{"id":23378,"date":"2025-04-13T17:39:38","date_gmt":"2025-04-13T17:39:38","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23378"},"modified":"2025-10-23T01:13:38","modified_gmt":"2025-10-23T01:13:38","slug":"eskalinijev-klorid","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/sl\/izdelek\/eskalinijev-klorid\/","title":{"rendered":"Eskalinijev klorid"},"content":{"rendered":"

Escaline Hydrochloride \u2013 Wetenschappelijke Productdocumentatie<\/strong><\/h3>\n

\ud83d\udd2c Kemijske specifikacije<\/strong><\/h4>\n

Escaline (4-ethoxy-3,5-dimethoxyfenethylamine) hydrochloride is een semi-synthetisch phenethylaminederivaat dat structureel verwant is aan mescaline. Deze onderzoeksstof wordt bestudeerd vanwege zijn interessante farmacologische profiel.<\/p>\n

Osnovni parametri:<\/em><\/p>\n

    \n
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    Ime IUPAC<\/strong>: 2-(4-ethoxy-3,5-dimethoxyphenyl)ethan-1-amine hydrochloride<\/p>\n<\/li>\n

  • \n

    Molekulska formula<\/strong>: C\u2081\u2082H\u2081\u2089NO\u2083 \u00b7 HCl<\/p>\n<\/li>\n

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    Molekulska te\u017ea<\/strong>: 261,75 g\/mol<\/p>\n<\/li>\n

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    \u010cistost<\/strong>: \u226598% (HPLC-UV bij 280 nm)<\/p>\n<\/li>\n

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    Obrazec<\/strong>Bel kristalini\u010den prah<\/p>\n<\/li>\n

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    Tali\u0161\u010de<\/strong>: 243-245\u00b0C (ontleedt)<\/p>\n<\/li>\n

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    Topnost<\/strong>: 50 mg\/ml in water, 30 mg\/ml in methanol<\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddea Znanstvene aplikacije<\/strong><\/h4>\n
      \n
    1. \n

      Nevrofarmakolo\u0161ke raziskave<\/strong>:<\/p>\n

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        5-HT\u2082A receptor binding studies (Ki = 120 nM)<\/p>\n<\/li>\n

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        Vergelijkende studies met mescaline en andere phenethylamines<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Gedragsonderzoek<\/strong>:<\/p>\n

          \n
        • \n

          Effecten op diergedrag in gecontroleerde settings<\/p>\n<\/li>\n

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          Dosis-responsrelaties bij zoogdier-modellen<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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          Metabolische studies<\/strong>:<\/p>\n

            \n
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            O-dealkylatie kinetiek onderzoek<\/p>\n<\/li>\n

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            Profil interakcij s CYP2D6<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0f Aanbevolen Doseringen voor Onderzoek<\/strong><\/h4>\n

            Eksperimentalne smernice:<\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Model<\/th>\nOdmerjanje<\/th>\nAdministrativna cesta<\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/td>\n10\u2013100 \u03bcM<\/td>\nGoji\u0161\u010de za celi\u010dne kulture<\/td>\n<\/tr>\n
            Kleine dieren<\/td>\n1\u20135 mg\/kg<\/td>\nIntraperitonealno<\/td>\n<\/tr>\n
            Primati<\/td>\n0,2-1 mg\/kg<\/td>\nUstno<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Let op: Dosisafhankelijke effecten boven 3 mg\/kg*<\/p>\n

            \u26a0\ufe0f Veiligheidsaspecten & Risico’s<\/strong><\/h4>\n
              \n
            1. \n

              Toksikolo\u0161ki podatki<\/strong>:<\/p>\n

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              • \n

                LD\u2085\u2080 (muis, i.v.): 185 mg\/kg<\/p>\n<\/li>\n

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                NOAEL: 0,75 mg\/kg\/dan (28-dnevna \u0161tudija)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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                Profil ne\u017eelenih u\u010dinkov<\/strong>:<\/p>\n

                  \n
                • \n

                  <2 mg\/kg: Minimale fysiologische effecten<\/p>\n<\/li>\n

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                  2-6 mg\/kg: Sensorische modulatie<\/p>\n<\/li>\n

                • \n
                  \n

                  6 mg\/kg: Potenti\u00eble hemodynamische effecten<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

