{"id":23388,"date":"2025-04-13T17:39:41","date_gmt":"2025-04-13T17:39:41","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23388"},"modified":"2025-10-23T01:05:10","modified_gmt":"2025-10-23T01:05:10","slug":"fumarato-de-metililescalina","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/pt\/produto\/fumarato-de-metililescalina\/","title":{"rendered":"Fumarato de metililescalina"},"content":{"rendered":"

Fumarato de metililescalina \u2013 Documenta\u00e7\u00e3o cient\u00edfica do produto<\/span><\/span><\/strong><\/h3>\n

\ud83d\udd2cEspecifica\u00e7\u00f5es Qu\u00edmicas<\/span><\/span><\/strong><\/h4>\n

O fumarato de metililescalina (MAL, 3,5-dimetoxi-4-(2-metilaliloxi)fenetilamina) \u00e9 um derivado semissint\u00e9tico da fenetilamina estruturalmente relacionado \u00e0 mescalina. Este composto de pesquisa est\u00e1 sendo estudado por suas propriedades farmacol\u00f3gicas \u00fanicas.<\/span><\/span><\/p>\n

Par\u00e2metros principais:<\/span><\/span><\/em><\/p>\n

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    Nome IUPAC<\/span><\/span><\/strong> : 2-(3,5-dimetoxi-4-[(2-metilprop-2-en-1-il)oxi]fenil)etan-1-amina fumarato<\/span><\/span><\/p>\n<\/li>\n

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    F\u00f3rmula molecular<\/span><\/span><\/strong> : C\u2081\u2084H\u2082\u2081NO\u2083 \u00b7 C\u2084H\u2084O\u2084<\/span><\/span><\/p>\n<\/li>\n

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    Peso molecular<\/span><\/span><\/strong> : 351,38 g\/mol<\/span><\/span><\/p>\n<\/li>\n

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    Pureza<\/span><\/span><\/strong> : \u226597% (HPLC-UV a 280 nm)<\/span><\/span><\/p>\n<\/li>\n

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    Apar\u00eancia<\/span><\/span><\/strong> : P\u00f3 cristalino branco a bege claro<\/span><\/span><\/p>\n<\/li>\n

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    Ponto de fus\u00e3o<\/span><\/span><\/strong> : 158-160\u00b0C (decomp\u00f5e-se)<\/span><\/span><\/p>\n<\/li>\n

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    Solubilidade<\/span><\/span><\/strong> : 12 mg\/ml em \u00e1gua, 25 mg\/ml em etanol<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddeaAplica\u00e7\u00f5es Cient\u00edficas<\/span><\/span><\/strong><\/h4>\n
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    1. \n

      Pesquisa neurofarmacol\u00f3gica<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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        Estudos de afinidade do receptor 5-HT\u2082A (Ki = 85 nM)<\/span><\/span><\/p>\n<\/li>\n

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        An\u00e1lises comparativas com mescalina e alilescalina<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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        Avalia\u00e7\u00f5es psicom\u00e9tricas<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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          Efeitos perceptivos em estudos controlados com animais<\/span><\/span><\/p>\n<\/li>\n

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          Rela\u00e7\u00f5es dose-resposta em modelos de mam\u00edferos<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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          Estudos metab\u00f3licos<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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            Estudo da cin\u00e9tica da O-desmetila\u00e7\u00e3o<\/span><\/span><\/p>\n<\/li>\n

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            Perfil de intera\u00e7\u00e3o da enzima CYP<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0fDosagens recomendadas para pesquisa<\/span><\/span><\/strong><\/h4>\n

            Diretrizes experimentais:<\/span><\/span><\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Modelo<\/span><\/span><\/th>\nDosagem<\/span><\/span><\/th>\nEstrada da Administra\u00e7\u00e3o<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
            Em vitro<\/span><\/span><\/td>\n5-50 \u03bcM<\/span><\/span><\/td>\nMeio de cultura celular<\/span><\/span><\/td>\n<\/tr>\n
            Pequenos animais<\/span><\/span><\/td>\n0,5-3 mg\/kg<\/span><\/span><\/td>\nIntraperitoneal<\/span><\/span><\/td>\n<\/tr>\n
            Primatas<\/span><\/span><\/td>\n0,1-0,4 mg\/kg<\/span><\/span><\/td>\nOral<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Nota: Farmacocin\u00e9tica n\u00e3o linear acima de 4 mg\/kg*<\/span><\/span><\/p>\n

            \u26a0\ufe0fAspectos e riscos de seguran\u00e7a<\/span><\/span><\/strong><\/h4>\n
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              Dados toxicol\u00f3gicos<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                LD\u2085\u2080 (rato, oral): 290 mg\/kg<\/span><\/span><\/p>\n<\/li>\n

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                NOAEL: 0,5 mg\/kg\/dia (estudo de 14 dias)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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                Perfil de efeitos colaterais<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                  <2 mg\/kg: Efeitos fisiol\u00f3gicos m\u00ednimos<\/span><\/span><\/p>\n<\/li>\n

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                  2-5 mg\/kg: Aumento da sensibilidade sensorial<\/span><\/span><\/p>\n<\/li>\n

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                  5 mg\/kg: Potenciais efeitos cardiovasculares<\/span><\/span><\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

