{"id":23425,"date":"2025-04-13T17:39:45","date_gmt":"2025-04-13T17:39:45","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23425"},"modified":"2025-10-23T00:49:40","modified_gmt":"2025-10-23T00:49:40","slug":"4-adet-fumaratli-avokado","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/tr\/urun\/4-adet-fumaratli-avokado\/","title":{"rendered":"4-AcO-MET fumarat"},"content":{"rendered":"

4-AcO-MET Fumarat \u2013 Ayr\u0131nt\u0131l\u0131 \u00dcr\u00fcn Bilgileri, Kullan\u0131m ve G\u00fcvenlik<\/strong><\/h3>\n

\ud83d\udd2c Bilimsel \u00dcr\u00fcn A\u00e7\u0131klamas\u0131<\/strong><\/h4>\n

4-AcO-MET (4-asetoksi-N-metil-N-etiltriptamin) fumarat, triptamin s\u0131n\u0131f\u0131na ait, yap\u0131sal olarak psilosin (4-HO-DMT) ve 4-AcO-DMT ile ili\u015fkili bir ara\u015ft\u0131rma kimyasal\u0131d\u0131r. Bu bile\u015fik, serotonin resept\u00f6rleriyle benzersiz etkile\u015fimi nedeniyle bilim \u00e7evrelerinde incelenmektedir.<\/p>\n

    \n
  • \n

    Kimyasal \u00f6zellikler:<\/strong><\/p>\n

      \n
    • \n

      IUPAC ad\u0131: [3-(2-(etil(metil)amino)etil)-1H-indol-4-il]asetat fumarat<\/p>\n<\/li>\n

    • \n

      Molek\u00fcler form\u00fcl: C\u2081\u2085H\u2082\u2080N\u2082O\u2082 \u00b7 C\u2084H\u2084O\u2084<\/p>\n<\/li>\n

    • \n

      Molek\u00fcler a\u011f\u0131rl\u0131k: 360,38 g\/mol<\/p>\n<\/li>\n

    • \n

      Safl\u0131k seviyesi: \u226599% (HPLC-MS ile analiz edildi)<\/p>\n<\/li>\n

    • \n

      Fiziksel \u00f6zellikleri: Beyaz ila krem rengi kristal toz<\/p>\n<\/li>\n

    • \n

      \u00c7\u00f6z\u00fcn\u00fcrl\u00fck: Suda 25 mg\/ml, etanolde 50 mg\/ml<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

      \ud83e\uddea Ara\u015ft\u0131rma uygulamalar\u0131<\/strong><\/h4>\n
        \n
      1. \n

        N\u00f6rofarmakolojik \u00e7al\u0131\u015fmalar<\/strong>:<\/p>\n

          \n
        • \n

          5-HT\u2082A resept\u00f6r afinitesinin kantitatif analizi (Ki = 4,7 nM)<\/p>\n<\/li>\n

        • \n

          Hayvan modellerinde doz-tepki ili\u015fkilerinin ara\u015ft\u0131r\u0131lmas\u0131<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

        • \n

          Psikometrik ara\u015ft\u0131rma<\/strong>:<\/p>\n

            \n
          • \n

            Kontroll\u00fc ortamlarda alg\u0131sal de\u011fi\u015fikli\u011fin incelenmesi<\/p>\n<\/li>\n

          • \n

            \u0130lgili triptaminlerle kar\u015f\u0131la\u015ft\u0131rmal\u0131 analizler<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

          • \n

            Metabolik yol analizi<\/strong>:<\/p>\n

              \n
            • \n

              Asetilhidrolaz aktivitesinin in vitro \u00e7al\u0131\u015fmas\u0131<\/p>\n<\/li>\n

            • \n

              Farmakokinetik profil belirleme<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

              \u2696\ufe0f Dozaj ve Protokol<\/strong><\/h4>\n

              Bilimsel deneyler i\u00e7in:<\/em><\/p>\n

              \n\n\n\n\n\n\n\n
              Ara\u015ft\u0131rma modeli<\/th>\nDozaj<\/th>\n\u0130dare Yolu<\/th>\n<\/tr>\n<\/thead>\n
              In vitro<\/td>\n10-100 \u03bcM<\/td>\nH\u00fccre k\u00fclt\u00fcr\u00fc ortam\u0131<\/td>\n<\/tr>\n
              K\u00fc\u00e7\u00fck kemirgenler<\/td>\n0,5-2 mg\/kg<\/td>\n\u0130ntraperitoneal<\/td>\n<\/tr>\n
              Primat \u00e7al\u0131\u015fmalar\u0131<\/td>\n0,1-0,5 mg\/kg<\/td>\nA\u011f\u0131zdan<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

              *Not: 3 mg\/kg'\u0131n \u00fczerindeki dozlar do\u011frusal olmayan farmakodinamikler sergiler*<\/p>\n

              \u26a0\ufe0f G\u00fcvenlik Protokol\u00fc ve Risk Y\u00f6netimi<\/strong><\/h4>\n
                \n
              1. \n

                Akut toksisite<\/strong>:<\/p>\n

                  \n
                • \n

                  LD\u2085\u2080 (fare): 185 mg\/kg (intraven\u00f6z)<\/p>\n<\/li>\n

                • \n

                  Terap\u00f6tik indeks: ~37 (hesaplanm\u0131\u015f)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

                • \n

                  Yan etki profili<\/strong>:<\/p>\n

                    \n
                  • \n

                    Doza ba\u011fl\u0131 etkiler:<\/p>\n

                      \n
                    • \n

                      <5 mg: Minimum fizyolojik etki<\/p>\n<\/li>\n

                    • \n

                      5-15 mg: Duyusal duyarl\u0131l\u0131\u011f\u0131n artmas\u0131<\/p>\n<\/li>\n

                    • \n
                      \n

                      15 mg: Potansiyel y\u00f6nelim bozuklu\u011fu<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n

