{"id":23504,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23504"},"modified":"2025-10-22T17:00:59","modified_gmt":"2025-10-22T17:00:59","slug":"5-meo-chlorowodorek-dmt","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/pl\/produkt\/5-meo-chlorowodorek-dmt\/","title":{"rendered":"chlorowodorek 5-MeO-DMT"},"content":{"rendered":"

Chlorowodorek 5-MeO-DMT \u2013 Dokumentacja naukowa produktu<\/span><\/span><\/strong><\/h3>\n

Opis og\u00f3lny<\/span><\/span><\/strong><\/h4>\n

Chlorowodorek 5-MeO-DMT (5-metoksy-N,N-dimetylotryptamina HCl) to rozpuszczalna w wodzie s\u00f3l klasycznej tryptaminy, szczeg\u00f3lnie przydatna do bada\u0144 farmakologicznych ze wzgl\u0119du na zwi\u0119kszon\u0105 stabilno\u015b\u0107 i biodost\u0119pno\u015b\u0107 w por\u00f3wnaniu z form\u0105 wolnej zasady.<\/span><\/span><\/p>\n

\n

Dane techniczne<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Parametr<\/span><\/span><\/strong><\/th>\nSpecyfikacja<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
Wz\u00f3r chemiczny<\/span><\/span><\/strong><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O \u00b7 HCl<\/span><\/span><\/td>\n<\/tr>\n
Masa cz\u0105steczkowa<\/span><\/span><\/strong><\/td>\n254,75 g\/mol<\/span><\/span><\/td>\n<\/tr>\n
Czysto\u015b\u0107<\/span><\/span><\/strong><\/td>\n\u226598% (analizowane metod\u0105 HPLC-UV)<\/span><\/span><\/td>\n<\/tr>\n
Wygl\u0105d<\/span><\/span><\/strong><\/td>\nBia\u0142y do jasno\u017c\u00f3\u0142tego krystaliczny proszek<\/span><\/span><\/td>\n<\/tr>\n
Rozpuszczalno\u015b\u0107<\/span><\/span><\/strong><\/td>\nWysoka zawarto\u015b\u0107 wody (>50 mg\/ml), metanolu, PBS<\/span><\/span><\/td>\n<\/tr>\n
Temperatura topnienia<\/span><\/span><\/strong><\/td>\n243-247\u00b0C (rozk\u0142ada si\u0119)<\/span><\/span><\/td>\n<\/tr>\n
Stabilno\u015b\u0107<\/span><\/span><\/strong><\/td>\nHigroskopijny; przechowywa\u0107 w suchych warunkach<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

Zastosowania naukowe<\/span><\/span><\/strong><\/h3>\n

1. Neurofarmakologia i badania behawioralne<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    Badania receptor\u00f3w serotoninowych:<\/span><\/span><\/strong> \u00a0Silny agonista 5-HT\u2081\u2090\/\u2082\u2090 o szybkim przenikaniu do m\u00f3zgu.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Eksperymenty na zwierz\u0119tach (in vivo):<\/span><\/span><\/strong> \u00a0Paradygmaty behawioralne (np. reakcja drgania g\u0142owy u gryzoni).<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Elektrofizjologia:<\/span><\/span><\/strong> \u00a0Wp\u0142yw na oscylacje neuronalne (np. aktywno\u015b\u0107 w pa\u015bmie gamma).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. Badania biochemiczne i molekularne<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      Sygnalizacja wewn\u0105trzkom\u00f3rkowa:<\/span><\/span><\/strong> \u00a0Badania akumulacji cAMP i rekrutacji \u03b2-arrestyny.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Kinetyka enzym\u00f3w:<\/span><\/span><\/strong> \u00a0Metabolizm MAO-A (IC\u2085\u2080 ~2-5 \u03bcM).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. Badania klinicznie istotne<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        Zale\u017cno\u015bci dawka-odpowied\u017a:<\/span><\/span><\/strong> \u00a0Profilowanie bezpiecze\u0144stwa przedklinicznego.<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Farmakologia por\u00f3wnawcza:<\/span><\/span><\/strong> \u00a0W stron\u0119 psylocybiny, DMT i innych tryptamin.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Wytyczne eksperymentalne<\/span><\/span><\/strong><\/h3>\n

