{"id":23358,"date":"2025-04-13T17:39:37","date_gmt":"2025-04-13T17:39:37","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23358"},"modified":"2025-10-23T01:15:38","modified_gmt":"2025-10-23T01:15:38","slug":"dmxe-40-mg-pelety-deoxymetoxetamin","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/sk\/produkt\/dmxe-40-mg-pelety-deoxymetoxetamin\/","title":{"rendered":"DMXE 40 mg pelety (deoxymetoxetam\u00edn)"},"content":{"rendered":"

DMXE (deoxymetoxetam\u00edn) 40 mg pelety \u2013 vedeck\u00e1 dokument\u00e1cia k produktu<\/span><\/span><\/strong><\/h3>\n

\ud83d\udd2cChemick\u00e9 \u0161pecifik\u00e1cie<\/span><\/span><\/strong><\/h4>\n

DMXE (2\u2032-Oxo-PCE-d10) je v\u00fdskumn\u00e1 chemik\u00e1lia patriaca do triedy arylcyklohexylam\u00ednov, \u0161truktur\u00e1lne pr\u00edbuzn\u00e1 MXE (metoxetam\u00ednu) a ketam\u00ednu. Tieto pelety s\u00fa ur\u010den\u00e9 na presn\u00fd vedeck\u00fd v\u00fdskum.<\/span><\/span><\/p>\n

Z\u00e1kladn\u00e9 parametre:<\/span><\/span><\/em><\/p>\n

    \n
  • \n

    N\u00e1zov IUPAC<\/span><\/span><\/strong> 2-(3,4-dimetylfenyl)-2-(etylamino)cyklohexan\u00f3n<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Molekul\u00e1rny vzorec<\/span><\/span><\/strong> C\u2081\u2086H\u2082\u2083NO<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Molekulov\u00e1 hmotnos\u0165<\/span><\/span><\/strong> : 245,36 g\/mol<\/span><\/span><\/p>\n<\/li>\n

  • \n

    \u010cistota<\/span><\/span><\/strong> : \u226598% (anal\u00fdza GC-MS)<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Tvar<\/span><\/span><\/strong> Okr\u00fahle pelety s priemerom 4 mm<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Farba<\/span><\/span><\/strong> Svetlob\u00e9\u017eov\u00e1 a\u017e biela<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Rozpustnos\u0165<\/span><\/span><\/strong> 15 mg\/ml vo vode (pri 25 \u00b0C)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddeaVedeck\u00e9 aplik\u00e1cie<\/span><\/span><\/strong><\/h4>\n
      \n
    1. \n

      Neurofarmakologick\u00fd v\u00fdskum<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

        \n
      • \n

        \u0160t\u00fadie antagonizmu NMDA receptorov<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Testy interakcie receptora sigma-1<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Behavior\u00e1lna neuroveda<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

          \n
        • \n

          Vplyv na spr\u00e1vanie pri u\u010den\u00ed u laborat\u00f3rnych zvierat<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Disocia\u010dn\u00e9 \u00fa\u010dinky z\u00e1visl\u00e9 od d\u00e1vky<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

        • \n

          Psychofarmakol\u00f3gia<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

            \n
          • \n

            Porovn\u00e1vacie \u0161t\u00fadie s pr\u00edbuzn\u00fdmi disociat\u00edvami<\/span><\/span><\/p>\n<\/li>\n

          • \n

            V\u00fdskum neuroplastick\u00fdch \u00fa\u010dinkov<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0fOdpor\u00fa\u010dan\u00e9 v\u00fdskumn\u00e9 protokoly<\/span><\/span><\/strong><\/h4>\n

