{"id":23378,"date":"2025-04-13T17:39:38","date_gmt":"2025-04-13T17:39:38","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23378"},"modified":"2025-10-23T01:13:38","modified_gmt":"2025-10-23T01:13:38","slug":"eskalin-hydrochlorid","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/sk\/produkt\/eskalin-hydrochlorid\/","title":{"rendered":"Eskal\u00edn hydrochlorid"},"content":{"rendered":"

Eskal\u00edn hydrochlorid \u2013 vedeck\u00e1 dokument\u00e1cia k produktu<\/strong><\/h3>\n

\ud83d\udd2c Chemick\u00e9 \u0161pecifik\u00e1cie<\/strong><\/h4>\n

Eskal\u00edn (4-etoxy-3,5-dimetoxyfenetylam\u00edn) hydrochlorid je polosyntetick\u00fd deriv\u00e1t fenetylam\u00ednu, ktor\u00fd je \u0161truktur\u00e1lne pr\u00edbuzn\u00fd meskal\u00ednu. T\u00e1to v\u00fdskumn\u00e1 zl\u00fa\u010denina sa sk\u00fama pre svoj zauj\u00edmav\u00fd farmakologick\u00fd profil.<\/p>\n

Z\u00e1kladn\u00e9 parametre:<\/em><\/p>\n

    \n
  • \n

    N\u00e1zov IUPAC<\/strong>2-(4-etoxy-3,5-dimetoxyfenyl)et\u00e1n-1-am\u00edn hydrochlorid<\/p>\n<\/li>\n

  • \n

    Molekul\u00e1rny vzorec<\/strong>C\u2081\u2082H\u2081\u2089NO\u2083 \u00b7 HCl<\/p>\n<\/li>\n

  • \n

    Molekulov\u00e1 hmotnos\u0165<\/strong>: 261,75 g\/mol<\/p>\n<\/li>\n

  • \n

    \u010cistota<\/strong>: \u226598% (HPLC-UV pri 280 nm)<\/p>\n<\/li>\n

  • \n

    Formul\u00e1r<\/strong>Biely kry\u0161talick\u00fd pr\u00e1\u0161ok<\/p>\n<\/li>\n

  • \n

    Bod topenia<\/strong>: 243 \u2013 245 \u00b0C (rozklad\u00e1 sa)<\/p>\n<\/li>\n

  • \n

    Rozpustnos\u0165<\/strong>50 mg\/ml vo vode, 30 mg\/ml v metanole<\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddea Vedeck\u00e9 aplik\u00e1cie<\/strong><\/h4>\n
      \n
    1. \n

      Neurofarmakologick\u00fd v\u00fdskum<\/strong>:<\/p>\n

        \n
      • \n

        \u0160t\u00fadie v\u00e4zby na receptor 5-HT\u2082A (Ki = 120 nM)<\/p>\n<\/li>\n

      • \n

        Porovn\u00e1vacie \u0161t\u00fadie meskal\u00ednu a in\u00fdch fenetylam\u00ednov<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Behavior\u00e1lny v\u00fdskum<\/strong>:<\/p>\n

          \n
        • \n

          Vplyv na spr\u00e1vanie zvierat v kontrolovan\u00fdch prostrediach<\/p>\n<\/li>\n

        • \n

          Vz\u0165ahy medzi d\u00e1vkou a odozvou v cicav\u010d\u00edch modeloch<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

        • \n

          Metabolick\u00e9 \u0161t\u00fadie<\/strong>:<\/p>\n

            \n
          • \n

            \u0160t\u00fadia kinetiky O-dealkyl\u00e1cie<\/p>\n<\/li>\n

          • \n

            Profil interakcie CYP2D6<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0f Odpor\u00fa\u010dan\u00e9 d\u00e1vkovanie pre v\u00fdskum<\/strong><\/h4>\n

            Experiment\u00e1lne pokyny:<\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Model<\/th>\nD\u00e1vkovanie<\/th>\nAdministrat\u00edvna cesta<\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/td>\n10 \u2013 100 \u03bcM<\/td>\nM\u00e9dium pre bunkov\u00fa kult\u00faru<\/td>\n<\/tr>\n
            Mal\u00e9 zvierat\u00e1<\/td>\n1 \u2013 5 mg\/kg<\/td>\nIntraperitone\u00e1lne<\/td>\n<\/tr>\n
            Prim\u00e1ty<\/td>\n0,2 \u2013 1 mg\/kg<\/td>\nOr\u00e1lne<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Pozn\u00e1mka: \u00da\u010dinky z\u00e1visl\u00e9 od d\u00e1vky nad 3 mg\/kg*<\/p>\n

            \u26a0\ufe0f Bezpe\u010dnostn\u00e9 aspekty a rizik\u00e1<\/strong><\/h4>\n
              \n
            1. \n

              Toxikologick\u00e9 \u00fadaje<\/strong>:<\/p>\n

                \n
              • \n

                LD\u2085\u2080 (my\u0161, i.v.): 185 mg\/kg<\/p>\n<\/li>\n

              • \n

                NOAEL: 0,75 mg\/kg\/de\u0148 (28-d\u0148ov\u00e1 \u0161t\u00fadia)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

              • \n

                Profil ved\u013eaj\u0161\u00edch \u00fa\u010dinkov<\/strong>:<\/p>\n

                  \n
                • \n

                  <2 mg\/kg: Minim\u00e1lne fyziologick\u00e9 \u00fa\u010dinky<\/p>\n<\/li>\n

                • \n

                  2 \u2013 6 mg\/kg: Senzorick\u00e1 modul\u00e1cia<\/p>\n<\/li>\n

                • \n
                  \n

                  6 mg\/kg: Potenci\u00e1lne hemodynamick\u00e9 \u00fa\u010dinky<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

