{"id":23399,"date":"2025-04-13T17:39:42","date_gmt":"2025-04-13T17:39:42","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23399"},"modified":"2025-10-23T00:56:39","modified_gmt":"2025-10-23T00:56:39","slug":"proskalin-fumarat","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/sk\/produkt\/proskalin-fumarat\/","title":{"rendered":"Proskal\u00edn fumar\u00e1t"},"content":{"rendered":"

Proskal\u00edn fumar\u00e1t \u2013 vedeck\u00e1 dokument\u00e1cia k produktu<\/strong><\/h3>\n

\ud83d\udd2c Chemick\u00e9 \u0161pecifik\u00e1cie<\/strong><\/h4>\n

Proskal\u00edn (4-propoxy-3,5-dimetoxyfenetylam\u00edn) fumar\u00e1t je polosyntetick\u00fd deriv\u00e1t fenetylam\u00ednu so \u0161truktur\u00e1lnou podobnos\u0165ou s meskal\u00ednom. T\u00e1to v\u00fdskumn\u00e1 zl\u00fa\u010denina sa sk\u00fama kv\u00f4li jej jedine\u010dn\u00e9mu interak\u010dn\u00e9mu profilu s receptormi.<\/p>\n

Z\u00e1kladn\u00e9 parametre:<\/em><\/p>\n

    \n
  • \n

    N\u00e1zov IUPAC<\/strong>2-(4-propoxy-3,5-dimetoxyfenyl)et\u00e1n-1-am\u00ednfumar\u00e1t<\/p>\n<\/li>\n

  • \n

    Molekul\u00e1rny vzorec<\/strong>C\u2081\u2083H\u2082\u2081NO\u2083 \u00b7 C\u2084H\u2084O\u2084<\/p>\n<\/li>\n

  • \n

    Molekulov\u00e1 hmotnos\u0165<\/strong>: 339,36 g\/mol<\/p>\n<\/li>\n

  • \n

    \u010cistota<\/strong>: \u226598% (HPLC-UV pri 254 nm)<\/p>\n<\/li>\n

  • \n

    Formul\u00e1r<\/strong>Biely kry\u0161talick\u00fd pr\u00e1\u0161ok<\/p>\n<\/li>\n

  • \n

    Bod topenia<\/strong>: 172 \u2013 174 \u00b0C (rozklad\u00e1 sa)<\/p>\n<\/li>\n

  • \n

    Rozpustnos\u0165<\/strong>15 mg\/ml vo vode, 30 mg\/ml v teplom etanole<\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddeb V\u00fdskumn\u00e9 aplik\u00e1cie<\/strong><\/h4>\n
      \n
    1. \n

      \u0160t\u00fadie v\u00e4zby na receptory<\/strong>:<\/p>\n

        \n
      • \n

        5-HT\u2082A agonizmus (EC\u2085\u2080 = 280 nM)<\/p>\n<\/li>\n

      • \n

        V\u00fdskum dopaminergnej modul\u00e1cie<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Neurofyziologick\u00fd v\u00fdskum<\/strong>:<\/p>\n

          \n
        • \n

          Anal\u00fdza EEG vzorcov u laborat\u00f3rnych zvierat<\/p>\n<\/li>\n

        • \n

          Porovn\u00e1vacie \u0161t\u00fadie s klasick\u00fdmi psychedelikami<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

        • \n

          Anal\u00fdza metabolick\u00fdch dr\u00e1h<\/strong>:<\/p>\n

            \n
          • \n

            Kinetika O-demetyl\u00e1cie<\/p>\n<\/li>\n

          • \n

            Profil interakcie CYP2D6<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2697\ufe0f Experiment\u00e1lne protokoly<\/strong><\/h4>\n

