{"id":23504,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&p=23504"},"modified":"2025-10-22T17:00:59","modified_gmt":"2025-10-22T17:00:59","slug":"5-meo-dmt-hidroklorur","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/tr\/urun\/5-meo-dmt-hidroklorur\/","title":{"rendered":"5-MeO-DMT hidroklor\u00fcr"},"content":{"rendered":"

5-MeO-DMT Hidroklor\u00fcr \u2013 Bilimsel \u00dcr\u00fcn Dok\u00fcmantasyonu<\/span><\/span><\/strong><\/h3>\n

Genel A\u00e7\u0131klama<\/span><\/span><\/strong><\/h4>\n

5-MeO-DMT hidroklor\u00fcr (5-Metoksi-N,N-dimetiltriptamin HCl), klasik triptaminin suda \u00e7\u00f6z\u00fcnen bir tuzudur ve serbest baz formuna k\u0131yasla daha y\u00fcksek stabilitesi ve biyoyararlan\u0131m\u0131 nedeniyle farmakolojik ara\u015ft\u0131rmalar i\u00e7in \u00f6zellikle uygundur.<\/span><\/span><\/p>\n

\n

Teknik \u00d6zellikler<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Parametre<\/span><\/span><\/strong><\/th>\n\u015eartname<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
Kimyasal Form\u00fcl<\/span><\/span><\/strong><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O \u00b7 HCl<\/span><\/span><\/td>\n<\/tr>\n
Molek\u00fcler A\u011f\u0131rl\u0131k<\/span><\/span><\/strong><\/td>\n254,75 g\/mol<\/span><\/span><\/td>\n<\/tr>\n
Safl\u0131k<\/span><\/span><\/strong><\/td>\n\u226598% (HPLC-UV ile analiz edildi)<\/span><\/span><\/td>\n<\/tr>\n
D\u0131\u015f g\u00f6r\u00fcn\u00fc\u015f<\/span><\/span><\/strong><\/td>\nBeyaz ila a\u00e7\u0131k sar\u0131 kristal toz<\/span><\/span><\/td>\n<\/tr>\n
\u00c7\u00f6z\u00fcn\u00fcrl\u00fck<\/span><\/span><\/strong><\/td>\nSu i\u00e7eri\u011fi y\u00fcksek (>50 mg\/ml), metanol, PBS<\/span><\/span><\/td>\n<\/tr>\n
Erime noktas\u0131<\/span><\/span><\/strong><\/td>\n243-247\u00b0C (ayr\u0131\u015f\u0131r)<\/span><\/span><\/td>\n<\/tr>\n
\u0130stikrar<\/span><\/span><\/strong><\/td>\nHigroskopiktir; kuru ko\u015fullarda saklay\u0131n<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

Bilimsel Uygulamalar<\/span><\/span><\/strong><\/h3>\n

1. N\u00f6rofarmakoloji ve Davran\u0131\u015fsal Ara\u015ft\u0131rma<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    Serotonin resept\u00f6r \u00e7al\u0131\u015fmalar\u0131:<\/span><\/span><\/strong> \u00a0H\u0131zl\u0131 serebral penetrasyona sahip g\u00fc\u00e7l\u00fc 5-HT\u2081\u2090\/\u2082\u2090 agonisti.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Hayvan deneyleri (in vivo):<\/span><\/span><\/strong> \u00a0Davran\u0131\u015fsal paradigmalar (\u00f6rne\u011fin kemirgenlerde ba\u015f se\u011firmesi tepkisi).<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Elektrofizyoloji:<\/span><\/span><\/strong> \u00a0N\u00f6ronal sal\u0131n\u0131mlar \u00fczerindeki etkiler (\u00f6rne\u011fin, gama band\u0131 aktivitesi).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. Biyokimyasal ve Molek\u00fcler \u00c7al\u0131\u015fmalar<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      H\u00fccre i\u00e7i sinyalleme:<\/span><\/span><\/strong> \u00a0cAMP birikimi ve \u03b2-arrestin al\u0131m testleri.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Enzim kineti\u011fi:<\/span><\/span><\/strong> \u00a0MAO-A metabolizmas\u0131 (IC\u2085\u2080 ~2-5 \u03bcM).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. Klinik Olarak \u0130lgili Ara\u015ft\u0131rma<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        Doz-tepki ili\u015fkileri:<\/span><\/span><\/strong> \u00a0Klinik \u00f6ncesi g\u00fcvenlik profili.<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Kar\u015f\u0131la\u015ft\u0131rmal\u0131 farmakoloji:<\/span><\/span><\/strong> \u00a0Psilocybin, DMT ve di\u011fer triptaminlere do\u011fru.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Deneysel K\u0131lavuzlar<\/span><\/span><\/strong><\/h3>\n

