{"id":27437,"date":"2025-08-30T09:12:39","date_gmt":"2025-08-30T09:12:39","guid":{"rendered":"https:\/\/researchchemicalstore.eu\/?post_type=product&#038;p=27437"},"modified":"2025-11-17T11:48:53","modified_gmt":"2025-11-17T11:48:53","slug":"jjc8-089","status":"publish","type":"product","link":"https:\/\/researchchemicalstore.eu\/tr\/urun\/jjc8-089\/","title":{"rendered":"JJC8-089"},"content":{"rendered":"<p class=\"ds-markdown-paragraph\"><strong>JJC8-089: Motivasyon Ara\u015ft\u0131rmalar\u0131 \u0130\u00e7in G\u00fc\u00e7l\u00fc ve Se\u00e7ici Bir DAT \u0130nhibit\u00f6r\u00fc<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">JJC8-089, motivasyon ve eforla ili\u015fkili davran\u0131\u015flar\u0131n incelenmesi i\u00e7in \u00f6zel olarak tasarlanm\u0131\u015f potansiyel bir ara\u015ft\u0131rma molek\u00fcl\u00fcd\u00fcr. Se\u00e7ici bir dopamin ta\u015f\u0131y\u0131c\u0131 (DAT) inhibit\u00f6r\u00fc olarak, beyindeki h\u00fccre d\u0131\u015f\u0131 dopamin seviyelerini art\u0131r\u0131r.<\/p>\n<p class=\"ds-markdown-paragraph\">Klinik \u00f6ncesi modellerde, JJC8-089&#039;un tetrabenazin (bir VMAT2 inhibit\u00f6r\u00fc) kaynakl\u0131 motivasyon eksikliklerini \u00f6nemli \u00f6l\u00e7\u00fcde giderdi\u011fi g\u00f6sterilmi\u015ftir. Daha kolay ve daha az \u00f6d\u00fcllendirici bir se\u00e7enek yerine, y\u00fcksek \u00e7aba harcama iste\u011fini (\u00f6rne\u011fin, 5 d\u00fc\u011fmeye bas\u0131larak bir g\u00f6rev se\u00e7mek gibi) geri kazand\u0131r\u0131r. Bu \u00f6zellikler, JJC8-089&#039;u (CAS No. 1627576-64-0) depresyon, ilgisizlik ve yorgunluk gibi bozukluklar \u00fczerine sinirbilim ara\u015ft\u0131rmalar\u0131 i\u00e7in de\u011ferli bir farmakolojik ara\u00e7 haline getirir.<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>Temel \u00d6zellikler:<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Molek\u00fcler Form\u00fcl:<\/strong>\u00a0C\u2082\u2082H\u2082\u2088F\u2082N\u2082OS<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Molek\u00fcler A\u011f\u0131rl\u0131k:<\/strong>\u00a0406,53 g\/mol<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Birincil Etki Mekanizmas\u0131:<\/strong>\u00a0Dopamin ta\u015f\u0131y\u0131c\u0131s\u0131n\u0131n (DAT) inhibisyonu<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Ana Ara\u015ft\u0131rma Ba\u015fvurusu:<\/strong>\u00a0Motivasyon ve \u00e7aba odakl\u0131 davran\u0131\u015flar\u0131n incelenmesi.<\/p>\n<\/li>\n<\/ul>\n<hr \/>\n<h3>S\u00fcr\u00fcm 2: Daha Ayr\u0131nt\u0131l\u0131 ve A\u00e7\u0131klay\u0131c\u0131 Metin (Bilimsel bir bro\u015f\u00fcr veya teknik bir sayfa i\u00e7in)<\/h3>\n<p class=\"ds-markdown-paragraph\"><strong>Ba\u015fl\u0131k: JJC8-089: Motivasyonel Patolojilerin \u0130ncelenmesi \u0130\u00e7in Umut Vadeden Bir Ara\u00e7 Bile\u015fi\u011fi<\/strong><\/p>\n<p class=\"ds-markdown-paragraph\">JJC8-089, motivasyonun n\u00f6robiyolojisinin \u00e7\u00f6z\u00fclmesinde \u00f6nemli bir rol oynayan sentezlenmi\u015f bir bile\u015fiktir. Birincil etki mekanizmas\u0131, sinaptik aral\u0131kta dopaminerjik n\u00f6rotransmisyonun artmas\u0131na yol a\u00e7an dopamin ta\u015f\u0131y\u0131c\u0131s\u0131n\u0131n (DAT) inhibisyonudur. Bu etki, \u00f6d\u00fcl, motivasyon ve \u00e7aba gerektiren hedefe y\u00f6nelik davran\u0131\u015flarda bulunma iste\u011fini d\u00fczenlemek i\u00e7in hayati \u00f6nem ta\u015f\u0131r.<\/p>\n<p class=\"ds-markdown-paragraph\">JJC8-089&#039;un ay\u0131rt edici potansiyeli deneysel olarak do\u011frulanm\u0131\u015ft\u0131r. Molek\u00fcl\u00fcn, VMAT2 inhibit\u00f6r\u00fc tetrabenazin (HY-B0590) taraf\u0131ndan tetiklenen yetersiz \u00e7aba motivasyonunu \u00f6nemli \u00f6l\u00e7\u00fcde tersine \u00e7evirdi\u011fi g\u00f6sterilmi\u015ftir. Operant davran\u0131\u015f testlerinde (\u00e7abaya dayal\u0131 se\u00e7im g\u00f6revleri), JJC8-089, hayvanlar\u0131n d\u00fc\u015f\u00fck \u00e7aba gerektiren bir alternatife g\u00f6re daha b\u00fcy\u00fck bir \u00f6d\u00fcl sa\u011flayan y\u00fcksek \u00e7aba gerektiren bir g\u00f6reve (sabit oranl\u0131 5 bar presleri) olan tercihlerini geri kazand\u0131rm\u0131\u015ft\u0131r. Bu bulgu, patolojik ilgisizlik ve motivasyon azalmas\u0131 ile karakterize durumlar\u0131n ara\u015ft\u0131r\u0131lmas\u0131 i\u00e7in g\u00fc\u00e7l\u00fc bir ara\u00e7 bile\u015fi\u011fi olma potansiyelini vurgulamaktad\u0131r.