysni<\/span><\/span><\/strong><\/td>\nR\u00edkt af vatni (>50 mg\/ml), metan\u00f3li, PBS<\/span><\/span><\/td>\n<\/tr>\n
Br\u00e6\u00f0slumark<\/span><\/span><\/strong><\/td>\n243-247\u00b0C (brotnar ni\u00f0ur)<\/span><\/span><\/td>\n<\/tr>\n
St\u00f6\u00f0ugleiki<\/span><\/span><\/strong><\/td>\nRakadr\u00e6gt; geymi\u00f0 \u00e1 \u00feurrum sta\u00f0<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

V\u00edsindaleg notkun<\/span><\/span><\/strong><\/h3>\n

1. Taugalyfjafr\u00e6\u00f0i og atferlisranns\u00f3knir<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    Ranns\u00f3knir \u00e1 ser\u00f3t\u00f3n\u00ednvi\u00f0t\u00f6kum:<\/span><\/span><\/strong> \u00a0\u00d6flugur 5-HT\u2081\u2090\/\u2082\u2090 \u00f6rvi me\u00f0 hra\u00f0ri heiladreifingu.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    D\u00fdratilraunir (in vivo):<\/span><\/span><\/strong> \u00a0Heg\u00f0unarfr\u00e6\u00f0ileg vi\u00f0mi\u00f0 (t.d. h\u00f6fu\u00f0kippsvi\u00f0br\u00f6g\u00f0 hj\u00e1 nagd\u00fdrum).<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Rafgreining:<\/span><\/span><\/strong> \u00a0\u00c1hrif \u00e1 taugasveiflur (t.d. gamma-bands virkni).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. L\u00edfefnafr\u00e6\u00f0ilegar og sameindafr\u00e6\u00f0ilegar ranns\u00f3knir<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      Innanfrumubo\u00f0lei\u00f0ir:<\/span><\/span><\/strong> \u00a0Upps\u00f6fnun cAMP og r\u00e1\u00f0ningarpr\u00f3fanir \u00e1 \u03b2-arrest\u00edni.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Hreyfifr\u00e6\u00f0i ens\u00edma:<\/span><\/span><\/strong> \u00a0MAO-A umbrot (IC\u2085\u2080 ~2-5 \u03bcM).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. Kl\u00edn\u00edskt vi\u00f0eigandi ranns\u00f3knir<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        Skammta-sv\u00f6runartengsl:<\/span><\/span><\/strong> \u00a0Forkl\u00edn\u00edsk \u00f6ryggisgreining.<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Samanbur\u00f0arlyfjafr\u00e6\u00f0i:<\/span><\/span><\/strong> \u00a0\u00cd \u00e1tt a\u00f0 psilocybin, DMT og \u00f6\u00f0rum tryptam\u00ednum.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Tilraunalei\u00f0beiningar<\/span><\/span><\/strong><\/h3>\n

        R\u00e1\u00f0lag\u00f0ur styrkur<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        Ums\u00f3kn<\/span><\/span><\/strong><\/th>\nStyrkleikasvi\u00f0<\/span><\/span><\/strong><\/th>\nLeysiefni<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
        Frumur\u00e6ktun (in vitro)<\/span><\/span><\/td>\n1 nM \u2013 10 \u03bcM<\/span><\/span><\/td>\nPBS\/DMEM (\u22640,1% DMSO)<\/span><\/span><\/td>\n<\/tr>\n
        Vi\u00f0takapr\u00f3fanir<\/span><\/span><\/td>\n0,1 \u2013 100 m\u00edkr\u00f3m\u00f3l<\/span><\/span><\/td>\nTris-HCl stu\u00f0p\u00fa\u00f0i (pH 7,4)<\/span><\/span><\/td>\n<\/tr>\n
        D\u00fdraranns\u00f3knir (ip\/iv)<\/span><\/span><\/td>\n0,1 \u2013 5 mg\/kg<\/span><\/span><\/td>\nS\u00f3tthreinsu\u00f0 saltlausn<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        \u00d6ryggisr\u00e1\u00f0stafanir<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          Pers\u00f3nuvernd:<\/span><\/span><\/strong> \u00a0Ranns\u00f3knarstofusloppur, hanskar (\u00far n\u00edtr\u00edl), \u00f6ryggisgleraugu.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Me\u00f0h\u00f6ndlun:<\/span><\/span><\/strong> \u00a0Rakadr\u00e6gt \u2013 lokast strax eftir notkun.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Geymsla:<\/span><\/span><\/strong> \u00a0Loft\u00fe\u00e9tt, undir argoni, vi\u00f0 -20\u00b0C (koma \u00ed veg fyrir vatnsrof).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          St\u00f6\u00f0ugleiki og geymsla<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            Geymslu\u00feol:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              -20\u00b0C:<\/span><\/span><\/strong> \u00a0>2 \u00e1r (\u00f3breytt hreinleiki).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4\u00b0C:<\/span><\/span><\/strong> \u00a06 m\u00e1nu\u00f0ir (\u00ed \u00feurru umhverfi).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              Fall:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Vatnsrof vi\u00f0 langvarandi raka (eftirlit me\u00f0 h\u00e1\u00fer\u00fdstiv\u00f6kvaskiljun).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Greiningarleg sta\u00f0festing<\/span><\/span><\/strong><\/h3>\n

