{"id":23504,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23504"},"modified":"2025-10-22T17:00:59","modified_gmt":"2025-10-22T17:00:59","slug":"5-meo-dmt-hidroklorid","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/sl\/izdelek\/5-meo-dmt-hidroklorid\/","title":{"rendered":"5-MeO-DMT hidroklorid"},"content":{"rendered":"

5-MeO-DMT hidroklorid \u2013 znanstvena dokumentacija izdelka<\/span><\/span><\/strong><\/h3>\n

Splo\u0161ni opis<\/span><\/span><\/strong><\/h4>\n

5-MeO-DMT hidroklorid (5-metoksi-N,N-dimetiltriptamin HCl) je vodotopna sol klasi\u010dnega triptamina, ki je zaradi ve\u010dje stabilnosti in biolo\u0161ke uporabnosti v primerjavi s prostobazno obliko \u0161e posebej primerna za farmakolo\u0161ke raziskave.<\/span><\/span><\/p>\n

\n

Tehni\u010dne specifikacije<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Parameter<\/span><\/span><\/strong><\/th>\nSpecifikacija<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
Kemijska formula<\/span><\/span><\/strong><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O \u00b7 HCl<\/span><\/span><\/td>\n<\/tr>\n
Molekulska te\u017ea<\/span><\/span><\/strong><\/td>\n254,75 g\/mol<\/span><\/span><\/td>\n<\/tr>\n
\u010cistost<\/span><\/span><\/strong><\/td>\n\u226598% (analizirano s HPLC-UV)<\/span><\/span><\/td>\n<\/tr>\n
Videz<\/span><\/span><\/strong><\/td>\nBel do svetlo rumen kristalini\u010den prah<\/span><\/span><\/td>\n<\/tr>\n
Topnost<\/span><\/span><\/strong><\/td>\nVisoka vsebnost vode (>50 mg\/ml), metanol, PBS<\/span><\/span><\/td>\n<\/tr>\n
Tali\u0161\u010de<\/span><\/span><\/strong><\/td>\n243\u2013247 \u00b0C (razpade)<\/span><\/span><\/td>\n<\/tr>\n
Stabilnost<\/span><\/span><\/strong><\/td>\nHigroskopi\u010den; hraniti v suhem prostoru<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

Znanstvene aplikacije<\/span><\/span><\/strong><\/h3>\n

1. Nevrofarmakologija in vedenjske raziskave<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    \u0160tudije serotoninskih receptorjev:<\/span><\/span><\/strong> \u00a0Mo\u010dan agonist 5-HT\u2081\u2090\/\u2082\u2090 s hitro penetracijo v mo\u017egane.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Poskusi na \u017eivalih (in vivo):<\/span><\/span><\/strong> \u00a0Vedenjske paradigme (npr. odziv na trzanje glave pri glodavcih).<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Elektrofiziologija:<\/span><\/span><\/strong> \u00a0Vplivi na nevronske oscilacije (npr. aktivnost gama pasov).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. Biokemijske in molekularne \u0161tudije<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      Znotrajceli\u010dna signalizacija:<\/span><\/span><\/strong> \u00a0Testi kopi\u010denja cAMP in rekrutiranja \u03b2-arestina.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Kinetika encimov:<\/span><\/span><\/strong> \u00a0Presnova MAO-A (IC\u2085\u2080 ~2\u20135 \u03bcM).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. Klini\u010dno relevantne raziskave<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        Razmerja med odmerkom in odzivom:<\/span><\/span><\/strong> \u00a0Predklini\u010dno varnostno profiliranje.<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Primerjalna farmakologija:<\/span><\/span><\/strong> \u00a0Proti psilocibinu, DMT in drugim triptaminom.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Eksperimentalne smernice<\/span><\/span><\/strong><\/h3>\n

        Priporo\u010dene koncentracije<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        Uporaba<\/span><\/span><\/strong><\/th>\nObmo\u010dje koncentracije<\/span><\/span><\/strong><\/th>\nTopilo<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
        Celi\u010dne kulture (in vitro)<\/span><\/span><\/td>\n1 nM \u2013 10 \u03bcM<\/span><\/span><\/td>\nPBS\/DMEM (\u22640,1% DMSO)<\/span><\/span><\/td>\n<\/tr>\n
        Receptorski testi<\/span><\/span><\/td>\n0,1\u2013100 \u03bcM<\/span><\/span><\/td>\nTris-HCl pufer (pH 7,4)<\/span><\/span><\/td>\n<\/tr>\n
        \u0160tudije na \u017eivalih (ip\/iv)<\/span><\/span><\/td>\n0,1\u20135 mg\/kg<\/span><\/span><\/td>\nSterilna fiziolo\u0161ka raztopina<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        Varnostni ukrepi<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          Osebna za\u0161\u010dita:<\/span><\/span><\/strong> \u00a0Laboratorijski pla\u0161\u010d, rokavice (nitrilne), za\u0161\u010ditna o\u010dala.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Ravnanje:<\/span><\/span><\/strong> \u00a0Higroskopi\u010dno \u2013 po uporabi takoj zaprite.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Shranjevanje:<\/span><\/span><\/strong> \u00a0Zra\u010dno zaprto, pod argonom, pri -20 \u00b0C (prepre\u010duje hidrolizo).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Stabilnost in shranjevanje<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            Rok uporabnosti:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              -20 \u00b0C:<\/span><\/span><\/strong> \u00a0>2 leti (nespremenjena \u010distost).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4 \u00b0C:<\/span><\/span><\/strong> \u00a06 mesecev (v suhem okolju).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              Izpad:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Hidroliza pri dolgotrajni izpostavljenosti vlagi (spremlja se s HPLC).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Analiti\u010dna validacija<\/span><\/span><\/strong><\/h3>\n

