{"id":23504,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23504"},"modified":"2025-10-22T17:00:59","modified_gmt":"2025-10-22T17:00:59","slug":"5-meo-dmt-hydrochlorid","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/sk\/produkt\/5-meo-dmt-hydrochlorid\/","title":{"rendered":"5-MeO-DMT hydrochlorid"},"content":{"rendered":"

5-MeO-DMT hydrochlorid \u2013 vedeck\u00e1 dokument\u00e1cia k produktu<\/span><\/span><\/strong><\/h3>\n

V\u0161eobecn\u00fd popis<\/span><\/span><\/strong><\/h4>\n

5-MeO-DMT hydrochlorid (5-metoxy-N,N-dimetyltryptam\u00edn HCl) je vo vode rozpustn\u00e1 so\u013e klasick\u00e9ho tryptam\u00ednu, obzvl\u00e1\u0161\u0165 vhodn\u00e1 pre farmakologick\u00fd v\u00fdskum v\u010faka svojej zv\u00fd\u0161enej stabilite a biologickej dostupnosti v porovnan\u00ed s vo\u013enou b\u00e1zou.<\/span><\/span><\/p>\n

\n

Technick\u00e9 \u0161pecifik\u00e1cie<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Parameter<\/span><\/span><\/strong><\/th>\n\u0160pecifik\u00e1cia<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
Chemick\u00fd vzorec<\/span><\/span><\/strong><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O \u00b7 HCl<\/span><\/span><\/td>\n<\/tr>\n
Molekulov\u00e1 hmotnos\u0165<\/span><\/span><\/strong><\/td>\n254,75 g\/mol<\/span><\/span><\/td>\n<\/tr>\n
\u010cistota<\/span><\/span><\/strong><\/td>\n\u226598% (analyzovan\u00e9 pomocou HPLC-UV)<\/span><\/span><\/td>\n<\/tr>\n
Vzh\u013ead<\/span><\/span><\/strong><\/td>\nBiely a\u017e svetlo\u017elt\u00fd kry\u0161talick\u00fd pr\u00e1\u0161ok<\/span><\/span><\/td>\n<\/tr>\n
Rozpustnos\u0165<\/span><\/span><\/strong><\/td>\nVysok\u00fd obsah vody (> 50 mg\/ml), metanolu, PBS<\/span><\/span><\/td>\n<\/tr>\n
Bod topenia<\/span><\/span><\/strong><\/td>\n243 \u2013 247 \u00b0C (rozklad\u00e1 sa)<\/span><\/span><\/td>\n<\/tr>\n
Stabilita<\/span><\/span><\/strong><\/td>\nHygroskopick\u00fd; skladujte v suchom prostred\u00ed<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

Vedeck\u00e9 aplik\u00e1cie<\/span><\/span><\/strong><\/h3>\n

1. Neurofarmakol\u00f3gia a behavior\u00e1lny v\u00fdskum<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    \u0160t\u00fadie seroton\u00ednov\u00fdch receptorov:<\/span><\/span><\/strong> \u00a0Siln\u00fd agonista 5-HT\u2081\u2090\/\u2082\u2090 s r\u00fdchlou penetr\u00e1ciou do mozgu.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Pokusy na zvierat\u00e1ch (in vivo):<\/span><\/span><\/strong> \u00a0Behavior\u00e1lne paradigmy (napr. reakcia na trhnutie hlavy u hlodavcov).<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Elektrofyziol\u00f3gia:<\/span><\/span><\/strong> \u00a0\u00da\u010dinky na neur\u00f3nov\u00e9 oscil\u00e1cie (napr. aktivita gama p\u00e1sma).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. Biochemick\u00e9 a molekul\u00e1rne \u0161t\u00fadie<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      Intracelul\u00e1rna signaliz\u00e1cia:<\/span><\/span><\/strong> \u00a0Testy akumul\u00e1cie cAMP a n\u00e1boru \u03b2-arest\u00ednu.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Kinetika enz\u00fdmov:<\/span><\/span><\/strong> \u00a0Metabolizmus MAO-A (IC\u2085\u2080 ~2 \u2013 5 \u03bcM).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. Klinicky relevantn\u00fd v\u00fdskum<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        Vz\u0165ahy medzi d\u00e1vkou a reakciou:<\/span><\/span><\/strong> \u00a0Predklinick\u00e9 bezpe\u010dnostn\u00e9 profilovanie.<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Porovn\u00e1vacia farmakol\u00f3gia:<\/span><\/span><\/strong> \u00a0Smerom k psilocyb\u00ednu, DMT a in\u00fdm tryptam\u00ednom.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Experiment\u00e1lne pokyny<\/span><\/span><\/strong><\/h3>\n