        \u00d6nerilen Konsantrasyonlar<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        Ba\u015fvuru<\/span><\/span><\/strong><\/th>\nKonsantrasyon aral\u0131\u011f\u0131<\/span><\/span><\/strong><\/th>\n\u00c7\u00f6z\u00fcc\u00fc<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
        H\u00fccre k\u00fclt\u00fcrleri (in vitro)<\/span><\/span><\/td>\n1 nM \u2013 10 \u03bcM<\/span><\/span><\/td>\nPBS\/DMEM (\u22640.1% DMSO)<\/span><\/span><\/td>\n<\/tr>\n
        Resept\u00f6r analizleri<\/span><\/span><\/td>\n0,1 \u2013 100 \u03bcM<\/span><\/span><\/td>\nTris-HCl tamponu (pH 7,4)<\/span><\/span><\/td>\n<\/tr>\n
        Hayvan \u00e7al\u0131\u015fmalar\u0131 (ip\/iv)<\/span><\/span><\/td>\n0,1 \u2013 5 mg\/kg<\/span><\/span><\/td>\nSteril tuzlu su \u00e7\u00f6zeltisi<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        G\u00fcvenlik \u00f6nlemleri<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          Ki\u015fisel koruma:<\/span><\/span><\/strong> \u00a0Laboratuvar \u00f6nl\u00fc\u011f\u00fc, eldiven (nitril), g\u00fcvenlik g\u00f6zl\u00fc\u011f\u00fc.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Kullan\u0131m:<\/span><\/span><\/strong> \u00a0Higroskopiktir \u2013 kulland\u0131ktan sonra hemen kapat\u0131n\u0131z.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Depolamak:<\/span><\/span><\/strong> \u00a0Hava ge\u00e7irmez, argon gaz\u0131 alt\u0131nda, -20\u00b0C'de (hidrolizi \u00f6nler).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Stabilite ve Depolama<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            Raf \u00f6mr\u00fc:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              -20\u00b0C:<\/span><\/span><\/strong> \u00a0>2 y\u0131l (safl\u0131\u011f\u0131 de\u011fi\u015fmeden).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4\u00b0C:<\/span><\/span><\/strong> \u00a06 ay (kuru ortamda).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              K\u00fcme d\u00fc\u015fme:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Uzun s\u00fcreli nem maruziyetinde hidroliz (HPLC ile izleme).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Analitik Do\u011frulama<\/span><\/span><\/strong><\/h3>\n

                Her partide \u015funlar bulunur:<\/span><\/span><\/p>\n

                  \n
                1. \n

                  HPLC-UV kromatogram\u0131<\/span><\/span><\/strong> \u00a0(C18 kolon, tutulma s\u00fcresi ~6,2 dakika).<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  MS\/MS par\u00e7alanmas\u0131<\/span><\/span><\/strong> \u00a0(karakteristik iyonlar: m\/z 219 \u2192 174, 160).<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  Art\u0131k \u00e7\u00f6z\u00fcc\u00fcler<\/span><\/span><\/strong> \u00a0(ICH Q3C y\u00f6nergelerini kar\u015f\u0131lay\u0131n).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  Yasal Durum (Hollanda\/AB)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    Narkotik mevzuat\u0131:<\/span><\/span><\/strong> \u00a0Afyon Yasas\u0131'nda a\u00e7\u0131k\u00e7a belirtilmemi\u015f, ancak muhtemelen benzer mevzuatta (Ek II) yer almaktad\u0131r.<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Bilimsel kullan\u0131m\u0131:<\/span><\/span><\/strong> \u00a0Kurumlar i\u00e7in izin gereklidir (hayvan deneyleri i\u00e7in CCMO onay\u0131).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    \u0130hracat kontrol\u00fc:<\/span><\/span><\/strong> \u00a0AB Y\u00f6netmeli\u011fi 2019\/1998'e (psikotropik maddeler) tabidir.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    S\u0131k\u00e7a Sorulan Sorular (SSS)<\/span><\/span><\/strong><\/h3>\n

                    Q1 <\/span>: HCl'nin serbest baza g\u00f6re avantajlar\u0131 nelerdir?<\/span><\/strong><\/span><\/p>\n