                    • \n

                      Etkile\u015fim uyar\u0131lar\u0131<\/strong>:<\/p>\n

                        \n
                      • \n

                        Kesin kontrendikasyon:<\/p>\n

                          \n
                        • \n

                          MAO inhibit\u00f6rleri (hipertansif kriz riski)<\/p>\n<\/li>\n

                        • \n

                          SSRI'lar (serotonerjik a\u015f\u0131r\u0131 uyar\u0131m)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

                        • \n

                          G\u00f6receli kontrendikasyon:<\/p>\n

                            \n
                          • \n

                            Vazokonstriktif ajanlar<\/p>\n<\/li>\n

                          • \n

                            MSS depresanlar\u0131<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                            \ud83d\udcca Kalite Kontrol ve Analitik Veriler<\/strong><\/h4>\n
                              \n
                            • \n

                              HPLC safl\u0131\u011f\u0131<\/strong>: 99.2% (280 nm'de UV alg\u0131lama)<\/p>\n<\/li>\n

                            • \n

                              Art\u0131k \u00e7\u00f6z\u00fcc\u00fcler<\/strong>: <0.1% (GC-MS analizi)<\/p>\n<\/li>\n

                            • \n

                              Kararl\u0131l\u0131k verileri<\/strong>:<\/p>\n

                                \n
                              • \n

                                Raf \u00f6mr\u00fc: -20\u00b0C'de 36 ay<\/p>\n<\/li>\n

                              • \n

                                Oda s\u0131cakl\u0131\u011f\u0131: 6 ay (argon alt\u0131nda)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                                \u2753 Bilimsel SSS<\/strong><\/h4>\n

                                S1: Metabolik yol nedir?<\/strong>
                                \nA: Hepatik deasetilasyon yoluyla 4-HO-MET'e primer metabolizma, ard\u0131ndan glukuronidasyon.<\/p>\n

                                S2: Resept\u00f6r afinitesi psilosinle nas\u0131l kar\u015f\u0131la\u015ft\u0131r\u0131l\u0131r?<\/strong>
                                \nA: 5-HT\u2082A ba\u011flanma afinitesi psilosin'den 1,8 kat daha d\u00fc\u015f\u00fckt\u00fcr, ancak daha y\u00fcksek se\u00e7icili\u011fe sahiptir.<\/p>\n

                                S3: Optimum depolama ko\u015fullar\u0131 nelerdir?<\/strong>
                                \nA: -20\u00b0C'de inert gaz alt\u0131nda, molek\u00fcler elek bulunan kehribar renkli \u015fi\u015felerde.<\/p>\n

                                S4: Bilinen genotoksik riskler var m\u0131d\u0131r?<\/strong>
                                \nA: Ames test sonu\u00e7lar\u0131 <100 \u03bcM'de mutajenik aktivite g\u00f6stermemektedir.<\/p>\n

                                \ud83d\udd0d Ara\u015ft\u0131rmac\u0131lar \u0130\u00e7in Sonu\u00e7<\/strong><\/h4>\n

                                4-AcO-MET fumarat, klasik triptaminlerden farkl\u0131, benzersiz bir farmakolojik profile sahip olup, serotonerjik ara\u015ft\u0131rmalar i\u00e7in de\u011ferli bir ara\u00e7t\u0131r. Kararl\u0131 fumarat formu, uzun s\u00fcreli \u00e7al\u0131\u015fmalar i\u00e7in daha uzun raf \u00f6mr\u00fc sa\u011flar.<\/p>\n

                                \u00d6nemli uyar\u0131: Bu \u00fcr\u00fcn yaln\u0131zca in vitro ara\u015ft\u0131rmalar ve yetkili hayvan \u00e7al\u0131\u015fmalar\u0131 i\u00e7in tasarlanm\u0131\u015ft\u0131r. \u0130nsan t\u00fcketimi veya te\u015fhis ama\u00e7l\u0131 kullan\u0131m i\u00e7in de\u011fildir. T\u00fcm deneyler yerel y\u00f6netmeliklere ve etik kurallara uygun olarak y\u00fcr\u00fct\u00fclmelidir.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                                4-AcO-MET fumarat \u00f6zellikleri<\/span><\/span><\/h2>\n

                                E\u015f anlaml\u0131s\u0131:<\/span><\/span><\/strong> 4-asetoksi-N-metil-N-etiltriptamin fumarat <\/span><\/span>
                                \nCAS Numaras\u0131:<\/span><\/span><\/strong> 246-87-2 <\/span><\/span>
                                \nForm\u00fcl:<\/span><\/span><\/strong> 3-[2-(etil(metil)amino)etil]-1H-indol-4-il asetat fumarat <\/span><\/span>
                                \nMol K\u00fctlesi:<\/span><\/span><\/strong> 376,4 g\/mol <\/span><\/span>
                                \nSafl\u0131k:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>","protected":false},"featured_media":28681,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[503,398,381],"product_tag":[326],"class_list":{"0":"post-23425","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-4-aco-met","7":"product_cat-verkoop","8":"product_cat-tryptamines","9":"product_tag-nl","11":"first","12":"instock","13":"sale","14":"taxable","15":"shipping-taxable","16":"purchasable","17":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product\/23425","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/comments?post=23425"}],"version-history":[{"count":3,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product\/23425\/revisions"}],"predecessor-version":[{"id":26540,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product\/23425\/revisions\/26540"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/media\/28681"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/media?parent=23425"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product_brand?post=23425"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product_cat?post=23425"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product_tag?post=23425"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}