            \u0160tandardn\u00e9 v\u00fdskumn\u00e9 podmienky:<\/em><\/p>\n

            \n\n\n\n\n\n\n
            Model<\/th>\nKoncentr\u00e1cia<\/th>\nDoba vystavenia<\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/td>\n10 \u2013 100 \u03bcM<\/td>\n15 \u2013 60 min\u00fat<\/td>\n<\/tr>\n
            In vivo<\/td>\n1 \u2013 5 mg\/kg<\/td>\nAk\u00fatne\/chronick\u00e9<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Pozn\u00e1mka: Vykazuje neline\u00e1rnu farmakokinetiku nad 8 mg\/kg*<\/p>\n

            \u26a0\ufe0f Bezpe\u010dnostn\u00fd profil<\/strong><\/h4>\n
              \n
            1. \n

              Toxikologick\u00e9 \u00fadaje<\/strong>:<\/p>\n

                \n
              • \n

                LD\u2085\u2080 (potkan, or\u00e1lne): 320 mg\/kg<\/p>\n<\/li>\n

              • \n

                NOAEL: 0,75 mg\/kg\/de\u0148 (28-d\u0148ov\u00e1 \u0161t\u00fadia)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

              • \n

                Spektrum ved\u013eaj\u0161\u00edch \u00fa\u010dinkov<\/strong>:<\/p>\n

                  \n
                • \n

                  \u00da\u010dinky z\u00e1visl\u00e9 od d\u00e1vky:<\/p>\n

                    \n
                  • \n

                    <3 mg\/kg: Jemn\u00e9 senzorick\u00e9 zmeny<\/p>\n<\/li>\n

                  • \n

                    3 \u2013 6 mg\/kg: Vegetat\u00edvne pr\u00edznaky<\/p>\n<\/li>\n

                  • \n
                    \n

                    6 mg\/kg: Potenci\u00e1lna hemodynamick\u00e1 nestabilita<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n

                  • \n

                    Kritick\u00e9 interakcie<\/strong>:<\/p>\n

                      \n
                    • \n

                      Nebezpe\u010dn\u00fd<\/strong>Inhib\u00edtory MAO, sympatomimetik\u00e1<\/p>\n<\/li>\n

                    • \n

                      Rizikov\u00e9<\/strong>Serotonergn\u00e9 l\u00e1tky, vazopresory<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                      \ud83d\udcc9 \u00dadaje o stabilite<\/strong><\/h4>\n
                        \n
                      • \n

                        Trvanlivos\u0165<\/strong>24 mesiacov pri -20 \u00b0C (pod arg\u00f3nom)<\/p>\n<\/li>\n

                      • \n

                        Produkty degrad\u00e1cie<\/strong><2% po 12 mesiacoch RT<\/p>\n<\/li>\n

                      • \n

                        Kompatibiln\u00e9 vyrovn\u00e1vacie pam\u00e4te<\/strong>PBS (pH 7,4), kyselina chlorovod\u00edkov\u00e1 (0,1N)<\/p>\n<\/li>\n<\/ul>\n

                        \ud83d\udd0d Analytick\u00e9 funkcie<\/strong><\/h4>\n
                          \n
                        • \n

                          Reten\u010dn\u00fd \u010das HPLC<\/strong>: 6,8 min (C18, 70:30 H20:MeCN)<\/p>\n<\/li>\n

                        • \n

                          Hmotnostn\u00e9 spektrum<\/strong>: [M+H]\u207a 240,2 m\/z<\/p>\n<\/li>\n

                        • \n

                          Absorpcia UV \u017eiarenia<\/strong>\u03bbmax 282 nm (\u03b5 = 4200)<\/p>\n<\/li>\n<\/ul>\n

                          \u2753 \u010casto kladen\u00e9 ot\u00e1zky zameran\u00e9 na v\u00fdskum<\/strong><\/h4>\n

                          Ot\u00e1zka 1: Ak\u00fd je mechanizmus \u00fa\u010dinku?<\/strong>
                          \nA: Prim\u00e1rny \u010diasto\u010dn\u00fd agonista receptora 5-HT\u2082A so sekund\u00e1rnou interakciou DAT.<\/p>\n