<\/p>\n<p class=\"ds-markdown-paragraph\"><strong>Teknik \u00d6zellikler:<\/strong><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Kimyasal Ad\u0131:<\/strong>\u00a0[Yap\u0131ya g\u00f6re, \u00f6rne\u011fin, benzhidril s\u00fclf\u00fcr\u00fcn bir t\u00fcrevi]<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>CAS numaras\u0131:<\/strong>\u00a01627576-64-0<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Molek\u00fcler Form\u00fcl:<\/strong>\u00a0C\u2082\u2082H\u2082\u2088F\u2082N\u2082OS<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>Molek\u00fcler A\u011f\u0131rl\u0131k:<\/strong>\u00a0406,53<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>G\u00dcL\u00dcMSEMELER Notasyonu:<\/strong>\u00a0CC(CN1CCN(CC1)CCSC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)<\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong>A\u00e7\u0131klama:<\/strong>\u00a0Sadece ara\u015ft\u0131rma ama\u00e7l\u0131d\u0131r\u00a0<em>in vitro<\/em>\u00a0ve klinik \u00f6ncesi modellerde. \u0130nsan veya veteriner kullan\u0131m\u0131 i\u00e7in de\u011fildir.<\/p>\n<\/li>\n<\/ul>\n<hr \/>\n<h3>S\u00fcr\u00fcm 3: \u00c7ok K\u0131sa &quot;Pitch&quot; (Bir arama motoru veya meta veri i\u00e7in)<\/h3>\n<p class=\"ds-markdown-paragraph\"><strong>JJC8-089 | DAT inhibit\u00f6r\u00fc | Motivasyon ve \u00e7aba \u00fczerine ara\u015ft\u0131rmalar i\u00e7in<\/strong><br \/>\nG\u00fc\u00e7l\u00fc ve se\u00e7ici bir dopamin ta\u015f\u0131y\u0131c\u0131 (DAT) inhibit\u00f6r\u00fcd\u00fcr. Sinirbilim i\u00e7in ara\u015ft\u0131rma kimyasal\u0131. Tetrabenazin etkilerini tersine \u00e7evirir ve klinik \u00f6ncesi modellerde egzersiz tolerans\u0131n\u0131 art\u0131r\u0131r. CAS 1627576-64-0. Form\u00fcl: C\u2082\u2082H\u2082\u2088F\u2082N\u2082OS. MW: 406,53.<\/p>\n<p>JC8-089, motivasyonel eksiklikleri giderebilen ve hedefe y\u00f6nelik aktivitelerde efor gerektiren davran\u0131\u015flar\u0131 art\u0131rabilen bir dopamin ta\u015f\u0131y\u0131c\u0131 (DAT) inhibit\u00f6r\u00fcd\u00fcr. JJC8-089, s\u0131\u00e7anlarda VMAT-2 inhibit\u00f6r\u00fc tetrabenazin (HY-B0590) taraf\u0131ndan olu\u015fturulan d\u00fc\u015f\u00fck efor etkilerini \u00f6nemli \u00f6l\u00e7\u00fcde tersine \u00e7evirmi\u015f ve y\u00fcksek eforlu, sabit oranl\u0131 5 bar presleri ile g\u0131da al\u0131m\u0131 aras\u0131ndaki tercihi art\u0131rm\u0131\u015ft\u0131r.<\/p>\n<p>Molek\u00fcler a\u011f\u0131rl\u0131k<br \/>\n406,53<\/p>\n<p>Form\u00fcl<br \/>\nC22H28F2N2OS<\/p>\n<p>CAS No.<br \/>\n1627576-64-0<\/p>\n<p>G\u00dcL\u00dcMSEMELER<br \/>\nCC(CN1CCN(CC1)CCSC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)<\/p>","protected":false},"excerpt":{"rendered":"<p>JJC8-089: Een Krachtige en Selectieve DAT-Remmer voor Motivatieonderzoek JJC8-089 is een potentieel onderzoeksmolecuul dat specifiek is ontworpen voor de studie<\/p>","protected":false},"featured_media":28805,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[1085],"product_tag":[],"class_list":{"0":"post-27437","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-okategoriserad","8":"first","9":"instock","10":"taxable","11":"shipping-taxable","12":"purchasable","13":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product\/27437","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/comments?post=27437"}],"version-history":[{"count":2,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product\/27437\/revisions"}],"predecessor-version":[{"id":27443,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product\/27437\/revisions\/27443"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/media\/28805"}],"wp:attachment":[{"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/media?parent=27437"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product_brand?post=27437"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product_cat?post=27437"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalstore.eu\/tr\/wp-json\/wp\/v2\/product_tag?post=27437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}