{"id":23497,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23497"},"modified":"2025-10-22T16:53:50","modified_gmt":"2025-10-22T16:53:50","slug":"5-meo-dmt-freebase","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/tr\/urun\/5-meo-dmt-freebase\/","title":{"rendered":"5-MeO-DMT serbest baz"},"content":{"rendered":"

5-MeO-DMT Freebase \u2013 Bilimsel \u00dcr\u00fcn Dok\u00fcmantasyonu<\/span><\/span><\/strong><\/h3>\n

Genel A\u00e7\u0131klama<\/span><\/span><\/strong><\/h4>\n

5-MeO-DMT (5-Metoksi-N,N-dimetiltriptamin) serbest baz\u0131, \u00e7e\u015fitli bitki ve hayvan salg\u0131lar\u0131nda bulunan, g\u00fc\u00e7l\u00fc bir psikoaktif profile sahip, do\u011fal olarak olu\u015fan bir triptamindir. Serbest baz formunda, belirli ara\u015ft\u0131rma y\u00f6ntemleri i\u00e7in \u00fcst\u00fcn bir u\u00e7uculuk sunarak, farmakolojik ve n\u00f6robilim \u00e7al\u0131\u015fmalar\u0131 i\u00e7in de\u011ferlidir.<\/span><\/span><\/p>\n

\n

Teknik \u00d6zellikler<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Parametre<\/span><\/span><\/strong><\/th>\n\u015eartname<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
Kimyasal Form\u00fcl<\/span><\/span><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O<\/span><\/span><\/td>\n<\/tr>\n
Molek\u00fcler A\u011f\u0131rl\u0131k<\/span><\/span><\/td>\n218,29 g\/mol<\/span><\/span><\/td>\n<\/tr>\n
Safl\u0131k<\/span><\/span><\/td>\n\u226598% (HPLC-UV analiz edildi)<\/span><\/span><\/td>\n<\/tr>\n
Bi\u00e7im<\/span><\/span><\/td>\nKristal\/beyaz toz<\/span><\/span><\/td>\n<\/tr>\n
\u00c7\u00f6z\u00fcn\u00fcrl\u00fck<\/span><\/span><\/td>\nOrganik \u00e7\u00f6z\u00fcc\u00fclerde (etanol, metanol, DMSO) \u00e7\u00f6z\u00fcn\u00fcr, suda s\u0131n\u0131rl\u0131d\u0131r<\/span><\/span><\/td>\n<\/tr>\n
Erime noktas\u0131<\/span><\/span><\/td>\n60-65\u00b0C (serbest baz)<\/span><\/span><\/td>\n<\/tr>\n
\u0130stikrar<\/span><\/span><\/td>\nI\u015f\u0131\u011fa ve oksijene duyarl\u0131d\u0131r; inert gaz alt\u0131nda saklay\u0131n<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

Bilimsel Uygulamalar<\/span><\/span><\/strong><\/h3>\n

1. N\u00f6rofarmakolojik Ara\u015ft\u0131rma<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    Serotonerjik Etki:<\/span><\/span><\/strong> \u00a0Bilin\u00e7 mod\u00fclasyonu \u00e7al\u0131\u015fmalar\u0131 i\u00e7in \u00f6nemli, g\u00fc\u00e7l\u00fc bir 5-HT\u2081\u2090\/\u2082\u2090 agonisti.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    EEG\/fMRI \u00e7al\u0131\u015fmalar\u0131:<\/span><\/span><\/strong> \u00a0Beyin dalgas\u0131 desenleri \u00fczerindeki akut etkilerin (\u00f6rne\u011fin gama sal\u0131n\u0131mlar\u0131) ara\u015ft\u0131r\u0131lmas\u0131.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    N\u00f6roplastisite:<\/span><\/span><\/strong> \u00a0Olas\u0131 BDNF artt\u0131r\u0131c\u0131 etkiler (hayvan modelleri \u00fczerinde).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. Metabolik ve Toksikolojik \u00c7al\u0131\u015fmalar<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      MAO'ya ba\u011f\u0131ml\u0131 metabolizma:<\/span><\/span><\/strong> \u00a0CYP2D6 ve MAO-A bozunma yollar\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Doza ba\u011fl\u0131 toksisite:<\/span><\/span><\/strong> \u00a0H\u00fccre k\u00fclt\u00fcrlerinde g\u00fcvenlik s\u0131n\u0131rlar\u0131n\u0131n belirlenmesi.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. Kar\u015f\u0131la\u015ft\u0131rmal\u0131 Farmakoloji<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        DMT ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda:<\/span><\/span><\/strong> \u00a0Daha y\u00fcksek etkili ancak daha k\u0131sa etki s\u00fcresi (inhalasyon yoluyla al\u0131nd\u0131\u011f\u0131nda 15-30 dakika).<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Psilocybin ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda:<\/span><\/span><\/strong> \u00a0Resept\u00f6r afinitesindeki farkl\u0131l\u0131klar ve \u00f6znel etkiler.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Deneysel K\u0131lavuzlar<\/span><\/span><\/strong><\/h3>\n