                Hverri lotu fylgir me\u00f0:<\/span><\/span><\/p>\n

                  \n
                1. \n

                  HPLC-UV litr\u00f3fsgreining<\/span><\/span><\/strong> \u00a0(C18 s\u00fala, var\u00f0veislut\u00edmi ~6,2 m\u00edn.).<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  MS\/MS sundrun<\/span><\/span><\/strong> \u00a0(einkennisj\u00f3nir: m\/z 219 \u2192 174, 160).<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  Leifar af leysiefnum<\/span><\/span><\/strong> \u00a0(uppfylla ICH Q3C lei\u00f0beiningar).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  L\u00f6gleg sta\u00f0a (Holland\/ESB)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    L\u00f6ggj\u00f6f um f\u00edkniefni:<\/span><\/span><\/strong> \u00a0Ekki s\u00e9rstaklega nefnt \u00ed \u00f3p\u00eduml\u00f6gunum, en hugsanlega samkv\u00e6mt samb\u00e6rilegum l\u00f6gum (vi\u00f0auki II).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    V\u00edsindaleg notkun:<\/span><\/span><\/strong> \u00a0Leyfi krafist fyrir stofnanir (sam\u00feykki CCMO fyrir d\u00fdratilraunir).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    \u00datflutningseftirlit:<\/span><\/span><\/strong> \u00a0Fellur undir regluger\u00f0 ESB 2019\/1998 (ge\u00f0virk efni).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    Algengar spurningar (FAQ)<\/span><\/span><\/strong><\/h3>\n

                    1. \u00e1rsfj\u00f3r\u00f0ungur <\/span>Hverjir eru kostir HCl umfram fr\u00edbasa?<\/span><\/strong><\/span><\/p>\n

                      \n
                    • \n

                      B\u00e6tt leysni<\/span><\/span><\/strong> \u00a0(tilvali\u00f0 fyrir ranns\u00f3knir \u00e1 stungulyfjum).<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Lengri geymslu\u00feol<\/span><\/span><\/strong> \u00a0vi\u00f0 stofuhita.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      Spurning 2: Er 5-MeO-DMT-HCl greinanlegt \u00ed lyfjapr\u00f3fum?<\/span><\/span><\/strong>
                      \n A: J\u00e1, \u00ed gegnum:<\/span><\/span><\/p>\n

                        \n
                      • \n

                        LC-MS\/MS<\/span><\/span><\/strong> \u00a0(\u00feekkt sem 5-MeO-DMT + HCl tengiefni).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        \u00d3n\u00e6mispr\u00f3fanir:<\/span><\/span><\/strong> \u00a0Krossvirkni vi\u00f0 DMT (~15-20%).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        Spurning 3: Eru einhverjar \u00e1h\u00e6ttur vi\u00f0 samhli\u00f0a notkun MAO-hemla?<\/span><\/span><\/strong>
                        \n A:\u00a0 <\/span><\/span>Algj\u00f6rlega.<\/span><\/span><\/strong><\/p>\n