                          Ot\u00e1zka 2: Ako sa \u00fa\u010dinnos\u0165 porovn\u00e1va s meskal\u00ednom?<\/strong>
                          \nA: ~3x vy\u0161\u0161ia afinita k 5-HT\u2082A, ale ni\u017e\u0161ia penetr\u00e1cia hematoencefalickou bari\u00e9rou.<\/p>\n

                          Ot\u00e1zka 3: Existuj\u00fa genotoxick\u00e9 rizik\u00e1?<\/strong>
                          \nA: Amesov test negat\u00edvny do 1 mM, ale obmedzen\u00e9 \u00fadaje z chromoz\u00f3mov\u00fdch testov.<\/p>\n

                          Ot\u00e1zka 4: Ak\u00e1 je optim\u00e1lna formul\u00e1cia?<\/strong>
                          \nA: Steriln\u00fd fyziologick\u00fd roztok (0,9% NaCl) pre \u0161t\u00fadie in vivo.<\/p>\n

                          \ud83d\udccc Obmedzenia v\u00fdskumu<\/strong><\/h4>\n
                            \n
                          • \n

                            Obmedzen\u00e9 \u00fadaje o chronickej expoz\u00edcii<\/p>\n<\/li>\n

                          • \n

                            Nezn\u00e1me neuroplastick\u00e9 \u00fa\u010dinky<\/p>\n<\/li>\n

                          • \n

                            Variabiln\u00fd medzidruhov\u00fd metabolizmus<\/p>\n<\/li>\n<\/ul>\n

                            Vedeck\u00e9 upozornenie: Tento produkt je ur\u010den\u00fd len na v\u00fdskumn\u00e9 pou\u017eitie v akreditovan\u00fdch laborat\u00f3ri\u00e1ch. Nie je ur\u010den\u00fd na hum\u00e1nne ani veterin\u00e1rne pou\u017eitie. V\u0161etky experimenty musia by\u0165 v s\u00falade s pr\u00edslu\u0161n\u00fdmi bezpe\u010dnostn\u00fdmi a etick\u00fdmi pokynmi. Pros\u00edm, majte na pam\u00e4ti miestne predpisy t\u00fdkaj\u00face sa psychoakt\u00edvnych v\u00fdskumn\u00fdch l\u00e1tok.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                            Proskal\u00edn fumar\u00e1t<\/span><\/span><\/h3>\n

                            Synonymum:<\/span><\/span><\/strong> 3,5-dimetoxy-4-propoxyfenetylam\u00edn fumar\u00e1t <\/span><\/span>
                            \n\u010c\u00edslo CAS:<\/span><\/span><\/strong> 39201-78-0 <\/span><\/span>
                            \nVzorec:<\/span><\/span><\/strong> 2-{3,5-dimetoxy-4-propyloxyfenyl}et\u00e1n-1-am\u00edn fumar\u00e1t <\/span><\/span>
                            \nMol\u00e1rna hmotnos\u0165:<\/span><\/span><\/strong> 355,4 g\/mol <\/span><\/span>
                            \n\u010cistota:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>","protected":false},"featured_media":28847,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,80,536],"product_tag":[326],"class_list":{"0":"post-23399","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-fenethylamine","8":"product_cat-proscaline","9":"product_tag-nl","11":"first","12":"instock","13":"taxable","14":"shipping-taxable","15":"purchasable","16":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product\/23399","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/comments?post=23399"}],"version-history":[{"count":3,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product\/23399\/revisions"}],"predecessor-version":[{"id":26541,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product\/23399\/revisions\/26541"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/media\/28847"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/media?parent=23399"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product_brand?post=23399"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product_cat?post=23399"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product_tag?post=23399"}],"curies":[{"name":"pracovn\u00fd list","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}