        \u00d6nerilen Konsantrasyonlar (In Vitro)<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        Ba\u015fvuru<\/span><\/span><\/th>\nKonsantrasyon aral\u0131\u011f\u0131<\/span><\/span><\/th>\n\u00c7\u00f6z\u00fcc\u00fc<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
        Resept\u00f6r ba\u011flanma deneyleri<\/span><\/span><\/td>\n1 nM \u2013 10 \u00b5M<\/span><\/span><\/td>\nPBS\/DMSO (\u22640.1%)<\/span><\/span><\/td>\n<\/tr>\n
        H\u00fccre k\u00fclt\u00fcr\u00fc deneyleri<\/span><\/span><\/td>\n0,1 \u2013 100 \u00b5M<\/span><\/span><\/td>\nDMEM\/FBS<\/span><\/span><\/td>\n<\/tr>\n
        Gaz kromatografisi<\/span><\/span><\/td>\n1 mg\/ml (metanolde)<\/span><\/span><\/td>\nMetanol (HPLC s\u0131n\u0131f\u0131)<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        G\u00fcvenlik protokolleri<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          Ki\u015fisel Koruma:<\/span><\/span><\/strong> \u00a0Laboratuvar \u00f6nl\u00fc\u011f\u00fc, nitril eldiven, koruyucu g\u00f6zl\u00fck, tozla \u00e7al\u0131\u015f\u0131rken FFP2 maske.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Havaland\u0131rma:<\/span><\/span><\/strong> \u00a0Is\u0131tma\/buharla\u015ft\u0131rma s\u0131ras\u0131nda daima bir davlumbaz\u0131n alt\u0131nda \u00e7al\u0131\u015f\u0131n.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Depolamak:<\/span><\/span><\/strong> \u00a0Kehribar renkli \u015fi\u015felerde, argon gaz\u0131 alt\u0131nda, -20\u00b0C'de (uzun s\u00fcreli).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Stabilite ve Depolama<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            Raf \u00f6mr\u00fc:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              Oda s\u0131cakl\u0131\u011f\u0131: <24 saat \u00e7\u00f6zeltide.<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4\u00b0C: 3 g\u00fcn s\u00fcreyle stabildir (argon alt\u0131nda).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              -20\u00b0C: >6 ay (safl\u0131k de\u011fi\u015fmeden).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              Bozunma \u00fcr\u00fcnleri:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                \u0130ndol t\u00fcrevlerine oksidasyon (TLC\/HPLC ile kontrol).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Analitik Sertifikasyon<\/span><\/span><\/strong><\/h3>\n

                Her parti \u015funlar\u0131 i\u00e7erir:<\/span><\/span><\/p>\n

                  \n
                1. \n

                  HPLC-UV kromatogram\u0131<\/span><\/span><\/strong> \u00a0(\u03bb=280 nm, C18 kolonu)<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  GC-MS onay\u0131<\/span><\/span><\/strong> \u00a0(karakteristik par\u00e7alar: m\/z 174, 160)<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  Kal\u0131nt\u0131 \u00e7\u00f6z\u00fcc\u00fc analizi<\/span><\/span><\/strong> \u00a0(\u2264500 ppm)<\/span><\/span><\/p>\n<\/li>\n

                4. \n

                  Su i\u00e7eri\u011fi<\/span><\/span><\/strong> \u00a0(Karl Fischer, <1%)<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  Yasal Durum (Hollanda)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    Afyon Yasas\u0131:<\/span><\/span><\/strong> \u00a0A\u00e7\u0131k\u00e7a d\u00fczenlenmemi\u015f, ancak muhtemelen benzer mevzuat alt\u0131nda.<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Mevzuat:<\/span><\/span><\/strong> \u00a0Bilimsel kurulu\u015flar i\u00e7in lisans \u015fart\u0131 aranmaktad\u0131r (Ek 2, Afyon Kanunu).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    \u0130hracat k\u0131s\u0131tlamalar\u0131:<\/span><\/span><\/strong> \u00a0CITES listesinde (do\u011fal kaynaklar gibi)\u00a0 <\/span><\/span>Incilius alvarius<\/span><\/span><\/em> ).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    S\u0131k\u00e7a Sorulan Sorular (SSS)<\/span><\/span><\/strong><\/h3>\n