                Vsaka serija vsebuje:<\/span><\/span><\/p>\n

                  \n
                1. \n

                  HPLC-UV kromatogram<\/span><\/span><\/strong> \u00a0(Kolona C18, retencijski \u010das ~6,2 min).<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  Fragmentacija MS\/MS<\/span><\/span><\/strong> \u00a0(karakteristi\u010dni ioni: m\/z 219 \u2192 174, 160).<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  Preostala topila<\/span><\/span><\/strong> \u00a0(ustrezajo smernicam ICH Q3C).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  Pravni status (Nizozemska\/EU)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    Zakonodaja o mamilih:<\/span><\/span><\/strong> \u00a0Ni izrecno omenjeno v Zakonu o opiju, vendar morda v analogni zakonodaji (Dodatek II).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Znanstvena uporaba:<\/span><\/span><\/strong> \u00a0Za ustanove je potrebno dovoljenje (odobritev CCMO za testiranje na \u017eivalih).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Nadzor izvoza:<\/span><\/span><\/strong> \u00a0Predmet Uredbe EU 2019\/1998 (psihotropne snovi).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    Pogosto zastavljena vpra\u0161anja (FAQ)<\/span><\/span><\/strong><\/h3>\n

                    1. \u010detrtletje <\/span>Kak\u0161ne so prednosti HCl pred prosto bazo?<\/span><\/strong><\/span><\/p>\n

                      \n
                    • \n

                      Izbolj\u0161ana topnost<\/span><\/span><\/strong> \u00a0(idealno za \u0161tudije injekcij).<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Dalj\u0161a obstojnost na policah<\/span><\/span><\/strong> \u00a0pri sobni temperaturi.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      V2: Ali je 5-MeO-DMT-HCl zaznaven v testih na droge?<\/span><\/span><\/strong>
                      \n O: Da, prek:<\/span><\/span><\/p>\n

                        \n
                      • \n

                        LC-MS\/MS<\/span><\/span><\/strong> \u00a0(prepoznan kot adukt 5-MeO-DMT + HCl).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Imunoanalize:<\/span><\/span><\/strong> \u00a0Navzkri\u017ena reaktivnost z DMT (~15-20%).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        V3: Ali obstajajo tveganja pri kombiniranju z zaviralci MAO?<\/span><\/span><\/strong>
                        \n O:\u00a0 <\/span><\/span>Absolutno.<\/span><\/span><\/strong><\/p>\n

                          \n
                        • \n

                          Pove\u010dano tveganje\u00a0 <\/span><\/span>serotoninski sindrom<\/span><\/span><\/strong> \u00a0(izogibajte se kombinaciji!).<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Uporabljajte samo v modelih brez MAO.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          V4: Kako odstraniti odpadke?<\/span><\/span><\/strong>
                          \n O:<\/span><\/span><\/p>\n

                            \n
                          1. \n

                            Nevtralizirajte z\u00a0 <\/span><\/span>natrijev bikarbonat<\/span><\/span><\/strong> \u00a0(pH 7\u20138).<\/span><\/span><\/p>\n<\/li>\n

                          2. \n

                            Adsorbirajte z\u00a0 <\/span><\/span>aktivno oglje<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n<\/li>\n

                          3. \n

                            Odstranite kot\u00a0 <\/span><\/span>nevarni kemi\u010dni odpadki<\/span><\/span><\/strong> \u00a0(UN 3249, razred 6.1).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                            \n

                            Reference in kontakt<\/span><\/span><\/strong><\/h3>\n

                            Osnovna literatura:<\/span><\/span><\/strong><\/p>\n

                              \n
                            1. \n

                              Shen et al. (2010). \u00bbFarmakologija derivatov 5-MeO-DMT\u00ab.\u00a0 <\/span><\/span>J Psychopharmacol<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n

                            2. \n

                              Kaasik in sod. (2021). \u00bbPresnovne poti 5-MeO-DMT\u00ab.\u00a0 <\/span><\/span>Ksenobiotiki<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                              \n

                              Ta izdelek je namenjen samo za poobla\u0161\u010dene znanstvene raziskave. Ni za u\u017eivanje ljudi ali diagnosti\u010dno uporabo. Upo\u0161tevajte lokalne predpise.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                              5-MeO-DMT hydrochloride properties<\/span><\/span><\/span><\/h3>\n

                              Synonym:<\/span><\/span><\/strong> 5-methoxy-N,N-dimethyltryptamine hydrochloride <\/span><\/span>
                              \nCAS Number:<\/span><\/span><\/strong> n\/a <\/span><\/span>
                              \nFormula:<\/span><\/span><\/strong> 3-[2-(dimethylamino)ethyl]-5-methoxyindole hydrochloride <\/span><\/span>
                              \nMolar mass:<\/span><\/span><\/strong> 254.8 g\/mol <\/span><\/span>
                              \nPurity:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>\n","protected":false},"featured_media":28720,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[511,381],"product_tag":[326],"class_list":["post-23504","product","type-product","status-publish","has-post-thumbnail","product_cat-5-meo-dmt-kopen","product_cat-tryptamines","product_tag-nl","first","instock","taxable","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/product\/23504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/comments?post=23504"}],"version-history":[{"count":6,"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/product\/23504\/revisions"}],"predecessor-version":[{"id":28467,"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/product\/23504\/revisions\/28467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/media\/28720"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/media?parent=23504"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/product_brand?post=23504"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/product_cat?post=23504"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/sl\/wp-json\/wp\/v2\/product_tag?post=23504"}],"curies":[{"name":"delovni list","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}