        Zalecane st\u0119\u017cenia<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        Aplikacja<\/span><\/span><\/strong><\/th>\nZakres st\u0119\u017ce\u0144<\/span><\/span><\/strong><\/th>\nRozpuszczalnik<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
        Hodowle kom\u00f3rkowe (in vitro)<\/span><\/span><\/td>\n1 nM \u2013 10 \u03bcM<\/span><\/span><\/td>\nPBS\/DMEM (\u22640,1% DMSO)<\/span><\/span><\/td>\n<\/tr>\n
        Testy receptorowe<\/span><\/span><\/td>\n0,1 \u2013 100 \u03bcM<\/span><\/span><\/td>\nBufor Tris-HCl (pH 7,4)<\/span><\/span><\/td>\n<\/tr>\n
        Badania na zwierz\u0119tach (ip\/iv)<\/span><\/span><\/td>\n0,1 \u2013 5 mg\/kg<\/span><\/span><\/td>\nSterylny roztw\u00f3r soli fizjologicznej<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        \u015arodki bezpiecze\u0144stwa<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          Ochrona osobista:<\/span><\/span><\/strong> \u00a0Fartuch laboratoryjny, r\u0119kawiczki (nitrylowe), okulary ochronne.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Obs\u0142ugiwanie:<\/span><\/span><\/strong> \u00a0Higroskopijne \u2013 zamkn\u0105\u0107 natychmiast po u\u017cyciu.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Sk\u0142adowanie:<\/span><\/span><\/strong> \u00a0Hermetyczne, w atmosferze argonu, w temperaturze -20\u00b0C (zapobiega hydrolizie).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Stabilno\u015b\u0107 i przechowywanie<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            Okres przydatno\u015bci do spo\u017cycia:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              -20\u00b0C:<\/span><\/span><\/strong> \u00a0>2 lata (niezmieniona czysto\u015b\u0107).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4\u00b0C:<\/span><\/span><\/strong> \u00a06 miesi\u0119cy (w suchym \u015brodowisku).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              Relegacja:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Hydroliza przy d\u0142u\u017cszym nara\u017ceniu na wilgo\u0107 (monitorowanie za pomoc\u0105 HPLC).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Walidacja analityczna<\/span><\/span><\/strong><\/h3>\n

                Ka\u017cda partia zawiera:<\/span><\/span><\/p>\n

                  \n
                1. \n

                  Chromatogram HPLC-UV<\/span><\/span><\/strong> \u00a0(kolumna C18, czas retencji ~6,2 min).<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  Fragmentacja MS\/MS<\/span><\/span><\/strong> \u00a0(jony charakterystyczne: m\/z 219 \u2192 174, 160).<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  Rozpuszczalniki resztkowe<\/span><\/span><\/strong> \u00a0(spe\u0142niaj\u0105 wytyczne ICH Q3C).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  Status prawny (Holandia\/UE)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    Ustawodawstwo dotycz\u0105ce narkotyk\u00f3w:<\/span><\/span><\/strong> \u00a0Nie jest to wprost wymienione w Ustawie o opium, ale prawdopodobnie istnieje w analogicznych przepisach (Za\u0142\u0105cznik II).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Zastosowanie naukowe:<\/span><\/span><\/strong> \u00a0Wymagane zezwolenie dla instytucji (zatwierdzenie CCMO na testy na zwierz\u0119tach).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Kontrola eksportu:<\/span><\/span><\/strong> \u00a0Z zastrze\u017ceniem Rozporz\u0105dzenia UE 2019\/1998 (substancje psychotropowe).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    Cz\u0119sto zadawane pytania (FAQ)<\/span><\/span><\/strong><\/h3>\n

                    Pytanie 1 <\/span>:Jakie s\u0105 zalety HCl w por\u00f3wnaniu z woln\u0105 zasad\u0105?<\/span><\/strong><\/span><\/p>\n

                      \n
                    • \n

                      Poprawiona rozpuszczalno\u015b\u0107<\/span><\/span><\/strong> \u00a0(idealny do bada\u0144 iniekcyjnych).<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      D\u0142u\u017csza trwa\u0142o\u015b\u0107 na p\u00f3\u0142ce<\/span><\/span><\/strong> \u00a0w temperaturze pokojowej.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      P2: Czy 5-MeO-DMT-HCl mo\u017cna wykry\u0107 w testach narkotykowych?<\/span><\/span><\/strong>
                      \n A: Tak, poprzez:<\/span><\/span><\/p>\n