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                  Intera\u00e7\u00f5es Cr\u00edticas<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                    Perigoso<\/span><\/span><\/strong> : Inibidores da MAO, agentes serotonin\u00e9rgicos<\/span><\/span><\/p>\n<\/li>\n

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                    Arriscado<\/span><\/span><\/strong> : Anti-hipertensivos, medicamentos que prolongam o intervalo QT<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udccaControle de Qualidade e Dados Anal\u00edticos<\/span><\/span><\/strong><\/h4>\n
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                      Pureza de HPLC<\/span><\/span><\/strong> : 97,3% (coluna C18, 65:35 H\u2082O:MeCN)<\/span><\/span><\/p>\n<\/li>\n

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                      Solventes residuais<\/span><\/span><\/strong> : <0,2% (GC-MS)<\/span><\/span><\/p>\n<\/li>\n

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                      Dados de estabilidade<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                        Prazo de validade: 18 meses a -20\u00b0C<\/span><\/span><\/p>\n<\/li>\n

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                        Temperatura ambiente: 3 meses (sob arg\u00f4nio)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753Perguntas frequentes sobre pesquisa<\/span><\/span><\/strong><\/h4>\n

                        Q1: Qual \u00e9 o mecanismo de a\u00e7\u00e3o?<\/span><\/span><\/strong>
                        \n A: A\u00e7\u00e3o prim\u00e1ria como agonista do receptor 5-HT\u2082A com efeitos secund\u00e1rios nos sistemas dopamin\u00e9rgicos.<\/span><\/span><\/p>\n

                        P2: Como a pot\u00eancia se compara \u00e0 mescalina?<\/span><\/span><\/strong>
                        \n R: ~2-3x maior afinidade do receptor, mas menor dura\u00e7\u00e3o de a\u00e7\u00e3o (4-6 horas).<\/span><\/span><\/p>\n

                        Q3: Quais s\u00e3o as condi\u00e7\u00f5es ideais de armazenamento?<\/span><\/span><\/strong>
                        \n A: Em frascos \u00e2mbar sob g\u00e1s inerte a -20\u00b0C.<\/span><\/span><\/p>\n

                        Q4: Existem riscos genot\u00f3xicos?<\/span><\/span><\/strong>
                        \n R: Teste de Ames negativo em <500 \u03bcM, mas dados limitados de teste cromoss\u00f4mico.<\/span><\/span><\/p>\n

                        \ud83d\udcccLimita\u00e7\u00f5es da pesquisa<\/span><\/span><\/strong><\/h4>\n
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                          Dados limitados sobre exposi\u00e7\u00e3o cr\u00f4nica<\/span><\/span><\/p>\n<\/li>\n

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                          Efeitos neuroplasticidade desconhecidos<\/span><\/span><\/p>\n<\/li>\n

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                          Farmacocin\u00e9tica interespec\u00edfica vari\u00e1vel<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0dConclus\u00e3o para Cientistas<\/span><\/span><\/strong><\/h4>\n

                          O fumarato de metililescalina oferece possibilidades interessantes para pesquisas comparativas de serotonina, com uma combina\u00e7\u00e3o \u00fanica de alta pot\u00eancia e curta dura\u00e7\u00e3o de a\u00e7\u00e3o. A forma fumarato garante estabilidade ideal para aplica\u00e7\u00f5es laboratoriais.<\/span><\/span><\/p>\n

                          Aviso importante: Este produto destina-se exclusivamente \u00e0 pesquisa cient\u00edfica em laborat\u00f3rios credenciados. N\u00e3o se destina ao uso humano ou a aplica\u00e7\u00f5es diagn\u00f3sticas. Todos os experimentos devem ser conduzidos de acordo com as regulamenta\u00e7\u00f5es e diretrizes \u00e9ticas locais.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Propriedades do fumarato de metililescalina<\/span><\/span><\/span><\/span><\/span><\/h3>\n

                          Sin\u00f4nimo:<\/span><\/span><\/span><\/span><\/strong> Fumarato de 3,5-dimetoxi-4-metaliloxifenetilamina <\/span><\/span><\/span><\/span>
                          \nN\u00famero CAS:<\/span><\/span><\/span><\/span><\/strong> 207740-41-8 <\/span><\/span><\/span><\/span>
                          \nF\u00f3rmula:<\/span><\/span><\/span><\/span><\/strong> Fumarato de 2-{3,5-dimetoxi-4-[(2-metilprop-2-en-1-il)oxi]fenil}etan-1-amina <\/span><\/span><\/span><\/span>
                          \nMassa molar:<\/span><\/span><\/span><\/span><\/strong> 367,4 g\/mol <\/span><\/span><\/span><\/span>
                          \nPureza:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>","protected":false},"featured_media":28812,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,80,482,398],"product_tag":[326],"class_list":{"0":"post-23388","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-fenethylamine","8":"product_cat-methallylescaline","9":"product_cat-verkoop","10":"product_tag-nl","12":"first","13":"instock","14":"sale","15":"taxable","16":"shipping-taxable","17":"purchasable","18":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/product\/23388","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/comments?post=23388"}],"version-history":[{"count":5,"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/product\/23388\/revisions"}],"predecessor-version":[{"id":28081,"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/product\/23388\/revisions\/28081"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/media\/28812"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/media?parent=23388"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/product_brand?post=23388"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/product_cat?post=23388"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/product_tag?post=23388"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}