                • \n

                  Kritick\u00e9 interakcie<\/strong>:<\/p>\n

                    \n
                  • \n

                    Nebezpe\u010dn\u00fd<\/strong>Inhib\u00edtory MAO, serotonergn\u00e9 l\u00e1tky<\/p>\n<\/li>\n

                  • \n

                    Rizikov\u00e9<\/strong>Vazokonstriktory, antipsychotik\u00e1<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udcca Kontrola kvality a analytick\u00e9 \u00fadaje<\/strong><\/h4>\n
                      \n
                    • \n

                      \u010cistota HPLC<\/strong>98,2% (kol\u00f3na C18, 60:40 H\u2082O:MeCN)<\/p>\n<\/li>\n

                    • \n

                      Zvy\u0161kov\u00e9 rozp\u00fa\u0161\u0165adl\u00e1<\/strong><0,1% (GC-MS)<\/p>\n<\/li>\n

                    • \n

                      \u00dadaje o stabilite<\/strong>:<\/p>\n

                        \n
                      • \n

                        Trvanlivos\u0165: 24 mesiacov pri -20 \u00b0C<\/p>\n<\/li>\n

                      • \n

                        Izbov\u00e1 teplota: 6 mesiacov (pod arg\u00f3nom)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753 \u010casto kladen\u00e9 v\u00fdskumn\u00e9 ot\u00e1zky<\/strong><\/h4>\n

                        Ot\u00e1zka 1: Ak\u00fd je mechanizmus \u00fa\u010dinku?<\/strong>
                        \nA: Prim\u00e1rny \u00fa\u010dinok ako agonista receptora 5-HT\u2082A so sekund\u00e1rnymi \u00fa\u010dinkami na dopaminergn\u00e9 syst\u00e9my.<\/p>\n

                        Ot\u00e1zka 2: Ako sa \u00fa\u010dinnos\u0165 porovn\u00e1va s meskal\u00ednom?<\/strong>
                        \nA: Pribli\u017ene 1,5-kr\u00e1t vy\u0161\u0161ia afinita k receptoru, ale dlh\u0161ie trvanie \u00fa\u010dinku (8 \u2013 10 hod\u00edn).<\/p>\n

                        Ot\u00e1zka 3: Ak\u00e9 s\u00fa optim\u00e1lne skladovacie podmienky?<\/strong>
                        \nA: V jant\u00e1rov\u00fdch f\u013ea\u0161ti\u010dk\u00e1ch pod inertn\u00fdm plynom pri teplote -20 \u00b0C.<\/p>\n

                        Ot\u00e1zka 4: Existuj\u00fa genotoxick\u00e9 rizik\u00e1?<\/strong>
                        \nA: Amesov test negat\u00edvny pri <1 mM, ale obmedzen\u00e9 \u00fadaje z chromoz\u00f3mov\u00fdch testov.<\/p>\n

                        \ud83d\udccc Obmedzenia v\u00fdskumu<\/strong><\/h4>\n
                          \n
                        • \n

                          Obmedzen\u00e9 \u00fadaje o chronickej expoz\u00edcii<\/p>\n<\/li>\n

                        • \n

                          Nezn\u00e1me \u00fa\u010dinky na neuroplasticitu<\/p>\n<\/li>\n

                        • \n

                          Variabiln\u00fd medzidruhov\u00fd metabolizmus<\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0d Z\u00e1ver pre vedcov<\/strong><\/h4>\n

                          Eskal\u00edn hydrochlorid pon\u00faka cenn\u00e9 pr\u00edle\u017eitosti pre porovn\u00e1vac\u00ed seroton\u00ednergn\u00fd v\u00fdskum s jedine\u010dnou kombin\u00e1ciou stability a trvania \u00fa\u010dinku. Hydrochloridov\u00e1 forma zais\u0165uje vynikaj\u00facu rozpustnos\u0165 pre laborat\u00f3rne aplik\u00e1cie.<\/p>\n

                          D\u00f4le\u017eit\u00e9 upozornenie: Tento produkt je ur\u010den\u00fd len na vedeck\u00fd v\u00fdskum v akreditovan\u00fdch laborat\u00f3ri\u00e1ch. Nie je ur\u010den\u00fd na pou\u017eitie u \u013eud\u00ed ani na diagnostick\u00e9 \u00fa\u010dely. V\u0161etky experimenty sa musia vykon\u00e1va\u0165 v s\u00falade s miestnymi predpismi a etick\u00fdmi pokynmi.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Vlastnosti eskal\u00edn hydrochloridu<\/span><\/h3>\n

                          Synonymum:<\/strong> 3,5-dimetoxy-4-etoxyfenetylam\u00edn hydrochlorid
                          \n\u010c\u00edslo CAS:<\/strong> 39201-82-6
                          \nVzorec:<\/strong> 2-{3,5-dimetoxy-4-etyloxyfenyl}et\u00e1n-1-am\u00edn hydrochlorid
                          \nMol\u00e1rna hmotnos\u0165:<\/strong> 261,8 g\/mol
                          \n\u010distota:<\/strong> >97%<\/p>","protected":false},"featured_media":28777,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,535,80],"product_tag":[326],"class_list":{"0":"post-23378","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-escaline","8":"product_cat-fenethylamine","9":"product_tag-nl","11":"first","12":"instock","13":"taxable","14":"shipping-taxable","15":"purchasable","16":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product\/23378","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/comments?post=23378"}],"version-history":[{"count":4,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product\/23378\/revisions"}],"predecessor-version":[{"id":26546,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product\/23378\/revisions\/26546"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/media\/28777"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/media?parent=23378"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product_brand?post=23378"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product_cat?post=23378"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product_tag?post=23378"}],"curies":[{"name":"pracovn\u00fd list","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}