{"id":23425,"date":"2025-04-13T17:39:45","date_gmt":"2025-04-13T17:39:45","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23425"},"modified":"2025-10-23T00:49:40","modified_gmt":"2025-10-23T00:49:40","slug":"4-avokada-s-fumaratom","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/sl\/izdelek\/4-avokada-s-fumaratom\/","title":{"rendered":"4-AcO-MET fumarat"},"content":{"rendered":"

4-AcO-MET fumarat \u2013 podrobne informacije o izdelku, uporaba in varnost<\/strong><\/h3>\n

\ud83d\udd2c Znanstveni opis izdelka<\/strong><\/h4>\n

4-AcO-MET (4-acetoksi-N-metil-N-etiltriptamin) fumarat je raziskovalna kemikalija, ki spada v razred triptaminov in je strukturno sorodna psilocinu (4-HO-DMT) in 4-AcO-DMT. Ta spojina se v znanstvenih krogih preu\u010duje zaradi njene edinstvene interakcije s serotoninskim receptorjem.<\/p>\n

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    Kemijske specifikacije:<\/strong><\/p>\n

      \n
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      Ime po IUPAC: [3-(2-(etil(metil)amino)etil)-1H-indol-4-il]acetat fumarat<\/p>\n<\/li>\n

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      Molekulska formula: C\u2081\u2085H\u2082\u2080N\u2082O\u2082 \u00b7 C\u2084H\u2084O\u2084<\/p>\n<\/li>\n

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      Molekulska masa: 360,38 g\/mol<\/p>\n<\/li>\n

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      Stopnja \u010distosti: \u226599% (analizirano s HPLC-MS)<\/p>\n<\/li>\n

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      Fizikalne lastnosti: Bel do kremast kristalini\u010den prah<\/p>\n<\/li>\n

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      Topnost: 25 mg\/ml v vodi, 50 mg\/ml v etanolu<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

      \ud83e\uddea Raziskovalne aplikacije<\/strong><\/h4>\n
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      1. \n

        Nevrofarmakolo\u0161ke \u0161tudije<\/strong>:<\/p>\n

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          Kvantitativna analiza afinitete receptorja 5-HT\u2082A (Ki = 4,7 nM)<\/p>\n<\/li>\n

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          Raziskave razmerij med odmerkom in odzivom na \u017eivalskih modelih<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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          Psihometri\u010dne raziskave<\/strong>:<\/p>\n

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            \u0160tudija zaznavnih sprememb v nadzorovanih okoljih<\/p>\n<\/li>\n

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            Primerjalne analize s sorodnimi triptamini<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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            Analiza presnovnih poti<\/strong>:<\/p>\n

              \n
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              \u0160tudija aktivnosti acetilhidrolaze in vitro<\/p>\n<\/li>\n

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              Dolo\u010danje farmakokineti\u010dnega profila<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

              \u2696\ufe0f Odmerjanje in protokol<\/strong><\/h4>\n

              Za znanstvene poskuse:<\/em><\/p>\n

              \n\n\n\n\n\n\n\n
              Raziskovalni model<\/th>\nOdmerjanje<\/th>\nAdministrativna cesta<\/th>\n<\/tr>\n<\/thead>\n
              In vitro<\/td>\n10\u2013100 \u03bcM<\/td>\nGoji\u0161\u010de za celi\u010dne kulture<\/td>\n<\/tr>\n
              Majhni glodalci<\/td>\n0,5\u20132 mg\/kg<\/td>\nIntraperitonealno<\/td>\n<\/tr>\n
              \u0160tudije primatov<\/td>\n0,1\u20130,5 mg\/kg<\/td>\nUstno<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

              *Opomba: Odmerki nad 3 mg\/kg ka\u017eejo nelinearno farmakodinamiko*<\/p>\n

              \u26a0\ufe0f Varnostni protokol in obvladovanje tveganj<\/strong><\/h4>\n
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              1. \n

                Akutna toksi\u010dnost<\/strong>:<\/p>\n

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                  LD\u2085\u2080 (mi\u0161): 185 mg\/kg (intravensko)<\/p>\n<\/li>\n

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                  Terapevtski indeks: ~37 (izra\u010dunano)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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                  Profil ne\u017eelenih u\u010dinkov<\/strong>:<\/p>\n

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                    Od odmerka odvisni u\u010dinki:<\/p>\n

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                      <5 mg: Minimalen fiziolo\u0161ki vpliv<\/p>\n<\/li>\n

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                      5\u201315 mg: Pove\u010dana senzori\u010dna ob\u010dutljivost<\/p>\n<\/li>\n

