{"id":23504,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23504"},"modified":"2025-10-22T17:00:59","modified_gmt":"2025-10-22T17:00:59","slug":"5-meo-dmt-cloridrato","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/pt\/produto\/5-meo-dmt-cloridrato\/","title":{"rendered":"Cloridrato de 5-MeO-DMT"},"content":{"rendered":"

Cloridrato de 5-MeO-DMT \u2013 Documenta\u00e7\u00e3o Cient\u00edfica do Produto<\/span><\/span><\/strong><\/h3>\n

Descri\u00e7\u00e3o geral<\/span><\/span><\/strong><\/h4>\n

O cloridrato de 5-MeO-DMT (5-metoxi-N,N-dimetiltriptamina HCl) \u00e9 um sal sol\u00favel em \u00e1gua da triptamina cl\u00e1ssica, particularmente adequado para pesquisa farmacol\u00f3gica devido \u00e0 sua maior estabilidade e biodisponibilidade em compara\u00e7\u00e3o \u00e0 forma de base livre.<\/span><\/span><\/p>\n

\n

Especifica\u00e7\u00f5es t\u00e9cnicas<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Par\u00e2metro<\/span><\/span><\/strong><\/th>\nEspecifica\u00e7\u00e3o<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
F\u00f3rmula Qu\u00edmica<\/span><\/span><\/strong><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O \u00b7 HCl<\/span><\/span><\/td>\n<\/tr>\n
Peso molecular<\/span><\/span><\/strong><\/td>\n254,75 g\/mol<\/span><\/span><\/td>\n<\/tr>\n
Pureza<\/span><\/span><\/strong><\/td>\n\u226598% (analisado por HPLC-UV)<\/span><\/span><\/td>\n<\/tr>\n
Apar\u00eancia<\/span><\/span><\/strong><\/td>\nP\u00f3 cristalino branco a amarelo claro<\/span><\/span><\/td>\n<\/tr>\n
Solubilidade<\/span><\/span><\/strong><\/td>\nRico em \u00e1gua (>50 mg\/ml), metanol, PBS<\/span><\/span><\/td>\n<\/tr>\n
Ponto de fus\u00e3o<\/span><\/span><\/strong><\/td>\n243-247\u00b0C (decomp\u00f5e-se)<\/span><\/span><\/td>\n<\/tr>\n
Estabilidade<\/span><\/span><\/strong><\/td>\nHigrosc\u00f3pico; armazenar em condi\u00e7\u00f5es secas<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

Aplica\u00e7\u00f5es Cient\u00edficas<\/span><\/span><\/strong><\/h3>\n

1. Neurofarmacologia e Pesquisa Comportamental<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    Estudos do receptor de serotonina:<\/span><\/span><\/strong> \u00a0Agonista potente de 5-HT\u2081\u2090\/\u2082\u2090 com r\u00e1pida penetra\u00e7\u00e3o cerebral.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Experimentos em animais (in vivo):<\/span><\/span><\/strong> \u00a0Paradigmas comportamentais (por exemplo, resposta de contra\u00e7\u00e3o da cabe\u00e7a em roedores).<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Eletrofisiologia:<\/span><\/span><\/strong> \u00a0Efeitos nas oscila\u00e7\u00f5es neuronais (por exemplo, atividade da banda gama).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. Estudos Bioqu\u00edmicos e Moleculares<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      Sinaliza\u00e7\u00e3o intracelular:<\/span><\/span><\/strong> \u00a0Ensaios de ac\u00famulo de AMPc e recrutamento de \u03b2-arrestina.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Cin\u00e9tica enzim\u00e1tica:<\/span><\/span><\/strong> \u00a0Metabolismo da MAO-A (IC\u2085\u2080 ~2-5 \u03bcM).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. Pesquisa Clinicamente Relevante<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        Rela\u00e7\u00f5es dose-resposta:<\/span><\/span><\/strong> \u00a0Perfil de seguran\u00e7a pr\u00e9-cl\u00ednica.<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Farmacologia comparativa:<\/span><\/span><\/strong> \u00a0Em dire\u00e7\u00e3o \u00e0 psilocibina, DMT e outras triptaminas.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Diretrizes Experimentais<\/span><\/span><\/strong><\/h3>\n