        Odpor\u00fa\u010dan\u00e9 koncentr\u00e1cie<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        Aplik\u00e1cia<\/span><\/span><\/strong><\/th>\nRozsah koncentr\u00e1cie<\/span><\/span><\/strong><\/th>\nRozp\u00fa\u0161\u0165adlo<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
        Bunkov\u00e9 kult\u00fary (in vitro)<\/span><\/span><\/td>\n1 nM \u2013 10 \u03bcM<\/span><\/span><\/td>\nPBS\/DMEM (\u22640,1% DMSO)<\/span><\/span><\/td>\n<\/tr>\n
        Receptorov\u00e9 testy<\/span><\/span><\/td>\n0,1 \u2013 100 \u03bcM<\/span><\/span><\/td>\nTris-HCl pufor (pH 7,4)<\/span><\/span><\/td>\n<\/tr>\n
        \u0160t\u00fadie na zvierat\u00e1ch (ip\/iv)<\/span><\/span><\/td>\n0,1 \u2013 5 mg\/kg<\/span><\/span><\/td>\nSteriln\u00fd so\u013en\u00fd roztok<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        Bezpe\u010dnostn\u00e9 opatrenia<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          Osobn\u00e1 ochrana:<\/span><\/span><\/strong> \u00a0Laborat\u00f3rny pl\u00e1\u0161\u0165, rukavice (nitrilov\u00e9), ochrann\u00e9 okuliare.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Manipul\u00e1cia:<\/span><\/span><\/strong> \u00a0Hygroskopick\u00e9 \u2013 po pou\u017eit\u00ed ihne\u010f zatvorte.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Skladovanie:<\/span><\/span><\/strong> \u00a0Vzduchotesn\u00e9, pod arg\u00f3nom, pri teplote -20 \u00b0C (zabr\u00e1\u0148te hydrol\u00fdze).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Stabilita a skladovanie<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            Trvanlivos\u0165:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              -20 \u00b0C:<\/span><\/span><\/strong> \u00a0> 2 roky (nezmenen\u00e1 \u010distota).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4 \u00b0C:<\/span><\/span><\/strong> \u00a06 mesiacov (v suchom prostred\u00ed).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              Zostup:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Hydrol\u00fdza pri dlhodobom vystaven\u00ed vlhkosti (monitorovan\u00e1 pomocou HPLC).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Analytick\u00e1 valid\u00e1cia<\/span><\/span><\/strong><\/h3>\n

                Ka\u017ed\u00e1 v\u00e1rka obsahuje:<\/span><\/span><\/p>\n

                  \n
                1. \n

                  HPLC-UV chromatogram<\/span><\/span><\/strong> \u00a0(kol\u00f3na C18, reten\u010dn\u00fd \u010das ~6,2 min).<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  Fragment\u00e1cia MS\/MS<\/span><\/span><\/strong> \u00a0(charakteristick\u00e9 i\u00f3ny: m\/z 219 \u2192 174, 160).<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  Zvy\u0161kov\u00e9 rozp\u00fa\u0161\u0165adl\u00e1<\/span><\/span><\/strong> \u00a0(sp\u013a\u0148aj\u00fa smernice ICH Q3C).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  Pr\u00e1vny status (Holandsko\/E\u00da)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    Legislat\u00edva o omamn\u00fdch l\u00e1tkach:<\/span><\/span><\/strong> \u00a0Nie je v\u00fdslovne uveden\u00e9 v z\u00e1kone o \u00f3piu, ale mo\u017eno v analogick\u00fdch pr\u00e1vnych predpisoch (dodatok II).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Vedeck\u00e9 vyu\u017eitie:<\/span><\/span><\/strong> \u00a0Pre in\u0161tit\u00facie je potrebn\u00e9 povolenie (schv\u00e1lenie CCMO na testovanie na zvierat\u00e1ch).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Kontrola v\u00fdvozu:<\/span><\/span><\/strong> \u00a0Podlieha nariadeniu E\u00da 2019\/1998 (psychotropn\u00e9 l\u00e1tky).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    \u010casto kladen\u00e9 ot\u00e1zky (FAQ)<\/span><\/span><\/strong><\/h3>\n

                    1. \u0161tvr\u0165rok <\/span>Ak\u00e9 s\u00fa v\u00fdhody HCl oproti vo\u013enej z\u00e1sade?<\/span><\/strong><\/span><\/p>\n

