{"id":27437,"date":"2025-08-30T09:12:39","date_gmt":"2025-08-30T09:12:39","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&#038;p=27437"},"modified":"2025-11-17T11:48:53","modified_gmt":"2025-11-17T11:48:53","slug":"jjc8-089","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/sk\/produkt\/jjc8-089\/","title":{"rendered":"JJC8-089"},"content":{"rendered":"<p class=\"ds-markdown-paragraph\"><strong>JJC8-089: Siln\u00fd a selekt\u00edvny inhib\u00edtor DAT pre v\u00fdskum motiv\u00e1cie<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">JJC8-089 je potenci\u00e1lna v\u00fdskumn\u00e1 molekula \u0161peci\u00e1lne navrhnut\u00e1 na \u0161t\u00fadium motiv\u00e1cie a spr\u00e1vania s\u00favisiaceho s \u00fasil\u00edm. Ako selekt\u00edvny inhib\u00edtor dopam\u00ednov\u00e9ho transport\u00e9ra (DAT) zvy\u0161uje extracelul\u00e1rne hladiny dopam\u00ednu v mozgu.<\/p>\n<p class=\"ds-markdown-paragraph\">V predklinick\u00fdch modeloch sa preuk\u00e1zalo, \u017ee JJC8-089 v\u00fdznamne zvr\u00e1ti motiva\u010dn\u00e9 deficity vyvolan\u00e9 tetrabenaz\u00ednom (inhib\u00edtor VMAT2). Obnovuje ochotu vynalo\u017ei\u0165 vysok\u00e9 \u00fasilie (napr\u00edklad v\u00fdber \u00falohy s 5 stla\u010deniami tla\u010didiel) namiesto jednoduch\u0161ej a menej obohacuj\u00facej mo\u017enosti. V\u010faka t\u00fdmto vlastnostiam je JJC8-089 (CAS \u010d. 1627576-64-0) cenn\u00fdm farmakologick\u00fdm n\u00e1strojom pre neurovedn\u00fd v\u00fdskum por\u00fach, ako je depresia, apatia a \u00fanava.<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>K\u013e\u00fa\u010dov\u00e9 vlastnosti:<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Molekul\u00e1rny vzorec:<\/strong>\u00a0C\u2082\u2082H\u2082\u2088F\u2082N\u2082OS<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Molekulov\u00e1 hmotnos\u0165:<\/strong>\u00a0406,53 g\/mol<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Prim\u00e1rny mechanizmus \u00fa\u010dinku:<\/strong>\u00a0Inhib\u00edcia dopam\u00ednov\u00e9ho transport\u00e9ra (DAT)<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Hlavn\u00e1 v\u00fdskumn\u00e1 aplik\u00e1cia:<\/strong>\u00a0\u0160t\u00fadium motiv\u00e1cie a spr\u00e1vania zameran\u00e9ho na \u00fasilie.<\/p>\n<\/li>\n<\/ul>\n<hr \/>\n<h3>Verzia 2: Podrobnej\u0161\u00ed a opisnej\u0161\u00ed text (pre vedeck\u00fa bro\u017e\u00faru alebo technick\u00fd list)<\/h3>\n<p class=\"ds-markdown-paragraph\"><strong>N\u00e1zov: JJC8-089: S\u013eubn\u00e1 n\u00e1strojov\u00e1 zl\u00fa\u010denina na \u0161t\u00fadium motiva\u010dn\u00fdch patol\u00f3gi\u00ed<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">JJC8-089 je syntetizovan\u00e1 zl\u00fa\u010denina, ktor\u00e1 hr\u00e1 k\u013e\u00fa\u010dov\u00fa \u00falohu v odha\u013eovan\u00ed neurobiol\u00f3gie motiv\u00e1cie. Jej prim\u00e1rnym mechanizmom \u00fa\u010dinku je inhib\u00edcia dopam\u00ednov\u00e9ho transport\u00e9ra (DAT), \u010do vedie k zv\u00fd\u0161enej dopaminergnej neurotransmisii v synaptickej \u0161trbine. Tento \u00fa\u010dinok je k\u013e\u00fa\u010dov\u00fd pre modul\u00e1ciu odmeny, motiv\u00e1cie a ochoty zapoji\u0165 sa do \u00fasilia a cie\u013eavedom\u00e9ho spr\u00e1vania.<\/p>\n<p class=\"ds-markdown-paragraph\">Diskrimina\u010dn\u00fd potenci\u00e1l molekuly JJC8-089 bol experiment\u00e1lne overen\u00fd. Uk\u00e1zalo sa, \u017ee molekula v\u00fdznamne zvr\u00e1tila nedostato\u010dn\u00fa motiv\u00e1ciu k \u00fasiliu vyvolan\u00fa inhib\u00edtorom VMAT2 tetrabenaz\u00ednom (HY-B0590). V operantn\u00fdch behavior\u00e1lnych testoch (\u00falohy s v\u00fdberom zalo\u017een\u00fdmi na \u00fasil\u00ed) JJC8-089 obnovil u zvierat preferenciu \u00falohy s vysok\u00fdm \u00fasil\u00edm (5-ty\u010dov\u00e9 tlaky s pevn\u00fdm pomerom), ktor\u00e1 priniesla v\u00e4\u010d\u0161iu odmenu oproti alternat\u00edve s n\u00edzkym \u00fasil\u00edm. Toto zistenie pod\u010diarkuje jej potenci\u00e1l ako siln\u00e9ho n\u00e1stroja pre v\u00fdskum stavov charakterizovan\u00fdch patologickou apatiou a zn\u00ed\u017eenou motiv\u00e1ciou.