            Experiment\u00e1lne pokyny:<\/span><\/span><\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Model<\/span><\/span><\/th>\nD\u00e1vkovanie<\/span><\/span><\/th>\nFrekvencia<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/span><\/span><\/td>\n10 \u2013 50 \u03bcM<\/span><\/span><\/td>\nJednorazov\u00e1 expoz\u00edcia<\/span><\/span><\/td>\n<\/tr>\n
            Mal\u00e9 hlodavce<\/span><\/span><\/td>\n5 \u2013 20 mg\/kg<\/span><\/span><\/td>\n1x\/de\u0148 (max. 3 dni)<\/span><\/span><\/td>\n<\/tr>\n
            Prim\u00e1ty<\/span><\/span><\/td>\n1 \u2013 5 mg\/kg<\/span><\/span><\/td>\nJednorazov\u00e1 d\u00e1vka<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Pozn\u00e1mka: Neline\u00e1rna farmakokinetika nad 25 mg\/kg*<\/span><\/span><\/p>\n

            \u26a0\ufe0fBezpe\u010dnostn\u00fd profil a riadenie riz\u00edk<\/span><\/span><\/strong><\/h4>\n
              \n
            1. \n

              Toxikologick\u00e9 \u00fadaje<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

                \n
              • \n

                LD\u2085\u2080 (potkan, or\u00e1lne): 320 mg\/kg<\/span><\/span><\/p>\n<\/li>\n

              • \n

                NOAEL: 5 mg\/kg\/de\u0148 (7-d\u0148ov\u00e1 \u0161t\u00fadia)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

              • \n

                Spektrum ved\u013eaj\u0161\u00edch \u00fa\u010dinkov<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

                  \n
                • \n

                  <10 mg: Jemn\u00e9 behavior\u00e1lne \u00fa\u010dinky<\/span><\/span><\/p>\n<\/li>\n

                • \n

                  10 \u2013 30 mg: Motorick\u00e1 nekoordinovanos\u0165<\/span><\/span><\/p>\n<\/li>\n

                • \n
                  \n

                  30 mg: Potenci\u00e1lna respira\u010dn\u00e1 depresia<\/span><\/span><\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

                • \n

                  Kritick\u00e9 interakcie<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

                    \n
                  • \n

                    Nebezpe\u010dn\u00fd<\/span><\/span><\/strong> Opioidy, GABA-ergik\u00e1<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Rizikov\u00e9<\/span><\/span><\/strong> Stimulanty, inhib\u00edtory MAO<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udccaKontrola kvality a analytick\u00e9 \u00fadaje<\/span><\/span><\/strong><\/h4>\n
                      \n
                    • \n

                      \u010cistota HPLC<\/span><\/span><\/strong> 98,5% (kol\u00f3na C18, 70:30 H\u2082O:MeCN)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Jednotnos\u0165<\/span><\/span><\/strong> Odch\u00fdlka hmotnosti \u00b151 TP3T (n=20 peliet)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      \u010cas rozpadu<\/span><\/span><\/strong> <15 min\u00fat (pri s\u00fa\u010dasnom vyl\u00fahovan\u00ed \u017eal\u00fado\u010dnej \u0161\u0165avy)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      \u00dadaje o stabilite<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

                        \n
                      • \n

                        Trvanlivos\u0165: 24 mesiacov pri teplote 15 \u2013 25 \u00b0C<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Citlivos\u0165 na vlhkos\u0165: <0,51 TP3T pr\u00edrastok hmotnosti (931 TP3T RH)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753\u010casto kladen\u00e9 v\u00fdskumn\u00e9 ot\u00e1zky<\/span><\/span><\/strong><\/h4>\n

                        Ot\u00e1zka 1: Ak\u00fd je mechanizmus \u00fa\u010dinku?<\/span><\/span><\/strong>
                        \n A: Prim\u00e1rny antagonizmus NMDA receptorov so sekund\u00e1rnou inhib\u00edciou sp\u00e4tn\u00e9ho vychyt\u00e1vania dopam\u00ednu.<\/span><\/span><\/p>\n

                        Ot\u00e1zka 2: Ak\u00e1 je \u00fa\u010dinnos\u0165 v porovnan\u00ed s ketam\u00ednom?<\/span><\/span><\/strong>
                        \n A: ~0,6x \u00fa\u010dinnos\u0165 ketam\u00ednu, ale dlh\u0161\u00ed pol\u010das rozpadu (4-6 hod\u00edn).<\/span><\/span><\/p>\n