                      \n
                    • \n

                      Zlep\u0161en\u00e1 rozpustnos\u0165<\/span><\/span><\/strong> \u00a0(ide\u00e1lne pre injek\u010dn\u00e9 \u0161t\u00fadie).<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Dlh\u0161ia skladovate\u013enos\u0165<\/span><\/span><\/strong> \u00a0pri izbovej teplote.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      Ot\u00e1zka 2: Je 5-MeO-DMT-HCl detekovate\u013en\u00fd v testoch na drogy?<\/span><\/span><\/strong>
                      \n A: \u00c1no, prostredn\u00edctvom:<\/span><\/span><\/p>\n

                        \n
                      • \n

                        LC-MS\/MS<\/span><\/span><\/strong> \u00a0(rozpoznan\u00fd ako adukt 5-MeO-DMT + HCl).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Imunotesty:<\/span><\/span><\/strong> \u00a0Kr\u00ed\u017eov\u00e1 reaktivita s DMT (~15-20%).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        Ot\u00e1zka 3: Existuj\u00fa nejak\u00e9 rizik\u00e1 pri kombin\u00e1cii s inhib\u00edtormi MAO?<\/span><\/span><\/strong>
                        \n A:\u00a0 <\/span><\/span>Rozhodne.<\/span><\/span><\/strong><\/p>\n

                          \n
                        • \n

                          Zv\u00fd\u0161en\u00e9 riziko\u00a0 <\/span><\/span>seroton\u00ednov\u00fd syndr\u00f3m<\/span><\/span><\/strong> \u00a0(vyhnite sa kombin\u00e1cii!).<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Pou\u017e\u00edvajte iba v modeloch bez MAO.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          Ot\u00e1zka 4: Ako sa zbavi\u0165 odpadu?<\/span><\/span><\/strong>
                          \n A:<\/span><\/span><\/p>\n

                            \n
                          1. \n

                            Neutralizova\u0165 pomocou\u00a0 <\/span><\/span>hydrog\u00e9nuhli\u010ditan sodn\u00fd<\/span><\/span><\/strong> \u00a0(pH 7-8).<\/span><\/span><\/p>\n<\/li>\n

                          2. \n

                            Adsorbova\u0165 s\u00a0 <\/span><\/span>akt\u00edvne uhlie<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n<\/li>\n

                          3. \n

                            Zlikvidujte ako\u00a0 <\/span><\/span>nebezpe\u010dn\u00fd chemick\u00fd odpad<\/span><\/span><\/strong> \u00a0(UN 3249, trieda 6.1).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                            \n

                            Referencie a kontakt<\/span><\/span><\/strong><\/h3>\n

                            Z\u00e1kladn\u00e1 literat\u00fara:<\/span><\/span><\/strong><\/p>\n

                              \n
                            1. \n

                              Shen a kol. (2010). \u201cFarmakol\u00f3gia deriv\u00e1tov 5-MeO-DMT\u201d.\u00a0 <\/span><\/span>J Psychopharmacol<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n

                            2. \n

                              Kaasik a kol. (2021). \u201cMetabolick\u00e9 dr\u00e1hy 5-MeO-DMT\u201d.\u00a0 <\/span><\/span>Xenobiotik\u00e1<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                              \n

                              Tento produkt je ur\u010den\u00fd len na autorizovan\u00fd vedeck\u00fd v\u00fdskum. Nie je ur\u010den\u00fd na \u013eudsk\u00fa spotrebu ani na diagnostick\u00e9 pou\u017eitie. Dodr\u017eiavajte miestne predpisy.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                              Vlastnosti hydrochloridu 5-MeO-DMT<\/span><\/span><\/span><\/h3>\n

                              Synonymum:<\/span><\/span><\/strong> 5-metoxy-N,N-dimetyltryptam\u00edn hydrochlorid <\/span><\/span>
                              \n\u010c\u00edslo CAS:<\/span><\/span><\/strong> po <\/span><\/span>
                              \nVzorec:<\/span><\/span><\/strong> 3-[2-(dimetylamino)etyl]-5-metoxyindol hydrochlorid <\/span><\/span>
                              \nMol\u00e1rna hmotnos\u0165:<\/span><\/span><\/strong> 254,8 g\/mol <\/span><\/span>
                              \n\u010cistota:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>","protected":false},"featured_media":28720,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[511,381],"product_tag":[326],"class_list":{"0":"post-23504","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-5-meo-dmt-kopen","7":"product_cat-tryptamines","8":"product_tag-nl","10":"first","11":"instock","12":"taxable","13":"shipping-taxable","14":"purchasable","15":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product\/23504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/comments?post=23504"}],"version-history":[{"count":6,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product\/23504\/revisions"}],"predecessor-version":[{"id":28467,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product\/23504\/revisions\/28467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/media\/28720"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/media?parent=23504"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product_brand?post=23504"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product_cat?post=23504"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product_tag?post=23504"}],"curies":[{"name":"pracovn\u00fd list","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}