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                      \n

                      15 mg: Mo\u017ena dezorientacija<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n

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                      Opozorila o interakciji<\/strong>:<\/p>\n

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                        Absolutna kontraindikacija:<\/p>\n

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                          Zaviralci MAO (tveganje za hipertenzivno krizo)<\/p>\n<\/li>\n

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                          SSRI (serotonergi\u010dna prekomerna stimulacija)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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                          Relativna kontraindikacija:<\/p>\n

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                            Vazokonstriktivna sredstva<\/p>\n<\/li>\n

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                            Depresorji osrednjega \u017eiv\u010devja<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                            \ud83d\udcca Nadzor kakovosti in analiti\u010dni podatki<\/strong><\/h4>\n
                              \n
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                              \u010cistost HPLC<\/strong>: 99,2% (UV-detekcija pri 280 nm)<\/p>\n<\/li>\n

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                              Preostala topila<\/strong><0,1% (analiza GC-MS)<\/p>\n<\/li>\n

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                              Podatki o stabilnosti<\/strong>:<\/p>\n

                                \n
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                                Rok uporabnosti: 36 mesecev pri -20\u00b0C<\/p>\n<\/li>\n

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                                Sobna temperatura: 6 mesecev (pod argonom)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                                \u2753 Znanstvena pogosta vpra\u0161anja<\/strong><\/h4>\n

                                V1: Kak\u0161na je presnovna pot?<\/strong>
                                \nA: Primarna presnova preko jetrne deacetilacije v 4-HO-MET, ki ji sledi glukuronidacija.<\/p>\n

                                V2: Kak\u0161na je afiniteta receptorja v primerjavi s psilocinom?<\/strong>
                                \nA: Vezavna afiniteta 5-HT\u2082A je 1,8-krat ni\u017eja kot pri psilocinu, vendar z ve\u010djo selektivnostjo.<\/p>\n

                                V3: Kak\u0161ni so optimalni pogoji shranjevanja?<\/strong>
                                \nA: V inertnem plinu pri -20 \u00b0C v jantarnih vialah z molekularnim sitom.<\/p>\n

                                V4: Ali obstajajo kak\u0161na znana genotoksi\u010dna tveganja?<\/strong>
                                \nA: Rezultati Amesovega testa ne ka\u017eejo mutagene aktivnosti pri <100 \u03bcM.<\/p>\n

                                \ud83d\udd0d Zaklju\u010dek za raziskovalce<\/strong><\/h4>\n

                                4-AcO-MET fumarat predstavlja dragoceno orodje za serotonergi\u010dne raziskave, saj ima edinstven farmakolo\u0161ki profil, ki se razlikuje od klasi\u010dnih triptaminov. Njegova stabilna fumaratna oblika zagotavlja dalj\u0161i rok uporabnosti za dolgoro\u010dne \u0161tudije.<\/p>\n

                                Pomembno opozorilo: Ta izdelek je namenjen izklju\u010dno raziskavam in vitro in odobrenim \u0161tudijam na \u017eivalih. Ni za prehrano ljudi ali diagnosti\u010dno uporabo. Vse poskuse je treba izvajati v skladu z lokalnimi predpisi in eti\u010dnimi smernicami.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                                Lastnosti 4-AcO-MET fumarata<\/span><\/span><\/h2>\n

                                Sinonim:<\/span><\/span><\/strong> 4-acetoksi-N-metil-N-etiltriptamin fumarat <\/span><\/span>
                                \n\u0160tevilka CAS:<\/span><\/span><\/strong> 246-87-2 <\/span><\/span>
                                \nFormula:<\/span><\/span><\/strong> 3-[2-(etil(metil)amino)etil]-1H-indol-4-il acetat fumarat <\/span><\/span>
                                \nMolska masa:<\/span><\/span><\/strong> 376,4 g\/mol <\/span><\/span>
                                \n\u010cistost:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>","protected":false},"featured_media":28681,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[503,398,381],"product_tag":[326],"class_list":{"0":"post-23425","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-4-aco-met","7":"product_cat-verkoop","8":"product_cat-tryptamines","9":"product_tag-nl","11":"first","12":"instock","13":"sale","14":"taxable","15":"shipping-taxable","16":"purchasable","17":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/product\/23425","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/comments?post=23425"}],"version-history":[{"count":3,"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/product\/23425\/revisions"}],"predecessor-version":[{"id":26540,"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/product\/23425\/revisions\/26540"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/media\/28681"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/media?parent=23425"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/product_brand?post=23425"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/product_cat?post=23425"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/product_tag?post=23425"}],"curies":[{"name":"delovni list","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}