                        Ot\u00e1zka 3: Existuj\u00fa neurotoxick\u00e9 rizik\u00e1?<\/span><\/span><\/strong>
                        \n A: Olneyho l\u00e9zie neboli pozorovan\u00e9 pri d\u00e1vke <50 mg\/kg (\u0161t\u00fadia na potkanoch).<\/span><\/span><\/p>\n

                        Ot\u00e1zka 4: Ak\u00fd je optim\u00e1lny sp\u00f4sob skladovania?<\/span><\/span><\/strong>
                        \n A: V p\u00f4vodnom obale pri teplote 15 \u2013 25 \u00b0C, chr\u00e1nen\u00e9 pred vlhkos\u0165ou.<\/span><\/span><\/p>\n

                        \ud83d\udcccObmedzenia v\u00fdskumu<\/span><\/span><\/strong><\/h4>\n
                          \n
                        • \n

                          Obmedzen\u00e9 \u00fadaje o chronickom pod\u00e1van\u00ed<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Nezn\u00e1me \u00fa\u010dinky na prenos glutam\u00e1tu<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Variabiln\u00e1 biotransform\u00e1cia medzi druhmi<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0dZ\u00e1ver pre v\u00fdskumn\u00edkov<\/span><\/span><\/strong><\/h4>\n

                          Pelety DMXE 40 mg pon\u00fakaj\u00fa \u0161tandardizovan\u00e9 zlo\u017eenie pre presn\u00fd disociat\u00edvny v\u00fdskum s konzistentn\u00fdm pod\u00e1van\u00edm d\u00e1vky a dobrou stabilitou. Forma peliet u\u013eah\u010duje kvantitat\u00edvne pod\u00e1vanie v \u0161t\u00fadi\u00e1ch na zvierat\u00e1ch.<\/span><\/span><\/p>\n

                          Vedeck\u00e9 vyhl\u00e1senie: Tento produkt je ur\u010den\u00fd v\u00fdhradne na v\u00fdskum in vitro a autorizovan\u00e9 predklinick\u00e9 \u0161t\u00fadie. Nie je ur\u010den\u00fd na pou\u017eitie u \u013eud\u00ed. V\u0161etky experimenty musia by\u0165 v s\u00falade s platn\u00fdmi etick\u00fdmi smernicami a miestnymi predpismi. Uvedomte si, pros\u00edm, osobitn\u00fd status psychoakt\u00edvnych v\u00fdskumn\u00fdch l\u00e1tok vo va\u0161ej jurisdikcii.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Funkcie DMXE<\/span><\/span><\/span><\/span><\/h3>\n

                          Synonymum:<\/span><\/span><\/span><\/span><\/strong> Deoxymetoxetam\u00edn hydrochlorid <\/span><\/span><\/span><\/span>
                          \n\u010c\u00edslo CAS:<\/span><\/span><\/span><\/span><\/strong> 681440-83-5 <\/span><\/span><\/span><\/span>
                          \nVzorec:<\/span><\/span><\/span><\/span><\/strong> 5-dehydro-1,3-chinodimet\u00e1n <\/span><\/span><\/span><\/span>
                          \nMol\u00e1rna hmotnos\u0165:<\/span><\/span><\/span><\/span><\/strong> 103,14 g\/mol <\/span><\/span><\/span><\/span>
                          \n\u010cistota:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>","protected":false},"featured_media":28769,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[71,406,429,324],"product_tag":[326],"class_list":{"0":"post-23358","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-arylcyclohexylamine","7":"product_cat-dmxe","8":"product_cat-dmxe-pellets","9":"product_cat-pellets-for-pellet","10":"product_tag-nl","12":"first","13":"instock","14":"taxable","15":"shipping-taxable","16":"purchasable","17":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product\/23358","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/comments?post=23358"}],"version-history":[{"count":5,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product\/23358\/revisions"}],"predecessor-version":[{"id":28083,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product\/23358\/revisions\/28083"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/media\/28769"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/media?parent=23358"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product_brand?post=23358"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product_cat?post=23358"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product_tag?post=23358"}],"curies":[{"name":"pracovn\u00fd list","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}