        Concentra\u00e7\u00f5es recomendadas<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        Aplicativo<\/span><\/span><\/strong><\/th>\nFaixa de concentra\u00e7\u00e3o<\/span><\/span><\/strong><\/th>\nSolvente<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
        Culturas de c\u00e9lulas (in vitro)<\/span><\/span><\/td>\n1 nM \u2013 10 \u03bcM<\/span><\/span><\/td>\nPBS\/DMEM (\u22640,1% DMSO)<\/span><\/span><\/td>\n<\/tr>\n
        Ensaios de receptores<\/span><\/span><\/td>\n0,1 \u2013 100 \u03bcM<\/span><\/span><\/td>\nTamp\u00e3o Tris-HCl (pH 7,4)<\/span><\/span><\/td>\n<\/tr>\n
        Estudos em animais (ip\/iv)<\/span><\/span><\/td>\n0,1 \u2013 5 mg\/kg<\/span><\/span><\/td>\nSolu\u00e7\u00e3o salina est\u00e9ril<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        Medidas de seguran\u00e7a<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          Prote\u00e7\u00e3o pessoal:<\/span><\/span><\/strong> \u00a0Jaleco, luvas (nitrila), \u00f3culos de seguran\u00e7a.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Manuseio:<\/span><\/span><\/strong> \u00a0Higrosc\u00f3pico \u2013 feche imediatamente ap\u00f3s o uso.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Armazenar:<\/span><\/span><\/strong> \u00a0Herm\u00e9tico, sob arg\u00f4nio, a -20\u00b0C (evita hidr\u00f3lise).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Estabilidade e Armazenamento<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            Prazo de validade:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              -20\u00b0C:<\/span><\/span><\/strong> \u00a0>2 anos (pureza inalterada).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4\u00b0C:<\/span><\/span><\/strong> \u00a06 meses (em ambiente seco).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              Rebaixamento:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Hidr\u00f3lise em exposi\u00e7\u00e3o prolongada \u00e0 umidade (monitoramento por HPLC).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Valida\u00e7\u00e3o Anal\u00edtica<\/span><\/span><\/strong><\/h3>\n

                Cada lote vem com:<\/span><\/span><\/p>\n

                  \n
                1. \n

                  Cromatograma HPLC-UV<\/span><\/span><\/strong> \u00a0(Coluna C18, tempo de reten\u00e7\u00e3o ~6,2 min).<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  Fragmenta\u00e7\u00e3o MS\/MS<\/span><\/span><\/strong> \u00a0(\u00edons caracter\u00edsticos: m\/z 219 \u2192 174, 160).<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  Solventes residuais<\/span><\/span><\/strong> \u00a0(atender \u00e0s diretrizes ICH Q3C).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  Situa\u00e7\u00e3o jur\u00eddica (Pa\u00edses Baixos\/UE)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    Legisla\u00e7\u00e3o sobre narc\u00f3ticos:<\/span><\/span><\/strong> \u00a0N\u00e3o mencionado explicitamente na Lei do \u00d3pio, mas possivelmente em legisla\u00e7\u00e3o an\u00e1loga (Ap\u00eandice II).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Uso cient\u00edfico:<\/span><\/span><\/strong> \u00a0Permiss\u00e3o necess\u00e1ria para institui\u00e7\u00f5es (aprova\u00e7\u00e3o do CCMO para testes em animais).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Controle de exporta\u00e7\u00e3o:<\/span><\/span><\/strong> \u00a0Sujeito ao Regulamento da UE 2019\/1998 (subst\u00e2ncias psicotr\u00f3picas).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    Perguntas Frequentes (FAQ)<\/span><\/span><\/strong><\/h3>\n

                    Q1 <\/span>:Quais s\u00e3o as vantagens do HCl em rela\u00e7\u00e3o \u00e0 base livre?<\/span><\/strong><\/span><\/p>\n