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                  Kriti\u010dne interakcije<\/strong>:<\/p>\n

                    \n
                  • \n

                    Nevarno<\/strong>: MAO-remmers, serotonergische middelen<\/p>\n<\/li>\n

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                    Tvegano<\/strong>: Vasoconstrictoren, antipsychotica<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udcca Nadzor kakovosti in analiti\u010dni podatki<\/strong><\/h4>\n
                      \n
                    • \n

                      \u010cistost HPLC<\/strong>: 98,2% (C18-kolom, 60:40 H\u2082O:MeCN)<\/p>\n<\/li>\n

                    • \n

                      Preostala topila<\/strong>: <0,1% (GC-MS)<\/p>\n<\/li>\n

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                      Podatki o stabilnosti<\/strong>:<\/p>\n

                        \n
                      • \n

                        Houdbaarheid: 24 maanden bij -20\u00b0C<\/p>\n<\/li>\n

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                        Sobna temperatura: 6 mesecev (pod argonom)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753 Pogosto zastavljena raziskovalna vpra\u0161anja<\/strong><\/h4>\n

                        V1: Kak\u0161en je mehanizem delovanja?<\/strong>
                        \nA: Primaire werking als 5-HT\u2082A receptoragonist met secundaire effecten op dopaminerge systemen.<\/p>\n

                        V2: Kak\u0161na je u\u010dinkovitost v primerjavi z meskalinom?<\/strong>
                        \nA: Ongeveer 1,5x hogere receptoraffiniteit maar langere werkingsduur (8-10 uur).<\/p>\n

                        Q3: Wat zijn optimale opslagcondities?<\/strong>
                        \nA: In amberkleurige vials onder inert gas bij -20\u00b0C.<\/p>\n

                        Q4: Zijn er genotoxische risico’s?<\/strong>
                        \nA: Ames-test negatief bij <1 mM, maar beperkte chromosoomtestdata.<\/p>\n

                        \ud83d\udccc Omejitve raziskav<\/strong><\/h4>\n
                          \n
                        • \n

                          Omejeni podatki o kroni\u010dni izpostavljenosti<\/p>\n<\/li>\n

                        • \n

                          Onbekende effecten op neuroplasticiteit<\/p>\n<\/li>\n

                        • \n

                          Spremenljiv medvrstni metabolizem<\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0d Conclusie voor Wetenschappers<\/strong><\/h4>\n

                          Escaline hydrochloride biedt waardevolle mogelijkheden voor vergelijkend serotoninerg onderzoek, met een unieke combinatie van stabiliteit en werkingsduur. De hydrochloridevorm garandeert uitstekende oplosbaarheid voor laboratoriumtoepassingen.<\/p>\n

                          Belangrijke disclaimer: Dit product is uitsluitend bestemd voor wetenschappelijk onderzoek in geaccrediteerde laboratoria. Niet voor humaan gebruik of diagnostische toepassingen. Alle experimenten moeten worden uitgevoerd in overeenstemming met lokale regelgeving en ethische richtlijnen.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Lastnosti eskalin hidroklorida<\/span><\/h3>\n

                          Sinonim:<\/strong> 3,5-dimetoksi-4-etoksifenetilamin hidroklorid
                          \n\u0160tevilka CAS:<\/strong> 39201-82-6
                          \nFormula:<\/strong> 2-{3,5-dimetoksi-4-etiloksifenil}etan-1-amin hidroklorid
                          \nMolska masa:<\/strong> 261,8 g\/mol
                          \n\u010cistost:<\/strong> >97%<\/p>","protected":false},"featured_media":28777,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,535,80],"product_tag":[326],"class_list":{"0":"post-23378","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-escaline","8":"product_cat-fenethylamine","9":"product_tag-nl","11":"first","12":"instock","13":"taxable","14":"shipping-taxable","15":"purchasable","16":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/product\/23378","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/comments?post=23378"}],"version-history":[{"count":4,"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/product\/23378\/revisions"}],"predecessor-version":[{"id":26546,"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/product\/23378\/revisions\/26546"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/media\/28777"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/media?parent=23378"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/product_brand?post=23378"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/product_cat?post=23378"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/product_tag?post=23378"}],"curies":[{"name":"delovni list","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}