                    S1: Serbest baz ile fumarik asit tuzu aras\u0131ndaki fark nedir?<\/span><\/span><\/strong>
                    \n A: Serbest baz daha u\u00e7ucudur (buharla\u015ft\u0131rma deneyleri i\u00e7in uygundur), fumarik asit tuzu ise \u00e7\u00f6zeltilerde daha kararl\u0131d\u0131r.<\/span><\/span><\/p>\n

                    S2: Toksikoloji taramalar\u0131nda 5-MeO-DFT nas\u0131l tespit edilir?<\/span><\/span><\/strong>
                    \n A: \u015eu \u015fekilde tan\u0131mlanabilir:<\/span><\/span><\/p>\n

                      \n
                    • \n

                      LC-MS\/MS (\u00f6nc\u00fc iyon m\/z 219 \u2192 \u00fcr\u00fcn iyon m\/z 174)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      \u0130mmunoassayler: Baz\u0131 DMT testleriyle \u00e7apraz reaksiyon (\u226430%).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      S3: Bilinen herhangi bir farmakokinetik etkile\u015fim var m\u0131d\u0131r?<\/span><\/span><\/strong>
                      \n A:\u00a0 <\/span><\/span>Tehlikeli kombinasyonlar:<\/span><\/span><\/strong><\/p>\n

                        \n
                      • \n

                        MAO inhibit\u00f6rleri (serotonin sendromu riski).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        SSRI'lar (rekabet nedeniyle etkinli\u011fi azalm\u0131\u015ft\u0131r).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        S4: At\u0131klar nas\u0131l bertaraf edilir?<\/span><\/span><\/strong>
                        \n A: \u015eununla devre d\u0131\u015f\u0131 b\u0131rak\u0131n:<\/span><\/span><\/p>\n

                          \n
                        1. \n

                          N\u00f6tralizasyon i\u00e7in seyreltik hidroklorik asit (0,1 M) kullan\u0131n.<\/span><\/span><\/p>\n<\/li>\n

                        2. \n

                          Aktif karbonla emilim.<\/span><\/span><\/p>\n<\/li>\n

                        3. \n

                          Olarak imha edin\u00a0 <\/span><\/span>tehlikeli kimyasal at\u0131k<\/span><\/span><\/em> \u00a0(BM numaras\u0131: 3249).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                          \n

                          Referanslar ve \u0130leti\u015fim<\/span><\/span><\/strong><\/h3>\n

                          \u00d6nemli yay\u0131nlar:<\/span><\/span><\/strong><\/p>\n

                            \n
                          • \n

                            Sz\u00e1ra, S. (2007). \u201cDMT ve 5-MeO-DMT: Erken insan \u00e7al\u0131\u015fmalar\u0131\u201d.<\/span><\/span><\/p>\n<\/li>\n

                          • \n

                            Uthaug ve ark. (2021). \u201c5-MeO-DMT'nin Psikofarmakolojisi\u201d.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                            \n

                            Bu \u00fcr\u00fcn yaln\u0131zca yasal bilimsel ara\u015ft\u0131rmalar i\u00e7in tasarlanm\u0131\u015ft\u0131r. \u0130nsan veya veteriner kullan\u0131m\u0131 i\u00e7in de\u011fildir. Kullan\u0131c\u0131lar t\u00fcm yerel d\u00fczenlemelere uymal\u0131d\u0131r.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                            5-MeO-DMT serbest baz \u00f6zellikleri<\/span><\/span><\/span><\/span><\/h3>\n

                            E\u015f anlaml\u0131s\u0131:<\/span><\/span><\/span><\/span><\/strong> 5-metoksi-N,N-dimetiltriptamin <\/span><\/span><\/span><\/span>
                            \nCAS Numaras\u0131:<\/span><\/span><\/span><\/span><\/strong> 1019-45-0 <\/span><\/span><\/span><\/span>
                            \nForm\u00fcl:<\/span><\/span><\/span><\/span><\/strong> 3-[2-(dimetilamino)etil]-5-metoksiindol <\/span><\/span><\/span><\/span>
                            \nMol K\u00fctlesi:<\/span><\/span><\/span><\/span><\/strong> 218,3 g\/mol <\/span><\/span><\/span><\/span>
                            \nSafl\u0131k:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>","protected":false},"featured_media":28719,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[511,381],"product_tag":[326],"class_list":{"0":"post-23497","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-5-meo-dmt-kopen","7":"product_cat-tryptamines","8":"product_tag-nl","10":"first","11":"instock","12":"taxable","13":"shipping-taxable","14":"purchasable","15":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product\/23497","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/comments?post=23497"}],"version-history":[{"count":4,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product\/23497\/revisions"}],"predecessor-version":[{"id":28072,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product\/23497\/revisions\/28072"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/media\/28719"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/media?parent=23497"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product_brand?post=23497"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product_cat?post=23497"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product_tag?post=23497"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}