                      \n
                    • \n

                      Solubilidade melhorada<\/span><\/span><\/strong> \u00a0(ideal para estudos de inje\u00e7\u00e3o).<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Maior estabilidade na prateleira<\/span><\/span><\/strong> \u00a0em temperatura ambiente.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      P2: O 5-MeO-DMT-HCl \u00e9 detect\u00e1vel em testes de drogas?<\/span><\/span><\/strong>
                      \n R: Sim, atrav\u00e9s de:<\/span><\/span><\/p>\n

                        \n
                      • \n

                        LC-MS\/MS<\/span><\/span><\/strong> \u00a0(reconhecido como aduto 5-MeO-DMT + HCl).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Imunoensaios:<\/span><\/span><\/strong> \u00a0Reatividade cruzada com DMT (~15-20%).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        Q3: H\u00e1 riscos ao combinar com inibidores da MAO?<\/span><\/span><\/strong>
                        \n UM:\u00a0 <\/span><\/span>Absolutamente.<\/span><\/span><\/strong><\/p>\n

                          \n
                        • \n

                          Aumento do risco de\u00a0 <\/span><\/span>s\u00edndrome da serotonina<\/span><\/span><\/strong> \u00a0(evite combina\u00e7\u00f5es!).<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Use somente em modelos sem MAO.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          Q4: Como descartar res\u00edduos?<\/span><\/span><\/strong>
                          \n UM:<\/span><\/span><\/p>\n

                            \n
                          1. \n

                            Neutralizar com\u00a0 <\/span><\/span>bicarbonato de s\u00f3dio<\/span><\/span><\/strong> \u00a0(pH 7-8).<\/span><\/span><\/p>\n<\/li>\n

                          2. \n

                            Adsorver com\u00a0 <\/span><\/span>carv\u00e3o ativado<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n<\/li>\n

                          3. \n

                            Descarte como\u00a0 <\/span><\/span>res\u00edduos qu\u00edmicos perigosos<\/span><\/span><\/strong> \u00a0(ONU 3249, Classe 6.1).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                            \n

                            Refer\u00eancias e Contato<\/span><\/span><\/strong><\/h3>\n

                            Literatura b\u00e1sica:<\/span><\/span><\/strong><\/p>\n

                              \n
                            1. \n

                              Shen et al. (2010). \u201cFarmacologia de derivados de 5-MeO-DMT\u201d.\u00a0 <\/span><\/span>J Psicofarmacol<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n

                            2. \n

                              Kaasik et al. (2021). \u201cVias metab\u00f3licas do 5-MeO-DMT\u201d.\u00a0 <\/span><\/span>Xenobi\u00f3ticos<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                              \n

                              Este produto destina-se apenas \u00e0 pesquisa cient\u00edfica autorizada. N\u00e3o se destina ao consumo humano ou uso diagn\u00f3stico. Observe as regulamenta\u00e7\u00f5es locais.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                              Propriedades do cloridrato de 5-MeO-DMT<\/span><\/span><\/span><\/h3>\n

                              Sin\u00f4nimo:<\/span><\/span><\/strong> Cloridrato de 5-metoxi-N,N-dimetiltriptamina <\/span><\/span>
                              \nN\u00famero CAS:<\/span><\/span><\/strong> depois <\/span><\/span>
                              \nF\u00f3rmula:<\/span><\/span><\/strong> Cloridrato de 3-[2-(dimetilamino)etil]-5-metoxiindol <\/span><\/span>
                              \nMassa molar:<\/span><\/span><\/strong> 254,8 g\/mol <\/span><\/span>
                              \nPureza:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>","protected":false},"featured_media":28720,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[511,381],"product_tag":[326],"class_list":{"0":"post-23504","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-5-meo-dmt-kopen","7":"product_cat-tryptamines","8":"product_tag-nl","10":"first","11":"instock","12":"taxable","13":"shipping-taxable","14":"purchasable","15":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/product\/23504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/comments?post=23504"}],"version-history":[{"count":6,"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/product\/23504\/revisions"}],"predecessor-version":[{"id":28467,"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/product\/23504\/revisions\/28467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/media\/28720"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/media?parent=23504"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/product_brand?post=23504"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/product_cat?post=23504"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/pt\/wp-json\/wp\/v2\/product_tag?post=23504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}