<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>Technick\u00e9 \u0161pecifik\u00e1cie:<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Chemick\u00fd n\u00e1zov:<\/strong>\u00a0[Na z\u00e1klade \u0161trukt\u00fary, napr. deriv\u00e1t benzhydrylsulfidu]<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>CAS \u010d\u00edslo:<\/strong>\u00a01627576-64-0<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Molekul\u00e1rny vzorec:<\/strong>\u00a0C\u2082\u2082H\u2082\u2088F\u2082N\u2082OS<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Molekulov\u00e1 hmotnos\u0165:<\/strong>\u00a0406,53<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>\u00daSMEVY Not\u00e1cia:<\/strong>\u00a0CC(CN1CCN(CC1)CCSC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Pozn\u00e1mka:<\/strong>\u00a0Len na v\u00fdskumn\u00e9 \u00fa\u010dely\u00a0<em>in vitro<\/em>\u00a0a v predklinick\u00fdch modeloch. Nie je ur\u010den\u00e9 na hum\u00e1nne ani veterin\u00e1rne pou\u017eitie.<\/p>\n<\/li>\n<\/ul>\n<hr \/>\n<h3>Verzia 3: Ve\u013emi kr\u00e1tka \u201eprezent\u00e1cia\u201c (pre vyh\u013ead\u00e1va\u010d alebo metad\u00e1ta)<\/h3>\n<p class=\"ds-markdown-paragraph\"><strong>JJC8-089 | Inhib\u00edtor DAT | Pre v\u00fdskum motiv\u00e1cie a \u00fasilia<\/strong><br \/>\nSiln\u00fd a selekt\u00edvny inhib\u00edtor dopam\u00ednov\u00e9ho transport\u00e9ra (DAT). V\u00fdskumn\u00e1 chemik\u00e1lia pre neurovedu. Zvr\u00e1ti \u00fa\u010dinky tetrabenaz\u00ednu a zvy\u0161uje toleranciu cvi\u010denia v predklinick\u00fdch modeloch. CAS 1627576-64-0. Vzorec: C\u2082\u2082H\u2082\u2088F\u2082N\u2082OS. MW: 406,53.<\/p>\n<p>JC8-089 je inhib\u00edtor dopam\u00ednov\u00e9ho transport\u00e9ra (DAT), ktor\u00fd m\u00f4\u017ee zlep\u0161i\u0165 motiva\u010dn\u00e9 deficity a zv\u00fd\u0161i\u0165 \u00fasilie pri cielen\u00fdch aktivit\u00e1ch. JJC8-089 v\u00fdznamne zvr\u00e1til \u00fa\u010dinky n\u00edzkej n\u00e1mahy vyvolan\u00e9 inhib\u00edtorom VMAT-2 tetrabenaz\u00ednom (HY-B0590) u potkanov a zv\u00fd\u0161il mo\u017enos\u0165 v\u00fdberu medzi vysok\u00fdm tlakom na 5 ty\u010d\u00ed s pevn\u00fdm pomerom a pr\u00edjmom potravy.<\/p>\n<p>Molekulov\u00e1 hmotnos\u0165<br \/>\n406,53<\/p>\n<p>Vzorec<br \/>\nC22H28F2N2OS<\/p>\n<p>\u010c\u00edslo CAS<br \/>\n1627576-64-0<\/p>\n<p>\u00daSMEVY<br \/>\nCC(CN1CCN(CC1)CCSC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)<\/p>","protected":false},"excerpt":{"rendered":"<p>JJC8-089: Een Krachtige en Selectieve DAT-Remmer voor Motivatieonderzoek JJC8-089 is een potentieel onderzoeksmolecuul dat specifiek is ontworpen voor de studie<\/p>","protected":false},"featured_media":28805,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[1085],"product_tag":[],"class_list":{"0":"post-27437","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-okategoriserad","8":"first","9":"instock","10":"taxable","11":"shipping-taxable","12":"purchasable","13":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product\/27437","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/comments?post=27437"}],"version-history":[{"count":2,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product\/27437\/revisions"}],"predecessor-version":[{"id":27443,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product\/27437\/revisions\/27443"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/media\/28805"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/media?parent=27437"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product_brand?post=27437"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product_cat?post=27437"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sk\/wp-json\/wp\/v2\/product_tag?post=27437"}],"curies":[{"name":"pracovn\u00fd list","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}