                          \n
                        • \n

                          Aukin h\u00e6tta \u00e1\u00a0 <\/span><\/span>ser\u00f3t\u00f3n\u00ednheilkenni<\/span><\/span><\/strong> \u00a0(for\u00f0ist samsetningu!).<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Noti\u00f0 a\u00f0eins \u00ed MAO-lausum ger\u00f0um.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          Q4: Hvernig \u00e1 a\u00f0 farga \u00fargangi?<\/span><\/span><\/strong>
                          \n A:<\/span><\/span><\/p>\n

                            \n
                          1. \n

                            Hlutleysa me\u00f0\u00a0 <\/span><\/span>natr\u00edumb\u00edkarb\u00f3nat<\/span><\/span><\/strong> \u00a0(pH 7-8).<\/span><\/span><\/p>\n<\/li>\n

                          2. \n

                            A\u00f0sogast me\u00f0\u00a0 <\/span><\/span>virkt kolefni<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n<\/li>\n

                          3. \n

                            Farga eins og\u00a0 <\/span><\/span>h\u00e6ttulegt efna\u00fargang<\/span><\/span><\/strong> \u00a0(Sameinu\u00f0u \u00fej\u00f3\u00f0irnar 3249, flokkur 6.1).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                            \n

                            Tilv\u00edsanir og tengili\u00f0ir<\/span><\/span><\/strong><\/h3>\n

                            Kjarnab\u00f3kmenntir:<\/span><\/span><\/strong><\/p>\n

                              \n
                            1. \n

                              Shen o.fl. (2010). \u201eLyfjafr\u00e6\u00f0i 5-MeO-DMT aflei\u00f0a\u201c.\u00a0 <\/span><\/span>J Psychopharmacol<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n

                            2. \n

                              Kaasik o.fl. (2021). \u201eEfnaskiptaferlar 5-MeO-DMT\u201c.\u00a0 <\/span><\/span>Xenobiotics<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                              \n

                              \u00deessi vara er eing\u00f6ngu \u00e6tlu\u00f0 til vi\u00f0urkenndra v\u00edsindaranns\u00f3kna. Ekki til manneldis e\u00f0a til greiningar. Vinsamlegast fylgi\u00f0 gildandi reglum.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                              Eiginleikar 5-MeO-DMT h\u00fddr\u00f3kl\u00f3r\u00ed\u00f0s<\/span><\/span><\/span><\/h3>\n

                              Samheiti:<\/span><\/span><\/strong> 5-metox\u00fd-N,N-d\u00edmet\u00fdltryptam\u00ednh\u00fddr\u00f3kl\u00f3r\u00ed\u00f0 <\/span><\/span>
                              \nCAS-n\u00famer:<\/span><\/span><\/strong> eftir <\/span><\/span>
                              \nForm\u00fala:<\/span><\/span><\/strong> 3-[2-(d\u00edmet\u00fdlam\u00edn\u00f3)et\u00fdl]-5-metox\u00fdind\u00f3lh\u00fddr\u00f3kl\u00f3r\u00ed\u00f0 <\/span><\/span>
                              \nM\u00f3lmassi:<\/span><\/span><\/strong> 254,8 g\/m\u00f3l <\/span><\/span>
                              \nHreinleiki:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>","protected":false},"featured_media":28720,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[511,381],"product_tag":[326],"class_list":{"0":"post-23504","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-5-meo-dmt-kopen","7":"product_cat-tryptamines","8":"product_tag-nl","10":"first","11":"instock","12":"taxable","13":"shipping-taxable","14":"purchasable","15":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/is\/wp-json\/wp\/v2\/product\/23504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/is\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/is\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/is\/wp-json\/wp\/v2\/comments?post=23504"}],"version-history":[{"count":6,"href":"https:\/\/researchchemicalstore.eu\/is\/wp-json\/wp\/v2\/product\/23504\/revisions"}],"predecessor-version":[{"id":28467,"href":"https:\/\/researchchemicalstore.eu\/is\/wp-json\/wp\/v2\/product\/23504\/revisions\/28467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/is\/wp-json\/wp\/v2\/media\/28720"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/is\/wp-json\/wp\/v2\/media?parent=23504"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/is\/wp-json\/wp\/v2\/product_brand?post=23504"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/is\/wp-json\/wp\/v2\/product_cat?post=23504"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/is\/wp-json\/wp\/v2\/product_tag?post=23504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}