                        \n
                      • \n

                        LC-MS\/MS<\/span><\/span><\/strong> \u00a0(rozpoznany jako addukt 5-MeO-DMT + HCl).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Testy immunologiczne:<\/span><\/span><\/strong> \u00a0Reaktywno\u015b\u0107 krzy\u017cowa z DMT (~15-20%).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        P3: Czy \u0142\u0105czenie z inhibitorami MAO wi\u0105\u017ce si\u0119 z ryzykiem?<\/span><\/span><\/strong>
                        \n A:\u00a0 <\/span><\/span>Absolutnie.<\/span><\/span><\/strong><\/p>\n

                          \n
                        • \n

                          Zwi\u0119kszone ryzyko\u00a0 <\/span><\/span>zesp\u00f3\u0142 serotoninowy<\/span><\/span><\/strong> \u00a0(unikaj kombinacji!).<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Stosowa\u0107 wy\u0142\u0105cznie w modelach wolnych od MAO.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          P4: Jak pozbywa\u0107 si\u0119 odpad\u00f3w?<\/span><\/span><\/strong>
                          \n A:<\/span><\/span><\/p>\n

                            \n
                          1. \n

                            Zneutralizowa\u0107 za pomoc\u0105\u00a0 <\/span><\/span>wodorow\u0119glan sodu<\/span><\/span><\/strong> \u00a0(pH 7-8).<\/span><\/span><\/p>\n<\/li>\n

                          2. \n

                            Adsorbowa\u0107 za pomoc\u0105\u00a0 <\/span><\/span>w\u0119giel aktywowany<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n<\/li>\n

                          3. \n

                            Wyrzuci\u0107 jako\u00a0 <\/span><\/span>niebezpieczne odpady chemiczne<\/span><\/span><\/strong> \u00a0(UN 3249, Klasa 6.1).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                            \n

                            Referencje i kontakt<\/span><\/span><\/strong><\/h3>\n

                            Literatura podstawowa:<\/span><\/span><\/strong><\/p>\n

                              \n
                            1. \n

                              Shen i wsp. (2010). \u201eFarmakologia pochodnych 5-MeO-DMT\u201d.\u00a0 <\/span><\/span>J Psychopharmacol<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n

                            2. \n

                              Kaasik i wsp. (2021). \u201eSzlaki metaboliczne 5-MeO-DMT\u201d.\u00a0 <\/span><\/span>Ksenobiotyki<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                              \n

                              Ten produkt jest przeznaczony wy\u0142\u0105cznie do autoryzowanych bada\u0144 naukowych. Nie nadaje si\u0119 do spo\u017cycia przez ludzi ani do cel\u00f3w diagnostycznych. Nale\u017cy przestrzega\u0107 lokalnych przepis\u00f3w.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                              W\u0142a\u015bciwo\u015bci chlorowodorku 5-MeO-DMT<\/span><\/span><\/span><\/h3>\n

                              Synonim:<\/span><\/span><\/strong> chlorowodorek 5-metoksy-N,N-dimetylotryptaminy <\/span><\/span>
                              \nNumer CAS:<\/span><\/span><\/strong> Po <\/span><\/span>
                              \nFormu\u0142a:<\/span><\/span><\/strong> chlorowodorek 3-[2-(dimetyloamino)etylo]-5-metoksyindolu <\/span><\/span>
                              \nMasa molowa:<\/span><\/span><\/strong> 254,8 g\/mol <\/span><\/span>
                              \nCzysto\u015b\u0107:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>","protected":false},"featured_media":28720,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[511,381],"product_tag":[326],"class_list":{"0":"post-23504","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-5-meo-dmt-kopen","7":"product_cat-tryptamines","8":"product_tag-nl","10":"first","11":"instock","12":"taxable","13":"shipping-taxable","14":"purchasable","15":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/pl\/wp-json\/wp\/v2\/product\/23504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/pl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/pl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/pl\/wp-json\/wp\/v2\/comments?post=23504"}],"version-history":[{"count":6,"href":"https:\/\/researchchemicalstore.eu\/pl\/wp-json\/wp\/v2\/product\/23504\/revisions"}],"predecessor-version":[{"id":28467,"href":"https:\/\/researchchemicalstore.eu\/pl\/wp-json\/wp\/v2\/product\/23504\/revisions\/28467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/pl\/wp-json\/wp\/v2\/media\/28720"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/pl\/wp-json\/wp\/v2\/media?parent=23504"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/pl\/wp-json\/wp\/v2\/product_brand?post=23504"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/pl\/wp-json\/wp\/v2\/product_cat?post=23504"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/pl\/wp-json\/wp\/v2\/product_tag?post=23504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}