                      \n
                    • \n

                      Geli\u015ftirilmi\u015f \u00e7\u00f6z\u00fcn\u00fcrl\u00fck<\/span><\/span><\/strong> \u00a0(enjeksiyon \u00e7al\u0131\u015fmalar\u0131 i\u00e7in idealdir).<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Daha uzun raf \u00f6mr\u00fc<\/span><\/span><\/strong> \u00a0oda s\u0131cakl\u0131\u011f\u0131nda.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      S2: 5-MeO-DMT-HCl uyu\u015fturucu testlerinde tespit edilebilir mi?<\/span><\/span><\/strong>
                      \n A: Evet, \u015fu \u015fekilde:<\/span><\/span><\/p>\n

                        \n
                      • \n

                        LC-MS\/MS<\/span><\/span><\/strong> \u00a0(5-MeO-DMT + HCl ad\u00fckt\u00fc olarak tan\u0131n\u0131r).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        \u0130mmunolojik testler:<\/span><\/span><\/strong> \u00a0DMT ile \u00e7apraz reaksiyon (~15-20%).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        S3: MAO inhibit\u00f6rleri ile birlikte kullan\u0131ld\u0131\u011f\u0131nda riskler var m\u0131d\u0131r?<\/span><\/span><\/strong>
                        \n A:\u00a0 <\/span><\/span>Kesinlikle.<\/span><\/span><\/strong><\/p>\n

                          \n
                        • \n

                          Artan risk\u00a0 <\/span><\/span>serotonin sendromu<\/span><\/span><\/strong> \u00a0(birle\u015fimden ka\u00e7\u0131n\u0131n!).<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Sadece MAO i\u00e7ermeyen modellerde kullan\u0131n.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          S4: At\u0131klar nas\u0131l bertaraf edilir?<\/span><\/span><\/strong>
                          \n A:<\/span><\/span><\/p>\n

                            \n
                          1. \n

                            \u0130le n\u00f6tralize edin\u00a0 <\/span><\/span>sodyum bikarbonat<\/span><\/span><\/strong> \u00a0(pH 7-8).<\/span><\/span><\/p>\n<\/li>\n

                          2. \n

                            Adsorbe etmek\u00a0 <\/span><\/span>aktif karbon<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n<\/li>\n

                          3. \n

                            Olarak imha edin\u00a0 <\/span><\/span>tehlikeli kimyasal at\u0131k<\/span><\/span><\/strong> \u00a0(BM 3249, S\u0131n\u0131f 6.1).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                            \n

                            Referanslar ve \u0130leti\u015fim<\/span><\/span><\/strong><\/h3>\n

                            Temel literat\u00fcr:<\/span><\/span><\/strong><\/p>\n

                              \n
                            1. \n

                              Shen ve ark. (2010). \u201c5-MeO-DMT t\u00fcrevlerinin farmakolojisi\u201d.\u00a0 <\/span><\/span>J Psikofarmakol<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n

                            2. \n

                              Kaasik ve ark. (2021). \u201c5-MeO-DMT'nin metabolik yollar\u0131\u201d.\u00a0 <\/span><\/span>Ksenobiyotikler<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                              \n

                              Bu \u00fcr\u00fcn yaln\u0131zca yetkili bilimsel ara\u015ft\u0131rmalar i\u00e7in tasarlanm\u0131\u015ft\u0131r. \u0130nsan t\u00fcketimi veya te\u015fhis ama\u00e7l\u0131 kullan\u0131lamaz. L\u00fctfen yerel y\u00f6netmeliklere uyun.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                              5-MeO-DMT hidroklor\u00fcr \u00f6zellikleri<\/span><\/span><\/span><\/h3>\n

                              E\u015f anlaml\u0131s\u0131:<\/span><\/span><\/strong> 5-metoksi-N,N-dimetiltriptamin hidroklor\u00fcr <\/span><\/span>
                              \nCAS Numaras\u0131:<\/span><\/span><\/strong> sonras\u0131nda <\/span><\/span>
                              \nForm\u00fcl:<\/span><\/span><\/strong> 3-[2-(dimetilamino)etil]-5-metoksiindol hidroklor\u00fcr <\/span><\/span>
                              \nMol k\u00fctlesi:<\/span><\/span><\/strong> 254,8 g\/mol <\/span><\/span>
                              \nSafl\u0131k:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>","protected":false},"featured_media":28720,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[511,381],"product_tag":[326],"class_list":{"0":"post-23504","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-5-meo-dmt-kopen","7":"product_cat-tryptamines","8":"product_tag-nl","10":"first","11":"instock","12":"taxable","13":"shipping-taxable","14":"purchasable","15":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product\/23504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/comments?post=23504"}],"version-history":[{"count":6,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product\/23504\/revisions"}],"predecessor-version":[{"id":28467,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product\/23504\/revisions\/28467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/media\/28720"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/media?parent=23504"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product_brand?post=23504"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product_cat?post=23504"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product_tag?post=23504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}